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List of works by Ifor R. Williams

A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

scientific article

Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent

scientific article

Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes

scientific article

Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria

scientific article

Autoantigen-Specific Interactions with CD4+ Thymocytes Control Mature Medullary Thymic Epithelial Cell Cellularity

scientific article published on 01 September 2008

CC chemokine receptor 6 expression by B lymphocytes is essential for the development of isolated lymphoid follicles

scientific article published on April 2007

CCR6 expression distinguishes mouse myeloid and lymphoid dendritic cell subsets: demonstration using a CCR6 EGFP knock-in mouse

scientific article published on 01 January 2002

CCR6 identifies lymphoid tissue inducer cells within cryptopatches

scientific article published on 10 February 2010

CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches.

scientific article

CCR6hiCD11c(int) B cells promote M-cell differentiation in Peyer's patch

scientific article published on 21 March 2011

CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML).

scientific article

CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice

scientific article

Characterization and application of two RANK-specific antibodies with different biological activities

scientific article published on 7 January 2016

Chemokine receptors and leukocyte trafficking in the mucosal immune system.

scientific article published on January 2004

Colonic neutrophils in inflammatory bowel disease: double-edged swords of the innate immune system with protective and destructive capacity

scientific article published on 01 December 2007

Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation.

scientific article published on 22 March 2005

Controlled overexpression of BCKD kinase expression: metabolic engineering applied to BCAA metabolism in a mammalian system.

scientific article

Cutaneous interleukin-7 transgenic mice display a propitious environment to Schistosoma mansoni infection

scientific article published on 01 March 2001

Dendritic epidermal T cells (DETC) are diminished in integrin alphaE(CD103)-deficient mice

scientific article published on 01 July 2002

Development and in vitro validation of a targeted delivery vehicle for DNA vaccines.

scientific article published on 6 March 2006

Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling.

scientific article published on 16 January 2018

Distinct developmental requirements for isolated lymphoid follicle formation in the small and large intestine: RANKL is essential only in the small intestine.

scientific article

Donor lymphoid organs are a major site of alloreactive T-cell priming following intestinal transplantation

scientific article published on 04 September 2006

Efficient norovirus and reovirus replication in the mouse intestine requires microfold (M) cells.

scientific article

Epidermal expression of intercellular adhesion molecule 1 is not a primary inducer of cutaneous inflammation in transgenic mice ⬇️

scientific article published on October 11, 1994

FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model.

scientific article published in November 2005

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

scientific article (publication date: 26 January 2007)

IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake

scientific article

Identification of novel genes selectively expressed in the follicle-associated epithelium from the meta-analysis of transcriptomics data from multiple mouse cell and tissue populations.

scientific article

Immunity at the surface: homeostatic mechanisms of the skin immune system.

scientific article published on January 1996

Increased Abundance of M Cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility

scientific article

Keratinocyte expression of B7-1 in transgenic mice amplifies the primary immune response to cutaneous antigens.

scientific article

Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses

scientific article published on 16 September 2007

Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice.

scientific article

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.

scientific article published on 22 March 2005

Lymphoid organogenesis in the intestine.

scientific article

M Cell Differentiation: Distinct Lineage or Phenotypic Transition? Salmonella Provides Answers ⬇️

scientific article (publication date: November 2012)

M cell-depletion blocks oral prion disease pathogenesis.

scientific article

M-Cells Contribute to the Entry of an Oral Vaccine but Are Not Essential for the Subsequent Induction of Protective Immunity against Francisella tularensis

scientific article

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

scientific article

Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma.

scientific article published in June 2007

Molecular cloning and promoter analysis of downregulated in adenoma (DRA)

scientific article (publication date: November 2007)

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

scientific journal article

NALT M cells are important for immune induction for the common mucosal immune system.

scientific article published on 27 November 2017

Neutrophil migration across the intestinal epithelial barrier--summary of in vitro data and description of a new transgenic mouse model with doxycycline-inducible interleukin-8 expression in intestinal epithelial cells.

scientific article

Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.

scientific article

PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease.

scientific article published on May 2003

PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model

scientific article

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

scientific article published in February 2005

RANKL Is Necessary and Sufficient to Initiate Development of Antigen-Sampling M Cells in the Intestinal Epithelium

scientific article (publication date: 14 October 2009)

Role of T-cell reconstitution in HIV-1 antiretroviral therapy-induced bone loss

scientific article

Selective removal of stratum corneum by microdermabrasion to increase skin permeability.

scientific article published on 25 June 2009

Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates neutrophil transmigration.

scientific article published on 15 January 2002

TGF-beta upregulation drives tertiary lymphoid organ formation and kidney dysfunction in calcineurin A-alpha heterozygous mice.

scientific article published on 07 January 2009

TNF-α augments RANKL-dependent intestinal M cell differentiation in enteroid cultures.

scientific article published on 13 July 2016

The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells

scientific article published on 17 June 2012

The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice

scientific article published on 30 January 2013

Toll-like receptor 5-dependent regulation of inflammation in systemic Salmonella enterica Serovar typhimurium infection.

scientific article published on 13 July 2009

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes ⬇️

scientific article published on September 15, 1998

Two decades of bridging immunological divides

scientific article published on 01 October 2020

p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.

scientific article

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