List of works - Patrick H. O'Farrell

A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics.

scientific article published in July 1994

A nuclear GFP that marks nuclei in living Drosophila embryos; maternal supply overcomes a delay in the appearance of zygotic fluorescence

scientific article

A restriction map of the bacteriophage T4 genome

scientific article published on January 1980

A universal target sequence is bound in vitro by diverse homeodomains.

scientific article published on September 1993

An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells.

scientific article

An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins.

scientific article published on September 1991

Anomalous centriole configurations are detected in Drosophila wing disc cells upon Cdk1 inactivation

scientific article published on January 2003

Barriers to Male Transmission of Mitochondrial DNA in Sperm Development ⬇️

scientific article published on March 13, 2012

Cdks and the Drosophila cell cycle

scientific article published on February 1997

Cell cycle control: many ways to skin a cat.

scientific article

Chromosome Association of Minichromosome Maintenance Proteins in Drosophila Mitotic Cycles ⬇️

scientific article published on October 6, 1997

Chromosome association of minichromosome maintenance proteins in Drosophila endoreplication cycles

scientific article

Cloning of Drosophila MCM homologs and analysis of their requirement during embryogenesis

scientific article published on June 1997

Connecting cell behavior to patterning: lessons from the cell cycle

scientific article published on February 1997

Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase

scientific article

Cyclin B3 is a mitotic cyclin that promotes the metaphase-anaphase transition.

scientific article published on 5 March 2015

DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos

scientific article published on 28 September 2009

Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein

scientific article published on November 1985

Developmental Control of Late Replication and S Phase Length ⬇️

scientific article published on November 11, 2010

Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis

scientific article

Embryonic cleavage cycles: how is a mouse like a fly?

scientific article published on January 2004

Embryonic onset of late replication requires Cdc25 down-regulation.

scientific article published on 19 March 2012

Expression and function of Drosophila cyclin A during embryonic cell cycle progression.

scientific article published on March 1989

From egg to gastrula: how the cell cycle is remodeled during the Drosophila mid-blastula transition

scientific article published on 5 September 2014

Growing an Embryo from a Single Cell: A Hurdle in Animal Life.

scientific article

High-resolution 2-dimensional electrophoresis of proteins

scientific article published on 1975

Identification of Drosophila gene products required for phagocytosis of Candida albicans

scientific article

Illuminating DNA replication during Drosophila development using TALE-lights

scientific article published on February 2014

Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo.

scientific article published on March 2009

Interphase-arrested Drosophila embryos activate zygotic gene expression and initiate mid-blastula transition events at a low nuclear-cytoplasmic ratio

scientific article published on 22 October 2020

Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila

scientific article

Manipulating the metazoan mitochondrial genome with targeted restriction enzymes.

scientific article published on July 2008

Mechanism and Regulation of Cdc25/Twine Protein Destruction in Embryonic Cell-Cycle Remodeling ⬇️

scientific article published on January 3, 2013

Mitigation of age-dependent accumulation of defective mitochondrial genomes

scientific article published in 2022

Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells

scientific article published on March 1977

Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila

scientific article published on July 1999

Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila.

scientific article

Nitric oxide synthase is not essential for Drosophila development.

scientific article

Nitric oxide-induced suspended animation promotes survival during hypoxia

scientific article

Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells

scientific article

Progression of the cell cycle through mitosis leads to abortion of nascent transcripts ⬇️

scientific article published on October 18, 1991

Quiescence: early evolutionary origins and universality do not imply uniformity ⬇️

scientific article published on December 27, 2011

RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle.

scientific article

Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in Drosophila

scientific article published on 26 February 2019

Rho-dependent control of anillin behavior during cytokinesis.

scientific article

Rho-kinase controls cell shape changes during cytokinesis

scientific article

Selections that isolate recombinant mitochondrial genomes in animals.

scientific article

Selfish drive can trump function when animal mitochondrial genomes compete

scientific article published on 06 June 2016

Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos

scientific article published on May 2002

TALE-light imaging reveals maternally guided, H3K9me2/3-independent emergence of functional heterochromatin in Drosophila embryos.

scientific article

Terminal cytokinesis events uncovered after an RNAi screen

scientific article

The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity

scientific article

The cell cycle program in germ cells of the Drosophila embryo

scientific article published in April 1998

The degradation of two mitotic cyclins contributes to the timing of cytokinesis

scientific article published on March 2003

The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing

scientific article published on 23 July 2006

The engrailed locus of Drosophila: in situ localization of transcripts reveals compartment-specific expression

scientific article published in January 1985

The glucocorticoid domain: steroid-mediated changes in the rate of synthesis of rat hepatoma proteins

scientific article published on January 1978

The making of a maggot: patterning the Drosophila embryonic epidermis

scientific article published on August 1994

The pre-omics era: the early days of two-dimensional gels.

scientific article

The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis

scientific article

The state of engrailed expression is not clonally transmitted during early Drosophila development

scientific article published on March 1992

The suppression of defective translation by ppGpp and its role in the stringent response ⬇️

scientific article published on July 1, 1978

Timing the Drosophila Mid-Blastula Transition: A Cell Cycle-Centered View

scientific article published on 20 June 2016

Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster

scientific article

Two-dimensional gel electrophoresis and the beginning of proteomics.

scientific article published on 25 February 2014

List of works by Patrick H. O'Farrell

A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics.

A nuclear GFP that marks nuclei in living Drosophila embryos; maternal supply overcomes a delay in the appearance of zygotic fluorescence

A restriction map of the bacteriophage T4 genome

A universal target sequence is bound in vitro by diverse homeodomains.

An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells.

An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins.

Anomalous centriole configurations are detected in Drosophila wing disc cells upon Cdk1 inactivation

Barriers to Male Transmission of Mitochondrial DNA in Sperm Development ⬇️

Cdks and the Drosophila cell cycle

Cell cycle control: many ways to skin a cat.

Chromosome Association of Minichromosome Maintenance Proteins in Drosophila Mitotic Cycles ⬇️

Chromosome association of minichromosome maintenance proteins in Drosophila endoreplication cycles

Cloning of Drosophila MCM homologs and analysis of their requirement during embryogenesis

Connecting cell behavior to patterning: lessons from the cell cycle

Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase

Cyclin B3 is a mitotic cyclin that promotes the metaphase-anaphase transition.

DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos

Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein

Developmental Control of Late Replication and S Phase Length ⬇️

Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis

Embryonic cleavage cycles: how is a mouse like a fly?

Embryonic onset of late replication requires Cdc25 down-regulation.

Expression and function of Drosophila cyclin A during embryonic cell cycle progression.

From egg to gastrula: how the cell cycle is remodeled during the Drosophila mid-blastula transition

Growing an Embryo from a Single Cell: A Hurdle in Animal Life.

High-resolution 2-dimensional electrophoresis of proteins

Identification of Drosophila gene products required for phagocytosis of Candida albicans

Illuminating DNA replication during Drosophila development using TALE-lights

Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo.

Interphase-arrested Drosophila embryos activate zygotic gene expression and initiate mid-blastula transition events at a low nuclear-cytoplasmic ratio

Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila

Manipulating the metazoan mitochondrial genome with targeted restriction enzymes.

Mechanism and Regulation of Cdc25/Twine Protein Destruction in Embryonic Cell-Cycle Remodeling ⬇️

Mitigation of age-dependent accumulation of defective mitochondrial genomes

Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells

Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila

Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila.

Nitric oxide synthase is not essential for Drosophila development.

Nitric oxide-induced suspended animation promotes survival during hypoxia

Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells

Progression of the cell cycle through mitosis leads to abortion of nascent transcripts ⬇️

Quiescence: early evolutionary origins and universality do not imply uniformity ⬇️

RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle.

Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in Drosophila

Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in Drosophila

Rho-dependent control of anillin behavior during cytokinesis.

Rho-kinase controls cell shape changes during cytokinesis

Selections that isolate recombinant mitochondrial genomes in animals.

Selfish drive can trump function when animal mitochondrial genomes compete

Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos

TALE-light imaging reveals maternally guided, H3K9me2/3-independent emergence of functional heterochromatin in Drosophila embryos.

Terminal cytokinesis events uncovered after an RNAi screen

The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity

The cell cycle program in germ cells of the Drosophila embryo

The degradation of two mitotic cyclins contributes to the timing of cytokinesis

The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing

The engrailed locus of Drosophila: in situ localization of transcripts reveals compartment-specific expression

The glucocorticoid domain: steroid-mediated changes in the rate of synthesis of rat hepatoma proteins

The making of a maggot: patterning the Drosophila embryonic epidermis

The pre-omics era: the early days of two-dimensional gels.

The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis

The state of engrailed expression is not clonally transmitted during early Drosophila development

The suppression of defective translation by ppGpp and its role in the stringent response ⬇️

Timing the Drosophila Mid-Blastula Transition: A Cell Cycle-Centered View

Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster

Two-dimensional gel electrophoresis and the beginning of proteomics.