List of works - Paul Mould

A small molecule alpha 4 beta 1 antagonist prevents development of murine Lyme arthritis without affecting protective immunity.

scientific article published on October 2005

A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.

scientific article published on 22 December 2004

Adhesion articulated

scientific article published in Nature

Analyzing integrin-dependent adhesion.

scientific article published on August 2002

Analyzing integrin-dependent adhesion.

scientific article

Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

scientific article published in Journal of Biological Chemistry

Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

scientific article published in Journal of Biological Chemistry

Demonstration of catch bonds between an integrin and its ligand.

scientific article published on June 2009

Disruption of integrin-fibronectin complexes by allosteric but not ligand-mimetic inhibitors.

scientific article published on December 2014

Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1.

scientific article published on 26 September 2008

Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors.

scientific article published on 4 January 2005

E-cadherin is a ligand for integrin α2β1

article

Evidence for the presence of a low-mass beta1 integrin on the cell surface.

scientific article published on 16 August 2005

Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.

scientific article published on 22 November 2004

Expression and characterisation of a very-late antigen-4 (alpha 4 beta 1) integrin-binding fragment of vascular cell-adhesion molecule-1.

scientific article published on December 1994

Extracellular Histones Inhibit Complement Activation through Interacting with Complement Component 4

scientific article published on 11 May 2018

Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.

scientific article published in December 1999

Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin alpha5beta1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding.

scientific article

Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit

scientific article published on 01 April 1995

Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin ⬇️

scientific article published on December 1, 1991

Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio)

scientific article

Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION.

scientific article

Mapping functional residues onto integrin crystal structures.

scientific article

Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach.

scientific article published on 11 November 2009

Molecular Basis of Ligand Recognition by Integrin α5β1

scientific article published in Journal of Biological Chemistry

Novel activating and inactivating mutations in the integrin beta1 subunit A domain.

scientific article published on June 2004

Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?

scientific article published in October 2004

Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.

scientific article published on 7 October 2003

Screen for multi-SUMO-binding proteins reveals a multi-SIM-binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin.

scientific article

Solid phase assays for studying ECM protein-protein interactions

scientific article published on 01 January 2009

Solid phase assays for studying ECM protein-protein interactions.

scientific article

Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1.

scientific article

Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP.

scientific article published on 30 May 2017

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

scientific article published on 19 July 2003

The "linker" region (amino acids 38-47) of the disintegrin elegantin is a novel inhibitory domain of integrin alpha5beta1-dependent cell adhesion on fibronectin: evidence for the negative regulation of fibronectin synergy site biological activity.

scientific article published on 18 September 2006

The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy

scientific article published in Journal of Biological Chemistry

The collagens of hydra provide insight into the evolution of metazoan extracellular matrices.

scientific article published on 3 January 2007

The herpes viral transcription factor ICP4 forms a novel DNA recognition complex

scientific article published on 13 May 2017

The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family.

scientific article

The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function

scientific article published on 22 August 2017

List of works by Paul Mould

A small molecule alpha 4 beta 1 antagonist prevents development of murine Lyme arthritis without affecting protective immunity.

A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.

Adhesion articulated

Analyzing integrin-dependent adhesion.

Analyzing integrin-dependent adhesion.

Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

Demonstration of catch bonds between an integrin and its ligand.

Disruption of integrin-fibronectin complexes by allosteric but not ligand-mimetic inhibitors.

Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1.

Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors.

E-cadherin is a ligand for integrin α2β1

Evidence for the presence of a low-mass beta1 integrin on the cell surface.

Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.

Expression and characterisation of a very-late antigen-4 (alpha 4 beta 1) integrin-binding fragment of vascular cell-adhesion molecule-1.

Extracellular Histones Inhibit Complement Activation through Interacting with Complement Component 4

Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.

Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin alpha5beta1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding.

Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit

Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin ⬇️

Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio)

Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION.

Mapping functional residues onto integrin crystal structures.

Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach.

Molecular Basis of Ligand Recognition by Integrin α5β1

Novel activating and inactivating mutations in the integrin beta1 subunit A domain.

Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?

Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.

Screen for multi-SUMO-binding proteins reveals a multi-SIM-binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin.

Solid phase assays for studying ECM protein-protein interactions

Solid phase assays for studying ECM protein-protein interactions.

Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1.

Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP.

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

The "linker" region (amino acids 38-47) of the disintegrin elegantin is a novel inhibitory domain of integrin alpha5beta1-dependent cell adhesion on fibronectin: evidence for the negative regulation of fibronectin synergy site biological activity.

The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy

The collagens of hydra provide insight into the evolution of metazoan extracellular matrices.

The herpes viral transcription factor ICP4 forms a novel DNA recognition complex

The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family.

The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function