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List of works by Hazel M. Holden

A Structural Study of GDP-4-Keto-6-Deoxy- d -Mannose-3-Dehydratase:  Caught in the Act of Geminal Diamine Formation † , ‡

scientific article

Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase

scientific article

Active site architecture of a sugar N-oxygenase

scientific article

Active site geometry of glucose-1-phosphate uridylyltransferase

scientific article

Bacterial Sugar 3,4-Ketoisomerases: Structural Insight into Product Stereochemistry

scientific article

Biochemical Characterization of WbkC, an N-Formyltransferase from Brucella melitensis

scientific article published on 21 June 2017

Biochemical Investigation of Rv3404c from Mycobacterium tuberculosis

scientific article

Biochemical analysis of a sugar 4,6-dehydratase from Acanthamoeba polyphaga Mimivirus

scientific article published on 21 February 2020

Biochemical and Structural Characterization of WlbA from Bordetella pertussis and Chromobacterium violaceum: Enzymes Required for the Biosynthesis of 2,3-Diacetamido-2,3-dideoxy-d-mannuronic Acid ⬇️

scientific article published on February 8, 2011

Biochemical studies on WbcA, a sugar epimerase from Yersinia enterocolitica

scientific article

Biosynthesis of Nucleoside Diphosphoramidates in Campylobacter jejuni

scientific article

Biosynthetic enzymes of unusual microbial sugars ⬇️

scientific article published on September 9, 2010

Carbamoyl-phosphate synthetase. Creation of an escape route for ammonia

scientific article

Catalytic Mechanism of Perosamine N -Acetyltransferase Revealed by High-Resolution X-ray Crystallographic Studies and Kinetic Analyses

scientific article

Characterization of the dTDP-Fuc3N and dTDP-Qui3N biosynthetic pathways in Campylobacter jejuni 81116.

scientific article published on 16 January 2017

Combined Structural and Functional Investigation of a C-3′′-Ketoreductase Involved in the Biosynthesis of dTDP-l-Digitoxose ⬇️

scientific article published on June 8, 2011

Crystal structure of gene locus At3g16990 from Arabidopsis thaliana

scientific article

Detection of mutations in whole genome-amplified DNA from laser-microdissected neurons

scientific article published on 14 April 2005

Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase

scientific journal article

Discovery of a Glutamine Kinase Required for the Biosynthesis of the O-Methyl Phosphoramidate Modifications Found in the Capsular Polysaccharides of Campylobacter jejuni

scientific article published on 26 June 2017

Divergence of Chemical Function in the Alkaline Phosphatase Superfamily: Structure and Mechanism of the P−C Bond Cleaving Enzyme Phosphonoacetate Hydrolase ⬇️

scientific article published on April 8, 2011

Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFdelta/delta mouse model of amyotrophic lateral sclerosis

scientific article

Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site

scientific article

Enzymes required for the biosynthesis of N-formylated sugars

scientific article published on 19 May 2016

Enzymes with molecular tunnels

scientific article

Evolution of enzymatic activity in the enolase superfamily: functional studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis

scientific article

Evolution of enzymatic activity in the enolase superfamily: structural studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis

scientific article

Functional characterization of the K257R and G319E-hGALE alleles found in patients with ostensibly peripheral epimerase deficiency galactosemia

scientific article

Functional significance of Glu-77 and Tyr-137 within the active site of isoaspartyl dipeptidase

scientific article

GDP-4-keto-6-deoxy-D-mannose 3-dehydratase, accommodating a sugar substrate in the active site

scientific article

GDP-perosamine synthase: structural analysis and production of a novel trideoxysugar

scientific article

High resolution X-ray structure of dTDP-glucose 4,6-dehydratase from Streptomyces venezuelae

scientific article

High resolution X-ray structure of galactose mutarotase from Lactococcus lactis

scientific article

High resolution x-ray structure of tyvelose epimerase from Salmonella typhi

scientific article (publication date: 6 June 2003)

High-resolution X-ray structure of isoaspartyl dipeptidase from Escherichia coli

scientific article (publication date: 6 May 2003)

Identification of inhibitors of N5-carboxyaminoimidazole ribonucleotide synthetase by high-throughput screening

scientific article published on 26 March 2009

Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen

scientific article published on 15 May 2006

Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin

scientific article

Kinetic and structural analysis of alpha-D-Glucose-1-phosphate cytidylyltransferase from Salmonella typhi

scientific article published on 5 January 2005

Kinetic mechanism of asparagine synthetase from Vibrio cholerae

scientific article published in April 2004

Long-range allosteric transitions in carbamoyl phosphate synthetase

scientific article published on September 2004

Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli

scientific article published in May 2005

Misannotations of the genes encoding sugar N-formyltransferases

scientific article published on 20 January 2020

Molecular Architecture of DesI:  A Key Enzyme in the Biosynthesis of Desosamine † , ‡

scientific article

Molecular Architecture of TylM1 from Streptomyces fradiae: An N,N-Dimethyltransferase Involved in the Production of dTDP-d-mycaminose, ⬇️

scientific article published on January 14, 2011

Molecular Architectures of Pen and Pal: Key Enzymes Required for CMP-Pseudaminic Acid Biosynthesis in Bacillus thuringiensis

scientific article published on 20 December 2017

Molecular Structure of WlbB, a Bacterial N -Acetyltransferase Involved in the Biosynthesis of 2,3-Diacetamido-2,3-dideoxy- d -mannuronic Acid,

scientific article

Molecular architecture of DesV fromStreptomyces venezuelae: A PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine

scientific article

Molecular architecture of KedS8, a sugar N-methyltransferase from Streptoalloteichus sp. ATCC 53650.

scientific article published on 14 July 2015

Molecular architecture of a C-3'-methyltransferase involved in the biosynthesis of D-tetronitrose

scientific article

Molecular architecture of an N-formyltransferase from Salmonella enterica O60.

scientific article published on 2 March 2017

Molecular structure of Saccharomyces cerevisiae Gal1p, a bifunctional galactokinase and transcriptional inducer

scientific article published on 22 August 2005

Molecular structure of alpha-D-glucose-1-phosphate cytidylyltransferase from Salmonella typhi

scientific article published on 3 August 2004

Molecular structure of an N-formyltransferase from Providencia alcalifaciens O30.

scientific article

Molecular structure of galactokinase

scientific article

Molecular structure of human galactokinase: implications for type II galactosemia

scientific article

Molecular structure of human galactose mutarotase

scientific article

Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS.

scientific article

New role for the ankyrin repeat revealed by a study of the N-formyltransferase from Providencia alcalifaciens

scientific article published on 15 January 2015

Probing the catalytic mechanism of a C‐3′‐methyltransferase involved in the biosynthesis of D‐tetronitrose ⬇️

scientific article published on April 24, 2012

Production of a Novel N -Monomethylated Dideoxysugar

scientific article

PurT-encoded glycinamide ribonucleotide transformylase. Accommodation of adenosine nucleotide analogs within the active site

scientific article

Structural Analysis of Cj1427, an Essential NAD-Dependent Dehydrogenase for the Biosynthesis of the Heptose Residues in the Capsular Polysaccharides of Campylobacter jejuni

scientific article published on 23 March 2020

Structural Analysis of QdtB, an Aminotransferase Required for the Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-α- d -glucose † ‡

scientific article

Structural Analysis of the Active Site Geometry of N 5 -Carboxyaminoimidazole Ribonucleotide Synthetase from Escherichia coli † , ‡

scientific article

Structural Studies of AntD: An N-Acyltransferase Involved in the Biosynthesis of d-Anthrose ⬇️

scientific article published on January 17, 2012

Structural Studies on a Glucosamine/Glucosaminide N-Acetyltransferase

scientific article

Structural analysis of the Y299C mutant of Escherichia coli UDP-galactose 4-epimerase. Teaching an old dog new tricks

scientific article

Structural and Biochemical Characterization of a Bifunctional Ketoisomerase/ N -Acetyltransferase from Shewanella denitrificans

scientific article

Structural and Biochemical Investigation of PglF from Campylobacter jejuni Reveals a New Mechanism for a Member of the Short Chain Dehydrogenase/Reductase Superfamily

scientific article

Structural and Functional Characterization of YdjI, an Aldolase of Unknown Specificity in Escherichia coli K12

scientific article published on 26 July 2019

Structural and Functional Investigation of FdhC from Acinetobacter nosocomialis: A Sugar N-Acyltransferase Belonging to the GNAT Superfamily

scientific article

Structural and Functional Studies of Aspergillus clavatus N 5 -Carboxyaminoimidazole Ribonucleotide Synthetase,

scientific article

Structural and Functional Studies of QdtC: An N -Acetyltransferase Required for the Biosynthesis of dTDP-3-Acetamido-3,6-dideoxy-α- d -glucose † ‡

scientific article

Structural and Functional Studies of WlbA: A Dehydrogenase Involved in the Biosynthesis of 2,3-Diacetamido-2,3-dideoxy-d-mannuronic Acid, ⬇️

scientific article published on September 14, 2010

Structural and functional studies on a 3'-epimerase involved in the biosynthesis of dTDP-6-deoxy-D-allose

scientific article

Structural and kinetic studies of sugar binding to galactose mutarotase from Lactococcus lactis

scientific article

Structural investigation on WlaRG from Campylobacter jejuni: A sugar aminotransferase

scientific article published on 28 December 2016

Structural studies on KijD1, a sugar C-3'-methyltransferase

scientific article

Structure and function of enzymes of the Leloir pathway for galactose metabolism

scientific article

Structure of CDP-D-glucose 4,6-dehydratase from Salmonella typhi complexed with CDP-D-xylose

scientific article published on 24 March 2005

Structure of EvaA: A Paradigm for Sugar 2,3-Dehydratases ⬇️

scientific article published on March 12, 2013

Structure of L-serine dehydratase from Legionella pneumophila: novel use of the C-terminal cysteine as an intrinsic competitive inhibitor

scientific article

Structure of a Sugar N -Formyltransferase from Campylobacter jejuni

scientific article

Structure of the Escherichia coli ArnA N-formyltransferase domain in complex with N(5) -formyltetrahydrofolate and UDP-Ara4N.

scientific article published on 12 May 2016

Structure of the external aldimine form of PglE, an aminotransferase required for N,N'-diacetylbacillosamine biosynthesis

scientific article

Structures of KdnB and KdnA from Shewanella oneidensis: Key Enzymes in the Formation of 8-Amino-3,8-Dideoxy-d-Manno-Octulosonic Acid

scientific article

The Catalytic Mechanism of the Hotdog-fold Enzyme Superfamily 4-Hydroxybenzoyl-CoA Thioesterase from Arthrobacter sp. Strain SU

scientific article

The High-Resolution Structure of a UDP-l-Rhamnose Synthase from Acanthamoeba polyphaga Mimivirus

scientific article published on 14 August 2020

The Interaction between an Acidic Transcriptional Activator and Its Inhibitor: THE MOLECULAR BASIS OF Gal4p RECOGNITION BY Gal80p

scientific article

The Mycobacterium tuberculosis Complex has a Pathway for the Biosynthesis of 4-Formamido-4,6-Dideoxy-d-Glucose.

scientific article

The catalytic mechanism of galactose mutarotase ⬇️

scientific article (publication date: May 2003)

The enzymes of biotin dependent CO2 metabolism: What structures reveal about their reaction mechanisms ⬇️

scientific article published on November 1, 2012

The molecular architecture of QdtA, a sugar 3,4-ketoisomerase fromThermoanaerobacterium thermosaccharolyticum

scientific article

The molecular architecture of galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae

scientific article published on 28 March 2005

The molecular architecture of glucose-1-phosphate uridylyltransferase

scientific article

The molecular architecture of human N-acetylgalactosamine kinase

scientific article

The structural determination of an insect sterol carrier protein-2 with a ligand-bound C16 fatty acid at 1.35-A resolution

scientific article

The structure of 4-hydroxybenzoyl-CoA thioesterase from arthrobacter sp. strain SU

scientific article

The structure of DesR from Streptomyces venezuelae, a β‐glucosidase involved in macrolide activation ⬇️

scientific article published on January 17, 2013

The structure of GDP-4-keto-6-deoxy-D-mannose-3-dehydratase: a unique coenzyme B6-dependent enzyme

scientific article published on September 2006

The structure of RbmB from Streptomyces ribosidificus, an aminotransferase involved in the biosynthesis of ribostamycin

scientific article

The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution

scientific article

The structure of glucose-1-phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA-type enzymes

scientific article

The three-dimensional structure of NeoB: An aminotransferase involved in the biosynthesis of neomycin

scientific article published on 8 March 2018

The three-dimensional structure of the core domain of Naf Y from Azotobacter vinelandii determined at 1.8-A resolution

scientific article (publication date: 22 August 2003)

The x-ray structure of dTDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase

scientific article

Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis

scientific article

Three-dimensional structure of a sugarN-formyltransferase fromFrancisella tularensis

scientific article

Two Site-Directed Mutations Are Required for the Conversion of a Sugar Dehydratase into an Aminotransferase §

scientific article

W. W. "Mo" Cleland: a catalytic life

scientific article published on 10 December 2013

X-ray crystallographic analyses of inhibitor and substrate complexes of wild-type and mutant 4-hydroxybenzoyl-CoA thioesterase

scientific article

X-ray structure of kijd3, a key enzyme involved in the biosynthesis of D-kijanose

scientific article

pH-rate profiles support a general base mechanism for galactokinase (Lactococcus lactis)

scientific article published on 19 July 2013

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