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List of works by Paul Klenerman

'Favourable' IL28B polymorphisms are associated with a marked increase in baseline viral load in hepatitis C virus subtype 3a infection and do not predict a sustained virological response after 24 weeks of therapy

scientific article published on 13 March 2013

A Rapid-Response Humoral Vaccine Platform Exploiting Pre-Existing Non-Cognate Populations of Anti-Vaccine or Anti-Viral CD4+ T Helper Cells to Confirm B Cell Activation

scientific article

A contaminant-free assessment of Endogenous Retroviral RNA in human plasma

scientific article

A dominant role for the immunoproteasome in CD8+ T cell responses to murine cytomegalovirus

scientific article

A functional and kinetic comparison of antiviral effector and memory cytotoxic T lymphocyte populations in vivo and in vitro ⬇️

scientific article published on December 1, 1997

A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus

scientific article

A highly restricted T-cell receptor dominates the CD8+ T-cell response to parvovirus B19 infection in HLA-A*2402-positive individuals

scientific article published in July 2006

A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory

scientific article published on November 2014

A modified RNA-Seq approach for whole genome sequencing of RNA viruses from faecal and blood samples

scientific article

A molecular assay for sensitive detection of pathogen-specific T-cells

scientific article

A new evolutionary model for hepatitis C virus chronic infection

scientific article

A new model for CD8+ T cell memory inflation based upon a recombinant adenoviral vector

scientific article published on 18 March 2013

A new perspective of the structural complexity of HCMV-specific T-cell responses

scientific article

A non-retroviral RNA virus persists in DNA form ⬇️

scientific article published on November 20, 1997

A novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis

scientific article

A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice

scientific article published on 6 February 2006

A theoretical framework for quantitative analysis of the molecular basis of costimulation

scientific article published in August 2005

AIDS/HIV. Finding footprints among the trees

scientific article published in March 2007

Activated T-Follicular Helper 2 Cells Are Associated With Disease Activity in IgG4-Related Sclerosing Cholangitis and Pancreatitis

scientific article published on 01 April 2019

Adaptation of HIV-1 to human leukocyte antigen class I

scientific article published on 25 February 2009

Additive effect of neutralizing antibody and antiviral drug treatment in preventing virus escape and persistence

scientific article

Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection

scientific article published on 4 July 2014

Adenoviral Vector Vaccination Induces a Conserved Program of CD8(+) T Cell Memory Differentiation in Mouse and Man.

scientific article published on 11 November 2015

Adenoviral vaccine induction of CD8+ T cell memory inflation: Impact of co-infection and infection order

scientific article published on 27 December 2017

Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells

Alterations in the phenotype of CMV-specific and total CD8+ T-cell populations in Wegener's granulomatosis

scientific article published in July 2003

An expanded taxonomy of hepatitis C virus genotype 6: Characterization of 22 new full-length viral genomes

scientific article

An immunodominant NP<sub>105-113</sub>-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

scientific article published on 01 December 2021

An update on hepatitis C virus

scientific article

Analysis of 'driver' and 'passenger' CD8+ T-cell responses against variable viruses

scientific article (publication date: 7 February 2004)

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

scientific article (publication date: 16 February 2010)

Analysis of successful immune responses in persons infected with hepatitis C virus

scientific article (publication date: May 2000)

Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population Level

scientific article

Antibody opsonization enhances MAIT cell responsiveness to bacteria via a TNF-dependent mechanism

scientific article published on 25 February 2019

Antibody responses to influenza viruses in paediatric patients and their contacts at the onset of the 2009 pandemic in Mexico.

scientific article

Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel

scientific article published on 20 April 2020

Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel

Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance

scientific article

Antiviral activity of bone morphogenetic proteins and activins

scientific article published on 3 December 2018

Antiviral prevention of sepsis induced cytomegalovirus reactivation in immunocompetent mice

scientific article

Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection

scientific article

Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses

scientific article published on 15 December 2020

B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection

scientific article

Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1.

scientific article published on 29 December 2015

Boosting immunity by antiviral drug therapy: a simple relationship among timing, efficacy, and success

scholarly article

Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients

scientific article published on 08 June 2020

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

scientific article published on 04 September 2020

CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells

scientific article published on 9 April 2018

CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages.

scientific article published on 23 October 2014

CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation

scientific article published in February 2008

CD161(+)CD4(+) T cells are enriched in the liver during chronic hepatitis and associated with co-secretion of IL-22 and IFN-γ

scientific article

CD161(int)CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut.

scientific article

CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner

scientific article published on October 2013

CD32 expressing doublets in HIV-infected gut-associated lymphoid tissue are associated with a T follicular helper cell phenotype

scientific article published on 25 June 2019

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

scientific article published on 20 October 2015

CD4+ T cell responses in hepatitis C virus infection

scientific article published on September 2007

CD73 is dispensable for the regulation of inflationary CD8+ T-cells after murine cytomegalovirus infection and adenovirus immunisation

scientific article published on 9 December 2014

CD8 Epitope Escape and Reversion in Acute HCV Infection

scientific article

CD8+ cytotoxic lymphocyte responses against cytomegalovirus after liver transplantation: correlation with time from transplant to receipt of tacrolimus

scientific article

CD8αα Expression Marks Terminally Differentiated Human CD8+ T Cells Expanded in Chronic Viral Infection.

scientific article published on 6 August 2013

CMV and the art of memory maintenance

scientific article published in October 2008

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

scientific article

CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver

scientific article published on 14 July 2012

Cellular immune responses against hepatitis C virus: the evidence base 2002

scientific article (publication date: May 2002)

Cellular immune responses against persistent hepatitis C virus: gone but not forgotten

scientific article (publication date: July 2006)

Cellular immune responses during high-dose interferon-alpha induction therapy for hepatitis C virus infection.

scientific article published on March 2009

Cellular immune responses to HCV core increase and HCV RNA levels decrease during successful antiretroviral therapy

scientific article published on 26 July 2010

Cellular immunity in children with successful immunoprophylactic treatment for mother-to-child transmission of hepatitis B virus

scientific article

Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK

scientific article

Changes in natural killer cells and exhausted memory regulatory T Cells with corticosteroid therapy in acute autoimmune hepatitis

scientific article published on 26 February 2018

Characterising HCV specific CD4+ T-cells following viral-vectored vaccination, directly acting anti-virals and spontaneous viral cure

scientific article published on 03 February 2020

Characterization of Hepatitis C Virus Recombination in Cameroon by Use of Nonspecific Next-Generation Sequencing

scientific article

Characterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope

scientific article

Characterization of secreted and intracellular forms of a truncated hepatitis C virus E2 protein expressed by a recombinant herpes simplex virus.

scientific article published on March 2003

Characterization of the Specificity, Functionality, and Durability of Host T-Cell Responses Against the Full-Length Hepatitis E Virus

scientific article published on 15 September 2016

Characterizing the epidemiology and interaction between HIV-1 and HBV co-infection in South Africa

scholarly article by Philippa C Matthews et al published 2014 in BMC Infectious Diseases

Chimpanzee adenovirus- and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults

scientific article

Chronic hepatitis C viral infection subverts vaccine-induced T-cell immunity in humans

scientific article published on 16 October 2015

Commentary: T cells get by with a little help from their friends

scientific article

Comparison of Next-Generation Sequencing Technologies for Comprehensive Assessment of Full-Length Hepatitis C Viral Genomes.

scientific article published on 06 July 2016

Comprehensive Analysis of CD8+-T-Cell Responses against Hepatitis C Virus Reveals Multiple Unpredicted Specificities

scientific article (publication date: June 2002)

Consequences of Identifying XIAP Deficiency in an Adult Patient With Inflammatory Bowel Disease

scientific article published in July 2018

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity

scientific article

Correction: Activated T-Follicular Helper 2 Cells Are Associated With Disease Activity in IgG4-Related Sclerosing Cholangitis and Pancreatitis

scientific article published on 01 July 2019

Cross-reactivity of hepatitis C virus specific vaccine-induced T cells at immunodominant epitopes

scientific article published on 30 October 2014

Cysteinyl leukotriene E4 activates human group 2 innate lymphoid cells and enhances the effect of prostaglandin D2 and epithelial cytokines

scientific article published on 20 January 2017

Cytomegalovirus (CMV) Epitope-Specific CD4(+) T Cells Are Inflated in HIV(+) CMV(+) Subjects

scientific article published on 2 October 2017

Cytomegalovirus Reinfections Stimulate CD8 T-Memory Inflation

scientific article

Cytometric Gating Stringency Impacts Studies of Type 2 Innate Lymphoid Cells in Asthma.

