List of works - T J Stout

<scp>ER</scp>+, <scp>HER2</scp>− advanced breast cancer treated with taselisib and fulvestrant: genomic landscape and associated clinical outcomes

scientific article published in 2023

An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q

scientific article

Can mosquitoes be bitten? A new hope for anti-malarial drug design.

scientific article published in November 2003

Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis

scientific article

Crystal structures of the phosphorylated and unphosphorylated kinase domains of the Cdc42-associated tyrosine kinase ACK1

scientific article

D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine

scientific article

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

scientific article

Discovery of XL413, a potent and selective CDC7 inhibitor

scientific article

Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase γ Inhibitors ⬇️

scientific article published on May 17, 2012

Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRβ

scientific article

Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition

scientific article

SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors ⬇️

scientific article published on October 16, 2012

Structure-based design of inhibitors specific for bacterial thymidylate synthase

scientific article

Structures of active and latent PAI-1: a possible stabilizing role for chloride ions

scientific article

The additivity of substrate fragments in enzyme–ligand binding ⬇️

scientific article published on July 15, 1998

The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition

scientific article

The design, synthesis, and biological evaluation of PIM kinase inhibitors

scientific article

The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors

scientific article

List of works by T J Stout

<scp>ER</scp>+, <scp>HER2</scp>− advanced breast cancer treated with taselisib and fulvestrant: genomic landscape and associated clinical outcomes

An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q

Can mosquitoes be bitten? A new hope for anti-malarial drug design.

Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis

Crystal structures of the phosphorylated and unphosphorylated kinase domains of the Cdc42-associated tyrosine kinase ACK1

D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

Discovery of XL413, a potent and selective CDC7 inhibitor

Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase γ Inhibitors ⬇️

Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRβ

Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition

SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors ⬇️

Structure-based design of inhibitors specific for bacterial thymidylate synthase

Structures of active and latent PAI-1: a possible stabilizing role for chloride ions

The additivity of substrate fragments in enzyme–ligand binding ⬇️

The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition

The design, synthesis, and biological evaluation of PIM kinase inhibitors

The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors