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List of works by Ashley Pike

A lower X-gate in TASK channels traps inhibitors within the vestibule

scientific article published on 29 April 2020

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels ⬇️

scientific article published on 01 February 2019

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.

scientific article published on 8 November 2010

A structural biologist's view of the oestrogen receptor.

scientific article

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

scientific article

An overview of heavy-atom derivatization of protein crystals

scientific article

Androgen receptor ligand-binding domain interaction and nuclear receptor specificity of FXXLF and LXXLL motifs as determined by L/F swapping

scientific article published on 20 April 2006

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

scientific article published on 24 March 2017

Crystal structures of guinea-pig, goat and bovine alpha-lactalbumin highlight the enhanced conformational flexibility of regions that are significant for its action in lactose synthase

scientific article

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures

scientific article

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

scientific article published in March 2015

Molecular basis of agonism and antagonism in the oestrogen receptor

scientific article

Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2

scientific journal article

Novel FXXFF and FXXMF motifs in androgen receptor cofactors mediate high affinity and specific interactions with the ligand-binding domain

scientific article published on 11 May 2006

Squeezing the most from every crystal: the fine details of data collection.

scientific article

Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase

scientific article

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases

scientific article published on 27 September 2013

Structural insights into the mechanisms of agonism and antagonism in oestrogen receptor isoforms

scientific article published on 01 September 2000

Structural insights into the mode of action of a pure antiestrogen

scientific article

Structure of Fab hGR-2 F6, a competitive antagonist of the glucagon receptor

scientific article

Structure of dystrophia myotonica protein kinase

scientific article

Structure of human factor VIIa and its implications for the triggering of blood coagulation

scientific article

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation

scientific article

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).

scientific article published on 19 December 2016

Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design

scientific article published on 01 November 2018

The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure

scientific article

The structural basis of ZMPSTE24-dependent laminopathies

scientific article

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

scientific article published on 02 September 2019

X-ray crystallography of agonist/antagonist-bound receptors

scientific article published on 01 January 2009

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