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List of works by Christopher Kevil

2nd European Conference on the Biology of Hydrogen Sulfide, Exeter, England 8th-11th September 2013.

scientific article

A tale of two gases: NO and H2S, foes or friends for life?

scientific article

Activated T-lymphocytes express occludin, a component of tight junctions

scientific article published on 01 December 1998

Alpha L-integrin I domain cyclic peptide antagonist selectively inhibits T cell adhesion to pancreatic islet microvascular endothelium.

scientific article

AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia

scientific article published on 20 September 2016

An improved, rapid Northern protocol.

scientific article

Analytical measurement of discrete hydrogen sulfide pools in biological specimens ⬇️

scientific article published on April 19, 2012

Application of Comparative Transcriptional Genomics to Identify Molecular Targets for Pediatric IBD.

scientific article published on 8 April 2015

Avidity modulation activates adhesion under flow and requires cooperativity among adhesion receptors.

scientific article published on December 2003

Beyond a Gasotransmitter: Hydrogen Sulfide and Polysulfide in Cardiovascular Health and Immune Response.

scientific article published on 11 April 2017

Biological activities of fusarochromanone: a potent anti-cancer agent

scientific article

Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology

scientific article published on 24 May 2018

CD18 deficiency protects against multiple low-dose streptozotocin-induced diabetes.

scientific article

Cardiac-specific inactivation of LPP3 in mice leads to myocardial dysfunction and heart failure.

scientific article published on 28 September 2017

Catalase as a regulator of reactive sulfur metabolism; a new interpretation beyond hydrogen peroxide✩

scientific article published on 24 March 2017

Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis

scholarly article

Contribution of human smooth muscle cells to amyloid angiopathy in AL (light-chain) amyloidosis.

scientific article

Contributions of LFA-1 and Mac-1 to brain injury and microvascular dysfunction induced by transient middle cerebral artery occlusion

scientific article published on 12 August 2004

Control of angiogenesis dictated by picomolar superoxide levels ⬇️

scientific article published on May 16, 2013

Cystathione β-Synthase Is Increased in Thyroid Malignancies

scientific article published on 01 November 2018

Cystathionine γ-Lyase Modulates Flow-Dependent Vascular Remodeling

scientific article published on 01 September 2018

Cystathionine γ-lyase regulates arteriogenesis through NO-dependent monocyte recruitment.

scientific article

Cystatin M suppresses the malignant phenotype of human MDA-MB-435S cells.

scientific article

Detection of hydrogen sulfide in biological samples: current and future.

scientific article published on January 2011

Diabetic neutrophil mitochondrial dysfunction: An inflammatory situation? ⬇️

scientific article published on February 19, 2011

Differential angiogenic regulation of experimental colitis.

scientific article published on December 2006

Dipyridamole reverses peripheral ischemia and induces angiogenesis in the Db/Db diabetic mouse hind-limb model by decreasing oxidative stress.

scientific article published on 9 November 2010

Effect of reactive oxygen metabolites on endothelial permeability: role of nitric oxide and iron

scientific article published on 01 June 1999

Emerging role of PKA/eNOS pathway in therapeutic angiogenesis for ischaemic tissue diseases

scientific article

Endothelial Dysfunction and Diabetes: Effects on Angiogenesis, Vascular Remodeling, and Wound Healing ⬇️

scientific article published on February 12, 2012

Endothelial caveolin-1 regulates pathologic angiogenesis in a mouse model of colitis.

scientific article

Endothelial cell activation in inflammation: lessons from mutant mouse models.

scientific article published on January 2003

Enhancing mitochondrial respiration suppresses tumor promoter TPA-induced PKM2 expression and cell transformation in skin epidermal JB6 cells.

scientific article published on 14 June 2011

EphA2 Expression Regulates Inflammation and Fibroproliferative Remodeling in Atherosclerosis.

scientific article published on 9 May 2017

Gasotransmitter Heterocellular Signaling

scientific article published on 9 January 2017

H2S regulation of nitric oxide metabolism

scientific article published on 17 January 2015

Human Mesenchymal Stromal Cell Sheet Enhances Allograft Repair in a Mouse Model

scientific article published on 11 August 2017

Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae

scientific article published on 01 July 2018

Hydrogen Sulfide and Hydrogen Sulfide-Synthesizing Enzymes Are Altered in a Case of Oral Adenoid Cystic Carcinoma

scientific article published on 01 May 2018

Hydrogen Sulfide-Synthesizing Enzymes Are Altered in a Case of Oral Cavity Mucoepidermoid Carcinoma.

scientific article

Hydrogen sulfide ameliorates aging-associated changes in the kidney.

scientific article

Hydrogen sulfide and nitric oxide metabolites in the blood of free-ranging brown bears and their potential roles in hibernation.

