List of works - A Eckly

A PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1

scientific article (publication date: 8 May 2003)

ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing

scientific article published on 07 June 2010

Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation.

scientific article

An essential role for α4A-tubulin in platelet biogenesis

scientific article published on 13 February 2019

Arterial thrombosis: relevance of a model with two levels of severity assessed by histologic, ultrastructural and functional characterization

scientific article published on 24 October 2009

Aryl hydrocarbon receptor-dependent enrichment of a megakaryocytic precursor with a high potential to produce proplatelets

scientific article published on 10 March 2016

Biogenesis of the demarcation membrane system (DMS) in megakaryocytes

scientific article

Blood platelet formation at a glance

scientific article published on 30 October 2020

Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage.

scientific article published on 17 December 2014

Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes

scientific article

Characterization of megakaryocyte development in the native bone marrow environment

scientific article published on 01 January 2012

Clot Contraction Drives the Translocation of Procoagulant Platelets to Thrombus Surface

scientific article published on 01 January 2019

Coagulation factors bound to procoagulant platelets concentrate in cap structures to promote clotting.

scientific article published on 18 July 2016

Cytochemical distribution of cyclic AMP-dependent 3',5'-nucleotide phosphodiesterase in the rat myocardium

scientific article published on 01 March 1996

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42.

scientific article

Dehydration of blood platelets by zeodration: in vitro characterization and hemostatic properties in vivo.

scientific article published on 9 April 2015

Desensitization of the platelet aggregation response to ADP: differential down-regulation of the P2Y1 and P2cyc receptors

scientific article published on 01 September 2000

Differential involvement of the P2Y1 and P2YT receptors in the morphological changes of platelet aggregation

scientific article published on 01 April 2001

Differential regulation and relocalization of the platelet P2Y receptors after activation: a way to avoid loss of hemostatic properties?

scientific article

Distinct localizations and roles of non-muscle myosin II during proplatelet formation and platelet release

scientific article published on 01 April 2015

Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation.

scientific article published in June 2001

Further evidence that fibrillar collagen is unable to promote platelet shape change and aggregation in the absence of secondary agonists

scientific article published on 01 September 2005

High-Resolution 3D Imaging of Megakaryocytes Using Focused Ion Beam-Scanning Electron Microscopy

scientific article published on 01 January 2018

Hirudin and heparin enable efficient megakaryocyte differentiation of mouse bone marrow progenitors

scientific article published on 08 October 2011

Immature myeloid dendritic cells capture and remove activated platelets from preformed aggregates

scientific article published on 01 October 2010

Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation.

scientific article published on 8 August 2016

Inhibition of adhesive and signaling functions of the platelet GPIb-V-IX complex by a cell penetrating GPIbalpha peptide.

scientific article published in December 2006

Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.

scientific article

Isoprenaline induces endothelium-independent relaxation and accumulation of cyclic nucleotides in the rat aorta

scientific article published on 01 December 1994

Lentiviral gene rescue of a Bernard-Soulier mouse model to study platelet glycoprotein Ibβ function.

scientific article

Lineage-specific overexpression of the P2Y1 receptor induces platelet hyper-reactivity in transgenic mice.

scientific article published in January 2003

Macrothrombocytopenia and dense granule deficiency associated with FLI1 variants: ultrastructural and pathogenic features.

scientific article

Mechanisms underlying FeCl3-induced arterial thrombosis

scientific article published on 01 April 2011

Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.

scientific article

Microtubule plus-end tracking Adenopolyposis Coli negatively regulates proplatelet formation

scientific article published in Scientific Reports

Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets.

scientific article

Myosin IIA is critical for organelle distribution and F-actin organization in megakaryocytes and platelets.

scientific article

Preserved functional and biochemical characteristics of platelet components prepared with amotosalen and ultraviolet A for pathogen inactivation ⬇️

scientific article published on October 15, 2012

Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice.

scientific article

Respective contributions of single and compound granule fusion to secretion by activated platelets.

scientific article

Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA.

scientific article

Species differences in localization of cardiac cAMP-phosphodiesterase activity: a cytochemical study

scientific article published on 01 August 1997

Synthesis of GPIb beta with novel transmembrane and cytoplasmic sequences in a Bernard-Soulier patient resulting in GPIb-defective signaling in CHO cells.

