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List of works by Willem Albert Hanekom

A Functional Toll-Interacting Protein Variant Is Associated with Bacillus Calmette-Guérin-Specific Immune Responses and Tuberculosis

scientific article published on 2 May 2017

A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans

scientific article

A blood RNA signature for tuberculosis disease risk: a prospective cohort study

scientific article

A comparative analysis of polyfunctional T cells and secreted cytokines induced by Bacille Calmette-Guérin immunisation in children and adults

scientific article (publication date: 2012)

A comparison of IFNgamma detection methods used in tuberculosis vaccine trials

scientific article published on 17 September 2008

A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

scientific article published in Nature

A new recombinant bacille Calmette-Guérin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers

scientific article

A phase IIa trial of the new tuberculosis vaccine, MVA85A, in HIV- and/or Mycobacterium tuberculosis-infected adults

scientific article published on 26 January 2012

A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents

scientific article

A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population

scientific article published on 8 February 2013

A whole blood assay to assess peripheral blood dendritic cell function in response to Toll-like receptor stimulation

scientific article published on 19 January 2006

Access to primary healthcare during lockdown measures for COVID-19 in rural South Africa: a longitudinal cohort study

scientific article published on 20 May 2020

Access to primary healthcare during lockdown measures for COVID-19 in rural South Africa: an interrupted time series analysis

scientific article published on 05 October 2020

Adjunctive thalidomide therapy for childhood tuberculous meningitis: results of a randomized study

scientific article

Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa

scientific article

Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis

scientific article published on June 2017

Application of a whole blood mycobacterial growth inhibition assay to study immunity against Mycobacterium tuberculosis in a high tuberculosis burden population

scientific article published on 8 September 2017

Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants

scientific article

Author Correction: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

scientific article published in Nature

BCG Vaccination of Infants Confers Mycobacterium tuberculosis Strain-Specific Immune Responses by Leukocytes

scientific article published on 23 November 2020

BCG vaccination induces HIV target cell activation in HIV-exposed infants in a randomized trial

scientific article published on 06 April 2017

Bacillus Calmette Guerin vaccination of human newborns induces a specific, functional CD8+ T cell response

scientific article published on 01 October 2006

Bacillus Calmette-Guérin (BCG) Revaccination of Adults with Latent Mycobacterium tuberculosis Infection Induces Long-Lived BCG-Reactive NK Cell Responses

scientific article published on 13 July 2016

Bacillus Calmette-Guérin vaccination of human newborns induces T cells with complex cytokine and phenotypic profiles

scientific article

Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases

scientific article published on 12 December 2018

CD4 and CD8 T-cell responses to mycobacterial antigens in African children

scientific article

CD8+ T-cell interleukin-7 receptor alpha expression as a potential indicator of disease status in HIV-infected children

scientific article

COMPASS identifies T-cell subsets correlated with clinical outcomes

scientific article

Childhood tuberculosis: old and new vaccines.

scientific article

Combined use of Mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses is a powerful diagnostic tool of active tuberculosis

scientific article

Comparable CD4 and CD8 T cell responses and cytokine release after at-birth and delayed BCG immunisation in infants born in Australia

scientific article published on 5 July 2016

Comparison of T-SPOT.TB assay and tuberculin skin test for the evaluation of young children at high risk for tuberculosis in a community setting

scientific article published in January 2009

Comparison of mantoux and tine tuberculin skin tests in BCG-vaccinated children investigated for tuberculosis

scientific article

Comparison of polyclonal expansion methods to improve the recovery of cervical cytobrush-derived T cells from the female genital tract of HIV-infected women

scientific article

Correction: Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study

scientific article published on 18 July 2019

Correction: Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells

article published in 2011

Correction: The Tuberculin Skin Test versus QuantiFERON TB Gold® in Predicting Tuberculosis Disease in an Adolescent Cohort Study in South Africa.

scientific article published on 30 June 2011

Corrigendum: T-cell activation is an immune correlate of risk in BCG vaccinated infants

scientific article published on 6 May 2016

Cytomegalovirus infection is a risk factor for tuberculosis disease in infants

scientific article published on 05 December 2019

Delaying BCG vaccination from birth to 10 weeks of age may result in an enhanced memory CD4 T cell response

scientific article published on 17 July 2009

Detection and treatment of subclinical tuberculosis

article

Developing vaccinology expertise for Africa: six years and counting

scientific article published on 28 June 2011

Diagnostic features associated with culture of Mycobacterium tuberculosis among young children in a vaccine trial setting

scientific article published on January 2012

Differential DNA methylation of potassium channel KCa3.1 and immune signalling pathways is associated with infant immune responses following BCG vaccination

scientific article published on 30 August 2018

Differential Recognition of Mycobacterium tuberculosis-Specific Epitopes as a Function of Tuberculosis Disease History

scientific article

Differential leukocyte counting and immunophenotyping in cryopreserved ex vivo whole blood

scientific article published on 16 December 2014

Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study

scientific article published on 16 April 2019

Dissection of regenerating T-Cell responses against tuberculosis in HIV-infected adults sensitized by Mycobacterium tuberculosis

scientific article

Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response

scientific article

Dominant TNF-α+ Mycobacterium tuberculosis–specific CD4+ T cell responses discriminate between latent infection and active disease

scientific article published on 20 February 2011

Dose Optimization of H56:IC31 Vaccine for TB Endemic Populations: A Double-Blind, Placebo-Controlled, Dose-Selection Trial

scientific article published on 01 January 2019

Dose-dependent immune response to Mycobacterium bovis BCG vaccination in neonates

scientific article published on 20 December 2006

Dose-finding study of the novel tuberculosis vaccine, MVA85A, in healthy BCG-vaccinated infants

scientific article published in June 2011

Effect of HIV on the Frequency and Number of Mycobacterium tuberculosis-Specific CD4+ T Cells in Blood and Airways During Latent M. tuberculosis Infection

scientific article

Effect of isoniazid therapy for latent TB infection on QuantiFERON-TB gold in-tube responses in adults with positive tuberculin skin test results in a high TB incidence area: a controlled study

scientific article published on March 2014

Effects of MVA85A vaccine on tuberculosis challenge in animals: systematic review

scientific article published on April 2016

Efficacy of percutaneous versus intradermal BCG in the prevention of tuberculosis in South African infants: randomised trial

scientific article published on 13 November 2008

Epstein-Barr nuclear antigen 1-specific CD4(+) Th1 cells kill Burkitt's lymphoma cells

scientific article published on August 2002

Escape of SARS-CoV-2 501Y.V2 variants from neutralization by convalescent plasma

scientific article published on 26 January 2021

Evaluation of Xpert® MTB/RIF Assay in Induced Sputum and Gastric Lavage Samples from Young Children with Suspected Tuberculosis from the MVA85A TB Vaccine Trial

scientific article published on 10 November 2015

Evaluation of the quality of informed consent in a vaccine field trial in a developing country setting

scientific article

Fetal public Vγ9Vδ2 T cells expand and gain potent cytotoxic functions early after birth

scientific article published on 14 July 2020

First-in-human trial of the post-exposure tuberculosis vaccine H56:IC31 in Mycobacterium tuberculosis infected and non-infected healthy adults

scientific article published on 19 June 2015

Four-gene Pan-African Blood Signature Predicts Progression to Tuberculosis

scientific article published on 6 April 2018

Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load

scientific article

Genetic variation in TLR genes in Ugandan and South African populations and comparison with HapMap data

scientific article

H1:IC31 vaccination is safe and induces long-lived TNF-α(+)IL-2(+)CD4 T cell responses in M. tuberculosis infected and uninfected adolescents: A randomized trial

scientific article

HIV Infection Is Associated With Downregulation of BTLA Expression on Mycobacterium tuberculosis-Specific CD4 T Cells in Active Tuberculosis Disease

scientific article published on 21 August 2019

HIV Is Associated with Modified Humoral Immune Responses in the Setting of HIV/TB Coinfection

scientific article published on 20 May 2020

HIV-1 Infection Is Associated with Depletion and Functional Impairment of Mycobacterium tuberculosis-Specific CD4 T Cells in Individuals with Latent Tuberculosis Infection

scientific article

HIV-1 infection alters CD4+ memory T-cell phenotype at the site of disease in extrapulmonary tuberculosis

scientific article published in January 2012

HIV-1 infection impairs the bronchoalveolar T-cell response to mycobacteria

scientific article

HIV-1 infection in infants severely impairs the immune response induced by Bacille Calmette-Guérin vaccine

scientific article

HIV-specific gag responses in early infancy correlate with clinical outcome and inversely with viral load

scientific article published on 12 May 2011

Heterologous vaccination against human tuberculosis modulates antigen-specific CD4+ T-cell function

scientific article published on 08 July 2013

High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease

scientific article published in January 2010

Higher human CD4 T cell response to novel Mycobacterium tuberculosis latency associated antigens Rv2660 and Rv2659 in latent infection compared with tuberculosis disease

scientific article

Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells

scientific article published on 15 November 2011

Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study

scientific article

Identification of antigens specific to non-tuberculous mycobacteria: the Mce family of proteins as a target of T cell immune responses

scientific article

Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV shedding

scientific article

Immunological biomarkers of tuberculosis

scientific article published on 08 April 2011

Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations

scientific article

Immunological protection against tuberculosis.

scientific article published on October 2007

Immunology of infants through adolescents: responses to emulate for HIV vaccines

scientific article published on September 2007

Impact of human immunodeficiency virus 1 infection and inflammation on the composition and yield of cervical mononuclear cells in the female genital tract

scientific article published on 26 March 2009

Induction and regulation of T-cell immunity by the novel tuberculosis vaccine M72/AS01 in South African adults

scientific article published on August 2013

Induction of Granulysin and Perforin Cytolytic Mediator Expression in 10-Week-Old Infants Vaccinated with BCG at Birth ⬇️

scientific article published on December 28, 2010

Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response

scientific article

Influence of BCG vaccine strain on the immune response and protection against tuberculosis.

scientific article

Isolation of non-tuberculous mycobacteria in children investigated for pulmonary tuberculosis

scientific article

Knowledge and acceptability of patient-specific infection control measures for pulmonary tuberculosis

scholarly article by Yulieth Gonzalez-Angulo et al published August 2013 in American Journal of Infection Control

Lessons learnt from the first efficacy trial of a new infant tuberculosis vaccine since BCG.

scientific article published on 12 February 2013

Local nerve damage in leprosy does not lead to an impaired cellular immune response or decreased wound healing in the skin

scientific article published on 3 July 2002

Longitudinal changes in CD4(+) T-cell memory responses induced by BCG vaccination of newborns

scientific article published on 4 January 2013

MR1-Independent Activation of Human Mucosal-Associated Invariant T Cells by Mycobacteria ⬇️

scientific article published on 14 October 2019

Maturation of innate responses to mycobacteria over the first nine months of life

scientific article

Meeting report: The International Conference on Human Immunity to Tuberculosis

scientific article published on 2 June 2012

Metabolite changes in blood predict the onset of tuberculosis

scientific article published in Nature Communications

Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells

scientific article

Moxifloxacin population pharmacokinetics in patients with pulmonary tuberculosis and the effect of intermittent high-dose rifapentine

scientific article published on 14 May 2012

Mycobacteria-Specific Cytokine Responses Detect Tuberculosis Infection and Distinguish Latent from Active Tuberculosis

scientific article

Mycobacteria-Specific Mono- and Polyfunctional CD4+ T Cell Profiles in Children With Latent and Active Tuberculosis: A Prospective Proof-of-Concept Study

scientific article published on 05 April 2019

Mycobacterium tuberculosis inhibits maturation of human monocyte-derived dendritic cells in vitro

scientific article published on 9 July 2003

Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity

scientific article

Mycobacterium tuberculosis-specific CD4 T cells are the principal source of IFN-γ in QuantiFERON assays in healthy persons

scientific article published on 10 March 2015

Mycobacterium tuberculosis-specific CD8+T cells are functionally and phenotypically different between latent infection and active disease

scientific article published on 01 June 2013

Mycobacterium ulcerans-specific immune response after immunisation with bacillus Calmette-Guérin (BCG) vaccine

scientific article published on 25 December 2020

New hope for tuberculosis vaccines

scientific article published on 01 July 2019

New vaccines against tuberculosis

scientific article published on 01 December 2009

Novel application of Ki67 to quantify antigen-specific in vitro lymphoproliferation

scientific article

Novel application of a whole blood intracellular cytokine detection assay to quantitate specific T-cell frequency in field studies

scientific article published in August 2004

Novel vaccine prime and selective BCG boost: a new tuberculosis vaccine strategy for infants of HIV-infected mothers

scientific article published on 14 May 2010

Optimization and Interpretation of Serial QuantiFERON Testing to Measure Acquisition of Mycobacterium tuberculosis Infection

scientific article

Optimization of a whole blood intracellular cytokine assay for measuring innate cell responses to mycobacteria

scientific article

PD-1 Expression on -Specific CD4 T Cells Is Associated With Bacterial Load in Human Tuberculosis

Patients with tuberculosis disease have Mycobacterium tuberculosis-specific CD8 T cells with a pro-apoptotic phenotype and impaired proliferative capacity, which is not restored following treatment

scientific article

Phenotypic variability in childhood TB: implications for diagnostic endpoints in tuberculosis vaccine trials

scientific article published on 27 April 2011

Postnatal Expansion, Maturation, and Functionality of MR1T Cells in Humans

scientific article published on 16 September 2020

Predicting tuberculosis risk - Authors' reply

scientific article published in November 2016

Predictive value of recent QuantiFERON conversion for tuberculosis disease in adolescents

scientific article

Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis

scientific article published on 20 July 2011

Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination.

scientific article published in July 2018

Process of assay selection and optimization for the study of case and control samples from a phase IIb efficacy trial of a candidate tuberculosis vaccine, MVA85A

scientific article

Protocol: Leveraging a demographic and health surveillance system for Covid-19 Surveillance in rural KwaZulu-Natal

scientific article published on 29 May 2020

Qualification of a whole blood intracellular cytokine staining assay to measure mycobacteria-specific CD4 and CD8 T cell immunity by flow cytometry

scientific article

Quantitative and functional differences between peripheral blood myeloid dendritic cells from patients with pleural and parenchymal lung tuberculosis

scientific article

RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

scientific article published on 25 May 2020

Randomized Trial of Type 1 and Type 3 Oral Monovalent Poliovirus Vaccines in Newborns in Africa

article

Relationship between chemokine receptor expression, chemokine levels and HIV-1 replication in the lungs of persons exposed to Mycobacterium tuberculosis

scientific article published on 13 December 2012

Reply: Bacille Calmette-Guérin Vaccine: Innate Immunity and Nonspecific Effects

Risk of Disease After Isoniazid Preventive Therapy for Mycobacterium tuberculosis Exposure in Young HIV-uninfected Children

scientific article

SATVI - after 10 years closing in on a new and better vaccine to prevent tuberculosis ⬇️

scientific article published on March 2, 2012

Safety and Immunogenicity of Adenovirus 35 Tuberculosis Vaccine Candidate in Adults with Active or Previous Tuberculosis. A Randomized Trial

scientific article published on 6 January 2017

Safety and Immunogenicity of Newborn MVA85A Vaccination and Selective, Delayed Bacille Calmette-Guerin (BCG) for Infants of HIV Infected Mothers: A Phase 2 Randomized Controlled Trial

scientific article

Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial

scientific article (publication date: 23 March 2013)

Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial

scientific article

Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa

scientific article

Safety and immunogenicity of candidate vaccine M72/AS01E in adolescents in a TB endemic setting

scientific article published on 10 June 2015

Safety and immunogenicity of the novel tuberculosis vaccine ID93 + GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial

scientific article published in April 2018

Safety and reactogenicity of BCG revaccination with isoniazid pretreatment in TST positive adults

scientific article

Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease.

scientific article

Serial QuantiFERON testing and tuberculosis disease risk among young children: an observational cohort study.

scientific article published on 16 February 2017

Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A

scientific article

Significantly skewed memory CD8+ T cell subsets in HIV-1 infected infants during the first year of life

scientific article

Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newborns

scientific article published on 17 June 2010

Structured approaches for the screening and diagnosis of childhood tuberculosis in a high prevalence region of South Africa

scientific article

T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents

scientific article

T cells and adaptive immunity to Mycobacterium tuberculosis in humans

scientific article

T-cell activation is an immune correlate of risk in BCG vaccinated infants

scientific article published on 12 April 2016

Targeting Unconventional Host Components for Vaccination-Induced Protection Against TB

scientific article published on 24 July 2020

Targeting innate immunity for tuberculosis vaccination

scientific article published on 01 September 2019

Thalidomide and a thalidomide analogue drug costimulate virus-specific CD8+ T cells in vitro

scientific article published on 6 March 2003

The Role of Clinical Symptoms in the Diagnosis of Intrathoracic Tuberculosis in Young Children

scientific article

The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes

scientific article published on 21 February 2017

The candidate TB vaccine, MVA85A, induces highly durable Th1 responses

scientific article published on 03 February 2014

The dynamics of QuantiFERON-TB gold in-tube conversion and reversion in a cohort of South African adolescents

scientific article

The effect of bacille Calmette-Guérin vaccine strain and route of administration on induced immune responses in vaccinated infants

scientific article published on 13 January 2006

The immune response to BCG vaccination of newborns

scientific article

The impact of a change in bacille Calmette-Guérin vaccine policy on tuberculosis incidence in children in Cape Town, South Africa

scientific article published in December 2006

The influence of bacille Calmette-Guerin vaccine strain on the immune response against tuberculosis: a randomized trial

scientific article published on 3 November 2011

The novel tuberculosis vaccine, AERAS-402, induces robust and polyfunctional CD4+ and CD8+ T cells in adults

scientific article

The novel tuberculosis vaccine, AERAS-402, is safe in healthy infants previously vaccinated with BCG, and induces dose-dependent CD4 and CD8T cell responses

scientific article published on 10 September 2014

The potential impact of helminth infection on trials of novel tuberculosis vaccines

scientific article published on 29 May 2009

The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa

scientific article

The tuberculosis vaccine H4:IC31 is safe and induces a persistent polyfunctional CD4 T cell response in South African adults: A randomized controlled trial

scientific article published on 3 June 2015

The utility of an interferon gamma release assay for diagnosis of latent tuberculosis infection and disease in children: a systematic review and meta-analysis

scientific article published on August 2011

The way forward for tuberculosis vaccines

scientific article published on 01 March 2019

Time to symptom resolution in young children treated for pulmonary tuberculosis

scientific article

Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria

scientific article published in PLoS ONE

Toward Tuberculosis Vaccine Development: Recommendations for NHP Study Design

scientific article

Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth

scientific article

Tuberculin Skin Test and In Vitro Assays Provide Complementary Measures of Antimycobacterial Immunity in Children and Adolescents

Tuberculosis vaccines and prevention of infection

scientific article

Tuberculosis vaccines: time for a global strategy

scientific article published on February 2015

Two loci control tuberculin skin test reactivity in an area hyperendemic for tuberculosis

scientific article

Vaccine-induced immunity in early life

scientific article published on 12 April 2013

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