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List of works by Howard L. Kaufman

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gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma

scientific article
Phase II clinical trial of a granulocyte-macrophage colony-stimulating factor-encoding, second-generation oncolytic herpesvirus in patients with unresectable metastatic melanoma

scientific article published on 02 November 2009
Oncolytic viruses: a new class of immunotherapy drugs

scientific article published on September 2015
Local and distant immunity induced by intralesional vaccination with an oncolytic herpes virus encoding GM-CSF in patients with stage IIIc and IV melanoma

scientific article published on 01 March 2010
OPTIM trial: a Phase III trial of an oncolytic herpes virus encoding GM-CSF for unresectable stage III or IV melanoma

scientific article published on June 2010
Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy

scientific article
Molecular Pathways: Mechanism of Action for Talimogene Laherparepvec, a New Oncolytic Virus Immunotherapy

scientific article published on December 30, 2015
Into the clinic: Talimogene laherparepvec (T-VEC), a first-in-class intratumoral oncolytic viral therapy

scientific article published on 20 September 2016
Integrating oncolytic viruses in combination cancer immunotherapy

scientific article published on 01 August 2018
Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer

scientific article
Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma

scientific article
Combination chemotherapy and ALVAC-CEA/B7.1 vaccine in patients with metastatic colorectal cancer

scientific article
Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma

scientific article published on 07 January 2009
Discovery and clinical introduction of first-in-class imipridone ONC201.

scientific article published on September 2016
Talimogene Laherparepvec (T-VEC) and Other Oncolytic Viruses for the Treatment of Melanoma

scientific article published on 17 December 2016
Activation of Rho kinase by TNF-alpha is required for JNK activation in human pulmonary microvascular endothelial cells

scientific article published in January 2008
The lymphoid chemokine CCL21 costimulates naive T cell expansion and Th1 polarization of non-regulatory CD4+ T cells

scientific article published on 01 September 2004
Mutant HSP70 reverses autoimmune depigmentation in vitiligo

scientific article published on February 2013
First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors.

scientific article published on 22 March 2017
Local delivery of vaccinia virus expressing multiple costimulatory molecules for the treatment of established tumors

scientific article
Local IL-21 promotes the therapeutic activity of effector T cells by decreasing regulatory T cells within the tumor microenvironment

scientific article
Pox viral vaccine approaches.

scientific article
Host lymphodepletion enhances the therapeutic activity of an oncolytic vaccinia virus expressing 4-1BB ligand

scientific article published on 20 October 2009
MEK inhibition enhances oncolytic virus immunotherapy through increased tumor cell killing and T cell activation

scientific article published on 01 December 2018
Contemporary experience with high-dose interleukin-2 therapy and impact on survival in patients with metastatic melanoma and metastatic renal cell carcinoma

scientific article published on 06 October 2016
Oncolytic virus therapy for cancer

scientific article
Biomarkers for Immunotherapy: Current Developments and Challenges

scientific article published in January 2016
NK cells and CD8+ T cells cooperate to improve therapeutic responses in melanoma treated with interleukin-2 (IL-2) and CTLA-4 blockade.

scientific article published on 19 May 2015
TroVax, a recombinant modified vaccinia Ankara virus encoding 5T4: Lessons learned and future development

scientific article published on October 1, 2010
Oncolytic Virus Immunotherapy for Melanoma

scientific article published on March 1, 2015
MVA-5T4-induced immune responses are an early marker of efficacy in renal cancer patients.

scientific article
Immunoglobulin-like transcript 2 (ILT2) is a biomarker of therapeutic response to oncolytic immunotherapy with vaccinia viruses

scientific article
Immune properties of recombinant vaccinia virus encoding CD154 (CD40L) are determined by expression of virally encoded CD40L and the presence of CD40L protein in viral particles

scientific article published in December 2004
Future perspectives in melanoma research. Meeting report from the "Melanoma Bridge. Napoli, December 2nd-4th 2012".

scientific article published on 3 June 2013
Immunotherapy for melanoma

scientific article published on 01 May 2004
Intratumoral Approaches for the Treatment of Melanoma

scientific article published on January 2017
Vaccines for Melanoma and Renal Cell Carcinoma

scientific article published on June 1, 2012
Intrarectal vaccination with recombinant vaccinia virus expressing carcinoembronic antigen induces mucosal and systemic immunity and prevents progression of colorectal cancer

scientific article published in December 2008
The tumour microenvironment and implications for cancer immunotherapy

scientific article published on July 2006
Poxviruses as vectors for cancer immunotherapy.

scientific article
Oncolytic virus immunotherapy induces immunogenic cell death and overcomes STING deficiency in melanoma

scientific article published on 07 April 2019
A retrospective analysis of High-Dose Interleukin-2 (HD IL-2) following Ipilimumab in metastatic melanoma

scientific article published on 20 September 2016
Final analyses of OPTiM: a randomized phase III trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor in unresectable stage III-IV melanoma

scientific article published on 06 June 2019
Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment

scientific article published on 13 March 2018
Gene therapy with poxvirus vectors.

scientific article
Immunotherapy for pancreatic cancer: current concepts

scientific article
Trovax ® Vaccine Therapy for Renal Cell Carcinoma

scientific article published on January 1, 2012
Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death.

scientific article
Pseudomonas aeruginosa exotoxin T induces potent cytotoxicity against a variety of murine and human cancer cell lines.

scientific article
IFN-λ cancer immunotherapy: new kid on the block

scientific article

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