List of works - Stuart Tangye

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

scientific article published on July 2008

Follicular B helper T cells in antibody responses and autoimmunity.

scientific article

Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.

scientific article published on October 2013

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

scientific article published on 01 January 2010

The origins, function, and regulation of T follicular helper cells

scientific article published on July 2, 2012

SLAM family receptors and SAP adaptors in immunity.

scientific article published on January 2011

Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.

scientific article published in September 2009

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

scientific article

Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

scientific article

Identification of Functional Human Splenic Memory B Cells by Expression of CD148 and CD27

scientific article published on November 2, 1998

International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity.

scientific article published on 11 December 2017

Regulation of NKT cell development by SAP, the protein defective in XLP

scientific article published on 13 February 2005

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

scientific article

Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.

scientific article

IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

scientific article

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

scientific article

Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses

article

The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies

scientific article published on 11 December 2017

Persistence of naive CD45RA+ regulatory T cells in adult life.

scientific article published on 6 December 2005

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

scientific article

Memory B cells: effectors of long-lived immune responses.

scientific article published on August 2009

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells.

scientific article

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells.

scientific article

BAFF, APRIL and human B cell disorders

scientific article

SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells.

scientific article

Staying alive: regulation of plasma cell survival.

scientific article published on 14 October 2011

Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease

scientific article

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

scientific article published on 07 July 2015

T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses.

scientific article published on 31 March 2015

Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation

scientific article

Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP

scientific article published on November 1, 2011

Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells.

scientific article

Decreased expression of Kruppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses.

scholarly article

Divide and conquer: the importance of cell division in regulating B-cell responses.

scientific article published in August 2004

A Subset of Interleukin-21+ Chemokine Receptor CCR9+ T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity

scientific article published on 01 April 2011

Auto-antibodies against type I IFNs in patients with life-threatening COVID-19

scientific article published on 24 September 2020

Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage.

scientific article published on 18 February 2014

Regulation of T follicular helper cell formation and function by antigen presenting cells.

scientific article

Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency

scientific article published on 23 December 2016

IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts.

scientific article published on 24 October 2013

STAT3 is required for IL-21-induced secretion of IgE from human naive B cells

scientific article published on 25 June 2008

XLP: clinical features and molecular etiology due to mutations in SH2D1A encoding SAP.

scientific article published on 02 August 2014

Human immunity against EBV-lessons from the clinic.

scientific article published on 20 January 2017

STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation

scientific article published on March 17, 2014

STAT3 is a central regulator of lymphocyte differentiation and function.

scientific article published on 06 March 2014

A recurrent dominant negative E47 mutation causes agammaglobulinemia and BCR(-) B cells.

scientific article

Advances in IL-21 biology - enhancing our understanding of human disease

scientific article published on 23 March 2015

Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs.

scientific article

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

scientific article published on 4 May 2015

Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity.

scientific article published in February 2018

List of works by Stuart Tangye

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

Follicular B helper T cells in antibody responses and autoimmunity.

Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

The origins, function, and regulation of T follicular helper cells

SLAM family receptors and SAP adaptors in immunity.

Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

Identification of Functional Human Splenic Memory B Cells by Expression of CD148 and CD27

International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity.

Regulation of NKT cell development by SAP, the protein defective in XLP

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.

IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses

The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies

Persistence of naive CD45RA+ regulatory T cells in adult life.

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

Memory B cells: effectors of long-lived immune responses.

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells.

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells.

BAFF, APRIL and human B cell disorders

SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells.

Staying alive: regulation of plasma cell survival.

Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses.

Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation

Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP

Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells.

Decreased expression of Kruppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses.

Divide and conquer: the importance of cell division in regulating B-cell responses.

A Subset of Interleukin-21+ Chemokine Receptor CCR9+ T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity

Auto-antibodies against type I IFNs in patients with life-threatening COVID-19

Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage.

Regulation of T follicular helper cell formation and function by antigen presenting cells.

Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency

IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts.

STAT3 is required for IL-21-induced secretion of IgE from human naive B cells

XLP: clinical features and molecular etiology due to mutations in SH2D1A encoding SAP.

Human immunity against EBV-lessons from the clinic.

STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation

STAT3 is a central regulator of lymphocyte differentiation and function.

A recurrent dominant negative E47 mutation causes agammaglobulinemia and BCR(-) B cells.

Advances in IL-21 biology - enhancing our understanding of human disease

Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs.

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity.