List of works - Julian Aragones Lopez

15-Deoxy-Delta(12,14)-prostaglandin-J(2) reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation.

scientific article

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

scientific journal article

Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase.

scientific article

Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors

scientific article published on 21 January 2020

Acute Vhl Gene Inactivation Induces Cardiac HIF-Dependent Erythropoietin Gene Expression ⬇️

scientific article published on July 21, 2011

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

scientific article

Dithiocarbamates trigger differentiation and induction of CD11c gene through AP-1 in the myeloid lineage.

scientific article published on May 1996

Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension

scientific article published on 02 January 2001

From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research"

scientific article

Genetic evidence for a tumor suppressor role of HIF-2alpha.

scientific article published in August 2005

HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction

scientific article

HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5.

scientific article

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

scientific article

Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity.

scientific article

Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension.

scientific article published on 28 January 2002

Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor.

scientific article

Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1

scientific article published on 01 November 2010

Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside

scientific article

Mitochondrial reprogramming through cardiac oxygen sensors in ischaemic heart disease ⬇️

scientific article published on 02 August 2010

Molecular pathways: hypoxia response in immune cells fighting or promoting cancer

scientific article

Mutant versions of von Hippel-Lindau (VHL) can protect HIF1α from SART1-mediated degradation in clear-cell renal cell carcinoma

scientific article published on 27 April 2015

Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation

scientific article published on 4 October 2014

Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC

scientific article published on 20 May 2015

Reduced intracellular oxidative metabolism promotes firm adhesion of human polymorphonuclear leukocytes to vascular endothelium under flow conditions

scientific article published on 01 August 1997

Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms.

scientific article published on 17 December 2003

Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation

scientific article published on 24 May 2010

The HIF-1α Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) for Immunotherapy

scientific article published on 19 June 2012

c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription.

scientific article published on January 2002

List of works by Julian Aragones Lopez

15-Deoxy-Delta(12,14)-prostaglandin-J(2) reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation.

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase.

Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors

Acute Vhl Gene Inactivation Induces Cardiac HIF-Dependent Erythropoietin Gene Expression ⬇️

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Dithiocarbamates trigger differentiation and induction of CD11c gene through AP-1 in the myeloid lineage.

Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension

From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research"

Genetic evidence for a tumor suppressor role of HIF-2alpha.

HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction

HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5.

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity.

Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension.

Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor.

Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1

Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside

Mitochondrial reprogramming through cardiac oxygen sensors in ischaemic heart disease ⬇️

Molecular pathways: hypoxia response in immune cells fighting or promoting cancer

Mutant versions of von Hippel-Lindau (VHL) can protect HIF1α from SART1-mediated degradation in clear-cell renal cell carcinoma

Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation

Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC

Reduced intracellular oxidative metabolism promotes firm adhesion of human polymorphonuclear leukocytes to vascular endothelium under flow conditions

Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms.

Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation

The HIF-1α Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) for Immunotherapy

c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription.