List of works - Björn Tyrberg

A method for the generation of human stem cell-derived alpha cells

scientific article published on 07 May 2020

Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors

scientific article published on 24 September 2013

Basic helix-loop-helix gene Hes6 delineates the sensory hair cell lineage in the inner ear.

scientific article

Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas.

scientific article published on 19 February 2006

Beta-cells, oxidative stress, lysosomal stability, and apoptotic/necrotic cell death

scientific article published on 01 January 1999

Current and future treatment strategies for type 2 diabetes: the beta-cell as a therapeutic target.

scientific article

Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling

scientific article published on 22 January 2019

Engraftment and growth of transplanted pancreatic islets.

scientific article

Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients

scientific article published in PLoS ONE

HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion

scientific article

Human islets in mixed islet grafts protect mouse pancreatic beta-cells from alloxan toxicity.

scientific article

Human pancreatic beta-cell deoxyribonucleic acid-synthesis in islet grafts decreases with increasing organ donor age but increases in response to glucose stimulation in vitro

scientific article published on 01 December 1996

Long noncoding RNAs are dynamically regulated during β-cell mass expansion in mouse pregnancy and control β-cell proliferation in vitro

scientific article

Microcirculation of human pancreatic islets transplanted under the renal capsule of nude mice

scientific article published on 01 August 2001

NeuroD1 in the endocrine pancreas: localization and dual function as an activator and repressor.

scientific article

No direct effect of SGLT2 activity on glucagon secretion

scientific article published on 22 March 2019

Promoting islet cell function after transplantation.

scientific article published in January 2004

Regulation of the β-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis

scientific article published on 16 August 2018

Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death

scientific article published on 01 October 1996

Stimulated endocrine cell proliferation and differentiation in transplanted human pancreatic islets: effects of the ob gene and compensatory growth of the implantation organ.

scientific article published on February 2001

Sweet taste receptor deficient mice have decreased adiposity and increased bone mass

scientific article published on 22 January 2014

Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion.

scientific article published on 6 February 2012

Sweet taste receptors regulate basal insulin secretion and contribute to compensatory insulin hypersecretion during the development of diabetes in male mice.

scientific article

T-cadherin (Cdh13) in association with pancreatic β-cell granules contributes to second phase insulin secretion ⬇️

scientific article published on November 1, 2011

The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets

scientific article published on 17 June 2020

The No-Go and Nonsense-Mediated RNA Decay Pathways Are Regulated by Inflammatory Cytokines in Insulin-Producing Cells and Human Islets and Determine β-Cell Insulin Biosynthesis and Survival

scientific article published on 31 July 2018

The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins ⬇️

scientific article published on March 1, 2012

“Tasting” fructose with pancreatic beta-cells: modulation of insulin release by sweet taste receptor signaling and its role in metabolic diseases.

scientific article published in June 2012

List of works by Björn Tyrberg

A method for the generation of human stem cell-derived alpha cells

Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors

Basic helix-loop-helix gene Hes6 delineates the sensory hair cell lineage in the inner ear.

Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas.

Beta-cells, oxidative stress, lysosomal stability, and apoptotic/necrotic cell death

Current and future treatment strategies for type 2 diabetes: the beta-cell as a therapeutic target.

Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling

Engraftment and growth of transplanted pancreatic islets.

Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients

HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion

Human islets in mixed islet grafts protect mouse pancreatic beta-cells from alloxan toxicity.

Human pancreatic beta-cell deoxyribonucleic acid-synthesis in islet grafts decreases with increasing organ donor age but increases in response to glucose stimulation in vitro

Long noncoding RNAs are dynamically regulated during β-cell mass expansion in mouse pregnancy and control β-cell proliferation in vitro

Microcirculation of human pancreatic islets transplanted under the renal capsule of nude mice

NeuroD1 in the endocrine pancreas: localization and dual function as an activator and repressor.

No direct effect of SGLT2 activity on glucagon secretion

Promoting islet cell function after transplantation.

Regulation of the β-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis

Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death

Stimulated endocrine cell proliferation and differentiation in transplanted human pancreatic islets: effects of the ob gene and compensatory growth of the implantation organ.

Sweet taste receptor deficient mice have decreased adiposity and increased bone mass

Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion.

Sweet taste receptors regulate basal insulin secretion and contribute to compensatory insulin hypersecretion during the development of diabetes in male mice.

T-cadherin (Cdh13) in association with pancreatic β-cell granules contributes to second phase insulin secretion ⬇️

The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets

The No-Go and Nonsense-Mediated RNA Decay Pathways Are Regulated by Inflammatory Cytokines in Insulin-Producing Cells and Human Islets and Determine β-Cell Insulin Biosynthesis and Survival

The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins ⬇️

“Tasting” fructose with pancreatic beta-cells: modulation of insulin release by sweet taste receptor signaling and its role in metabolic diseases.