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List of works by Renske D. Steenbergen

A Strategy to Find Suitable Reference Genes for miRNA Quantitative PCR Analysis and Its Application to Cervical Specimens.

scientific article

A protocol for urine collection and storage prior to DNA methylation analysis

scientific article published in PLoS ONE

A role for EZH2 in silencing of IFN-gamma inducible MHC2TA transcription in uveal melanoma.

scientific article

Aberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence.

scientific article published on 30 May 2016

Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide

scientific article

Age-dependence of human papillomavirus DNA presence in oral squamous cell carcinomas

scientific article published on January 1996

Alterations in AP-1 and AP-1 regulatory genes during HPV-induced carcinogenesis.

scientific article published in January 2008

Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis

scientific article

Alternative splicing of human papillomavirus type-16 E6/E6* early mRNA is coupled to EGF signaling via Erk1/2 activation

scientific article

Analysis of p53 status in tonsillar carcinomas associated with human papillomavirus

scientific article published on 01 October 1994

Assessment of TGF-beta1-mediated growth inhibition of HPV-16- and HPV-18-transfected foreskin keratinocytes during and following immortalization.

scientific article published on 24 October 2003

Association Between Type-specific HPV Infections and hTERT DNA Methylation in Patients with Invasive Cervical Cancer.

scientific article published on January 2016

Association between dense CADM1 promoter methylation and reduced protein expression in high-grade CIN and cervical SCC.

scientific article

Bladder cancer detection in urine using DNA methylation markers: a technical and prospective preclinical validation

scientific article published on 5 February 2022

CADM1 and MAL promoter methylation levels in hrHPV-positive cervical scrapes increase proportional to degree and duration of underlying cervical disease.

scientific article published on 4 April 2013

CADM1, MAL and miR124-2 methylation analysis in cervical scrapes to detect cervical and endometrial cancer.

scientific article published on 3 October 2014

CGH arrays compared for DNA isolated from formalin-fixed, paraffin-embedded material

scientific article published on 08 December 2011

Cancer risk stratification of anal intraepithelial neoplasia in HIV-positive men by validated methylation markers associated with progression to cancer

scientific article published on 08 April 2020

Cervical cancer detection by DNA methylation analysis in urine

Cervical cancer risk in HPV-positive women after a negative FAM19A4/mir124-2 methylation test: A post hoc analysis in the POBASCAM trial with 14 year follow-up

scientific article published on 27 April 2018

Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract - a systematic review and meta-analysis.

scientific article

Chromosomal profiles of high-grade cervical intraepithelial neoplasia relate to duration of preceding high-risk human papillomavirus infection

scientific article published on 17 November 2011

Chromosomal signatures of a subset of high-grade premalignant cervical lesions closely resemble invasive carcinomas

scientific article published in January 2009

Circulating Tumor DNA Analysis: Clinical Implications for Colorectal Cancer Patients. A Systematic Review

scientific article published on 19 June 2019

Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions.

scientific article published on June 2014

Clinical relevance of human papillomavirus testing in cytopathology.

scientific article

Clonal selection for transcriptionally active viral oncogenes during progression to cancer.

scientific article

Combined CADM1 and MAL promoter methylation analysis to detect (pre-)malignant cervical lesions in high-risk HPV-positive women.

scientific article published on 11 March 2011

Combined CADM1/MAL methylation and cytology testing for colposcopy triage of high-risk HPV-positive women.

scientific article published on 24 June 2014

Combined promoter methylation analysis of CADM1 and MAL: an objective triage tool for high-risk human papillomavirus DNA-positive women

scientific article published on 9 March 2011

Combined sputum hypermethylation and eNose analysis for lung cancer diagnosis.

scientific article published on 10 June 2014

Comparative Analysis of Urine Fractions for Optimal Bladder Cancer Detection Using DNA Methylation Markers

scientific article published on 02 April 2020

Comparing the performance of FAM19A4 methylation analysis, cytology and HPV16/18 genotyping for the detection of cervical (pre)cancer in high-risk HPV-positive women of a gynecologic outpatient population (COMETH study).

scientific article published on 28 August 2015

Complementarity between miRNA expression analysis and DNA methylation analysis in hrHPV-positive cervical scrapes for the detection of cervical disease

scientific article published on 08 April 2019

Comprehensive CADM1 promoter methylation analysis in NSCLC and normal lung specimens.

scientific article published on 9 November 2010

Comprehensive analysis of human papillomavirus prevalence and the potential role of low-risk types in verrucous carcinoma

scientific article published on 08 June 2012

DNA hypermethylation analysis in sputum for the diagnosis of lung cancer: training validation set approach.

scientific article

DNA hypermethylation analysis in sputum of asymptomatic subjects at risk for lung cancer participating in the NELSON trial: argument for maximum screening interval of 2 years

scientific article published on 5 August 2016

DNA methylation markers for endometrial cancer detection in minimally invasive samples: a systematic review

scientific article published on 17 September 2020

DNA methylation markers have universal prognostic value for anal cancer risk in HIV-negative and HIV-positive individuals

scientific article published on 16 March 2021

DPHL: A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery

scientific article published on 11 August 2020

Detection limits of DNA copy number alterations in heterogeneous cell populations

scientific article published on 02 November 2012

Detection of hypermethylated genes as markers for cervical screening in women living with HIV

article

Development of a multiplex methylation-specific PCR as candidate triage test for women with an HPV-positive cervical scrape

scientific article

Development of a replication-deficient adenoviral vector-based vaccine candidate for the interception of HPV16- and HPV18-induced infections and disease

scientific article published on 6 March 2017

Differential In Vitro Immortalization Capacity of Eleven (Probable) High-Risk Human Papillomavirus Types

scientific article published in May 2014

Differential in vitro immortalization capacity of eleven (probable) [corrected] high-risk human papillomavirus types

scientific article

Disc large 1 expression is altered by human papillomavirus E6/E7 proteins in organotypic cultures of human keratinocytes

scientific article published on 9 December 2015

Down-regulation of GATA-3 expression during human papillomavirus-mediated immortalization and cervical carcinogenesis

scientific article

EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration

scientific article published on December 2009

Elevated hTERT mRNA levels: A potential determinant of bronchial squamous cell carcinoma (in situ).

scientific article published on April 2004

Epigenetic markers for early detection of nasopharyngeal carcinoma in a high risk population.

scientific article

Ets proteins: new factors that regulate immunoglobulin heavy-chain gene expression

scientific article published on November 1993

Evaluation of six methylation markers derived from genome-wide screens for detection of cervical precancer and cancer

scientific article published on 17 September 2020

FAM19A4 methylation analysis in self-samples compared with cervical scrapes for detecting cervical (pre)cancer in HPV-positive women

scientific article published on 14 July 2016

FAM19A4/miR124-2 methylation analysis as a triage test for HPV-positive women: cross-sectional and longitudinal data from a Dutch screening cohort

scientific article published on 25 March 2020

FAM19A4/miR124-2 methylation in invasive cervical cancer: A retrospective cross-sectional worldwide study

scientific article published on 07 August 2019

Focal aberrations indicate EYA2 and hsa-miR-375 as oncogene and tumor suppressor in cervical carcinogenesis

scientific article

Focal chromosomal copy number aberrations in cancer-Needles in a genome haystack

scientific article published in 2014

Follow-up of high-risk HPV positive women by combined cytology and bi-marker CADM1/MAL methylation analysis on cervical scrapes.

scientific article published on 8 February 2015

Functional Screen for microRNAs Suppressing Anchorage-Independent Growth in Human Cervical Cancer Cells

scientific article published on 26 April 2022

Gene expression profiling to identify markers associated with deregulated hTERT in HPV-transformed keratinocytes and cervical cancer

scientific article published on February 2008

Gene-dosage dependent overexpression at the 13q amplicon identifies DIS3 as candidate oncogene in colorectal cancer progression.

scientific article published on 29 January 2014

Genome-wide DNA Methylation Profiling Reveals Methylation Markers Associated with 3q Gain for Detection of Cervical Precancer and Cancer.

scientific article published on 24 January 2017

Genome-wide methylome analysis using MethylCap-seq uncovers 4 hypermethylated markers with high sensitivity for both adeno- and squamous-cell cervical carcinoma

scientific article published on 12 October 2016

Genome-wide microRNA analysis of HPV-positive self-samples yields novel triage markers for early detection of cervical cancer.

scientific article

Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck.

scientific article

Good performance of p16/ki-67 dual-stained cytology for surveillance of women treated for high-grade CIN.

scientific article published on 27 September 2016

Gynaecological cancer: Novel molecular subtypes of cervical cancer - potential clinical consequences.

scientific article

HPV E4 expression and DNA hypermethylation of CADM1, MAL, and miR124-2 genes in cervical cancer and precursor lesions

scientific article published on 22 August 2018

HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia.

scientific article

HPV-mediated cervical carcinogenesis: concepts and clinical implications

scientific article

HPV-mediated transformation of the anogenital tract.

scientific article

HPV-negative carcinoma of the uterine cervix: a distinct type of cervical cancer with poor prognosis

scientific article published on 17 September 2014

HPV16 variant analysis in primary and recurrent CIN2/3 lesions demonstrates presence of the same consensus variant

