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List of works by Paul Schimmel

A domain for editing by an archaebacterial tRNA synthetase

scholarly article

A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase

scientific article

A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities

scientific article published on 18 May 2007

Acinetobacter sp. ADP1: an ideal model organism for genetic analysis and genome engineering

scientific article published on 28 October 2004

Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition

scientific article

Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy

scientific article published on 22 May 2017

Aminoacyl tRNA synthetases and their connections to disease

scholarly article

An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response

scholarly article

Ancient tRNA synthetase meets modern structural biology

scientific article published in March 2009

Author Correction: The selective tRNA aminoacylation mechanism based on a single G•U pair.

scientific article published in December 2018

Bi-allelic Mutations in Phe-tRNA Synthetase Associated with a Multi-system Pulmonary Disease Support Non-translational Function

article

Blocking site-to-site translocation of a misactivated amino acid by mutation of a class I tRNA synthetase

scientific article

CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells

scientific article published on 09 September 2019

Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect.

scholarly article

Crystal structure of a human aminoacyl-tRNA synthetase cytokine

scientific article

Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity

scientific article

Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains

scientific article

Crystallization and preliminary X-ray analysis of a native human tRNA synthetase whose allelic variants are associated with Charcot-Marie-Tooth disease

scientific article

Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme

scientific article

Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy.

scientific article

Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs

scientific article

Dissociating Quaternary Structure Regulates Cell-signaling Functions of a Secreted Human tRNA Synthetase ⬇️

scientific article published on February 10, 2011

Distinct domains of tRNA synthetase recognize the same base pair

scientific journal article

Distinct ways of G:U recognition by conserved tRNA binding motifs

article published in the Proceedings of the National Academy of Sciences of the United States of America

Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy

scientific article

Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration

scientific journal article

Effect of mini-tyrosyl-tRNA synthetase on ischemic angiogenesis, leukocyte recruitment, and vascular permeability

scientific article

Essential nontranslational functions of tRNA synthetases

scientific article published on March 2013

Evidence for annexin II-S100A10 complex and plasmin in mobilization of cytokine activity of human TrpRS

scientific article published on 13 November 2007

Extracellular tyrosyl-tRNA synthetase cleaved by plasma proteinases and stored in platelet α-granules: Potential role in monocyte activation

scientific article published on 14 September 2020

Functional Expansion of the tRNA World under Stress ⬇️

scientific article published on August 19, 2011

Functional and Crystal Structure Analysis of Active Site Adaptations of a Potent Anti-Angiogenic Human tRNA Synthetase

scientific article

Functional expansion of human tRNA synthetases achieved by structural inventions

scientific article

Genetic code ambiguity confers a selective advantage on Acinetobacter baylyi

scientific article

Genetic code ambiguity. Cell viability related to the severity of editing defects in mutant tRNA synthetases

scientific article published on 18 September 2002

Homeostatic mechanisms by alternative forms of tRNA synthetases ⬇️

scientific article published on 02 August 2012

Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine

scientific article (publication date: 20 February 2004)

Identification of the tRNA-dihydrouridine synthase family.

scientific article

Incorporation of nonnatural amino acids into proteins

scientific article published on January 2004

Introduction of a leucine half-zipper engenders multiple high-quality crystals of a recalcitrant tRNA synthetase

scientific article published on 12 February 2010

Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase

scientific article

Major biocontrol of plant tumors targets tRNA synthetase

scientific article

Molecular biology: genetic code seizes pyrrolysine

scientific article published in September 2004

Mutational separation of two pathways for editing by a class I tRNA synthetase.

scientific article published in February 2002

Natural homolog of tRNA synthetase editing domain rescues conditional lethality caused by mistranslation

scientific article published on 22 August 2008

New functions of aminoacyl-tRNA synthetases beyond translation

scientific article

Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality

scientific article

Packaging HIV virion components through dynamic equilibria of a human tRNA synthetase

scientific article

Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma

scientific article

Perfecting the genetic code with an RNP complex

scientific article published on 01 December 2006

Positional recognition of a tRNA determinant dependent on a peptide insertion

scientific article

Relationship of two human tRNA synthetases used in cell signaling

scientific article published on May 2004

Role of a tRNA base modification and its precursors in frameshifting in eukaryotes

scientific article

Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis ⬇️

scientific article published on February 15, 2012

Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor

scientific article

Specificity for aminoacylation of an RNA helix: an unpaired, exocyclic amino group in the minor groove

scientific article

Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription

scientific article

Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex ⬇️

scientific article published on May 2, 2011

The C-Ala Domain Brings Together Editing and Aminoacylation Functions on One tRNA

scientific article

The selective tRNA aminoacylation mechanism based on a single G•U pair

scientific article

The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA.

scientific article

Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling ⬇️

scientific article published on April 15, 2012

Tumor endothelial cell tube formation model for determining anti-angiogenic activity of a tRNA synthetase cytokine

scientific article published on February 2008

Two classes give lessons about CCA.

scientific article

Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis

scientific article

Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.

scientific article

Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia

article published in the Proceedings of the National Academy of Sciences of the United States of America

Uncovering of a short internal peptide activates a tRNA synthetase procytokine

scientific article

VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function.

scientific article published on 3 December 2004

Zinc-Independent Folate Biosynthesis: Genetic, Biochemical, and Structural Investigations Reveal New Metal Dependence for GTP Cyclohydrolase IB

scientific article

p23 H implicated as cis/trans regulator of AlaXp-directed editing for mammalian cell homeostasis ⬇️

scientific article published on February 15, 2011

p53-Dependent DNA damage response sensitive to editing-defective tRNA synthetase in zebrafish

scientific article published on 08 July 2016

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