scientific article

Hydrogen sulfide chemical biology: Pathophysiological roles and detection ⬇️

scientific article published on July 9, 2013

Hydrogen sulfide measurement using sulfide dibimane: critical evaluation with electrospray ion trap mass spectrometry

scientific article published on 14 June 2014

Hydrogen sulfide metabolism regulates endothelial solute barrier function

scientific article published on 11 August 2016

Hydrogen sulfide stimulates ischemic vascular remodeling through nitric oxide synthase and nitrite reduction activity regulating hypoxia-inducible factor-1α and vascular endothelial growth factor-dependent angiogenesis.

scientific article published on 25 October 2012

Hyperhomocysteinemia potentiates diabetes-impaired EDHF-induced vascular relaxation: Role of insufficient hydrogen sulfide.

scientific article published on 14 February 2018

ICAM-1 cross-linking stimulates endothelial glutathione synthesis.

scientific article

ICAM-1 cytoplasmic tail regulates endothelial glutathione synthesis through a NOX4/PI3-kinase-dependent pathway.

scientific article published on 13 July 2010

In vitro culture and characterization of gene targeted mouse endothelium

scientific article published on 01 September 2001

Inflammatory mediators induce sequestration of VE-cadherin in cultured human endothelial cells

scientific article published on 01 April 2000

Inorganic nitrite and chronic tissue ischaemia: a novel therapeutic modality for peripheral vascular diseases.

scientific article

Inorganic nitrite therapy: historical perspective and future directions.

scientific article published on 4 May 2011

Intravascular radiocontrast iodixanol increases permeability of proximal tubule epithelium: a possible mechanism of contrast-induced nephropathy.

scientific article published on 4 September 2013

Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune disease

scientific article

Measurement of H2S in vivo and in vitro by the monobromobimane method

scientific article published on 10 January 2015

Mechanistic investigations reveal that dibromobimane extrudes sulfur from biological sulfhydryl sources other than hydrogen sulfide†Electronic supplementary information (ESI) available: Experimental details, pH stability data for BTE, NMR spectra. S

scientific article

Methamphetamine induces cardiomyopathy by Sigmar1 inhibition-dependent impairment of mitochondrial dynamics and function

scientific article published on 17 November 2020

MicroRNA-31-3p Is Involved in Substance P (SP)-Associated Inflammation in Human Colonic Epithelial Cells and Experimental Colitis

scientific article published on 15 December 2017

Neuronal repellent Slit2 inhibits dendritic cell migration and the development of immune responses.

scientific article published on December 2003

Nicotinamide nucleotide transhydrogenase activity impacts mitochondrial redox balance and the development of hypertension in mice.

scientific article published on 16 December 2016

Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Remodeling.

scientific article published on 18 September 2015

Nitrite and nitrate: from bench to bedside.

scientific article published on May 2012

Nitrite and nitric oxide metabolism in peripheral artery disease.

scientific article

Nitrite anion stimulates ischemic arteriogenesis involving NO metabolism.

scientific article

Nitrite anion therapy protects against chronic ischemic tissue injury in db/db diabetic mice in a NO/VEGF-dependent manner

scientific article

Notch ligand Jagged1 promotes mesenchymal stromal cell-based cartilage repair

scientific article published on 21 September 2018

Organ preservation solutions increase endothelial permeability and promote loss of junctional proteins

scientific article published on 01 July 1999

Paying the Toll for Glucose Regulation: A Central Role for TLR3.

scientific article

Plasma free H2S levels are elevated in patients with cardiovascular disease.

scientific article published on 23 October 2013

Preserving vessel function during ischemic disease: new possibilities of inorganic nitrite therapy.

scientific article published on October 2008

Radical innate regulation of autoimmune diabetes.

scientific article published on 26 February 2012

Recruitment of the adaptor protein Nck to PECAM-1 couples oxidative stress to canonical NF-κB signaling and inflammation

scientific article published on 24 February 2015

Redox balance dynamically regulates vascular growth and remodeling

scientific article

Regulation and Maintenance of Vascular Tone and Patency in Cardiovascular Health and Disease ⬇️

scientific article published on April 9, 2012

Regulation of dextran sodium sulfate induced colitis by leukocyte beta 2 integrins

scientific article published on 01 April 2006

Regulation of endothelial glutathione by ICAM-1 governs VEGF-A-mediated eNOS activity and angiogenesis

scientific article published on 16 December 2006

Regulation of endothelial glutathione by ICAM-1: implications for inflammation.

scientific article

Reperfusion of chronic tissue ischemia: nitrite and dipyridamole regulation of innate immune responses.

scientific article published on October 2010

Review focus on inorganic nitrite and nitrate in cardiovascular health and disease.

scientific article published on 23 December 2010

Role of Cadherin Internalization in Hydrogen Peroxide-Mediated Endothelial Permeability ⬇️

scientific article published on April 1, 1998

Role of T-cell-associated lymphocyte function-associated antigen-1 in the pathogenesis of experimental colitis

scientific article published on 13 January 2006

Role of hydrogen sulfide in early blood-brain barrier disruption following transient focal cerebral ischemia.

scientific article

Role of thiosulfate in hydrogen sulfide-dependent redox signaling in endothelial cells.

scientific article published on 26 May 2017

SDF-1-CXCR4 differentially regulates autoimmune diabetogenic T cell adhesion through ROBO1-SLIT2 interactions in mice.

scientific article published on 28 June 2013

Self-Immolative Thiocarbamates Provide Access to Triggered H2S Donors and Analyte Replacement Fluorescent Probes

scientific article

Sildenafil promotes ischemia-induced angiogenesis through a PKG-dependent pathway.

scientific article published on 21 June 2007

Single-dose pharmacokinetics of different oral sodium nitrite formulations in diabetes patients

scientific article

Sodium nitrite in patients with peripheral artery disease and diabetes mellitus: safety, walking distance and endothelial function

scientific article published on 20 December 2013

Sodium nitrite therapy rescues ischemia-induced neovascularization and blood flow recovery in hypertension.

scientific article

Sodium sulfide selectively induces oxidative stress, DNA damage, and mitochondrial dysfunction and radiosensitizes glioblastoma (GBM) cells.

scientific article published on 16 May 2019

Stromal cell-derived factor-1/CXCL12 stimulates chemorepulsion of NOD/LtJ T-cell adhesion to islet microvascular endothelium.

scientific article published in October 2007

Sulfide catabolism ameliorates hypoxic brain injury

scientific article published on 25 May 2021

T cell-associated CD18 but not CD62L, ICAM-1, or PSGL-1 is required for the induction of chronic colitis

scientific article published on 01 March 2007

T cell-associated α4β7 but not α4β1 integrin is required for the induction and perpetuation of chronic colitis

scientific article published on 9 April 2014

Temporal genome expression profile analysis during t-cell-mediated colitis: identification of novel targets and pathways.

scientific article published on 16 December 2011

The Ataxia telangiectasia-mutated and Rad3-related protein kinase regulates cellular hydrogen sulfide concentrations

scientific article published on 13 November 2018

The Type 1 Diabetes-Resistance Locus Idd22 Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice

scientific article published on 6 November 2017

The effect of endothelial nitric oxide synthase on the hemodynamics and wall mechanics in murine arteriovenous fistulas

scientific article published on 12 March 2019

The pleiotropic effects of hydrogen sulfide

scientific article

The polyphenol epigallocatechin-3-gallate affects lipid rafts to block activation of the c-Met receptor in prostate cancer cells.

scientific article published on August 2010

The red blood cell and vascular function in health and disease.

scientific article

The role of cadherin endocytosis in endothelial barrier regulation: involvement of protein kinase C and actin-cadherin interactions

scientific article published on August 1, 1998

The role of p38 MAP kinase in hydrogen peroxide mediated endothelial solute permeability.

scientific article published in January 2001

Therapeutic treatment with sustained-release platelet-rich plasma restores blood perfusion by augmenting ischemia-induced angiogenesis and arteriogenesis in diabetic mice.

scientific article

Tissue-dependent variation of hydrogen sulfide homeostasis in anoxic freshwater turtles

scientific article published on 19 June 2019

Total sulfane sulfur bioavailability reflects ethnic and gender disparities in cardiovascular disease.

scientific article published on 25 January 2018

Translational regulation of vascular permeability factor by eukaryotic initiation factor 4E: implications for tumor angiogenesis

scientific article published on 01 March 1996

UCP2 knockout suppresses mouse skin carcinogenesis.

scientific article published on 17 March 2015

VEGF-A isoform modulation in an preclinical TNBS model of ulcerative colitis: protective effects of a VEGF164b therapy

scientific article published on 11 September 2013

VEGF-A stimulation of leukocyte adhesion to colonic microvascular endothelium: implications for inflammatory bowel disease

scientific article published on 17 November 2005

VEGF164 isoform specific regulation of T-cell-dependent experimental colitis in mice ⬇️

scientific article published on November 9, 2010

VEGF₁₆₄ differentially regulates neutrophil and T cell adhesion through ItgaL- and ItgaM-dependent mechanisms.

scientific article published on 30 September 2010

Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins.

scientific article published in June 1998

Withaferin A suppresses the up-regulation of acetyl-coA carboxylase 1 and skin tumor formation in a skin carcinogenesis mouse model.

scientific article published on 16 October 2015

Working with nitric oxide and hydrogen sulfide in biological systems

scientific article

eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling.

scientific article published on 8 June 2006

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