List of works - Stuart Tangye

A Subset of Interleukin-21+ Chemokine Receptor CCR9+ T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity

scientific article published on 01 April 2011

A helping hand from neutrophils in T cell-independent antibody responses?

scientific article published on 19 January 2012

A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes

scientific article published on 20 April 2022

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

scientific article published on 01 June 2018

A recurrent dominant negative E47 mutation causes agammaglobulinemia and BCR(-) B cells.

scientific article

Advances in IL-21 biology - enhancing our understanding of human disease

scientific article published on 23 March 2015

An essential role for the Zn2+ transporter ZIP7 in B cell development

scientific article published on 04 February 2019

Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation.

scientific article published on 12 October 2017

Auto-antibodies against type I IFNs in patients with life-threatening COVID-19

scientific article published on 24 September 2020

B cells race the clock to get a second wind

scientific article published on 01 August 2018

B-cell-specific STAT3 deficiency: Insight into the molecular basis of autosomal-dominant hyper-IgE syndrome.

scientific article published on 11 June 2016

BAFF, APRIL and human B cell disorders

scientific article

CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity.

scientific article published in December 2017

CD8<sup>+</sup> T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

scientific article published on 18 May 2021

Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells

scientific article published on 03 May 2011

Cell membrane associated free kappa light chains are found on a subset of tonsil and in vitro-derived plasmablasts

scientific article published on 19 August 2014

Cerebral Vasculitis in X-linked Lymphoproliferative Disease Cured by Matched Unrelated Cord Blood Transplant.

scientific article published on 3 October 2015

Chronic mucocutaneous candidiasis and connective tissue disorder in humans with impaired JNK1-dependent responses to IL-17A/F and TGF-β

scientific article published on 01 November 2019

Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity.

scientific article published in February 2018

Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.

scientific article published on October 2013

Combined Immunodeficiency with Ring Chromosome 21.

scientific article published on 15 April 2018

Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency

scientific article published on 23 December 2016

Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs.

scientific article

Comprehensive analysis of the cytokine-rich chromosome 5q31.1 region suggests a role for IL-4 gene variants in prostate cancer risk

article

Correction to: Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee

scientific article published on 01 January 2020

Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies.

scientific article

Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage.

scientific article published on 18 February 2014

Cytokines and cross-linking of sIgM augment PMA-induced activation of human leukaemic CD5+ B cells

scientific article published on 01 December 1997

DOCK8 Drives Src-Dependent NK Cell Effector Function

scientific article published on 9 August 2017

Decreased expression of Kruppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses.

scholarly article

Dedicator of cytokinesis 8-deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells.

scientific article published on 20 August 2016

Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency

scientific article published on 4 May 2017

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

scientific article published on July 2008

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

scientific article published on 18 September 2019

Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells.

scientific article

Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency

scientific article published on 20 August 2018

Divide and conquer: the importance of cell division in regulating B-cell responses.

scientific article published in August 2004

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

scientific article

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

scientific article

Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.

scientific article published on 19 September 2016

Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.

scientific article published in September 2009

Editorial overview: Lymphocyte activation and effector functions

scientific article published on 18 April 2014

Elucidating the effects of disease-causing mutations on STAT3 function in autosomal-dominant hyper-IgE syndrome

scientific article published on 13 May 2016

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

scientific article published on 01 January 2010

Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus.

scientific article

FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production

scientific article published on 12 May 2015

Follicular B helper T cells in antibody responses and autoimmunity.

scientific article

Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

scientific article

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

scientific article

Genetic cause of immune dysregulation - one gene or two?

scientific article

Germline-activating mutations in PIK3CD compromise B cell development and function

scientific article published on 17 July 2018

Helper T cell immunity in humans with inherited CD4 deficiency

scientific article published in 2024

Helping the Helpers!

scientific article published on 01 July 2009

Human CD8+ T cell cross-reactivity across influenza A, B and C viruses

scientific article published on 18 February 2019

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

scientific article published on 01 December 2018

Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee

scientific article published on 17 January 2020

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

scientific article

Human Th9 cells: inflammatory cytokines modulate IL-9 production through the induction of IL-21

scientific article published on 08 June 2010

Human cytokines suppress apoptosis of leukaemic CD5+ B cells and preserve expression of bcl-2

scientific article published on 01 April 1997

Human immunity against EBV-lessons from the clinic.

scientific article published on 20 January 2017

Human inborn errors of the actin cytoskeleton affecting immunity: way beyond WAS and WIP

scientific article published on 08 March 2019

Human plasma C3 is essential for the development of memory B, but not T, lymphocytes.

