List of works - Frédéric Saudou

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

scientific article published in October 1998

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

scientific journal article

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

scientific article published on March 2007

Enhanced aggressive behavior in mice lacking 5-HT1B receptor.

scientific article published in September 1994

Vesicular glycolysis provides on-board energy for fast axonal transport

scientific article

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

scientific article

The Biology of Huntingtin.

scientific article published on March 2016

Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

scientific article

Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis

scientific article

Identifying polyglutamine protein species in situ that best predict neurodegeneration

scientific article published on 30 October 2011

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

scientific article

Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.

scientific article published on November 2006

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

scientific article

Potential function for the Huntingtin protein as a scaffold for selective autophagy

scientific article published on November 10, 2014

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.

scientific article published on 4 September 2008

Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites.

scientific article published on April 2013

Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.

scientific article

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis.

scientific article published on 21 January 2011

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

scientific article published in February 2006

In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: implication of a calpain-mediated cleavage of active caspase-3.

scientific article published on 12 August 2003

Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease

scientific article

Releasing the brake: restoring fast axonal transport in neurodegenerative disorders.

scientific article published on 30 September 2013

Elongator – an emerging role in neurological disorders

scientific article published on 23 December 2009

Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.

scientific article

Gpr158 mediates osteocalcin's regulation of cognition

scientific article published on 29 August 2017

Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway

scientific journal article

Screening for proteins with polyglutamine expansions in autosomal dominant cerebellar ataxias

scientific article published on 01 December 1996

Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington's Disease

scientific article

IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice.

scientific article published on 18 December 2013

Huntington's disease knock-in male mice show specific anxiety-like behaviour and altered neuronal maturation

scientific article published on December 9, 2011

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.

scientific article published on 12 August 2010

Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms

scientific article published on 23 April 2014

Huntingtin's function in axonal transport is conserved in Drosophila melanogaster

scientific article

Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport.

scientific article

Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.

scientific article

Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells

scientific article

Serine 421 regulates mutant huntingtin toxicity and clearance in mice.

scientific article

Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's Disease human lymphoblasts.

scientific article published on 20 May 2014

Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.

scientific article published in May 2013

Serotonin transporter oligomerization documented in RN46A cells and neurons by sensitized acceptor emission FRET and fluorescence lifetime imaging microscopy.

scientific article published on 27 January 2009

Huntington's disease: how does huntingtin, an anti-apoptotic protein, become toxic?

scientific article

Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington's disease models

scientific article published in Nature Communications

Neuronal network maturation differently affects secretory vesicles and mitochondria transport in axons

scientific article published in Scientific Reports

CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington's disease

scientific article published on 01 August 2019

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

scientific article published on 9 March 2018

Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouse

scientific article

Toward cell specificity in SCA1

scientific article (publication date: 30 May 2002)

Huntington's disease alters human neurodevelopment

scientific article published on 16 July 2020

ATAT1-enriched vesicles promote microtubule acetylation via axonal transport

scientific article published on 18 December 2019

The biology of Huntington's disease.

scientific article published in January 2008

List of works by Frédéric Saudou

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

Enhanced aggressive behavior in mice lacking 5-HT1B receptor.

Vesicular glycolysis provides on-board energy for fast axonal transport

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

The Biology of Huntingtin.

Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis

Identifying polyglutamine protein species in situ that best predict neurodegeneration

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

Potential function for the Huntingtin protein as a scaffold for selective autophagy

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.

Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites.

Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis.

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: implication of a calpain-mediated cleavage of active caspase-3.

Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease

Releasing the brake: restoring fast axonal transport in neurodegenerative disorders.

Elongator – an emerging role in neurological disorders

Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.

Gpr158 mediates osteocalcin's regulation of cognition

Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway

Screening for proteins with polyglutamine expansions in autosomal dominant cerebellar ataxias

Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington's Disease

IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice.

Huntington's disease knock-in male mice show specific anxiety-like behaviour and altered neuronal maturation

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.

Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms

Huntingtin's function in axonal transport is conserved in Drosophila melanogaster

Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport.

Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.

Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells

Serine 421 regulates mutant huntingtin toxicity and clearance in mice.

Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's Disease human lymphoblasts.

Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.

Serotonin transporter oligomerization documented in RN46A cells and neurons by sensitized acceptor emission FRET and fluorescence lifetime imaging microscopy.

Huntington's disease: how does huntingtin, an anti-apoptotic protein, become toxic?

Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington's disease models

Neuronal network maturation differently affects secretory vesicles and mitochondria transport in axons

CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington's disease

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouse

Toward cell specificity in SCA1

Huntington's disease alters human neurodevelopment

ATAT1-enriched vesicles promote microtubule acetylation via axonal transport

The biology of Huntington's disease.