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List of works by Bob Löwenberg

A 17-gene stemness score for rapid determination of risk in acute leukaemia

scientific article published on 7 December 2016

A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia

scientific article published on 26 December 2007

A catalyst for change: the European cancer Patient's Bill of Rights

scientific article published on 03 February 2014

A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects

scientific article published on 14 August 2008

A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1).

scientific article

A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relapsed acute myeloid leukemia.

scientific article published on 9 March 2007

A phase I first-in-human study with tefinostat - a monocyte/macrophage targeted histone deacetylase inhibitor - in patients with advanced haematological malignancies

scientific article

A randomized multicenter comparison of CD34(+)-selected progenitor cells from blood vs from bone marrow in recipients of HLA-identical allogeneic transplants for hematological malignancies

scientific article published in October 2003

A series of reviews on "Hematologic Disease at Older Age".

scientific article published on 15 November 2017

A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia

scientific article

A standardized microarray assay for the independent gene expression markers in AML: EVI1 and BAALC.

scientific article published on 6 March 2013

A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia

scientific article

ABCB1 gene polymorphisms are not associated with treatment outcome in elderly acute myeloid leukemia patients

scientific article

AML at older age: age-related gene expression profiles reveal a paradoxical down-regulation of p16INK4A mRNA with prognostic significance.

scientific article

AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion

scientific article

Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1.

scientific article

Acquired mutations in ASXL1 in acute myeloid leukemia: prevalence and prognostic value

scientific article published on November 4, 2011

Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value

scientific article

Acute myeloid leukemia and acute promyelocytic leukemia.

scientific article published on January 2003

Acute myeloid leukemia and the position of autologous stem cell transplantation

scientific article published on October 2007

Acute myeloid leukemia with monosomal karyotype at the far end of the unfavorable prognostic spectrum

scientific article published on April 1, 2011

Acute myeloid leukemia: the challenge of capturing disease variety

scientific article published on January 2008

Aerosolized liposomal amphotericin B for the prevention of invasive pulmonary aspergillosis during prolonged neutropenia: a randomized, placebo-controlled trial

scientific article published in May 2008

Age-specific differences in oncogenic pathway dysregulation and anthracycline sensitivity in patients with acute myeloid leukemia

scientific article published on 26 October 2009

All-trans retinoic acid with daunorubicin or idarubicin for risk-adapted treatment of acute promyelocytic leukaemia: a matched-pair analysis of the PETHEMA LPA-2005 and IC-APL studies

scientific article published on 15 May 2015

Antithymocyteglobulin as prophylaxis of graft failure and graft-versus-host disease in recipients of partially T-cell—depleted grafts from matched unrelated donors: A dose-finding study

scientific article published on November 1, 2003

Autologous stem cell transplantation in the treatment of adults with acute myeloid leukaemia

scientific article

Azacitidine maintenance after intensive chemotherapy improves DFS in older AML patients

scientific article published on 10 January 2019

Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia

scientific article

Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.

scientific article published in January 2003

Blood's 70th anniversary: a rich history

scientific article published in December 2015

CD34-related coexpression of MDR1 and BCRP indicates a clinically resistant phenotype in patients with acute myeloid leukemia (AML) of older age.

scientific article published on 6 March 2007

Candida krusei transmission among hematology patients resolved by adapted antifungal prophylaxis and infection control measures

scientific article published on March 2006

Clinical significance of CD56 expression in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based regimens

scientific article published on December 8, 2010

Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy

scientific article published on 11 December 2018

Combining gene mutation with gene expression analysis improves outcome prediction in acute promyelocytic leukemia

scientific article published on 10 July 2019

Correction

scholarly article published in Journal of Experimental Medicine

Criteria for defining a complete remission in acute myeloid leukaemia revisited. An analysis of patients treated in HOVON-SAKK co-operative group studies

scientific article published in January 2005

Current challenges in clinical development of "targeted therapies": the case of acute myeloid leukemia

scientific article published on 11 March 2015

Cytarabine dose for acute myeloid leukemia

scientific article

Deregulated expression of EVI1 defines a poor prognostic subset of MLL-rearranged acute myeloid leukemias: a study of the German-Austrian Acute Myeloid Leukemia Study Group and the Dutch-Belgian-Swiss HOVON/SAKK Cooperative Group

scientific article published on 24 September 2012

Detection of CEBPA double mutants in acute myeloid leukemia using a custom gene expression array

scientific article published on 13 March 2013

Detection of mutant NPM1 mRNA in acute myeloid leukemia using custom gene expression arrays

scientific article published on April 2013

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

scientific article

Dick W. van Bekkum, 1925-2015.

scientific article published in December 2015

Differential regulation of Foxo3a target genes in erythropoiesis

scientific article published on May 2007

Dirk Willem van Bekkum: a pioneer in haematology, transplantation and radiobiology (1925-2015).

scientific article published in December 2015

Disseminated intravascular coagulation at diagnosis is a strong predictor for both arterial and venous thrombosis in newly diagnosed acute myeloid leukemia

scientific article published on 28 June 2016

Distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status

scientific article (publication date: 15 February 2004)

Dose-finding study of imatinib in combination with intravenous cytarabine: feasibility in newly diagnosed patients with chronic myeloid leukemia

scientific article published on 2 January 2008

Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome

scientific article

Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia

scientific article published on 24 March 2015

Dynamics of protein binding to telomeres in living cells: implications for telomere structure and function

scientific article

Effect of priming with granulocyte colony-stimulating factor on the outcome of chemotherapy for acute myeloid leukemia

scientific article

Efficacy of escalated imatinib combined with cytarabine in newly diagnosed patients with chronic myeloid leukemia

scientific article

Empiric definition of eligibility criteria for clinical trials in relapsed/refractory acute myeloid leukemia: analysis of 1,892 patients from HOVON/SAKK and SWOG.

scientific article published on 9 July 2015

Evidence for acute neurotoxicity after chemotherapy

scientific article published on December 1, 2010

FLT3 inhibition as a targeted therapy for acute myeloid leukemia

scientific article

Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence

scientific article

Flt3 ligand expands lymphoid progenitors prior to recovery of thymopoiesis and accelerates T cell reconstitution after bone marrow transplantation

scientific article

FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1

scientific article

Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: results of a multicenter phase 3 study

scientific article published on 26 January 2010

Gemtuzumab ozogamicin in acute myeloid leukemia: a remarkable saga about an active drug

scientific article published on 16 April 2013

Gene expression profiling in acute myeloid leukemia

scientific article

Gene transactivation without direct DNA binding defines a novel gain-of-function for PML-RARalpha

scientific article published on 19 November 2007

Germline loss ofMBD4predisposes to leukaemia due to a mutagenic cascade driven by 5mC

HeatMapper: powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristics

scientific article

Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol

scientific article published on April 2002

Hierarchical Bayesian formulations for selecting variables in regression models

scientific article published on 25 January 2012

High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients

scientific article (publication date: February 2003)

High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated.

scientific article

High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome

scientific article

High VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia.

scientific article published on 3 June 2010

High prognostic impact of flow cytometric minimal residual disease detection in acute myeloid leukemia: data from the HOVON/SAKK AML 42A study

scientific article

High ΔNp73/TAp73 ratio is associated with poor prognosis in acute promyelocytic leukemia

scientific article published on October 2015

High-dose daunorubicin in older patients with acute myeloid leukemia

scientific article

How I treat the older patient with acute myeloid leukemia

scientific article

Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study

scientific article published on 4 February 2013

Identification of molecular predictors of response in a study of tipifarnib treatment in relapsed and refractory acute myelogenous leukemia

scientific article published in April 2007

Impaired health-related quality of life in acute myeloid leukemia survivors: a single-center study

scientific article published on 18 April 2014

Impaired recovery of Epstein-Barr virus (EBV)--specific CD8+ T lymphocytes after partially T-depleted allogeneic stem cell transplantation may identify patients at very high risk for progressive EBV reactivation and lymphoproliferative disease

scientific article published on 6 February 2003

Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL.

scientific article published on 14 January 2013

Including historical data in the analysis of clinical trials: Is it worth the effort?

scientific article

Integrated genome-wide genotyping and gene expression profiling reveals BCL11B as a putative oncogene in acute myeloid leukemia with 14q32 aberrations

scientific article published on 17 January 2014

Integrative prognostic risk score in acute myeloid leukemia with normal karyotype

scientific article published on March 3, 2011

Interleukin-7 improves T-cell recovery after experimental T-cell-depleted bone marrow transplantation in T-cell-deficient mice by strong expansion of recent thymic emigrants

scientific article published on 24 April 2003

Introduction to a review series on myelodysplastic syndromes

scientific article published on 22 January 2019

Introduction to the review series on leukemic stem cells

scientific article published on 3 February 2017

Keratinocyte growth factor improves allogeneic bone marrow engraftment through a CD4+Foxp3+ regulatory T cell-dependent mechanism

scientific article published in June 2009

Large-scale identification of novel potential disease loci in mouse leukemia applying an improved strategy for cloning common virus integration sites

scientific article published in October 2002

Leukemic stem cell frequency: a strong biomarker for clinical outcome in acute myeloid leukemia

scientific article published on 22 September 2014

Low expression of MDS1-EVI1–like-1 (MEL1) and EVI1-like-1 (EL1) genes in favorable-risk acute myeloid leukemia

scientific article published on November 1, 2003

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML

scientific article

MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia

scientific article

Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet

scientific article

Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet

scholarly article by Miguel A Sanz et al published 11 April 2019 in Blood

MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1-regulated pathways in mice

scientific article

MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia

scientific article

Minimal residual disease in chronic myeloid leukemia

scientific article published in October 2003

Minimal residual disease quantification in patients with acute myeloid leukaemia and inv(16)/CBFB-MYH11 gene fusion

scientific article published on August 2002

Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal.

scientific article

Molecular Minimal Residual Disease in Acute Myeloid Leukemia

Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

scientific article published on April 5, 2012

Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways

scientific article

Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance

scientific article

Osteopontin is a prognostic factor for survival of acute myeloid leukemia patients

scientific article

PBX3 is an important cofactor of HOXA9 in leukemogenesis

scientific article published on 20 December 2012

PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells

scientific article

Paradoxical effects of interleukin‐10 on the maturation of murine myeloid dendritic cells

scientific article published on October 1, 2003

Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia

scientific article

Phase I/II clinical study of Tosedostat, an inhibitor of aminopeptidases, in patients with acute myeloid leukemia and myelodysplasia

scientific article

Post-remission treatment with allogeneic stem cell transplantation in patients aged 60 years and older with acute myeloid leukaemia: a time-dependent analysis

scientific article published on 18 September 2015

Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling

scientific article published on 06 October 2008

Prevention of Epstein-Barr virus-lymphoproliferative disease by molecular monitoring and preemptive rituximab in high-risk patients after allogeneic stem cell transplantation

scientific article published in June 2002

Prognostic impact of KMT2E transcript levels on outcome of patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukaemia study.

scientific article

Prognostic value of FLT3 mutations in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemotherapy

scientific article

Prognostically useful gene-expression profiles in acute myeloid leukemia

scientific article published in April 2004

Publisher Correction: miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia.

scientific article published on 10 April 2018

Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia

scientific article published on 30 March 2004

Relationship between event-free survival and overall survival in acute myeloid leukemia: a report from SWOG, HOVON/SAKK, and MRC/NCRI.

scientific article published on 24 March 2016

Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: benefits for whom?

scientific article

Retroviral integration mutagenesis in mice and comparative analysis in human AML identify reduced PTP4A3 expression as a prognostic indicator

scientific article

Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia

scientific article published on December 2003

Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients: further improvements in treatment outcome

scientific article

Role of allogeneic stem cell transplantation in current treatment of acute myeloid leukemia

scientific article published in January 2005

SNPExpress: integrated visualization of genome-wide genotypes, copy numbers and gene expression levels

scientific article

Sense and nonsense of high-dose cytarabine for acute myeloid leukemia

scientific article published on January 2013

Significance of FAB subclassification of "acute myeloid leukemia, NOS" in the 2008 WHO classification: analysis of 5848 newly diagnosed patients

scientific article published on 16 January 2013

Somatostatin is a selective chemoattractant for primitive (CD34(+)) hematopoietic progenitor cells

scientific article

Strict infection control measures do not prevent clonal spread of coagulase negative staphylococci colonizing central venous catheters in neutropenic hemato-oncologic patients

scientific article published in September 2003

Sustainability and affordability of cancer drugs: a novel pricing model

The Btk inhibitor LFM-A13 is a potent inhibitor of Jak2 kinase activity

scientific article

The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells

scientific article

The European Cancer Patient's Bill of Rights, update and implementation 2016.

scientific article

The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach

scientific article published on 04 September 2012

The Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy

scientific article published in 2024

The common viral insertion site Evi12 is located in the 5'-noncoding region of Gnn, a novel gene with enhanced expression in two subclasses of human acute myeloid leukemia

scientific journal article

The development and validation of a decision-analytic model representing the full disease course of acute myeloid leukemia

scientific article published in July 2013

The effect of oligonucleotide microarray data pre-processing on the analysis of patient-cohort studies

scientific article

The emerging role of targeted therapy for hematologic malignancies: update on bortezomib and tipifarnib

scientific article published on March 2007

The impact of abn(17p) and monosomy -5/del(5q) on the prognostic value of the monosomal karyotype in acute myeloid leukemia

scientific article

The peripheral cannabinoid receptor Cb2, a novel oncoprotein, induces a reversible block in neutrophilic differentiation

scientific article published on 24 October 2002

The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner

scientific article (publication date: 15 July 2004)

The value of alloantibody detection in predicting response to HLA-matched platelet transfusions

scientific article

The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA.

scientific article published on 17 July 2013

The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients

scientific article published on 4 December 2003

The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis

scientific article published on 30 June 2005

Therapeutic Advances in Acute Myeloid Leukemia

scientific article published on January 10, 2011

Therapeutic value of clofarabine in younger and middle-aged (18-65 years) adults with newly diagnosed AML.

scientific article published on 3 January 2017

Therapy-related myeloid neoplasms in patients with acute promyelocytic leukemia treated with all-trans-retinoic Acid and anthracycline-based chemotherapy

scientific article published on 12 July 2010

Translational control of putative protooncogene Nm23-M2 by cytokines via phosphoinositide 3-kinase signaling

scientific article published on 7 July 2004

Two splice-factor mutant leukemia subgroups uncovered at the boundaries of MDS and AML using combined gene expression and DNA-methylation profiling

scientific article

Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors

scientific article (publication date: 15 June 2004)

Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.

scientific article published on 17 January 2012

Various distinctive cytogenetic abnormalities in patients with acute myeloid leukaemia aged 60 years and older express adverse prognostic value: results from a prospective clinical trial

scientific article

miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia

scientific article