scientific article

IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts.

scientific article published on 24 October 2013

IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice

scientific article published on 12 September 2016

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. ⬇️

scientific article

IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

scientific article

IRF4 haploinsufficiency in a family with Whipple's disease.

scientific article

Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses

article

Identification of Functional Human Splenic Memory B Cells by Expression of CD148 and CD27 ⬇️

scientific article published on November 2, 1998

IgM expressed by leukemic CD5(+) B cells binds mouse immunoglobulin light chain.

scientific article

Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes

scientific article published on 21 June 2006

Immunology: Cytotoxic T cells that escape exhaustion.

scientific article published on 24 August 2016

Immunology: Helpful T cells are sticky

scientific article published in Nature

Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child

scientific article published on 28 June 2021

Interleukin-10 inhibits the in vitro proliferation of human activated leukemic CD5+ B-cells.

scientific article published in September 1998

International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity.

scientific article published on 11 December 2017

Is it dead or alive? TLR8 can tell.

scientific article published on 19 March 2018

Leukaemic CD5+ B-cell apoptosis: co-incidence of cell death and DNA fragmentation with reduced bcl-2 expression

scientific article published on 01 March 1996

Low IgE Is Insufficiently Sensitive to Guide Genetic Testing of STAT3 Gain-of-Function Mutations

scientific article published on 30 June 2017

Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

scientific article published in Nature Communications

Memory B cells: effectors of long-lived immune responses.

scientific article published on August 2009

Memory B cells: total recall.

scientific article published on 28 March 2017

Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases.

scientific article published on 5 July 2016

Missense mutations in SH2D1A identified in patients with X-linked lymphoproliferative disease differentially affect the expression and function of SAP

scientific article published on 23 May 2006

Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP ⬇️

scientific article published on November 1, 2011

Molecular requirements for human lymphopoiesis as defined by inborn errors of immunity

scientific article published on 05 January 2021

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

scientific article published on 07 July 2015

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells.

scientific article

Naïve and memory B cells exhibit distinct biochemical responses following BCR engagement

scientific article published on 22 April 2016

Pathogenic CD4+ T cells regulating B-cell differentiation in autoimmunity: not exactly Tfh cells.

scientific article published on 18 April 2017

Persistence of naive CD45RA+ regulatory T cells in adult life.

scientific article published on 6 December 2005

Phorbol ester activates CD5+ leukaemic B cells via a T cell-independent mechanism

scientific article published on 01 February 1995

Plasmacytoid DCs induce gutsy plasma cells

scientific article published on 01 February 2011

Primary immune deficiencies affecting lymphocyte differentiation: lessons from the spectrum of resulting infections.

scientific article published on 03 August 2009

Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation

scientific article

Reduced memory B-cell populations in boys with B-cell dysfunction after bone marrow transplantation for X-linked severe combined immunodeficiency.

scientific article

Regulation of NKT cell development by SAP, the protein defective in XLP

scientific article published on 13 February 2005

Regulation of T follicular helper cell formation and function by antigen presenting cells.

scientific article

Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.

scientific article

Reversible Suppression of Lymphoproliferation and Thrombocytopenia with Rapamycin in a Patient with Common Variable Immunodeficiency

scientific article

SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells.

scientific article

SLAM family receptors and SAP adaptors in immunity.

scientific article published on January 2011

STAT3 is a central regulator of lymphocyte differentiation and function.

scientific article published on 06 March 2014

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

scientific article published on 4 May 2015

STAT3 is required for IL-21-induced secretion of IgE from human naive B cells

scientific article published on 25 June 2008

STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles

scientific article published on 23 February 2018

Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease

scientific article

Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.

scientific article published on 04 July 2013

Signal transducer and activator of transcription 3 limits Epstein-Barr virus lytic activation in B lymphocytes.

scientific article published on 21 August 2013

SnapShot: Interactions between B Cells and T Cells

scientific article published on August 2015

Staying alive: regulation of plasma cell survival.

scientific article published on 14 October 2011

T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses.

scientific article published on 31 March 2015

The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies

scientific article published on 11 December 2017

The Clinical Immunogenomics Research Consortium Australasia (CIRCA): a Distributed Network Model for Genomic Healthcare Delivery

scientific article published on 01 June 2020

The Expanding Spectrum of NFkB1 Deficiency

scientific article published on 23 June 2016

The Integrin LFA-1 Controls T Follicular Helper Cell Generation and Maintenance.

