List of works - Richard Lenski

A Comparison of Methods to Measure Fitness in Escherichia coli

scientific article published on 11 May 2015

A lac of interest in evolution

scientific article published on 01 February 1993

A road map for in vivo evolution experiments with blood‐borne parasitic microbes

scientific article published in 2022

Adaptation, Clonal Interference, and Frequency-Dependent Interactions in a Long-Term Evolution Experiment with Escherichia coli

scientific article

Adaptive evolution of highly mutable loci in pathogenic bacteria

scientific article published on January 1994

Adaptive radiation from resource competition in digital organisms

scientific article published in July 2004

Altered regulation of the OmpF porin by Fis in Escherichia coli during an evolution experiment and between B and K-12 strains

scientific article

An experimental test of evolutionary trade-offs during temperature adaptation

scholarly article

Analysis of bacterial genomes from an evolution experiment with horizontal gene transfer shows that recombination can sometimes overwhelm selection

scientific article published on 31 January 2018

Analysis of epistatic interactions and fitness landscapes using a new geometric approach

scientific article

Application of Traditional and Phylogenetically Based Comparative Methods to Test for a Trade-off in Bacterial Growth Rate at Low versus High Substrate Concentration

scientific article published on 01 October 1999

Are some mutations directed? ⬇️

scientific article published on May 1, 1989

Balancing robustness and evolvability

scientific article

Chance and necessity in the evolution of a bacterial pathogen

scientific article published on 28 November 2011

Changes in Cell Size and Shape during 50,000 Generations of Experimental Evolution with Escherichia coli

scientific article published in 2021

Changes in Intrinsic Antibiotic Susceptibility during a Long-Term Evolution Experiment with Escherichia coli

scientific article published on 05 March 2019

Changing fitness effects of mutations through long-term bacterial evolution

scientific article published on 25 January 2024

Chemical warfare from an ecological perspective

scientific article

Climate change and the integrity of science

scientific article

Coevolution drives the emergence of complex traits and promotes evolvability

scientific article published on 16 December 2014

Coevolution of bacteria and phage: are there endless cycles of bacterial defenses and phage counterdefenses?

scientific article published on June 1984

Coexistence of evolving bacteria stabilized by a shared Black Queen function

scientific article

Coexistence of two competitors on one resource and one inhibitor: a chemostat model based on bacteria and antibiotics

scientific article published on September 1986

Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding

scientific article

Contribution of individual random mutations to genotype-by-environment interactions in Escherichia coli

scientific article

Convergence and Divergence in a Long-Term Experiment with Bacteria

scientific article

Core Genes Evolve Rapidly in the Long-term Evolution Experiment with Escherichia coli

scientific article

Cryptic population dynamics: rapid evolution masks trophic interactions

scientific article

Death and cannibalism in a seasonal environment facilitate bacterial coexistence

scientific article

Developmental cheating in the social bacterium Myxococcus xanthus

scientific article (publication date: 6 April 2000)

Diminishing Returns from Mutation Supply Rate in Asexual Populations

scientific article published in Science

Does evolutionary theory need a rethink?

scientific article

Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations

scientific article (publication date: 19 July 1994)

Dynamics of insertion sequence elements during experimental evolution of bacteria

scientific article published on June 2004

E. coli long-term evolution experiment

study of E. coli bacteria evolution in controlled conditions

Ecological and evolutionary dynamics of coexisting lineages during a long-term experiment with Escherichia coli

scientific article

Ecological specialization and adaptive decay in digital organisms

scientific article published on 4 December 2006

Ecological speciation of bacteriophage lambda in allopatry and sympatry

scientific article

Ecological variables affecting predatory success in Myxococcus xanthus

scientific article published on 5 April 2007

Effects of population size and mutation rate on the evolution of mutational robustness

scientific article published on March 2007

Epistasis and allele specificity in the emergence of a stable polymorphism in Escherichia coli

scientific article published on 6 March 2014

Escherichia coli rpoB mutants have increased evolvability in proportion to their fitness defects

scientific article

Evaluating the fate of genetically modified microorganisms in the environment: are they inherently less fit?

scientific article

Evidence for multiple adaptive peaks from populations of bacteria evolving in a structured habitat

scientific article published on September 1994

Evolution of competitive fitness in experimental populations of E. coli: what makes one genotype a better competitor than another?

scientific article published on 01 January 1998

Evolution of global regulatory networks during a long-term experiment with Escherichia coli

scientific article published on September 2007

Evolution of high mutation rates in experimental populations of E. coli

scientific article

Evolution of organismal stoichiometry in a long-term experiment with Escherichia coli

scientific article published on 19 July 2017

Evolution of penicillin-binding protein 2 concentration and cell shape during a long-term experiment with Escherichia coli

scientific article

Evolutionary Response of Escherichia coli to Thermal Stress

article

Evolutionary adaptation to freeze-thaw-growth cycles in Escherichia coli

scientific article published on 7 May 2007

Evolutionary dynamics, epistatic interactions, and biological information

scientific article published on 24 July 2010

Evolutionary genetics. Directed mutations slip-sliding away?

scientific article published on February 1995

Experimental evolution

scientific article

Experimental evolution and the dynamics of adaptation and genome evolution in microbial populations

scientific article published on 16 May 2017

Experimental evolution of a microbial predator's ability to find prey.

scientific article published in February 2009

Experimental evolution with E. coli in diverse resource environments. I. Fluctuating environments promote divergence of replicate populations

scientific article

Experimental tests for an evolutionary trade-off between growth rate and yield in E. coli

scientific article

Experiments on the role of deleterious mutations as stepping stones in adaptive evolution

scientific article

Experiments with digital organisms on the origin and maintenance of sex in changing environments

scientific article

Expression profiles reveal parallel evolution of epistatic interactions involving the CRP regulon in Escherichia coli

scientific article

From Here to Eternity--The Theory and Practice of a Really Long Experiment

scientific article

Genetic basis of evolutionary adaptation by Escherichia coli to stressful cycles of freezing, thawing and growth

scientific article published on 30 August 2008

Genetically integrated traits and rugged adaptive landscapes in digital organisms

scientific article published on 12 May 2015

Genetics and evolution. Come fly, and leave the baggage behind

scientific article published in October 2001

Genome complexity, robustness and genetic interactions in digital organisms.

scientific article

Genome dynamics during experimental evolution

scientific article

Genome evolution and adaptation in a long-term experiment with Escherichia coli

scientific article

Genome sequences of Escherichia coli B strains REL606 and BL21(DE3).

scientific article published on 26 September 2009

Genomic analysis of a key innovation in an experimental Escherichia coli population

scientific article

Genomic comparisons among Escherichia coli strains B, K-12, and O157:H7 using IS elements as molecular markers

scientific article

Genomic evolution during a 10,000-generation experiment with bacteria

scientific article

Historical and contingent factors affect re-evolution of a complex feature lost during mass extinction in communities of digital organisms

scientific article

Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli

scientific article

Historical contingency in the evolution of antibiotic resistance after decades of relaxed selection

scientific article published on 23 October 2019

Host coevolution alters the adaptive landscape of a virus.

scientific article published in September 2016

Identification and dynamics of a beneficial mutation in a long-term evolution experiment with Escherichia coli

scientific article

Idiosyncratic Fitness Costs of Ampicillin-Resistant Mutants Derived from a Long-Term Experiment with Escherichia coli

scientific article published in 2022

Increased susceptibility to repeated freeze-thaw cycles in Escherichia coli following long-term evolution in a benign environment

scientific article (publication date: 5 December 2006)

L'enfant terrible at 30: the maturation of evolutionary developmental biology

scientific article published in July 2011

Large chromosomal rearrangements during a long-term evolution experiment with Escherichia coli

scientific article

Long-Term Experimental Evolution in Escherichia coli. VIII. Dynamics of a Balanced Polymorphism

scientific article

Long-term dynamics of adaptation in asexual populations

scientific article published on 14 November 2013

Long-term experimental evolution in Escherichia coli. XI. Rejection of non-transitive interactions as cause of declining rate of adaptation

scientific article

Long-term experimental evolution in Escherichia coli. XII. DNA topology as a key target of selection

scientific article

Long-term experimental evolution in Escherichia coli. XIII. Phylogenetic history of a balanced polymorphism

scientific article

Loss of social behaviors by myxococcus xanthus during evolution in an unstructured habitat

scientific article published on October 1998

Mechanisms causing rapid and parallel losses of ribose catabolism in evolving populations of Escherichia coli B.

scientific article

Metabolic modelling in a dynamic evolutionary framework predicts adaptive diversification of bacteria in a long-term evolution experiment

scientific article published on 20 August 2016

Microbial genetics: Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation

scientific article

Modeling and quantifying frequency-dependent fitness in microbial populations with cross-feeding interactions

scientific article published on 29 April 2015

Mutation Rate Inferred From Synonymous Substitutions in a Long-Term Evolution Experiment With Escherichia coli

scientific article

Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load

scientific article (publication date: 2 January 2013)

Mutation, recombination, and incipient speciation of bacteria in the laboratory

scientific article

Mutator genomes decay, despite sustained fitness gains, in a long-term experiment with bacteria

scientific article published on 10 October 2017

Natural selection fails to optimize mutation rates for long-term adaptation on rugged fitness landscapes

scientific article

Negative epistasis between beneficial mutations in an evolving bacterial population

scientific article published in June 2011

Ontogeny tends to recapitulate phylogeny in digital organisms

scientific article published on 16 July 2012

Parallel Genetic and Phenotypic Evolution of DNA Superhelicity in Experimental Populations of Escherichia coli

scientific article published on 14 April 2010

Parallel changes in gene expression after 20,000 generations of evolution in Escherichiacoli

scientific article

Parallel changes in global protein profiles during long-term experimental evolution in Escherichia coli

scientific article

Parallel changes in host resistance to viral infection during 45,000 generations of relaxed selection

scientific article published on 19 August 2010

Parasites and mutational load: an experimental test of a pluralistic theory for the evolution of sex.

scientific article published in February 2005

Pervasive joint influence of epistasis and plasticity on mutational effects in Escherichia coli

scientific article

Rates of DNA sequence evolution in experimental populations of Escherichia coli during 20,000 generations

scientific article published in April 2003

Repeatability and contingency in the evolution of a key innovation in phage lambda

scientific article

Replaying Evolution to Test the Cause of Extinction of One Ecotype in an Experimentally Evolved Population

scientific article

Rescue of social motility lost during evolution of Myxococcus xanthus in an asocial environment

scientific article

Second-order selection for evolvability in a large Escherichia coli population

scientific article

Selective press extinctions, but not random pulse extinctions, cause delayed ecological recovery in communities of digital organisms

scientific article published on April 2009

Sexual reproduction reshapes the genetic architecture of digital organisms

scientific article published in February 2006

Specificity of genome evolution in experimental populations of Escherichia coli evolved at different temperatures

scientific article published on 15 February 2017

Stability of recombinant DNA and its effects on fitness.

scientific article

Sustained coevolution of phage Lambda and Escherichia coli involves inner- as well as outer-membrane defences and counter-defences

scientific article published in 2021

Sustained fitness gains and variability in fitness trajectories in the long-term evolution experiment with Escherichia coli.

scientific article published in December 2015

Synonymous Genetic Variation in Natural Isolates of Escherichia coli Does Not Predict Where Synonymous Substitutions Occur in a Long-Term Experiment

scientific article

Tempo and mode of genome evolution in a 50,000-generation experiment

scientific article

Test of synergistic interactions among deleterious mutations in bacteria ⬇️

scientific article published on November 27, 1997

Tests of parallel molecular evolution in a long-term experiment with Escherichia coli

scholarly article

The Black Queen Hypothesis: evolution of dependencies through adaptive gene loss

scientific article (publication date: 2012)

The curse of the pharaoh: the evolution of virulence in pathogens with long living propagules

scientific article published in June 1996

The dynamics of molecular evolution over 60,000 generations.

scientific article

The ecology, genetics and evolution of bacteria in an experimental setting

scientific article published on June 2003

The evolution of virulence in parasites and pathogens: reconciliation between two competing hypotheses

scientific article published in August 1994

The evolutionary origin of complex features

scientific article (publication date: 8 May 2003)

The genetic basis of parallel and divergent phenotypic responses in evolving populations of Escherichia coli

scientific article published in February 2008

The population genetics of ecological specialization in evolving Escherichia coli populations

scientific article

Tracing ancestors and relatives of Escherichia coli B, and the derivation of B strains REL606 and BL21(DE3).

scientific article

Twice as natural ⬇️

scientific article published on November 15, 2001

Understanding the differences between genome sequences of Escherichia coli B strains REL606 and BL21(DE3) and comparison of the E. coli B and K-12 genomes

scientific article published on 15 September 2009

What is adaptation by natural selection? Perspectives of an experimental microbiologist

scientific article

You lookin' at me?

scientific article published on 14 July 2016

List of works by Richard Lenski

A Comparison of Methods to Measure Fitness in Escherichia coli

A lac of interest in evolution

A road map for in vivo evolution experiments with blood‐borne parasitic microbes

Adaptation, Clonal Interference, and Frequency-Dependent Interactions in a Long-Term Evolution Experiment with Escherichia coli

Adaptive evolution of highly mutable loci in pathogenic bacteria

Adaptive radiation from resource competition in digital organisms

Altered regulation of the OmpF porin by Fis in Escherichia coli during an evolution experiment and between B and K-12 strains

An experimental test of evolutionary trade-offs during temperature adaptation

Analysis of bacterial genomes from an evolution experiment with horizontal gene transfer shows that recombination can sometimes overwhelm selection

Analysis of epistatic interactions and fitness landscapes using a new geometric approach

Application of Traditional and Phylogenetically Based Comparative Methods to Test for a Trade-off in Bacterial Growth Rate at Low versus High Substrate Concentration

Are some mutations directed? ⬇️

Balancing robustness and evolvability

Chance and necessity in the evolution of a bacterial pathogen

Changes in Cell Size and Shape during 50,000 Generations of Experimental Evolution with Escherichia coli

Changes in Intrinsic Antibiotic Susceptibility during a Long-Term Evolution Experiment with Escherichia coli

Changing fitness effects of mutations through long-term bacterial evolution

Chemical warfare from an ecological perspective

Climate change and the integrity of science

Coevolution drives the emergence of complex traits and promotes evolvability

Coevolution of bacteria and phage: are there endless cycles of bacterial defenses and phage counterdefenses?

Coexistence of evolving bacteria stabilized by a shared Black Queen function

Coexistence of two competitors on one resource and one inhibitor: a chemostat model based on bacteria and antibiotics

Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding

Contribution of individual random mutations to genotype-by-environment interactions in Escherichia coli

Convergence and Divergence in a Long-Term Experiment with Bacteria

Core Genes Evolve Rapidly in the Long-term Evolution Experiment with Escherichia coli

Cryptic population dynamics: rapid evolution masks trophic interactions

Death and cannibalism in a seasonal environment facilitate bacterial coexistence

Developmental cheating in the social bacterium Myxococcus xanthus

Diminishing Returns from Mutation Supply Rate in Asexual Populations

Does evolutionary theory need a rethink?

Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations

Dynamics of insertion sequence elements during experimental evolution of bacteria

E. coli long-term evolution experiment

Ecological and evolutionary dynamics of coexisting lineages during a long-term experiment with Escherichia coli

Ecological specialization and adaptive decay in digital organisms

Ecological speciation of bacteriophage lambda in allopatry and sympatry

Ecological variables affecting predatory success in Myxococcus xanthus

Effects of population size and mutation rate on the evolution of mutational robustness

Epistasis and allele specificity in the emergence of a stable polymorphism in Escherichia coli

Escherichia coli rpoB mutants have increased evolvability in proportion to their fitness defects

Evaluating the fate of genetically modified microorganisms in the environment: are they inherently less fit?

Evidence for multiple adaptive peaks from populations of bacteria evolving in a structured habitat

Evolution of competitive fitness in experimental populations of E. coli: what makes one genotype a better competitor than another?

Evolution of global regulatory networks during a long-term experiment with Escherichia coli

Evolution of high mutation rates in experimental populations of E. coli

Evolution of organismal stoichiometry in a long-term experiment with Escherichia coli

Evolution of penicillin-binding protein 2 concentration and cell shape during a long-term experiment with Escherichia coli

Evolutionary Response of Escherichia coli to Thermal Stress

Evolutionary adaptation to freeze-thaw-growth cycles in Escherichia coli

Evolutionary dynamics, epistatic interactions, and biological information

Evolutionary genetics. Directed mutations slip-sliding away?

Experimental evolution

Experimental evolution and the dynamics of adaptation and genome evolution in microbial populations

Experimental evolution of a microbial predator's ability to find prey.

Experimental evolution with E. coli in diverse resource environments. I. Fluctuating environments promote divergence of replicate populations

Experimental tests for an evolutionary trade-off between growth rate and yield in E. coli

Experiments on the role of deleterious mutations as stepping stones in adaptive evolution

Experiments with digital organisms on the origin and maintenance of sex in changing environments

Expression profiles reveal parallel evolution of epistatic interactions involving the CRP regulon in Escherichia coli

From Here to Eternity--The Theory and Practice of a Really Long Experiment

Genetic basis of evolutionary adaptation by Escherichia coli to stressful cycles of freezing, thawing and growth

Genetically integrated traits and rugged adaptive landscapes in digital organisms

Genetics and evolution. Come fly, and leave the baggage behind

Genome complexity, robustness and genetic interactions in digital organisms.

Genome dynamics during experimental evolution

Genome evolution and adaptation in a long-term experiment with Escherichia coli

Genome sequences of Escherichia coli B strains REL606 and BL21(DE3).

Genomic analysis of a key innovation in an experimental Escherichia coli population

Genomic comparisons among Escherichia coli strains B, K-12, and O157:H7 using IS elements as molecular markers

Genomic evolution during a 10,000-generation experiment with bacteria

Historical and contingent factors affect re-evolution of a complex feature lost during mass extinction in communities of digital organisms

Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli

Historical contingency in the evolution of antibiotic resistance after decades of relaxed selection

Host coevolution alters the adaptive landscape of a virus.

Identification and dynamics of a beneficial mutation in a long-term evolution experiment with Escherichia coli

Idiosyncratic Fitness Costs of Ampicillin-Resistant Mutants Derived from a Long-Term Experiment with Escherichia coli

Increased susceptibility to repeated freeze-thaw cycles in Escherichia coli following long-term evolution in a benign environment