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List of works by James Degregori

A Critical Examination of the "Bad Luck" Explanation of Cancer Risk.

scientific article

A generalized theory of age-dependent carcinogenesis

scientific article published on 29 April 2019

A murine homolog of the yeast RNA1 gene is required for postimplantation development.

scientific article published in February 1994

A new role for E2F1 in DNA repair: all for the greater good.

scientific article published in June 2011

A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head

scientific article published on 31 January 2013

A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection

scientific article published on 01 December 1999

ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer.

scientific article published on 16 January 2018

ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53 ⬇️

scientific article published on June 3, 2012

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.

scientific article published on 10 October 2016

AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non-Small Cell Lung Cancer Cells Following EGFR Inhibition ⬇️

scientific article published on 23 September 2016

Active RB elicits late G1/S inhibition.

scientific article published in June 2002

Adenoviral vectors transduce alveolar macrophages in lung cancer models.

scientific article

Adenoviral-mediated gene transfer in lymphocytes.

scientific article published on October 1998

Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection?

scientific article

Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors

scientific article

CUSP/p63 expression in basal cell carcinoma.

scientific article

Cancer evolution is associated with pervasive positive selection on globally expressed genes

scientific article (publication date: March 2014)

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells ⬇️

scientific article published on March 31, 1998

Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?

scientific article

Changing mutational and adaptive landscapes and the genesis of cancer

scientific article published on 3 February 2017

Connecting Cancer to Its Causes Requires Incorporation of Effects on Tissue Microenvironments.

scientific article published on 28 July 2017

Construction of stable coxsackievirus and adenovirus receptor-expressing 3T3-L1 cells.

scientific article published on June 2001

Contrasting roles for C/EBPα and Notch in irradiation-induced multipotent hematopoietic progenitor cell defects.

scientific article published on April 2015

Coupling an EML4-ALK-centric interactome with RNA interference identifies sensitizers to ALK inhibitors

scientific article published on 18 October 2016

Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II

scientific article published on 17 May 2019

Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations.

scientific article

Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.

scientific article

Decoy fitness peaks, tumor suppression, and aging.

scientific article published on 8 March 2019

Defective gene expression, S phase progression, and maturation during hematopoiesis in E2F1/E2F2 mutant mice.

scientific article published on May 2003

Deficiency of mitochondrial modulator MCJ promotes chemoresistance in breast cancer

scientific article published on May 2016

E2F and cell survival: context really is key.

scientific article published in October 2005

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity

scientific article published on 01 December 1995

E2F1 and E2F2 are differentially required for homeostasis-driven and antigen-induced T cell proliferation in vivo.

scientific article published in July 2005

E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.

scientific article

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

scientific article published in April 1995

E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2.

scientific article

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.

scientific article

Elimination of unfit cells in young and ageing skin

scientific article published on 01 April 2019

Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci

scientific article

Evolved Cellular Mechanisms to Respond to Genotoxic Insults: Implications for Radiation-Induced Hematologic Malignancies

scientific article

Evolved tumor suppression: why are we so good at not getting cancer?

scientific article (publication date: June 2011)

FERMI: A Novel Method for Sensitive Detection of Rare Mutations in Somatic Tissue

scientific article published on 04 September 2019

Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis.

scientific article published on 7 September 2017

Functional analysis of E2F transcription factor ⬇️

scientific article published on January 1, 1997

Gene trap mutagenesis of hnRNP A2/B1: a cryptic 3' splice site in the neomycin resistance gene allows continued expression of the disrupted cellular gene

scientific article

Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia.

scientific article

How cancer shapes evolution, and how evolution shapes cancer

scientific article (publication date: December 2011)

Impaired DNA replication within progenitor cell pools promotes leukemogenesis.

scientific article

Inhibiting tyrosine phosphorylation of protein kinase Cδ (PKCδ) protects the salivary gland from radiation damage

scientific article

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

scientific article published on 01 February 2019

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

scientific article published on 01 November 2018

Inhibition of calcineurin combined with dasatinib has direct and indirect anti-leukemia effects against BCR-ABL1(+) leukemia

scientific article

Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity.

scientific article published on April 1996

Integrated genomic analyses identify WEE1 as a critical mediator of cell fate and a novel therapeutic target in acute myeloid leukemia.

scientific article published on 13 January 2012

Ionizing radiation and hematopoietic malignancies: Altering the adaptive landscape ⬇️

scientific article published on August 7, 2010

Irradiation alters selection for oncogenic mutations in hematopoietic progenitors.

scientific article published on 08 September 2009

Irradiation selects for p53-deficient hematopoietic progenitors.

scientific article

Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma

scientific article

Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors

scientific article published on 01 December 2019

Mechanisms of oncogene cooperation: activation and inactivation of a growth antagonist ⬇️

scientific article published on June 1, 1991

Mutation-specific control of BCR-ABL T315I positive leukemia with a recombinant yeast-based therapeutic vaccine in a murine model

scientific article

Oncogenic drivers and mitochondrial dependency.

scientific article published in March 2015

PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer

scientific article published on 6 April 2015

Patterns of somatically acquired amplifications and deletions in apparently normal tissues of ovarian cancer patients

scientific article

Personalized one-two punches for lung cancer.

scientific article published on 30 December 2014

Prolactin stimulates activation of c-jun N-terminal kinase (JNK).

scientific article

Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration.

scientific article published on 17 May 2005

Publishing flow cytometry data

scientific article

Ras enhances Myc protein stability.

scientific article published on February 1999

Recombinant adenoviral vectors can induce expression of p73 via the E4-orf6/7 protein

scientific article

Relative fitness of hematopoietic progenitors influences leukemia progression.

scientific article published on 18 February 2011

Resilience integrates concepts in aging research

scientific article published on 20 May 2022

Role of the Rb/E2F pathway in cell growth control ⬇️

scientific article published on November 1, 1997

SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program

scientific article published on 03 January 2019

Selective disruption of genes expressed in totipotent embryonal stem cells

scientific article published on June 1, 1992

Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia

scientific article

Solution characterization of the extracellular region of CD147 and its interaction with its enzyme ligand cyclophilin A

scientific article

Somatic maintenance impacts the evolution of mutation rate

scientific article published on 23 August 2019

Stochastic modeling indicates that aging and somatic evolution in the hematopoetic system are driven by non-cell-autonomous processes.

scientific article published on December 2014

Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia

scientific article

Studying Cancer Evolution and Therapeutic Responses in Different Organs: The Pros and Cons of a Broad Focus

scientific article published on 22 August 2019

Surprising dependency for retinoblastoma protein in ras-mediated tumorigenesis

scientific article

TNF-α-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging

scientific article published on 16 July 2019

Tankyrase and the Canonical Wnt Pathway Protect Lung Cancer Cells from EGFR Inhibition ⬇️

scientific article published on June 27, 2012

Targeting Glutamine Metabolism and Redox State for Leukemia Therapy

scientific article published on 02 April 2019

Targeting developmental pathways in children with cancer: what price success?

scientific article published on February 2013

Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion

scientific article published in 2021

The CUSP DeltaNp63alpha isoform of human p63 is downregulated by solar-simulated ultraviolet radiation.

scientific article published on June 2003

The Rb network

scientific article published on 01 July 2004

The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state.

scientific article published on December 1996

The evolution of lifespan and age-dependent cancer risk

scientific article

The landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selection

scientific article

The special issue on cancer and evolution: Lessons learned

scientific article published on 13 July 2020

The survival of antigen-stimulated T cells requires NFkappaB-mediated inhibition of p73 expression

scientific article published on 01 March 2003

The three dimensions of somatic evolution: Integrating the role of genetic damage, life-history traits, and aging in carcinogenesis

scientific article published on 20 March 2020

Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations

scientific article

Trisomy 21 consistently activates the interferon response.

scientific article published on 29 July 2016

Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations

scientific article

Urea Cycle Sustains Cellular Energetics upon EGFR Inhibition in EGFR-Mutant NSCLC

scientific article published on 26 February 2019

Using functional genomics to overcome therapeutic resistance in hematological malignancies.

scientific article

Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.

scientific article

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