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List of works by Linda Troeberg

A trypanosome oligopeptidase as a target for the trypanocidal agents pentamidine, diminazene and suramin ⬇️

scientific article published on August 21, 1998

ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells

scientific article published on 02 April 2019

ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the 'usual suspects'.

scientific article

Analysis of TIMP expression and activity

scientific article published on 01 January 2007

Brief Report: JNK-2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis.

scientific article published on 14 December 2015

Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases.

scientific article published on 16 July 2008

Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function.

scientific article

Characterisation of the antitrypanosomal activity of peptidyl alpha-aminoalkyl phosphonate diphenyl esters.

scientific article

Differential Regulation of Extracellular Tissue Inhibitor of Metalloproteinases-3 Levels by Cell Membrane-bound and Shed Low Density Lipoprotein Receptor-related Protein 1 ⬇️

scientific article published on November 19, 2012

Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.

scientific article published on 29 July 2016

E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A)

scientific article (publication date: 17 December 2002)

Effect of Polarization and Chronic Inflammation on Macrophage Expression of Heparan Sulfate Proteoglycans and Biosynthesis Enzymes

scientific article published on 11 September 2018

Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.

scientific article published on 31 August 2016

Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.

scientific article

Extracellular regulation of metalloproteinases.

scientific article

Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity

scientific article

Heparan Sulfate Proteoglycan Synthesis Is Dysregulated in Human Osteoarthritic Cartilage

scientific article published on 14 December 2018

Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor

scientific article published in Scientific Reports

Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis.

scientific article published on 24 February 2017

Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes.

scientific article published in July 2015

Invasive potential of human rheumatoid tenosynovial cells is in part MT1-MMP dependent.

scientific article published on 12 July 2009

Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage

scientific article published on 12 January 2011

LRP1 Controls TNF Release via the TIMP-3/ADAM17 Axis in Endotoxin-Activated Macrophages

scientific article published on 18 January 2019

LRP‐1‐mediated endocytosis regulates extracellular activity of ADAMTS‐5 in articular cartilage ⬇️

scientific article published on October 11, 2012

Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 b

scientific article published on 28 January 2014

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

scientific article published on 12 April 2016

Measurement of matrix metalloproteinase activities in the medium of cultured synoviocytes using zymography.

scientific article

Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity

scientific article

Monitoring metalloproteinase activity using synthetic fluorogenic substrates

scientific article published on 01 November 2004

Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma

scientific article published on 29 November 2017

Production of anti-peptide antibodies against trypanopain-Tb from Trypanosoma brucei brucei: effects of antibodies on enzyme activity against Z-Phe-Arg-AMC

article

Production of cytokines, vascular endothelial growth factor, matrix metalloproteinases, and tissue inhibitor of metalloproteinases 1 by tenosynovium demonstrates its potential for tendon destruction in rheumatoid arthritis

scientific article published on 01 August 2001

Proteases from Trypanosoma brucei brucei. Purification, characterisation and interactions with host regulatory molecules

scientific article published on 01 June 1996

Proteases involved in cartilage matrix degradation in osteoarthritis.

scientific article published on 8 July 2011

Purification and characterisation of a trypsin-like serine oligopeptidase from Trypanosoma congolense.

scientific article published in July 1999

Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3.

scientific article

Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3.

scientific article published on 10 August 2017

The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.

scientific article

The role of matrix metalloproteinases in rheumatoid tendon disease

scientific article published on 01 November 2002

Zymography of metalloproteinases

scientific article published on 01 November 2004

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