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List of works by Frédéric Saudou

A pathogenic proteolysis-resistant huntingtin isoform induced by an antisense oligonucleotide maintains huntingtin function

scientific article published in 2022

A “so cilia” network: cilia proteins start “social” networking ⬇️

scientific article published on March 26, 2012

ATAT1-enriched vesicles promote microtubule acetylation via axonal transport

scientific article published on 18 December 2019

ATP-citrate lyase promotes axonal transport across species

scientific article published on 07 October 2021

Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's Disease human lymphoblasts.

scientific article published on 20 May 2014

Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells

scientific article

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.

scientific article published on 12 August 2010

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

scientific article published on 24 July 2020

CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington's disease

scientific article published on 01 August 2019

Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease

scientific article

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

scientific article

Cysteamine restores intracellular dynamics and BDNF secretion in Huntington's disease

scientific article

Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

scientific article

Elongator – an emerging role in neurological disorders

scientific article published on 23 December 2009

Enhanced aggressive behavior in mice lacking 5-HT1B receptor.

scientific article published in September 1994

Gpr158 mediates osteocalcin's regulation of cognition

scientific article published on 29 August 2017

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

scientific article published on March 2007

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

scientific article published in October 1998

Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouse

scientific article

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

scientific journal article

Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis

scientific article

Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.

scientific article published in May 2013

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

scientific article

Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice

scientific article published on 08 January 2020

Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.

scientific article

Huntingtin's function in axonal transport is conserved in Drosophila melanogaster

scientific article

Huntington's disease alters human neurodevelopment

scientific article published on 16 July 2020

Huntington's disease knock-in male mice show specific anxiety-like behaviour and altered neuronal maturation ⬇️

scientific article published on December 9, 2011

Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.

scientific article published on November 2006

Huntington's disease: how does huntingtin, an anti-apoptotic protein, become toxic?

scientific article

IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice.

scientific article published on 18 December 2013

Identifying polyglutamine protein species in situ that best predict neurodegeneration

scientific article published on 30 October 2011

In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: implication of a calpain-mediated cleavage of active caspase-3.

scientific article published on 12 August 2003

Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.

scientific article

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

scientific article published in February 2006

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

scientific article

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis.

scientific article published on 21 January 2011

Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway

scientific journal article

Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington's disease models

scientific article published in Nature Communications

Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms

scientific article published on 23 April 2014

Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites.

scientific article published on April 2013

Mutations in the KIF21B kinesin gene cause neurodevelopmental disorders through imbalanced canonical motor activity

scientific article published on 15 May 2020

Neuronal network maturation differently affects secretory vesicles and mitochondria transport in axons

scientific article published in Scientific Reports

Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.

scientific article

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.

scientific article published on 4 September 2008

Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of Huntingtin

scientific article published on 26 May 2020

Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington's Disease

scientific article

Releasing the brake: restoring fast axonal transport in neurodegenerative disorders.

scientific article published on 30 September 2013

Screening for proteins with polyglutamine expansions in autosomal dominant cerebellar ataxias

scientific article published on 01 December 1996

Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport.

scientific article

Serine 421 regulates mutant huntingtin toxicity and clearance in mice.

scientific article

Serotonin transporter oligomerization documented in RN46A cells and neurons by sensitized acceptor emission FRET and fluorescence lifetime imaging microscopy.

scientific article published on 27 January 2009

The Biology of Huntingtin.

scientific article published on March 2016

The biology of Huntington's disease.

scientific article published in January 2008

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

scientific article published on 9 March 2018

Toward cell specificity in SCA1

scientific article (publication date: 30 May 2002)

Vesicular glycolysis provides on-board energy for fast axonal transport

scientific article

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