List of works - T J Stout

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

scientific article

Structures of active and latent PAI-1: a possible stabilizing role for chloride ions

scientific article

The additivity of substrate fragments in enzyme–ligand binding

scientific article published on July 15, 1998

Discovery of XL413, a potent and selective CDC7 inhibitor

scientific article

Crystal structures of the phosphorylated and unphosphorylated kinase domains of the Cdc42-associated tyrosine kinase ACK1

scientific article

Structure-based design of inhibitors specific for bacterial thymidylate synthase

scientific article

The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition

scientific article

An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q

scientific article

Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRβ

scientific article

D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine

scientific article

Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition

scientific article

The design, synthesis, and biological evaluation of PIM kinase inhibitors

scientific article

Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis

scientific article

The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors

scientific article

SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors

scientific article published on October 16, 2012

Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase γ Inhibitors

scientific article published on May 17, 2012

Can mosquitoes be bitten? A new hope for anti-malarial drug design.

scientific article published in November 2003

<scp>ER</scp>+, <scp>HER2</scp>− advanced breast cancer treated with taselisib and fulvestrant: genomic landscape and associated clinical outcomes

scientific article published in 2023

List of works by T J Stout

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

Structures of active and latent PAI-1: a possible stabilizing role for chloride ions

The additivity of substrate fragments in enzyme–ligand binding

Discovery of XL413, a potent and selective CDC7 inhibitor

Crystal structures of the phosphorylated and unphosphorylated kinase domains of the Cdc42-associated tyrosine kinase ACK1

Structure-based design of inhibitors specific for bacterial thymidylate synthase

The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition

An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q

Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRβ

D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine

Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition

The design, synthesis, and biological evaluation of PIM kinase inhibitors

Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis

The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors

SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors

Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase γ Inhibitors

Can mosquitoes be bitten? A new hope for anti-malarial drug design.

<scp>ER</scp>+, <scp>HER2</scp>− advanced breast cancer treated with taselisib and fulvestrant: genomic landscape and associated clinical outcomes