List of works - Sean W Limesand

A Synthetic Heterobivalent Ligand Composed of Glucagon-Like Peptide 1 and Yohimbine Specifically Targets β Cells Within the Pancreas

scientific article

Adaptation of ovine fetal pancreatic insulin secretion to chronic hypoglycaemia and euglycaemic correction.

scientific article

Adrenal Demedullation and Oxygen Supplementation Independently Increase Glucose-Stimulated Insulin Concentrations in Fetal Sheep With Intrauterine Growth Restriction

scientific article published on 3 March 2016

Adrenergic receptor stimulation suppresses oxidative metabolism in isolated rat islets and Min6 cells.

scientific article published on 19 January 2018

An islet-stabilizing implant constructed using a preformed vasculature.

scientific article published in March 2008

Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction.

scientific article

Characterization of glucose transporter 8 (GLUT8) in the ovine placenta of normal and growth restricted fetuses.

scientific article published in January 2004

Characterization of glucose-insulin responsiveness and impact of fetal number and sex difference on insulin response in the sheep fetus ⬇️

scientific article published on February 22, 2011

Chronic Adrenergic Signaling Causes Abnormal RNA Expression of Proliferative Genes in Fetal Sheep Islets

scientific article published on 01 October 2018

Chronic fetal hypoglycemia inhibits the later steps of stimulus-secretion coupling in pancreatic beta-cells

scientific article published on 09 January 2007

Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep.

scientific article published on 04 December 2007

Chronic pulsatile hyperglycemia reduces insulin secretion and increases accumulation of reactive oxygen species in fetal sheep islets.

scientific article

Classic solutions to a modern problem: exercise training improves metabolic disorders in offspring from fathers on a high fat diet

scientific article published on 05 December 2018

Decreased nutrient-stimulated insulin secretion in chronically hypoglycemic late-gestation fetal sheep is due to an intrinsic islet defect

scientific article published on 28 March 2006

Differential effects of chronic pulsatile versus chronic constant maternal hyperglycemia on fetal pancreatic β-cells.

scientific article published on 22 October 2012

Diminished β-cell replication contributes to reduced β-cell mass in fetal sheep with intrauterine growth restriction

article

Effects of bacterial lipopolysaccharide injection on white blood cell counts, hematological variables, and serum glucose, insulin, and cortisol concentrations in ewes fed low- or high-protein diets.

scientific article published on 25 July 2011

Effects of chronic hypoglycemia and euglycemic correction on lysine metabolism in fetal sheep

scientific article published on 03 February 2009

Effects of oxytocin, lipopolysaccharide (LPS), and polyunsaturated fatty acids on prostaglandin secretion and gene expression in equine endometrial explant cultures

scientific article published on 29 September 2012

Elevated plasma norepinephrine inhibits insulin secretion, but adrenergic blockade reveals enhanced β-cell responsiveness in an ovine model of placental insufficiency at 0.7 of gestation

scientific article published on October 2013

Enhanced insulin secretion responsiveness and islet adrenergic desensitization after chronic norepinephrine suppression is discontinued in fetal sheep.

scientific article

Fetal adaptations in insulin secretion result from high catecholamines during placental insufficiency.

scientific article

Fetal adrenal demedullation lowers circulating norepinephrine and attenuates growth restriction but not reduction of endocrine cell mass in an ovine model of intrauterine growth restriction

scientific article

Function and expression of sulfonylurea, adrenergic, and glucagon-like peptide 1 receptors in isolated porcine islets

scientific article

Gestational Diabetes-Induced Programming of Pancreatic Islets

scientific article published on 01 September 2019

Hetero-bivalent GLP-1/glibenclamide for targeting pancreatic β-cells.

scientific article published on 20 November 2013

Hypothyroidism in utero stimulates pancreatic beta cell proliferation and hyperinsulinaemia in the ovine fetus during late gestation.

scientific article

Hypoxaemia-induced catecholamine secretion from adrenal chromaffin cells inhibits glucose-stimulated hyperinsulinaemia in fetal sheep.

scientific article published on 20 August 2012

Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus

scientific article

Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction.

scientific article published on 25 September 2007

Insights Into the Progression of β-Cell Dysfunction Caused by Preterm Birth

scientific article

Insulin-like growth factor and fibroblast growth factor expression profiles in growth-restricted fetal sheep pancreas.

scientific article

Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine.

scientific article

Localisation of glucose transport in the ruminant placenta: implications for sequential use of transporter isoforms.

scientific article published on 8 December 2004

Myoblasts from intrauterine growth-restricted sheep fetuses exhibit intrinsic deficiencies in proliferation that contribute to smaller semitendinosus myofibres.

scientific article

Pattern of vitellogenesis and follicle maturational competence during the ovarian follicular cycle of Fundulus heteroclitus.

scientific article published in July 1996

Placental insufficiency decreases pancreatic vascularity and disrupts hepatocyte growth factor signaling in the pancreatic islet endothelial cell in fetal sheep

scientific article

Postnatal β2 adrenergic treatment improves insulin sensitivity in lambs with IUGR but not persistent defects in pancreatic islets or skeletal muscle

scientific article published on 29 November 2019

Reductions in insulin concentrations and β-cell mass precede growth restriction in sheep fetuses with placental insufficiency

scientific article published on 31 December 2012

Remembering development - epigenetic responses to fetal malnutrition.

scientific article published in May 2010

Semilunar follicular cycle of an intertidal fish: the Fundulus model.