scientific article

The TORC that Gets the GC Cycling.

scientific article published in June 2017

The origins, function, and regulation of T follicular helper cells ⬇️

scientific article published on July 2, 2012

The right "Job" for STAT3 mutant mice!

scientific article published on 01 May 2014

Therapeutic implications of advances in our understanding of transitional B-cell development in humans ⬇️

scientific article published on September 1, 2010

Thucydides and longer-lived plasma cells.

scientific article published in March 2015

To B1 or not to B1: that really is still the question!

scientific article published in June 2013

Transitional B cell subsets in human bone marrow

scientific article published on 01 October 2013

Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common missense variant

scientific article published on 01 December 2018

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.

scientific article published on 11 July 2016

Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes

scientific article published on 01 October 2020

XLP: clinical features and molecular etiology due to mutations in SH2D1A encoding SAP.

scientific article published on 02 August 2014

List of works by Stuart Tangye

A Subset of Interleukin-21+ Chemokine Receptor CCR9+ T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity

A helping hand from neutrophils in T cell-independent antibody responses?

A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

A recurrent dominant negative E47 mutation causes agammaglobulinemia and BCR(-) B cells.

Advances in IL-21 biology - enhancing our understanding of human disease

An essential role for the Zn2+ transporter ZIP7 in B cell development

Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation.

Auto-antibodies against type I IFNs in patients with life-threatening COVID-19

B cells race the clock to get a second wind

B-cell-specific STAT3 deficiency: Insight into the molecular basis of autosomal-dominant hyper-IgE syndrome.

BAFF, APRIL and human B cell disorders

CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity.

CD8<sup>+</sup> T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells

Cell membrane associated free kappa light chains are found on a subset of tonsil and in vitro-derived plasmablasts

Cerebral Vasculitis in X-linked Lymphoproliferative Disease Cured by Matched Unrelated Cord Blood Transplant.

Chronic mucocutaneous candidiasis and connective tissue disorder in humans with impaired JNK1-dependent responses to IL-17A/F and TGF-β

Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity.

Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.

Combined Immunodeficiency with Ring Chromosome 21.

Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency

Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs.

Comprehensive analysis of the cytokine-rich chromosome 5q31.1 region suggests a role for IL-4 gene variants in prostate cancer risk

Correction to: Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee

Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies.

Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage.

Cytokines and cross-linking of sIgM augment PMA-induced activation of human leukaemic CD5+ B cells

DOCK8 Drives Src-Dependent NK Cell Effector Function

Decreased expression of Kruppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses.

Dedicator of cytokinesis 8-deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells.

Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells.

Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency

Divide and conquer: the importance of cell division in regulating B-cell responses.

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.

Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.

Editorial overview: Lymphocyte activation and effector functions

Elucidating the effects of disease-causing mutations on STAT3 function in autosomal-dominant hyper-IgE syndrome

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus.

FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production

Follicular B helper T cells in antibody responses and autoimmunity.

Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

Genetic cause of immune dysregulation - one gene or two?

Germline-activating mutations in PIK3CD compromise B cell development and function

Helper T cell immunity in humans with inherited CD4 deficiency

Helping the Helpers!

Human CD8+ T cell cross-reactivity across influenza A, B and C viruses

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

Human Th9 cells: inflammatory cytokines modulate IL-9 production through the induction of IL-21

Human cytokines suppress apoptosis of leukaemic CD5+ B cells and preserve expression of bcl-2

Human immunity against EBV-lessons from the clinic.

Human inborn errors of the actin cytoskeleton affecting immunity: way beyond WAS and WIP

Human plasma C3 is essential for the development of memory B, but not T, lymphocytes.

IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts.

IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. ⬇️

IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

IRF4 haploinsufficiency in a family with Whipple's disease.

Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses

Identification of Functional Human Splenic Memory B Cells by Expression of CD148 and CD27 ⬇️

IgM expressed by leukemic CD5(+) B cells binds mouse immunoglobulin light chain.

Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes

Immunology: Cytotoxic T cells that escape exhaustion.

Immunology: Helpful T cells are sticky

Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child

Interleukin-10 inhibits the in vitro proliferation of human activated leukemic CD5+ B-cells.

International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity.

Is it dead or alive? TLR8 can tell.

Leukaemic CD5+ B-cell apoptosis: co-incidence of cell death and DNA fragmentation with reduced bcl-2 expression

Low IgE Is Insufficiently Sensitive to Guide Genetic Testing of STAT3 Gain-of-Function Mutations