scientific article published in December 2017

Cytotoxic T lymphocytes and viral adaptation in HIV infection

scientific article published on May 2006

Cytotoxic T lymphocytes, chemokines and antiviral immunity

scientific article

Defining T Cell Subsets in Human Tonsils Using ChipCytometry

scientific article published on 07 June 2021

Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus

scientific article

Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020

scientific article published on 01 October 2020

Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons

scientific article published in April 2008

Determining the validity of hospital laboratory reference intervals for healthy young adults participating in early clinical trials of candidate vaccines

scientific article published on 03 June 2013

Development of novel treatments for hepatitis C.

scientific article published on February 2009

Diabetes alters immune response patterns to acute melioidosis in humans

scientific article published on 08 May 2019

Differential B7-CD28 costimulatory requirements for stable and inflationary mouse cytomegalovirus-specific memory CD8 T cell populations

scientific article published on 28 February 2011

Differential Immune Profiles in Two Pandemic Influenza A(H1N1)pdm09 Virus Waves at Pandemic Epicenter.

scientific article

Diminished frequency of hepatitis C virus specific interferon secreting CD4+ T cells in human immunodeficiency virus/hepatitis C virus coinfected patients

scientific article (publication date: October 2006)

Direct Ex Vivo Analysis of Antigen-Specific IFN-γ-Secreting CD4 T Cells in Mycobacterium tuberculosis-Infected Individuals: Associations with Clinical Disease State and Effect of Treatment ⬇️

scientific article published on 01 November 2001

Direct ex vivo evaluation of long-lived protective antiviral memory B cell responses against hepatitis B virus

scientific article published in September 2008

Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study

scientific article (publication date: 2012)

Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure

scientific article

Does memory improve with age? CD85j (ILT-2/LIR-1) expression on CD8 T cells correlates with 'memory inflation' in human cytomegalovirus infection

scientific article

Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.

scientific article published in December 2004

Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution

scientific article published in March 2006

Donor and recipient CMV serostatus and antigenemia after renal transplantation: an analysis of 486 patients

scientific article published on 26 November 2007

Dynamic coinfection with multiple viral subtypes in acute hepatitis C.

scientific article

Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load

scientific article published on April 2007

Dynamics of cytotoxic T–lymphocyte exhaustion ⬇️

scientific article published on February 7, 1998

Dynamics of killer T cell inflation in viral infections

scientific article published on June 2007

Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection

scientific article published on 18 December 2012

Effect of immune pressure on hepatitis C virus evolution: insights from a single-source outbreak ⬇️

scientific article

Effect of interferon-α on cortical glutamate in patients with hepatitis C: a proton magnetic resonance spectroscopy study.

scientific article published on 10 May 2013

Effects of neutralizing antibodies on escape from CD8+ T-cell responses in HIV-1 infection

scientific article published on August 2015

Effects of promyelocytic leukemia protein on virus-host balance

scientific article

Eight novel hepatitis C virus genomes reveal the changing taxonomic structure of genotype 6.

scientific article published on 26 September 2012

Elevated Serum IgG4 Levels in Diagnosis, Treatment Response, Organ Involvement, and Relapse in a Prospective IgG4-Related Disease UK Cohort.

scientific article

Endemic SARS-CoV-2 will maintain post-pandemic immunity

scientific article published on 05 January 2021

Epidemiology and impact of HIV coinfection with hepatitis B and hepatitis C viruses in Sub-Saharan Africa.

scientific article

Erratum to “A novel technique for the fluorometric assessment of T lymphocyte antigen specific lysis” [J. Immunol. Methods 249 (2001) 99–110]

scholarly article published in Journal of Immunological Methods

Erratum: MAIT cells: new guardians of the liver

scientific article published on 24 February 2017

Escape from HLA-B*08-Restricted CD8 T Cells by Hepatitis C Virus Is Associated with Fitness Costs

scientific article (publication date: December 2008)

Estimating the net contribution of interleukin-28B variation to spontaneous hepatitis C virus clearance

scientific article

Evaluation of Viremia Frequencies of a Novel Human Pegivirus by Using Bioinformatic Screening and PCR

scientific article

Ever closer to a prophylactic vaccine for HCV.

scientific article published on 07 May 2013

Evidence for lack of cross-genotype protection of CD4+ T cell responses during chronic hepatitis C virus infection

scientific article

Evidence of CD4+ T cell-mediated immune pressure on the Hepatitis C virus genome.

scientific article

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine induced sera

scientific article published in February 2021

Evolution of CD8+ T cell responses after acute PARV4 infection

scientific article published on 2 January 2013

Evolution of diverse antiviral CD8+ T cell populations after murine cytomegalovirus infection

scientific article published in April 2005

Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers

scientific article

Ex vivo phenotype and frequency of influenza virus-specific CD4 memory T cells

scientific article

Exceptional Heterogeneity in Viral Evolutionary Dynamics Characterises Chronic Hepatitis C Virus Infection

scientific article (publication date: September 2016)

Exhaustion of cytotoxic T cells during adoptive immunotherapy of virus carrier mice can be prevented by B cells or CD4+ T cells

scientific article published in February 2002

Expansion of circulating NKG2D+ effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener's granulomatosis

scientific article published on 4 March 2008

Expansion of protective CD8+ T-cell responses driven by recombinant cytomegaloviruses

scientific article published on March 2004

Expression of lectin-like transcript-1 in human tissues

scientific article published on 29 December 2016

Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses

scientific article published in 2022

Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections

scientific article published on 16 February 2018

Four distinct patterns of memory CD8 T cell responses to chronic murine cytomegalovirus infection

scientific article published on July 2006

Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C virus infection

scientific article

Full-Length Characterization of Hepatitis C Virus Subtype 3a Reveals Novel Hypervariable Regions under Positive Selection during Acute Infection

scientific article

Full-Length Characterization of Hepatitis C Virus Subtype 3a Reveals Novel Hypervariable Regions under Positive Selection during Acute Infection

scientific article published in February 2010

Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy

scientific article

Gamma Delta T-lymphocytes in Hepatitis C and Chronic Liver Disease

scientific article published on 26 August 2014

Genetic history of hepatitis C virus in East Asia

scientific article

Genetic mechanisms of critical illness in Covid-19

scientific article published on 11 December 2020

Genetic mechanisms of critical illness in Covid-19

scientific article published on 25 September 2020

Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus.

scientific article published on 10 April 2017

Genome-wide genetic association of complex traits in heterogeneous stock mice

article

HBV vaccination and PMTCT as elimination tools in the presence of HIV: insights from a clinical cohort and dynamic model

HCV genotype-3a T cell immunity: specificity, function and impact of therapy

scientific article (publication date: November 2012)

HCV immunology--death and the maiden T cell.

scientific article

HCV-HIV coinfection: simple messages from a complex disease

scientific article

HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells

scientific article published in February 2010

HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response

scientific article published in June 2005

HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral rebound

scientific article

HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory

scientific article published on 24 July 2006

HIV: current opinion in escapology

scientific article

HLA contributes to immune control of hepatitis B in HIV-positive African adults

article

HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering

scientific article published on 25 February 2009

HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults

scientific article published on 9 December 2015

Hepatitis C

scientific article

Hepatitis C Virus (HCV) Sequence Variation Induces an HCV-Specific T-Cell Phenotype Analogous to Spontaneous Resolution

scientific article (publication date: February 2010)

Hepatitis C Virus (HCV) Sequence Variation Induces an HCV-Specific T-Cell Phenotype Analogous to Spontaneous Resolution

scientific article

Hepatitis C vaccine: supply and demand

scientific article

Hepatitis C virus drug resistance and immune-driven adaptations: relevance to new antiviral therapy

scientific article

Hepatitis C virus infections in the Democratic Republic of Congo exhibit a cohort effect

scientific article published on 16 February 2013

Hepatitis C virus: current concepts and future challenges ⬇️

scientific article published on November 28, 2011

Hepatitis E virus infection, Papua New Guinea, Fiji, and Kiribati, 2003-2005.