scientific article published on April 1996

Specificity protein-1 and -3 trans-activate the ovine placental lactogen gene promoter.

scientific article published on 21 April 2009

Structure and transcriptional regulation of the ovine placental lactogen gene.

scientific article published on November 1999

The bovine mammary gland expresses multiple functional isoforms of serotonin receptors.

scientific article published on 04 August 2009

Transcriptional regulation in the placenta during normal and compromised fetal growth.

scientific article

β2-Adrenergic receptor desensitization in perirenal adipose tissue in fetuses and lambs with placental insufficiency-induced intrauterine growth restriction.

scientific article published on 19 July 2010

List of works by Sean W Limesand

A Synthetic Heterobivalent Ligand Composed of Glucagon-Like Peptide 1 and Yohimbine Specifically Targets β Cells Within the Pancreas

Adaptation of ovine fetal pancreatic insulin secretion to chronic hypoglycaemia and euglycaemic correction.

Adrenal Demedullation and Oxygen Supplementation Independently Increase Glucose-Stimulated Insulin Concentrations in Fetal Sheep With Intrauterine Growth Restriction

Adrenergic receptor stimulation suppresses oxidative metabolism in isolated rat islets and Min6 cells.

An islet-stabilizing implant constructed using a preformed vasculature.

Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction.

Characterization of glucose transporter 8 (GLUT8) in the ovine placenta of normal and growth restricted fetuses.

Characterization of glucose-insulin responsiveness and impact of fetal number and sex difference on insulin response in the sheep fetus ⬇️

Chronic Adrenergic Signaling Causes Abnormal RNA Expression of Proliferative Genes in Fetal Sheep Islets

Chronic fetal hypoglycemia inhibits the later steps of stimulus-secretion coupling in pancreatic beta-cells

Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep.

Chronic pulsatile hyperglycemia reduces insulin secretion and increases accumulation of reactive oxygen species in fetal sheep islets.

Classic solutions to a modern problem: exercise training improves metabolic disorders in offspring from fathers on a high fat diet

Decreased nutrient-stimulated insulin secretion in chronically hypoglycemic late-gestation fetal sheep is due to an intrinsic islet defect

Differential effects of chronic pulsatile versus chronic constant maternal hyperglycemia on fetal pancreatic β-cells.

Diminished β-cell replication contributes to reduced β-cell mass in fetal sheep with intrauterine growth restriction

Effects of bacterial lipopolysaccharide injection on white blood cell counts, hematological variables, and serum glucose, insulin, and cortisol concentrations in ewes fed low- or high-protein diets.

Effects of chronic hypoglycemia and euglycemic correction on lysine metabolism in fetal sheep

Effects of oxytocin, lipopolysaccharide (LPS), and polyunsaturated fatty acids on prostaglandin secretion and gene expression in equine endometrial explant cultures

Elevated plasma norepinephrine inhibits insulin secretion, but adrenergic blockade reveals enhanced β-cell responsiveness in an ovine model of placental insufficiency at 0.7 of gestation

Enhanced insulin secretion responsiveness and islet adrenergic desensitization after chronic norepinephrine suppression is discontinued in fetal sheep.

Fetal adaptations in insulin secretion result from high catecholamines during placental insufficiency.

Fetal adrenal demedullation lowers circulating norepinephrine and attenuates growth restriction but not reduction of endocrine cell mass in an ovine model of intrauterine growth restriction

Function and expression of sulfonylurea, adrenergic, and glucagon-like peptide 1 receptors in isolated porcine islets

Gestational Diabetes-Induced Programming of Pancreatic Islets

Hetero-bivalent GLP-1/glibenclamide for targeting pancreatic β-cells.

Hypothyroidism in utero stimulates pancreatic beta cell proliferation and hyperinsulinaemia in the ovine fetus during late gestation.

Hypoxaemia-induced catecholamine secretion from adrenal chromaffin cells inhibits glucose-stimulated hyperinsulinaemia in fetal sheep.

Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus

Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction.

Insights Into the Progression of β-Cell Dysfunction Caused by Preterm Birth

Insulin-like growth factor and fibroblast growth factor expression profiles in growth-restricted fetal sheep pancreas.

Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine.

Localisation of glucose transport in the ruminant placenta: implications for sequential use of transporter isoforms.

Myoblasts from intrauterine growth-restricted sheep fetuses exhibit intrinsic deficiencies in proliferation that contribute to smaller semitendinosus myofibres.

Pattern of vitellogenesis and follicle maturational competence during the ovarian follicular cycle of Fundulus heteroclitus.

Placental insufficiency decreases pancreatic vascularity and disrupts hepatocyte growth factor signaling in the pancreatic islet endothelial cell in fetal sheep

Postnatal β2 adrenergic treatment improves insulin sensitivity in lambs with IUGR but not persistent defects in pancreatic islets or skeletal muscle

Reductions in insulin concentrations and β-cell mass precede growth restriction in sheep fetuses with placental insufficiency

Remembering development - epigenetic responses to fetal malnutrition.

Semilunar follicular cycle of an intertidal fish: the Fundulus model.

Specificity protein-1 and -3 trans-activate the ovine placental lactogen gene promoter.

Structure and transcriptional regulation of the ovine placental lactogen gene.

The bovine mammary gland expresses multiple functional isoforms of serotonin receptors.

Transcriptional regulation in the placenta during normal and compromised fetal growth.

β2-Adrenergic receptor desensitization in perirenal adipose tissue in fetuses and lambs with placental insufficiency-induced intrauterine growth restriction.