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List of works by Sian E. Harding

A Software Tool for High-Throughput Real-Time Measurement of Intensity-Based Ratio-Metric FRET

scientific article published on 29 November 2019

A conducting polymer with enhanced electronic stability applied in cardiac models.

scientific article

A novel Z-groove index characterizing myocardial surface structure.

scientific article published on 20 September 2006

Acceleration of contraction by beta-adrenoceptor stimulation is greater in ventricular myocytes from failing than non-failing human hearts

Alterations in β-adrenoceptor mechanisms in the aging heart. Relationship with heart failure ⬇️

scientific article published on December 1, 1997

Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null-mutant mice

scientific journal article

An elastomeric patch derived from poly(glycerol sebacate) for delivery of embryonic stem cells to the heart.

scientific article

An inhibitor of nitric oxide synthase does not increase contraction or beta-adrenoceptor sensitivity of ventricular myocytes from failing human heart

scientific article published on 01 December 1998

Are there functional β3‐adrenoceptors in the human heart? ⬇️

scientific article published on February 1, 2011

Assessment of cellular toxicity of TiO2 nanoparticles for cardiac tissue engineering applications.

scientific article published on 21 September 2010

Auxetic Cardiac Patches with Tunable Mechanical and Conductive Properties toward Treating Myocardial Infarction.

scientific article published in May 2018

Beta-adrenoceptor function changes with age of subject in myocytes from non-failing human ventricle

scientific article published on 01 January 1996

Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation.

scientific article published on 25 February 2010

Biomarkers as predictors of recurrence of atrial fibrillation post ablation: an updated and expanded systematic review and meta-analysis

scientific article published on 09 January 2022

Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro

scientific article published on 15 May 2019

Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study.

scientific article published on 6 June 2008

Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β2AR-cAMP Responsiveness in Murine Hearts.

scientific article published in April 2018

Cardiomyocytes from embryonic stem cells: towards human therapy

scientific article published in October 2008

Cardiostimulant and cardiodepressant effects through overexpressed human beta2-adrenoceptors in murine heart: regional differences and functional role of beta1-adrenoceptors.

scientific article published on 4 March 2003

Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling.

scientific article

Cell geometry and contractile abnormalities of myocytes from failing human left ventricle.

scientific article published in August 1995

Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapy

scientific article published on 01 July 2003

Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue.

scientific article published in January 2008

Characterization of acute TLR-7 agonist-induced hemorrhagic myocarditis in mice by multiparametric quantitative cardiac magnetic resonance imaging

scientific article published on 16 August 2019

Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying β-adrenergic stimulation in the rat left ventricle

scientific article

Concise Review: Pluripotent Stem Cell-Derived Cardiac Cells, A Promising Cell Source for Therapy of Heart Failure: Where Do We Stand?

scientific article published on 09 September 2015

Contractile effects of adenovirally-mediated increases in SERCA2a activity: a comparison between adult rat and rabbit ventricular myocytes

scientific article published on 01 September 2003

Cyclic AMP levels in ventricular myocytes from noradrenaline-treated guinea-pigs

scientific article published on 01 August 1996

Effect of overexpressed adenylyl cyclase VI on beta 1- and beta 2-adrenoceptor responses in adult rat ventricular myocytes

scientific article

Effects of Na(+)/Ca(2+)-exchanger overexpression on excitation-contraction coupling in adult rabbit ventricular myocytes.

scientific article published in April 2002

Effects of clenbuterol on contractility and Ca2+ homeostasis of isolated rat ventricular myocytes

scientific article published on 05 September 2008

Effects of inhibition of sarcoplasmic reticulum calcium uptake on contraction in myocytes isolated from failing human ventricle

scientific article published on 01 January 1997

Effects of phorbol ester on contraction, intracellular pH and intracellular Ca2+ in isolated mammalian ventricular myocytes ⬇️

scientific article published on December 1, 1991

Electrospun aniline-tetramer-co-polycaprolactone fibres for conductive, biodegradable scaffolds

scientific article published on 10 July 2017

Enhancement of adenoviral gene transfer to adult rat cardiomyocytes in vivo by immobilization and ultrasound treatment of the heart.

scientific article published in June 2005

Erratum: High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes: [J. Biophotonics 9, No. 3, 311-323 (2016)].

scientific article

Estrogen deficiency compromised the β2AR-Gs/Gi coupling: implications for arrhythmia and cardiac injury.

scientific article published on 2 January 2018

Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes

scientific article (publication date: March 2003)

From overload to failure: what happens inside the myocyte

scientific article published on 01 August 1998

Frontiers in Cardiovascular Biology: A New Federation of European Scientists ⬇️

scientific article published on November 1, 2010

Frontiers in Cardiovascular Biology: London 2012 – a Scientific ‘olympiad‘ ⬇️

scientific article published on September 1, 2012

Functional and morphological maturation of implanted neonatal cardiomyocytes as a comparator for cell therapy.

scientific article published in July 2010

Functional characterization of embryonic stem cell-derived cardiomyocytes using scanning ion conductance microscopy.

scientific article published on April 2006

Functional evidence for a cyclic-AMP related mechanism of action of the beta(2)-adrenoceptor in human ventricular myocytes.

scientific article published on July 2000

Future potential of engineered heart tissue patches for repairing the damage caused by heart attacks

scientific article published on 06 December 2019

G-protein Coupled Receptor Signaling in Pluripotent Stem Cell-derived Cardiovascular Cells: Implications for Disease Modeling

scientific article

Gene transfer in cardiac myocytes.

scientific article published on February 2004

Heart failure therapy: drugs, genes or stem cells?: by Caroline Telfer

scientific article published in September 2013

Hierarchical statistical techniques are necessary to draw reliable conclusions from analysis of isolated cardiomyocyte studies.

scientific article published on 30 August 2017

High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes

scientific article published on 21 October 2015

Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Encapsulating Bioactive Hydrogels Improve Rat Heart Function Post Myocardial Infarction

scientific article published on 4 October 2017

Human stem cell‐derived cardiomyocytes for pharmacological and toxicological modeling ⬇️

scientific article published on 01 December 2011

Identification and characterization of a dysfunctional cardiac myocyte phenotype: role of bacteria, Toll-like receptors, and endothelin.

scientific article published in October 2007

Immunomodulatory interventions in myocardial infarction and heart failure: a systematic review of clinical trials and meta-analysis of IL-1 inhibition

scientific article published on 01 September 2018

Immunosuppressive agents modulate function, growth, and survival of cardiomyocytes and endothelial cells derived from human embryonic stem cells.

scientific article published on 24 December 2013

Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation

scientific article published on 16 May 2021

Incomplete reversal of β‐adrenoceptor desensitization in human and guinea‐pig cardiomyocytes by cyclic nucleotide phosphodiesterase inhibitors ⬇️

scientific article published on August 1, 1993

Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis

scientific article published on 17 May 2017

Innate immunity in human embryonic stem cells: comparison with adult human endothelial cells

scientific article (publication date: 2010)

Intact myocardial preparations reveal intrinsic transmural heterogeneity in cardiac mechanics

scientific article published on 19 March 2020

Interaction between increased SERCA2a activity and beta -adrenoceptor stimulation in adult rabbit myocytes.

scientific article

Investigation of a transgenic mouse model of familial dilated cardiomyopathy.

scientific article published on 17 June 2010

Investigation of cardiac fibroblasts using myocardial slices.

scientific article published on 18 August 2017

Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits

scientific article published on 01 November 2018

Isolated ventricular myocytes from failing and non-failing human heart; the relation of age and clinical status of patients to isoproterenol response

scientific article published on 01 May 1992

MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo

article

Mediastinal Lymphadenopathy, Class-Switched Auto-Antibodies and Myocardial Immune-Complexes During Heart Failure in Rodents and Humans

scientific article published on 07 August 2020

Mentoring perception, scientific collaboration and research performance: is there a 'gender gap' in academic medicine? An Academic Health Science Centre perspective.