HPV16-Related Cervical Cancers and Precancers Have Increased Levels of Host Cell DNA Methylation in Women Living with HIV

scientific article published on 23 October 2018

Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180

scientific article

High Levels of EBV-Encoded RNA 1 (EBER1) Trigger Interferon and Inflammation-Related Genes in Keratinocytes Expressing HPV16 E6/E7

scientific article

High-risk human papillomavirus-positive lung cancer: molecular evidence for a pattern of pulmonary metastasis.

scientific article published on June 2013

Host Cell Deoxyribonucleic Acid Methylation Markers for the Detection of High-grade Anal Intraepithelial Neoplasia and Anal Cancer

scientific article published on 01 March 2019

Host-cell DNA methylation patterns during high-risk HPV-induced carcinogenesis reveal a heterogeneous nature of cervical pre-cancer

scientific article published on 24 August 2018

Human serum leads to differentiation of human hepatoma cells, restoration of very-low-density lipoprotein secretion, and a 1000-fold increase in HCV Japanese fulminant hepatitis type 1 titers.

scientific article published on 17 October 2013

Identification and Validation of a 3-Gene Methylation Classifier for HPV-Based Cervical Screening on Self-Samples

scientific article published on 09 April 2018

Identification of Deregulated Pathways, Key Regulators, and Novel miRNA-mRNA Interactions in HPV-Mediated Transformation

scientific article published on 16 March 2020

Identification of eight candidate target genes of the recurrent 3p12-p14 loss in cervical cancer by integrative genomic profiling

scientific article published on 14 March 2013

Immortalization capacity of HPV types is inversely related to chromosomal instability.

scientific article published on 14 March 2016

Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways.

scientific article

Increased gene copy numbers at chromosome 20q are frequent in both squamous cell carcinomas and adenocarcinomas of the cervix

scientific article

Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer

scientific article

Integrated human papillomavirus type 16 and loss of heterozygosity at 11q22 and 18q21 in an oral carcinoma and its derivative cell line.

scientific article published on November 1995

Interplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14 in cervical cancer

scientific article published on 20 August 2015

Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix.

scientific article

Localization of E2A mRNA expression in developing and adult rat tissues

scientific article

Long-term CIN3+ risk of HPV positive women after triage with FAM19A4/miR124-2 methylation analysis

scientific article published on 08 June 2019

Longitudinal assessment of DNA methylation changes during HPVE6E7-induced immortalization of primary keratinocytes.

scientific article

MAL promoter hypermethylation as a novel prognostic marker in gastric cancer

scientific article

Management of high-risk HPV-positive women for detection of cervical (pre)cancer.

scientific article published on 26 July 2016

Methylation analysis in urine fractions for optimal CIN3 and cervical cancer detection

scientific article published on 13 March 2020

Methylation analysis of the FAM19A4 gene in cervical scrapes is highly efficient in detecting cervical carcinomas and advanced CIN2/3 lesions.

scientific article published on 3 October 2014

Methylation marker analysis and HPV16/18 genotyping in high-risk HPV positive self-sampled specimens to identify women with high grade CIN or cervical cancer.

scientific article published on 8 August 2014

Methylation marker analysis of self-sampled cervico-vaginal lavage specimens to triage high-risk HPV-positive women for colposcopy.

scientific article published on 28 January 2014

Methylation status of the E2 binding sites of HPV16 in cervical lesions determined with the Luminex® xMAP™ system.

scientific article published on 2 December 2011

Methylation-mediated repression of PRDM14 contributes to apoptosis evasion in HPV-positive cancers.

scientific article published on 18 September 2014

Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer.

scientific article

Methylation-mediated transcriptional repression of microRNAs during cervical carcinogenesis

scientific article published on 16 January 2013

Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis

scientific article published on 8 July 2013

Mining for viral fragments in methylation enriched sequencing data

scientific article

Molecular events leading to HPV-induced high grade neoplasia

scientific article

Molecular heterogeneity in human papillomavirus-dependent and -independent vulvar carcinogenesis.

scientific article

Non-invasive detection of endometrial cancer by DNA methylation analysis in urine

scientific article published on 03 November 2020

Non-random allelic losses at 3p, 11p and 13q during HPV-mediated immortalization and concomitant loss of terminal differentiation of human keratinocytes.

scientific article published on May 1998

Oncogenic Role of miR-15a-3p in 13q Amplicon-Driven Colorectal Adenoma-to-Carcinoma Progression

scientific article published on 6 July 2015

Oncolytic adenovirus expressing a p53 variant resistant to degradation by HPV E6 protein exhibits potent and selective replication in cervical cancer.

scientific article

PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro

scientific article

Performance of CADM1/MAL-methylation analysis for monitoring of women treated for high-grade CIN.