scientific article published on June 2014

Hepatitis virus (HCV) diagnosis and access to treatment in a UK cohort

scientific article published on 14 September 2018

Hepitopes: A live interactive database of HLA class I epitopes in hepatitis B virus

scientific article

High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

scientific article

High frequencies of exposure to the novel human parvovirus PARV4 in hemophiliacs and injection drug users, as detected by a serological assay for PARV4 antibodies

scientific article

High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection

scientific article published on September 2004

High-resolution phylogenetic analysis of hepatitis C virus adaptation and its relationship to disease progression

scientific article published on April 2004

Highly-Immunogenic Virally-Vectored T-cell Vaccines Cannot Overcome Subversion of the T-cell Response by HCV during Chronic Infection

scientific article published on 2 August 2016

Human Immunodeficiency Virus Type 1-Hepatitis C Virus Coinfection: Intraindividual Comparison of Cellular Immune Responses against Two Persistent Viruses

scientific article (publication date: March 2002)

Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency

scientific article published on 6 December 2016

Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells

scientific article published on 15 November 2011

Human MAIT cells show metabolic quiescence with rapid glucose-dependent upregulation of granzyme B upon stimulation.

scientific article published on 9 February 2018

Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T(EMRA) cells in early infection are linked to control of HIV-1 viremia and predict the subsequent viral load set point

scientific article published on 21 March 2007

Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets

scientific article published on 01 January 2021

Human parvovirus 4 'PARV4' remains elusive despite a decade of study

scientific article

Human parvovirus 4 infection among mothers and children in South Africa

scientific article published on April 2015

Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes

scientific article

Immune escape through T cell antagonism?

Immune phenotype and function of natural killer and T cells in chronic hepatitis C patients who received a single dose of anti-MicroRNA-122, RG-101.

scientific article published on 11 March 2017

Immune responses in DAA treated chronic hepatitis C patients with and without prior RG-101 dosing

scientific article published on 24 August 2017

Immune surveillance and AIDS progression ⬇️

scientific article published on 01 July 1997

Immunity to hepatitis C virus: stunned but not defeated

scientific article

Immunology of viral co-infections with HIV.

scientific article

Immunology taught by rats

scientific article published on 01 July 2017

Impact of IFNL4 genotype on Interferon-stimulated Gene Expression during DAA therapy for Hepatitis C.

scientific article published on 13 March 2018

Impact of IL-27 on hepatocyte antiviral gene expression and function

scientific article

Impact of Interferon-α Receptor-1 Promoter Polymorphisms on the Transcriptome of the Hepatitis B Virus-Associated Hepatocellular Carcinoma.

scientific article

Impact of alpha interferon and ribavirin on the function of maturing dendritic cells

scientific article

Impact of host responses on control of hepatitis C virus infection in Chinese blood donors

scientific article published on 29 October 2011

Increased IgG4 responses to multiple food and animal antigens indicate a polyclonal expansion and differentiation of pre-existing B cells in IgG4-related disease.

scientific article

Increased frequency of IL-7 and IL-15 receptor alpha chain (CD127, CD215) co-expressing CD4(+) T cells in granulomatosis with polyangiitis (Wegener's)

scientific article published on January 1, 2012

Increasing inflationary T-cell responses following transient depletion of MCMV-specific memory T cells

scientific article published on 17 November 2014

Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines.

scientific article

Infection frequency of hepatitis C virus and IL28B haplotypes in Papua New Guinea, Fiji, and Kiribati

scientific article

Inflammation in common variable immunodeficiency is associated with a distinct CD8(+) response to cytomegalovirus

scientific article published on 4 May 2011

Innate-like CD8+ T-cells and NK cells: converging functions and phenotypes

scientific article published on 14 March 2018

Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells.

scientific article published on 28 June 2018

Interferon lambda 4 impacts broadly on hepatitis C virus diversity

Interferon lambda 4 impacts the genetic diversity of hepatitis C virus

scientific article published on 03 September 2019

Interferon lambda 4 variant rs12979860 is not associated with RAV NS5A Y93H in hepatitis C virus genotype 3a.

scientific article published on 4 March 2016

Interferon lambdas: the next cytokine storm

scientific article

Killer T cells show their kinder side

scientific article published in Nature

LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.

scientific article published on February 2016

Large scale analysis of pediatric antiviral CD8+ T cell populations reveals sustained, functional and mature responses

scientific article published on 8 December 2006

Leukotriene E4 activates human Th2 cells for exaggerated proinflammatory cytokine production in response to prostaglandin D2.