scientific article

Targeting platelet GPIbβ reduces platelet adhesion, GPIb signaling and thrombin generation and prevents arterial thrombosis.

scientific article

The P2Y1 receptor plays an essential role in the platelet shape change induced by collagen when TxA2 formation is prevented

scientific article (publication date: June 2004)

The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel

scientific article published on 01 December 1998

The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition

scientific article published on 24 November 2018

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

scientific article

The platelet glycoprotein GPIbbeta intracellular domain participates in von Willebrand factor induced-filopodia formation independently of the Ser 166 phosphorylation site.

scientific article published on 19 August 2009

Use of electron microscopy to study megakaryocytes

scientific article published on 05 January 2020

Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells

scientific article published on 27 September 2019

List of works by A Eckly

A PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1

ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing

Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation.

An essential role for α4A-tubulin in platelet biogenesis

Arterial thrombosis: relevance of a model with two levels of severity assessed by histologic, ultrastructural and functional characterization

Aryl hydrocarbon receptor-dependent enrichment of a megakaryocytic precursor with a high potential to produce proplatelets

Biogenesis of the demarcation membrane system (DMS) in megakaryocytes

Blood platelet formation at a glance

Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage.

Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes

Characterization of megakaryocyte development in the native bone marrow environment

Clot Contraction Drives the Translocation of Procoagulant Platelets to Thrombus Surface

Coagulation factors bound to procoagulant platelets concentrate in cap structures to promote clotting.

Cytochemical distribution of cyclic AMP-dependent 3',5'-nucleotide phosphodiesterase in the rat myocardium

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42.

Dehydration of blood platelets by zeodration: in vitro characterization and hemostatic properties in vivo.

Desensitization of the platelet aggregation response to ADP: differential down-regulation of the P2Y1 and P2cyc receptors

Differential involvement of the P2Y1 and P2YT receptors in the morphological changes of platelet aggregation

Differential regulation and relocalization of the platelet P2Y receptors after activation: a way to avoid loss of hemostatic properties?

Distinct localizations and roles of non-muscle myosin II during proplatelet formation and platelet release

Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation.

Further evidence that fibrillar collagen is unable to promote platelet shape change and aggregation in the absence of secondary agonists

High-Resolution 3D Imaging of Megakaryocytes Using Focused Ion Beam-Scanning Electron Microscopy

Hirudin and heparin enable efficient megakaryocyte differentiation of mouse bone marrow progenitors

Immature myeloid dendritic cells capture and remove activated platelets from preformed aggregates

Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation.

Inhibition of adhesive and signaling functions of the platelet GPIb-V-IX complex by a cell penetrating GPIbalpha peptide.

Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.

Isoprenaline induces endothelium-independent relaxation and accumulation of cyclic nucleotides in the rat aorta

Lentiviral gene rescue of a Bernard-Soulier mouse model to study platelet glycoprotein Ibβ function.

Lineage-specific overexpression of the P2Y1 receptor induces platelet hyper-reactivity in transgenic mice.

Macrothrombocytopenia and dense granule deficiency associated with FLI1 variants: ultrastructural and pathogenic features.

Mechanisms underlying FeCl3-induced arterial thrombosis

Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.

Microtubule plus-end tracking Adenopolyposis Coli negatively regulates proplatelet formation

Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets.

Myosin IIA is critical for organelle distribution and F-actin organization in megakaryocytes and platelets.

Preserved functional and biochemical characteristics of platelet components prepared with amotosalen and ultraviolet A for pathogen inactivation ⬇️

Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice.

Respective contributions of single and compound granule fusion to secretion by activated platelets.

Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA.

Species differences in localization of cardiac cAMP-phosphodiesterase activity: a cytochemical study

Synthesis of GPIb beta with novel transmembrane and cytoplasmic sequences in a Bernard-Soulier patient resulting in GPIb-defective signaling in CHO cells.

Targeting platelet GPIbβ reduces platelet adhesion, GPIb signaling and thrombin generation and prevents arterial thrombosis.

The P2Y1 receptor plays an essential role in the platelet shape change induced by collagen when TxA2 formation is prevented

The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel

The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

The platelet glycoprotein GPIbbeta intracellular domain participates in von Willebrand factor induced-filopodia formation independently of the Ser 166 phosphorylation site.

Use of electron microscopy to study megakaryocytes

Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells