List of works - Laia de Nadal

A Synthetic Multicellular Memory Device.

scientific article published on 21 July 2016

A genetic analysis reveals novel histone residues required for transcriptional reprogramming upon stress

scientific article published on 17 February 2020

A novel mechanism for the prevention of transcription replication conflicts

scientific article published on 28 March 2018

A novel role for lncRNAs in cell cycle control during stress adaptation

scientific article published on 28 September 2014

A role for the Ppz Ser/Thr protein phosphatases in the regulation of translation elongation factor 1Balpha.

scientific article

Activation of the Hog1 MAPK by the Ssk2/Ssk22 MAP3Ks, in the absence of the osmosensors, is not sufficient to trigger osmostress adaptation in Saccharomyces cerevisiae.

scientific article published on 17 January 2018

An RB insensitive to CDK regulation.

scientific article published on 14 December 2016

Biochemical and genetic analyses of the role of yeast casein kinase 2 in salt tolerance

scientific article published on October 1999

Control of Cdc28 CDK1 by a stress-induced lncRNA

scientific article

Control of Ubp3 ubiquitin protease activity by the Hog1 SAPK modulates transcription upon osmostress.

scientific article

Controlling gene expression in response to stress.

scientific article

Coordinated control of replication and transcription by a SAPK protects genomic integrity.

scientific article

Data-driven identification of inherent features of eukaryotic stress-responsive genes

scientific article published on 07 March 2022

Dealing with osmostress through MAP kinase activation.

scientific article

Dealing with transcriptional outbursts during S phase to protect genomic integrity.

scientific article published on 07 September 2013

Distributed biological computation with multicellular engineered networks

scientific article

Elongating under Stress.

scientific article published on 7 September 2011

Evolution of protein phosphorylation across 18 fungal species.

scientific article published in October 2016

Functional Network Analysis Reveals the Relevance of SKIIP in the Regulation of Alternative Splicing by p38 SAPK

scientific article published on 01 April 2019

H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes

scientific article published on 26 March 2015

Hog1 activation delays mitotic exit via phosphorylation of Net1

scientific article published on 07 April 2020

Hog1 bypasses stress-mediated down-regulation of transcription by RNA polymerase II redistribution and chromatin remodeling

scientific article

Hog1 targets Whi5 and Msa1 transcription factors to downregulate cyclin expression upon stress.

scientific article

Implementation of Complex Biological Logic Circuits Using Spatially Distributed Multicellular Consortia

scientific article published in February 2016

Interaction Dynamics Determine Signaling and Output Pathway Responses.

scientific article

Maize protein kinase CK2: regulation and functionality of three beta regulatory subunits.

scientific article

Mucins, osmosensors in eukaryotic cells?

scientific article published on 05 November 2007

Multilayered control of gene expression by stress-activated protein kinases.

scientific article

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts.

scientific article published on 25 January 2018

Osmostress-induced gene expression--a model to understand how stress-activated protein kinases (SAPKs) regulate transcription

scientific article

Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II.

scientific article

Osteoblast-secreted factors mediate dormancy of metastatic prostate cancer in the bone via activation of the TGFβRIII-p38MAPK-pS249/T252RB pathway.

scientific article published on 7 March 2018

Phosphorylation and Proteasome Recognition of the mRNA-Binding Protein Cth2 Facilitates Yeast Adaptation to Iron Deficiency

scientific article published in 2018

Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity

scientific article

Plug-and-Play Multicellular Circuits with Time-Dependent Dynamic Responses.

scientific article published on 27 March 2018

Rapid reversible changes in compartments and local chromatin organization revealed by hyperosmotic shock

scientific article published on 06 December 2018

Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes.

scientific article published on 15 January 2009

Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress

scientific article

Regulation of transcription elongation in response to osmostress.

scientific article published on 20 November 2017

Role of the Sln1-phosphorelay pathway in the response to hyperosmotic stress in the yeast Kluyveromyces lactis.

scientific article published on 13 March 2017

Selective requirement for SAGA in Hog1-mediated gene expression depending on the severity of the external osmostress conditions

scientific article published on 2 April 2007

Sensitive high-throughput single-cell RNA-seq reveals within-clonal transcript correlations in yeast populations

scientific article published on 04 February 2019

Synthetic biology: insights into biological computation.

scientific article

Targeting the MEF2-like transcription factor Smp1 by the stress-activated Hog1 mitogen-activated protein kinase

scientific article

The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms

scientific article published on 5 September 2012

The Hog1 stress-activated protein kinase targets nucleoporins to control mRNA export upon stress

scientific article

The Hog1 stress-activated protein kinase targets nucleoporins to control mRNA export upon stress

scientific article published in 2015

The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation

scientific article published on 11 October 2017

The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes.

scientific article

The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells.

scientific article published on 14 September 2016

The NH2-terminal extension of protein phosphatase PPZ1 has an essential functional role.

scientific article

The Rpd3L HDAC complex is essential for the heat stress response in yeast.