scientific article published on 15 July 2016

Point-of-care CRISPR/Cas nucleic acid detection: Recent advances, challenges and opportunities

scientific article published on 26 July 2020

Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7.

scientific article published on 30 April 2012

Prevalence of Epstein-Barr virus in oral squamous cell carcinomas, premalignant lesions and normal mucosa--a study using the polymerase chain reaction.

scientific article published on May 1997

Prevalence of Neovaginal High-Risk Human Papillomavirus Among Transgender Women in The Netherlands.

scientific article published on August 2016

Promoter methylation analysis of WNT/β-catenin signaling pathway regulators to detect adenocarcinoma or its precursor lesion of the cervix.

scientific article published on 2 July 2011

Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas

scientific article

Quantitative reverse transcription-polymerase chain reaction measurement of HASH1 (ASCL1), a marker for small cell lung carcinomas with neuroendocrine features

scientific article (publication date: April 2002)

Repression of MAL tumour suppressor activity by promoter methylation during cervical carcinogenesis.

scientific article

Role of human papillomaviruses in cancer of the respiratory and upper digestive tract.

scientific article published on May 1997

Selection of women at risk for cervical cancer in an HIV-infected South African population.

scientific article published on 7 July 2017

Sequential gene promoter methylation during HPV-induced cervical carcinogenesis

scientific article published on 30 October 2007

Somatic mutation in PIK3CA is a late event in cervical carcinogenesis

scientific article published on 21 September 2015

Specific betapapillomaviruses associated with squamous cell carcinoma of the skin inhibit UVB-induced apoptosis of primary human keratinocytes

scientific article published on 01 September 2008

Symptomatic HPV-related neovaginal lesions in transgender women: case series and review of literature.

scientific article

TSLC1 gene silencing in cervical cancer cell lines and cervical neoplasia

scientific article published on February 2004

Telomerase activity exclusively in cervical carcinomas and a subset of cervical intraepithelial neoplasia grade III lesions: strong association with elevated messenger RNA levels of its catalytic subunit and high-risk human papillomavirus DNA

scientific article published on 01 September 1998

Telomerase activity in high-grade cervical lesions is associated with allelic imbalance at 6Q14-22.

scientific article published on July 2003

Telomerase suppression by chromosome 6 in a human papillomavirus type 16-immortalized keratinocyte cell line and in a cervical cancer cell line

scientific article

The Origin of Tumor DNA in Urine of Urogenital Cancer Patients: Local Shedding and Transrenal Excretion

scientific article published on 31 January 2021

The diagnostic accuracy of methylation markers in urine for the detection of bladder cancer: a systematic review

scientific article published on 25 April 2018

The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer

scientific article published on 10 February 2009

The effect of ART on cervical cancer precursor lesions.

scientific article published on 26 October 2017

The functional role of Notch signaling in HPV-mediated transformation is dose-dependent and linked to AP-1 alterations

scientific article published on 24 January 2012

The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation.

scientific article published on 24 July 2006

The use of host cell DNA methylation analysis in the detection and management of women with advanced cervical intraepithelial neoplasia: a review

scientific article published on 03 July 2020

The use of molecular markers for cervical screening of women living with HIV in South Africa

scientific article published on 01 November 2019

Three sensitive methods for the detection of cytomegalovirus in lung tissue of patients with interstitial pneumonitis

scientific article published on April 1990

Three-tiered score for Ki-67 and p16 improves accuracy and reproducibility of grading CIN lesions

scientific article published on 16 July 2018

Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes towards immortality: activation of telomerase and allele losses at 3p, 10p, 11q and/or 18q.

scientific article published on September 1996

Triage by methylation-marker testing versus cytology in women who test HPV-positive on self-collected cervicovaginal specimens (PROHTECT-3): a randomised controlled non-inferiority trial

scientific article published on 13 February 2014

Triage of high-risk HPV-positive women in population-based screening by miRNA expression analysis in cervical scrapes; a feasibility study.

scientific article

Validation of the FAM19A4/mir124-2 DNA methylation test for both lavage- and brush-based self-samples to detect cervical (pre)cancer in HPV-positive women

scientific article published on 24 February 2016

Viral E6-E7 transcription in the basal layer of organotypic cultures without apparent p21cip1 protein precedes immortalization of human papillomavirus type 16- and 18-transfected human keratinocytes

scientific article

[Human papillomavirus and the development of cervical cancer: concept of carcinogenesis]

scientific article published on 01 August 2000

hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis

scientific article

miR-9-5p Exerts a Dual Role in Cervical Cancer and Targets Transcription Factor TWIST1

scientific article published on 26 December 2019

tigaR: integrative significance analysis of temporal differential gene expression induced by genomic abnormalities

scientific article