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List of works by Isidro Hotzel

A dual host vector for Fab phage display and expression of native IgG in mammalian cells.

scientific article

A maedi-visna virus strain K1514 receptor gene is located in sheep chromosome 3p and the syntenic region of human chromosome 2.

scientific article published on July 2002

A strategy for risk mitigation of antibodies with fast clearance.

scientific article published on November 2012

An improved and robust DNA immunization method to develop antibodies against extracellular loops of multi-transmembrane proteins

scientific article published on January 2014

Automated Affinity Capture and On-Tip Digestion to Accurately Quantitate in Vivo Deamidation of Therapeutic Antibodies.

scientific article published on 31 October 2016

Barcoded sequencing workflow for high throughput digitization of hybridoma antibody variable domain sequences.

scientific article published on 18 January 2018

Characterization of helper T cell responses against rhoptry-associated protein 1 (RAP-1) of babesial parasites

scientific article published on 01 July 1996

Conservation of human immunodeficiency virus type 1 gp120 inner-domain sequences in lentivirus and type A and B retrovirus envelope surface glycoproteins.

scientific article published on February 2001

Conservation of inner domain modules in the surface envelope glycoproteins of an ancient rabbit lentivirus and extant lentiviruses and betaretroviruses

scientific article published on 26 November 2007

Conservation of the Human Immunodeficiency Virus Type 1 gp120 V1/V2 Stem/Loop Structure in the Equine Infectious Anemia Virus (EIAV) gp90 ⬇️

scientific article published on October 1, 2003

Deep-Time Structural Evolution of Retroviral and Filoviral Surface Envelope Proteins

scientific article published in 2022

Depletion of major pathogenic cells in asthma by targeting CRTh2.

scientific article published on 19 May 2016

Differential receptor usage of small ruminant lentiviruses in ovine and caprine cells: host range but not cytopathic phenotype is determined by receptor usage.

scientific article published on September 2002

Dimorphic sequences of rap-1 genes encode B and CD4+ T helper lymphocyte epitopes in the Babesia bigemina rhoptry associated protein-1.

scientific article

Domain Organization of Lentiviral and Betaretroviral Surface Envelope Glycoproteins Modeled with AlphaFold

scientific article published in 2022

Dynamics of heavy chain junctional length biases in antibody repertoires

scientific article published on 01 May 2020

Efficient production of antibodies against a mammalian integral membrane protein by phage display.

scientific article

Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics

scientific article

Extrachromosomal nucleic acids in bovine Babesia

scientific article published on January 1, 1992

High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants

scientific article published on 11 September 2018

Immune repertoire mining for rapid affinity optimization of mouse monoclonal antibodies

scientific article published on 22 March 2019

Immune response to caprine arthritis-encephalitis virus surface protein induced by coimmunization with recombinant vaccinia viruses expressing the caprine arthritis-encephalitis virus envelope gene and caprine interleukin-12.

scientific article published in May 2000

Immunization with plasmid DNA expressing the caprine arthritis-encephalitis virus envelope gene: quantitative and qualitative aspects of antibody response to viral surface glycoprotein.

scientific article

Immunodominant T-cell antigens and epitopes of Babesia bovis and Babesia bigemina.

scientific article

In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation

scientific article

Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor

scientific article

Massively parallel single-cell B-cell receptor sequencing enables rapid discovery of diverse antigen-reactive antibodies

scientific article published on 09 August 2019

Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing

scientific article published on 20 February 2017

Modular protein expression by RNA trans-splicing enables flexible expression of antibody formats in mammalian cells from a dual-host phage display vector.

scientific article published on 7 April 2015

Molecular basis for negative regulation of the glucagon receptor

scientific article

Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS

scientific article published on 04 December 2018

Mutations increasing exposure of a receptor binding site epitope in the soluble and oligomeric forms of the caprine arthritis-encephalitis lentivirus envelope glycoprotein.

scientific article published on September 2005

Preclinical Safety Profile of a Depleting Antibody against CRTh2 for Asthma: Well Tolerated Despite Unexpected CRTh2 Expression on Vascular Pericytes in the Central Nervous System and Gastric Mucosa.

scientific article published on 21 April 2016

Rapid evolution of two discrete regions of the caprine arthritis-encephalitis virus envelope surface glycoprotein during persistent infection.

scientific article published in March 2002

Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires

scientific article published on 01 January 2020

Sequence similarity between the envelope surface unit (SU) glycoproteins of primate and small ruminant lentiviruses

scientific article published on 01 August 2000

Seven new ovine progressive pneumonia virus (OPPV) field isolates from Dubois Idaho sheep comprise part of OPPV clade II based on surface envelope glycoprotein (SU) sequences.

scientific article published in June 2004

Small extrachromosomal nucleic acid segments in protozoan parasites

scientific article published on 01 March 1995

Structural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid

scientific article published on 23 August 2018

Surface envelope glycoprotein is B-lymphocyte immunodominant in sheep naturally infected with ovine progressive pneumonia virus

scientific article published on June 2005

Susceptibility of Antibody CDR Residues to Chemical Modifications Can Be Revealed Prior to Antibody Humanization and Aid in the Lead Selection Process

scientific article published on 29 August 2018

The INNs and outs of antibody nonproprietary names

scientific article published in January 2016

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