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List of works by Yoshiki Kawabe

A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

scientific article published in Nature

Acid-promoted epimerization of arbaprostil, 15(R)-15-methylprostaglandin E2, elicits gastric antisecretory activities in rats

scientific article published on 01 December 1991

An anti-glypican 3/CD3 bispecific T cell-redirecting antibody for treatment of solid tumors.

scientific article published in October 2017

Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A.

scientific article published on October 2014

Anti-factor IXa/X bispecific antibody (ACE910): hemostatic potency against ongoing bleeds in a hemophilia A model and the possibility of routine supplementation

scientific article published in February 2014

Antiatherogenic effects of the antioxidant BO-653 in three different animal models.

scientific article

Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody

scientific article published in PLoS ONE

Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization.

scientific article

Antibody to CD137 activated by extracellular adenosine triphosphate is tumor selective and broadly effective in vivo without systemic immune activation

scientific article published on 25 August 2020

Characterization of aggregated low density lipoproteins induced by copper-catalyzed oxidation

scientific article published on 01 January 1994

Characterization of cleavage enzymes for sterol regulatory element binding protein in hamster liver microsomes

scientific article published on 01 May 1999

Competitive inhibition of SGLT2 by tofogliflozin or phlorizin induces urinary glucose excretion through extending splay in cynomolgus monkeys

scientific article published on 23 April 2014

Cynomolgus monkey model of interleukin-31-induced scratching depicts blockade of human interleukin-31 receptor A by a humanized monoclonal antibody

scientific article published on 7 October 2016

Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants.

scientific article

Effect of BO-653 and probucol on c-MYC and PDGF-A messenger RNA of the iliac artery after balloon denudation in cholesterol-fed rabbits.

scientific article published in April 2002

Effect of SGLT2 inhibitors in a murine model of urinary tract infection with Candida albicans.

scientific article published on 29 January 2014

Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens.

scientific article published on 28 April 2017

Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism.

scientific article

Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples.

scientific article published on 29 March 2018

Inhibition of MEK1 Signaling Pathway in the Liver Ameliorates Insulin Resistance

scientific article published on 28 December 2015

Lipid accumulation in smooth muscle cells under LDL loading is independent of LDL receptor pathway and enhanced by hypoxic conditions.

scientific article published in October 2002

Localization of advanced glycation end products of Maillard reaction in bovine tissues and their endocytosis by macrophage scavenger receptors

scientific article published on 01 October 1995

Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases

scientific article published on 24 April 2017

Oxidation-induced aggregation of rabbit low-density lipoprotein by azo initiator

scientific article published on 01 May 1994

Peroxisome proliferator-activated receptor alpha (PPARalpha) activators induce hepatic farnesyl diphosphate synthase gene expression in rodents

scientific journal article

Pharmacodynamic Actions of a Long-Acting PTH Analog (LA-PTH) in Thyroparathyroidectomized (TPTX) Rats and Normal Monkeys.

scientific article published on 10 February 2016

Pharmacological analysis of SGLT2 inhibitor (tofogliflozin) using in vivo glucose clamp and titration protocols in rats and cynomolgus monkeys

scientific article published on 01 January 2016

Regulation of fatty acid synthase expression by cholesterol in human cultured cells.

scientific article published on February 1996

SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose

scientific article

Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo- or euglycemic conditions in rats.

scientific article

Sterol mediated regulation of SREBP-1a,1b,1c and SREBP-2 in cultured human cells

scientific journal article

Stronger Uricosuric Effects of the Novel Selective URAT1 Inhibitor UR-1102 Lowered Plasma Urate in Tufted Capuchin Monkeys to a Greater Extent than Benzbromarone

scientific article published on 23 February 2016

Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist

scientific article published on 11 November 2020

The molecular mechanism of the induction of the low density lipoprotein receptor by chenodeoxycholic acid in cultured human cells.

scientific article published on March 1995

Tofogliflozin, a novel sodium-glucose co-transporter 2 inhibitor, improves renal and pancreatic function in db/db mice.

scientific article published on October 2013

Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice

scientific article published on 12 March 2012

Tofogliflozin, a sodium/glucose cotransporter 2 inhibitor, attenuates body weight gain and fat accumulation in diabetic and obese animal models.

scientific article published on 07 July 2014

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