scientific article published on 14 December 2011

Liver cell lines for the study of hepatocyte functions and immunological response

scientific article published on April 2005

Liver sinusoidal endothelial cells: an antiviral "defendothelium".

scientific article published on 18 December 2014

Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol

scientific article

Longitudinal analysis of CD8 T-cell responses to HIV and hepatitis C virus in a cohort of co-infected haemophiliacs

scientific article

Longitudinal mapping of protective CD4+ T cell responses against HCV: analysis of fluctuating dominant and subdominant HLA-DR11 restricted epitopes.

scientific article

Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27–restricted human immune response

scientific article

Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection

scientific article

MAIT cells and Viruses

scientific article published on 19 January 2018

MAIT cells are activated during human viral infections

scientific article

MAIT cells: new guardians of the liver

scientific article

MAIT cells: the end of the beginning?

scientific article published on 2 June 2018

MHC class II invariant chain-adjuvanted viral vectored vaccines enhances T cell responses in humans

scientific article published on 01 June 2020

MHC-peptide tetramers for the analysis of antigen-specific T cells

scientific article published on July 2010

MIGRAs: are they the new IGRAs? Development of monokine-amplified IFN-γ release assays

scientific article published on April 2012

Maintenance of HCV-specific T-cell responses in antibody-deficient patients a decade after early therapy

scientific article published in June 2006

Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

scientific article published in April 2002

Memory T cell inflation: understanding cause and effect

scientific article published on 03 January 2012

Memory inflation following adenoviral vaccination depends on IL-21

scholarly article by Claire L Gordon et al published 29 September 2018 in Vaccine

Memory inflation: continuous accumulation of antiviral CD8+ T cells over time

scientific article published in February 2003

Methodologies for the Analysis of HCV-Specific CD4(+) T Cells

scientific article published on 25 February 2015

Modelling the dynamics of LCMV infection in mice: II. Compartmental structure and immunopathology

scientific article published in April 2003

Modification of Antigen Impacts on Memory Quality after Adenovirus Vaccination

scientific article published on 4 March 2016

Molecular Analyses Define Vα7.2-Jα33+ MAIT Cell Depletion in HIV Infection: A Case-Control Study

scientific article

Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection

scientific article

Monocyte derived dendritic cells retain their functional capacity in patients following infection with hepatitis C virus

scientific article

Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease

scientific article published on 2 November 2017

Multi-functional lectin-like transcript-1: A new player in human immune regulation

scientific article

Mutant prolactin receptor and familial hyperprolactinemia

scientific article

Nanopore sequencing and full genome de novo assembly of human cytomegalovirus TB40/E reveals clonal diversity and structural variations

Neutralising antibodies to SARS coronavirus 2 in Scottish blood donors - a pilot study of the value of serology to determine population exposure

scientific article published on 17 April 2020

Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.

scientific article published on April 2014

New approaches for biomarker discovery: the search for liver fibrosis markers in hepatitis C patients

scientific article published on 30 March 2011

No evidence to support a role for Helicobacter pylori infection and plasminogen binding protein in autoimmune pancreatitis and IgG4-related disease in a UK cohort.

scientific article

Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man.

scientific article published on January 2012

Ongoing burden of disease and mortality from HIV/CMV coinfection in Africa in the antiretroviral therapy era

scientific article

Optimising T cell (re)boosting strategies for adenoviral and modified vaccinia Ankara vaccine regimens in humans

scientific article published on 12 October 2020

Optimization of peptide linker length in production of MHC class II/peptide tetrameric complexes increases yield and stability, and allows identification of antigen-specific CD4+T cells in peripheral blood mononuclear cells

scientific article published on 01 December 2002

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes

scientific article published in Nature

PARV4 prevalence, phylogeny, immunology and coinfection with HIV, HBV and HCV in a multicentre African cohort

scientific article

PARV4: an emerging tetraparvovirus

scientific article

POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

scientific article

Paediatric PARV4 infection in South Africa: relationship to age, maternal PARV4 status, and HIV infection.

scientific article published on 23 May 2014

Parvovirus 4 infection and clinical outcome in high-risk populations

scientific article

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors

scientific article

Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8+ T cells

scientific article published on February 2004

Plasma lactate dehydrogenase estimation in the diagnosis of malaria

scientific article published on October 1, 1992

Predicting spontaneous clearance of acute hepatitis C virus in a large cohort of HIV-1-infected men. ⬇️

scientific article

Preferential loss of IL-2-secreting CD4+ T helper cells in chronic HCV infection

scientific article

Prevalence and Characteristics of Hepatitis B Virus (HBV) Coinfection among HIV-Positive Women in South Africa and Botswana

scientific article

Prevalence of HIV type-1 drug-associated mutations in pre-therapy patients in the Free State, South Africa

scientific article published in January 2009

Profibrogenic chemokines and viral evolution predict rapid progression of hepatitis C to cirrhosis

scientific article

Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load

scientific article

Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations

scientific article

Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection

scientific article published on 18 October 2006

Prolonged Evolution of Virus-Specific Memory T Cell Immunity after Severe Avian Influenza A (H7N9) Virus Infection

scholarly article by Min Zhao published in September 2018

Prolonged activation of virus-specific CD8+T cells after acute B19 infection

scientific article published in November 2005

Properties of murine (CD8+)CD27- T cells

scientific article published in November 2005

Prospective monitoring reveals dynamic levels of T cell immunity to Mycobacterium tuberculosis in HIV infected individuals

scientific article

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

scientific article published on 31 December 2013

Protection of hepatocytes from cytotoxic T cell mediated killing by interferon-alpha ⬇️

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Protective effect of HLA-B57 on HCV genotype 2 infection in a West African population

scientific article published in June 2007

Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection

scientific article published on 12 April 2007

Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope

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Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection

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Report from the second cytomegalovirus and immunosenescence workshop

scientific article published on 28 October 2011

Robust, reproducible clinical patterns in hospitalised patients with COVID-19

scientific article published on 16 August 2020

SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus

scientific article published in 2020

SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020

scientific article published on 01 October 2020

SARS-CoV-2-Specific T Cell Responses Are Not Associated with Protection against Reinfection in Hemodialysis Patients

scientific article published in 2022

Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

scientific article published on 18 November 2020

Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities

scientific article published on 11 October 2017

Screening and treatment for hepatitis C: a balanced perspective

scientific article published in the British Medical Journal

Seasonal cryptogenic organising pneumonia with biochemical cholestasis: a new clinical entity

scientific article published on 01 August 1992

Shared alterations in NK cell frequency, phenotype, and function in chronic human immunodeficiency virus and hepatitis C virus infections

scientific article published on October 2005

Significance of anti-HBc alone serological status in clinical practice

scientific article published on 12 January 2017

Single-cell transcriptome analysis of CD8 + T-cell memory inflation

scientific article published on 09 May 2019

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

scientific article published in February 2021

Suppression of hepatitis C virus replication is maintained long term following HAART therapy, in an individual with HCV/HIV co-infection.

scientific article published on February 2004

Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans

scientific article published in September 2005

Sustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C Virus

scientific article

Symptoms at presentation for patients admitted to hospital with Covid-19: results from the ISARIC prospective multinational observational study

scientific article published on 27 October 2020

T cell failure in hepatitis C virus infection

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T cell responses in hepatitis C: the good, the bad and the unconventional

scientific article published on 28 August 2011

T cell responses to cytomegalovirus

scientific article published on 25 April 2016

T cells and viral persistence: lessons from diverse infections

scientific article

T lymphocyte responses against human parvovirus B19: small virus, big response

scientific article published in June 2002

T-cell responses and previous exposure to hepatitis C virus in indeterminate blood donors

scientific article published on January 2005

TLR signaling in human antigen-presenting cells regulates MR1-dependent activation of MAIT cells

scientific article published on 23 April 2016

Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state

scientific article published on September 2017

Temporal analysis of early immune responses in patients with acute hepatitis B virus infection

scientific article published on 7 July 2009

The (gradual) rise of memory inflation

scientific article published in May 2018

The Design and Development of a Multi-HBV Antigen Encoded in Chimpanzee Adenoviral and Modified Vaccinia Ankara Viral Vectors; A Novel Therapeutic Vaccine Strategy against HBV

scientific article published on 14 April 2020

The Human Cell Atlas

The Impact of Variation in the Number of CD8+T-Cell Precursors on the Outcome of Virus Infection ⬇️

scientific article published on October 10, 1998

The Roles of Type 2 Cytotoxic T Cells in Inflammation, Tissue Remodeling, and Prostaglandin (PG) D<sub>2</sub> Production Are Attenuated by PGD<sub>2</sub> Receptor 2 Antagonism

scientific article published on 19 May 2021

The broad assessment of HCV genotypes 1 and 3 antigenic targets reveals limited cross-reactivity with implications for vaccine design

scientific article

The dynamics of T-lymphocyte responses during combination therapy for chronic hepatitis C virus infection

scientific article published in September 2002

The generation of a simian adenoviral vectored HCV vaccine encoding genetically conserved gene segments to target multiple HCV genotypes

scientific article

The immune system of the liver: 50 years of strangeness

scientific article published on 8 December 2017

The impact of differential antiviral immunity in children and adults

scientific article published on September 2012

The infective causes of hepatitis and jaundice amongst hospitalised patients in Vientiane, Laos

scientific article

The influence of macrophage inflammatory protein-1alpha on protective immunity mediated by antiviral cytotoxic T cells

The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1.

scientific article published on 30 September 2004

The natural history of early hepatitis C virus evolution; lessons from a global outbreak in human immunodeficiency virus-1-infected individuals

scientific article published on 20 July 2011

The relationship between human effector and memory T cells measured by ex vivo and cultured ELISPOT following recent and distal priming

scientific article published on September 2009

Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver

scientific article

Tracking T cells with tetramers: new tales from new tools

scientific article

Tracking Virus-Specific CD4+ T Cells during and after Acute Hepatitis C Virus Infection

scientific article (publication date: 25 July 2007)

Tracking of peptide-specific CD4+ T-cell responses after an acute resolving viral infection: a study of parvovirus B19.

scientific article published on 30 August 2006

Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis C virus infection in vitro

scientific article published on August 2010

Transient CD8-memory contraction: a potential contributor to latent cytomegalovirus reactivation

scientific article

Transient immunological control during acute hepatitis C virus infection: ex vivo analysis of helper T-cell responses

scientific article published in October 2006

Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.

scientific article

Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report

scientific article published on 14 December 2020

Ultra-sensitive class I tetramer analysis reveals previously undetectable populations of antiviral CD8+ T cells

scientific article published on June 2004

Ultrasensitive detection and phenotyping of CD4+ T cells with optimized HLA class II tetramer staining

scientific article published on November 2005

Underwhelming the immune response: effect of slow virus growth on CD8+-T-lymphocyte responses

scientific article published on March 2004

Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection

scientific article

Use of an Outbred Rat Hepacivirus Challenge Model for Design and Evaluation of Efficacy of Different Immunization Strategies for Hepatitis C Virus

scientific article published on 11 October 2019

Vaccination for hepatitis C virus: closing in on an evasive target

scientific article

Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species

scientific article published on January 2012

Validation of Multiplex Serology for human hepatitis viruses B and C, human T-lymphotropic virus 1 and Toxoplasma gondii

scientific article published in PLoS ONE

Viral coinfections among African children infected with human immunodeficiency virus type 1.

scientific article published on 19 March 2003

Viral escape and T cell exhaustion in hepatitis C virus infection analysed using Class I peptide tetramers

scientific article published in January 2003

Viral escape mechanisms--escapology taught by viruses

scientific article

Viral infection and immunity: balancing protection and pathology ⬇️

scientific article published on November 26, 2011

Virological footprint of CD4+ T-cell responses during chronic hepatitis C virus infection ⬇️

scientific article

Virus scores a perfect 10.

scientific article published in November 2006

Virus-specific CD4+ T cell responses in chronic HCV infection in blood and liver identified by antigen-specific upregulation of CD154.

scientific article published on 26 March 2010

Virus-specific CD8+ T lymphocytes within the normal human liver

scientific article published in June 2004

What Are the Prospects for Controlling Hepatitis C?

scientific article

What can we learn about human immunodeficiency virus infection from a study of lymphocytic choriomeningitis virus? ⬇️

scientific article published on October 1, 1997

Why do cytotoxic T lymphocytes fail to eliminate hepatitis C virus? Lessons from studies using major histocompatibility complex class I peptide tetramers

scientific article (publication date: 29 August 2000)

ve-SEQ: Robust, unbiased enrichment for streamlined detection and whole-genome sequencing of HCV and other highly diverse pathogens

scientific article published on 13 October 2015

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