scientific article

The Stress-Activated Hog1 Kinase Is a Selective Transcriptional Elongation Factor for Genes Responding to Osmotic Stress

article

The p38 Pathway: From Biology to Cancer Therapy

scientific article published on 11 March 2020

The p38 and Hog1 SAPKs control cell cycle progression in response to environmental stresses

scientific article published on 20 July 2012

The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress

scientific article

The regulation of Net1/Cdc14 by the Hog1 MAPK upon osmostress unravels a new mechanism regulating mitosis

scientific article published on 14 August 2020

The yeast halotolerance determinant Hal3p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase.

scientific article

Timing of gene expression in a cell-fate decision system

scientific article published on 25 April 2018

Transient activation of the HOG MAPK pathway regulates bimodal gene expression.

scientific article

Yeast Single-cell RNA-seq, Cell by Cell and Step by Step

publication published on 05 September 2019

List of works by Laia de Nadal

A Synthetic Multicellular Memory Device.

A genetic analysis reveals novel histone residues required for transcriptional reprogramming upon stress

A novel mechanism for the prevention of transcription replication conflicts

A novel role for lncRNAs in cell cycle control during stress adaptation

A role for the Ppz Ser/Thr protein phosphatases in the regulation of translation elongation factor 1Balpha.

Activation of the Hog1 MAPK by the Ssk2/Ssk22 MAP3Ks, in the absence of the osmosensors, is not sufficient to trigger osmostress adaptation in Saccharomyces cerevisiae.

An RB insensitive to CDK regulation.

Biochemical and genetic analyses of the role of yeast casein kinase 2 in salt tolerance

Control of Cdc28 CDK1 by a stress-induced lncRNA

Control of Ubp3 ubiquitin protease activity by the Hog1 SAPK modulates transcription upon osmostress.

Controlling gene expression in response to stress.

Coordinated control of replication and transcription by a SAPK protects genomic integrity.

Data-driven identification of inherent features of eukaryotic stress-responsive genes

Dealing with osmostress through MAP kinase activation.

Dealing with transcriptional outbursts during S phase to protect genomic integrity.

Distributed biological computation with multicellular engineered networks

Elongating under Stress.

Evolution of protein phosphorylation across 18 fungal species.

Functional Network Analysis Reveals the Relevance of SKIIP in the Regulation of Alternative Splicing by p38 SAPK

H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes

Hog1 activation delays mitotic exit via phosphorylation of Net1

Hog1 bypasses stress-mediated down-regulation of transcription by RNA polymerase II redistribution and chromatin remodeling

Hog1 targets Whi5 and Msa1 transcription factors to downregulate cyclin expression upon stress.

Implementation of Complex Biological Logic Circuits Using Spatially Distributed Multicellular Consortia

Interaction Dynamics Determine Signaling and Output Pathway Responses.

Maize protein kinase CK2: regulation and functionality of three beta regulatory subunits.

Mucins, osmosensors in eukaryotic cells?

Multilayered control of gene expression by stress-activated protein kinases.

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts.

Osmostress-induced gene expression--a model to understand how stress-activated protein kinases (SAPKs) regulate transcription

Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II.

Osteoblast-secreted factors mediate dormancy of metastatic prostate cancer in the bone via activation of the TGFβRIII-p38MAPK-pS249/T252RB pathway.

Phosphorylation and Proteasome Recognition of the mRNA-Binding Protein Cth2 Facilitates Yeast Adaptation to Iron Deficiency

Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity

Plug-and-Play Multicellular Circuits with Time-Dependent Dynamic Responses.

Rapid reversible changes in compartments and local chromatin organization revealed by hyperosmotic shock

Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes.

Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress

Regulation of transcription elongation in response to osmostress.

Role of the Sln1-phosphorelay pathway in the response to hyperosmotic stress in the yeast Kluyveromyces lactis.

Selective requirement for SAGA in Hog1-mediated gene expression depending on the severity of the external osmostress conditions

Sensitive high-throughput single-cell RNA-seq reveals within-clonal transcript correlations in yeast populations

Synthetic biology: insights into biological computation.

Targeting the MEF2-like transcription factor Smp1 by the stress-activated Hog1 mitogen-activated protein kinase

The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms

The Hog1 stress-activated protein kinase targets nucleoporins to control mRNA export upon stress

The Hog1 stress-activated protein kinase targets nucleoporins to control mRNA export upon stress

The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation

The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes.

The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells.

The NH2-terminal extension of protein phosphatase PPZ1 has an essential functional role.

The Rpd3L HDAC complex is essential for the heat stress response in yeast.

The Stress-Activated Hog1 Kinase Is a Selective Transcriptional Elongation Factor for Genes Responding to Osmotic Stress

The p38 Pathway: From Biology to Cancer Therapy

The p38 and Hog1 SAPKs control cell cycle progression in response to environmental stresses

The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress

The regulation of Net1/Cdc14 by the Hog1 MAPK upon osmostress unravels a new mechanism regulating mitosis

The yeast halotolerance determinant Hal3p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase.

Timing of gene expression in a cell-fate decision system

Transient activation of the HOG MAPK pathway regulates bimodal gene expression.

Yeast Single-cell RNA-seq, Cell by Cell and Step by Step