scientific article

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

scientific article

Modification of the negative inotropic effect of lanthanum by ouabain and some other positive inotropic agents [proceedings] ⬇️

scientific article published on May 1, 1979

Modulation of human embryonic stem cell-derived cardiomyocyte growth: a testbed for studying human cardiac hypertrophy?

scientific article

Molecular Mechanism of the E99K Mutation in Cardiac Actin (ACTC Gene) That Causes Apical Hypertrophy in Man and Mouse ⬇️

scientific article published on May 26, 2011

Molecular pathways of oestrogen receptors and β-adrenergic receptors in cardiac cells: Recognition of their similarities, interactions and therapeutic value

scientific article

Morphology and vasoactive hormone profiles from endothelial cells derived from stem cells of different sources

scientific article

Multi-cellularity in cardiac tissue engineering, how close are we to native heart tissue?

scientific article published on 20 June 2019

Murine ventricular L-type Ca(2+) current is enhanced by zinterol via beta(1)-adrenoceptors, and is reduced in TG4 mice overexpressing the human beta(2)-adrenoceptor

scientific article

Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in β-adrenergic signaling and enhances apoptosis

scientific journal article

Myocardial tissue engineering

scientific article published on 01 January 2008

Myocardial tissue engineering: a review.

scientific article published on September 2007

Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia

scientific article published on December 1, 1992

Non-invasive imaging of stem cells by scanning ion conductance microscopy: future perspective

scientific article

Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and human failing hearts

scientific journal article

Overexpression of beta 1-adrenoceptors in adult rat ventricular myocytes enhances CGP 12177A cardiostimulation: implications for 'putative' beta 4-adrenoceptor pharmacology

scientific article

Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells.

scientific article published on 29 September 2017

Overwhelming evidence of the beneficial effects of SERCA gene transfer in heart failure

scientific article published on 01 June 2001

PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium

scientific article published on 18 May 2015

Pathogen sensing pathways in human embryonic stem cell derived-endothelial cells: role of NOD1 receptors

scientific article

Poly(3-hydroxyoctanoate), a promising new material for cardiac tissue engineering.

scientific article

Positive inotropic effects of NO donors in isolated guinea-pig and human cardiomyocytes independent of NO species and cyclic nucleotides

scientific article published on 01 December 2000

Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy.

scientific article published on 7 March 2016

Profiling of cAMP and cGMP phosphodiesterases in isolated ventricular cardiomyocytes from human hearts: Comparison with rat and guinea pig ⬇️

scientific article published on January 10, 2012

Proteomic Analysis Reveals Temporal Changes in Protein Expression in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes In Vitro

scientific article published on 20 March 2019

Quantifying the Release of Biomarkers of Myocardial Necrosis from Cardiac Myocytes and Intact Myocardium.

scientific article

Reduced Contraction and Altered Frequency Response of Isolated Ventricular Myocytes From Patients With Heart Failure ⬇️

scientific article published on 01 November 1995

Reduced contractile responses to forskolin and a cyclic AMP analogue in myocytes from failing human ventricle

scientific article published on November 13, 1992

Refinement of in vivo surgical procedures for cardiac gene and cell transfer in rats.

scientific article published in March 2009

Remodelling of adult cardiac tissue subjected to physiological and pathological mechanical load in vitro

scientific article published on 01 February 2022

Repolarization abnormalities unmasked with exercise in sudden cardiac death survivors with structurally normal hearts

scientific article published in November 2017

Role of basal release of nitric oxide on coronary flow and mechanical performance of the isolated rat heart ⬇️

scientific article published on 01 October 1992

Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock.

scientific article published on January 2004

SERCA2a Gene Transfer Decreases Sarcoplasmic Reticulum Calcium Leak and Reduces Ventricular Arrhythmias in a Model of Chronic Heart Failure ⬇️

scientific article published on March 15, 2011

SERCA2a gene therapy in heart failure: an anti-arrhythmic positive inotrope.

scientific article published on January 2014

SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway

scientific journal article

ST-Elevation Magnitude Correlates With Right Ventricular Outflow Tract Conduction Delay in Type I Brugada ECG.

scientific article published in October 2017

Sarcolemmal Na+/H+ exchanger activity and expression in human ventricular myocardium

scientific article published on 01 August 2000

Sarcoplasmic reticulum Ca content, sarcolemmal Ca influx and the genesis of arrhythmias in isolated guinea-pig cardiomyocytes

scientific article published on 01 February 2000

Scanning ion conductance microscopy: a convergent high-resolution technology for multi-parametric analysis of living cardiovascular cells ⬇️

scientific article

Sensitization of Human Atrial 5-HT 4 Receptors by Chronic β-Blocker Treatment ⬇️

scientific article published on 01 November 1995

Signaling via PI3K/FOXO1A pathway modulates formation and survival of human embryonic stem cell-derived endothelial cells

scientific article

Spatial control of the βAR system in heart failure: the transverse tubule and beyond.

scientific article published on 23 January 2013

Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart.

scientific article

Stem cell‐derived endothelial cells for cardiovascular disease: a therapeutic perspective ⬇️

scientific article published on April 1, 2013

Stress (Takotsubo) cardiomyopathy--a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning.

scientific article published on January 2008

Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease.

scientific article published on March 2017

T-tubule remodelling disturbs localized β2-adrenergic signalling in rat ventricular myocytes during the progression of heart failure

scientific article

Takotsubo Cardiomyopathy and Sepsis

scientific article published on 14 June 2016

Takotsubo Syndrome: Latest Addition to the Expanding Family of Immune-Mediated Diseases?

article

Takotsubo Syndrome: Stress or NO Stress?

scientific article published on 01 April 2018

Targeting genes and cells in the progression to heart failure.

scientific article published on July 2005

The Current and Future Landscape of SERCA Gene Therapy for Heart Failure: A Clinical Perspective.

scientific article published on May 2015

The adaptive immune response to cardiac injury-the true roadblock to effective regenerative therapies?

scientific article published on 19 June 2017

The case for induced pluripotent stem cell-derived cardiomyocytes in pharmacological screening ⬇️

scientific article published on May 1, 2013

The effect of microgrooved culture substrates on calcium cycling of cardiac myocytes derived from human induced pluripotent stem cells

scientific article published on 20 December 2012

The effect of pertussis toxin on beta-adrenoceptor responses in isolated cardiac myocytes from noradrenaline-treated guinea-pigs and patients with cardiac failure ⬇️

scientific article published on May 1, 1992

The mitochondrial permeability transition pore as a target for cardioprotection in hypertrophic cardiomyopathy.

scientific article

The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy

scientific article

The role of Gi-proteins and beta-adrenoceptors in the age-related decline of contraction in guinea-pig ventricular myocytes

scientific article published on 01 February 1997

The role of cAMP in the frequency-dependent changes in contraction of guinea-pig cardiomyocytes ⬇️

scientific article published on February 1, 1998

Three Huntington's Disease Specific Mutation-Carrying Human Embryonic Stem Cell Lines Have Stable Number of CAG Repeats upon In Vitro Differentiation into Cardiomyocytes.

scientific article published on 20 May 2015

Transcriptional co-activators YAP1-TAZ of Hippo signalling in doxorubicin-induced cardiomyopathy

scientific article published on 21 December 2021

Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia: reply.

scientific article published on 27 March 2013

Understanding dynamic tissue organization by studying the human body one cell at a time: the human cell atlas (HCA) project

scientific article published on 01 October 2018

Ventricular conduction stability test: a method to identify and quantify changes in whole heart activation patterns during physiological stress

scientific article published on 01 September 2019

β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes

scientific article published on 31 March 2020

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