List of works - Chas Bountra

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

scientific article

Assessing histone demethylase inhibitors in cells: lessons learned.

scientific article

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.

scientific article published on 23 March 2015

Donated chemical probes for open science

scientific article published on 20 April 2018

Erratum: Corrigendum: The promise and peril of chemical probes

scientific article published in November 2015

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

scientific article

Leveraging crowdsourcing to facilitate the discovery of new medicines

scientific article

MON-468 Selective Inhibition of Epigenetic Pathways Has Anti-Proliferative and Pro-Apoptotic Effects on the Mouse Corticotroph Tumor Cells, AtT20.

scientific article published on 30 April 2019

Open access chemical and clinical probes to support drug discovery

scientific article

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

scientific article

Preclinical target validation using patient-derived cells

scientific article

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

scientific article

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

scientific article published on 13 November 2015

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

scientific article

The promise and peril of chemical probes

scientific article

The structural basis of ZMPSTE24-dependent laminopathies

scientific article

List of works by Chas Bountra

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

Assessing histone demethylase inhibitors in cells: lessons learned.

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.

Donated chemical probes for open science

Erratum: Corrigendum: The promise and peril of chemical probes

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

Leveraging crowdsourcing to facilitate the discovery of new medicines

MON-468 Selective Inhibition of Epigenetic Pathways Has Anti-Proliferative and Pro-Apoptotic Effects on the Mouse Corticotroph Tumor Cells, AtT20.

Open access chemical and clinical probes to support drug discovery

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

Preclinical target validation using patient-derived cells

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

The promise and peril of chemical probes

The structural basis of ZMPSTE24-dependent laminopathies