List of works by Hiroshi Shiku

A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy.

scientific article

A Promising Vector for TCR Gene Therapy: Differential Effect of siRNA, 2A Peptide, and Disulfide Bond on the Introduced TCR Expression.

scientific article published on 18 December 2012

A novel human-derived antibody against NY-ESO-1 improves the efficacy of chemotherapy

scientific article (publication date: 2013)

A novel role for Notch ligand Delta-1 as a regulator of human Langerhans cell development from blood monocytes.

scientific article published on 21 July 2005

Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells.

scientific article published on 30 January 2018

Activity of interleukin 6 in the differentiation of monocytes to macrophages and dendritic cells

scientific article published on 01 May 2000

Acute interstitial pneumonitis during chemotherapy for haematological malignancy.

scientific article

Additional t(11;17)(q23;q21) in a patient with Philadelphia-positive mixed lineage antigen-expressing leukemia

scientific article published on 01 April 2001

Adoptive Transfer of MAGE-A4 T-cell Receptor Gene-Transduced Lymphocytes in Patients with Recurrent Esophageal Cancer.

scientific article published on 8 April 2015

Adoptive immunotherapy of cancer utilizing genetically engineered lymphocytes.

scientific article published on 04 June 2015

Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury

scientific article published on 6 January 2014

Adoptive transfer of genetically modified Wilms' tumor 1-specific T cells in a novel malignant skull base meningioma model

scientific article

Adult T cell leukaemia cells are of CD4+ CDw29+ T cell origin and secrete a B cell differentiation factor

Alloantigen-induced T-cell proliferation: Lyt phenotype of responding cells and blocking of proliferation by Lyt antisera

scientific article

Analysis of peripheral and local anti-tumor immune response in esophageal cancer patients after NY-ESO-1 protein vaccination

scientific article published on 01 November 2008

Antibody response against NY-ESO-1 in CHP-NY-ESO-1 vaccinated patients

scientific article published on 01 May 2007

Antibody responses against NY-ESO-1 and HER2 antigens in patients vaccinated with combinations of cholesteryl pullulan (CHP)-NY-ESO-1 and CHP-HER2 with OK-432

scientific article published on 15 September 2009

Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance

scientific article published on 11 February 2019

Antileukemia multifunctionality of CD4(+) T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer.

scientific article published on 24 June 2015

Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination

scientific article published on 25 July 2018

Attempt to Harvest a Sufficient Number of Mononuclear Cells in an Appropriate Blood Product Volume By Modification of the Default Apheresis Setting

scientific article published on 21 July 2017

CD21S antigen expression in tumour cells of diffuse large B-cell lymphomas is an independent prognostic factor indicating better overall survival.

scientific article published in April 2004

CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-alphabetaTCR interaction and become IL-10-producing active regulatory cells.

scientific article published on 20 May 2008

CD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity

scientific article published on 11 February 2016

Cell surface antigens of human malignant melanoma. III. Recognition of autoantibodies with unusual characteristics ⬇️

scientific article published on March 1, 1977

Cell surface antigens of human renal cancer defined by autologous typing ⬇️

scientific article published on September 19, 1979

Cell surface antigens of murine leukemias induced by radiation leukemia virus. Recognition of individually distinct cell surface antigens by cytotoxic T cells on leukemias expressing crossreactive transplantation antigens

scientific article

Cell-mediated cytotoxicity for cultured autologous melanoma cells

scientific article published on July 15, 1979

Classification of current anticancer immunotherapies

scientific article

Clinical Implications of CD4+CD25+Foxp3+Regulatory T Cell Frequencies After CHP-MAGE-A4 Cancer Vaccination

scientific article published on 01 March 2018

Clinical relevance of antigen spreading pattern induced by CHP-MAGE-A4 cancer vaccination.

scientific article

Clinicopathologic significance of loss of CD19 expression in diffuse large B-cell lymphoma.

scientific article published in January 2007

Co-introduced functional CCR2 potentiates in vivo anti-lung cancer functionality mediated by T cells double gene-modified to express WT1-specific T-cell receptor.

scientific article published on 18 February 2013

Comparison of diagnostic criteria for disseminated intravascular coagulation (DIC): diagnostic criteria of the International Society of Thrombosis and Hemostasis and of the Japanese Ministry of Health and Welfare for overt DIC.

scientific article published in September 2003

Cyclin D1 expression is useful as a prognostic indicator for advanced esophageal carcinomas, but not for superficial tumors

scientific article published on 01 May 2000

Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera ⬇️

scientific article published on April 1, 1979

Cytotoxic reactions of murine lymphoid cells studied with a tritiated proline microcytotoxicity test

scientific article published on February 1, 1975

De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients.

scientific article

De novo CD5-positive diffuse large B-cell lymphoma of the temporal bone presenting with an external auditory canal tumor.

scientific article published on 3 July 2006

De novo CD5-positive diffuse large B-cell lymphoma: clinical characteristics and therapeutic outcome

scientific article published on 01 June 1999

Decreased ADAMTS13 activity in plasma from patients with thrombotic thrombocytopenic purpura.

scientific article

Defining the critical hurdles in cancer immunotherapy

scientific article published on 14 December 2011

Definition of a unique cell surface antigen of mouse leukemia RL male 1 by cell-mediated cytotoxicity ⬇️

scientific article published on July 1, 1979

Definition of target antigens for naturally occurring CD4(+) CD25(+) regulatory T cells

scientific article

Detection of the CBFB/MYH11 fusion gene in de novo acute myeloid leukemia (AML): a single-institution study of 224 Japanese AML patients.

scientific article published on 18 October 2006

Determination of cellularly processed HLA-A2402-restricted novel CTL epitopes derived from two cancer germ line genes, MAGE-A4 and SAGE

scientific article

Development of Engineered T Cells Expressing a Chimeric CD16-CD3ζ Receptor to Improve the Clinical Efficacy of Mogamulizumab Therapy Against Adult T-Cell Leukemia

scientific article published on 18 April 2016

Development of a novel redirected T-cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia.

scientific article published on 2 May 2013

Differential cell division history between neutrophils and macrophages in their development from granulocyte-macrophage progenitors.

scientific article published in December 2006

Differential regulatory function of resting and preactivated allergen-specific CD4+ CD25+ regulatory T cells in Th2-type airway inflammation

scientific article published on 01 November 2008

Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion-exchange method

scientific article published on 01 March 2022

Dose-dependent effects of NY-ESO-1 protein vaccine complexed with cholesteryl pullulan (CHP-NY-ESO-1) on immune responses and survival benefits of esophageal cancer patients

scientific article

Early tumor regression following severe lung injury after allogeneic stem cell transplantation in a patient with renal cell carcinoma

scientific article published on 15 March 2007

Efficient tumor regression by adoptively transferred CEA-specific CAR-T cells associated with symptoms of mild cytokine release syndrome.

scientific article

Engineering hybrid exosomes by membrane fusion with liposomes

scientific article

Epirubicin, Identified Using a Novel Luciferase Reporter Assay for Foxp3 Inhibitors, Inhibits Regulatory T Cell Activity

scientific article

Exosomal regulation of lymphocyte homing to the gut

scientific article published on 01 January 2019

Exosome-mediated regulation of tumor immunology

scientific article published on 01 August 2018

Expression of T-cell differentiation antigens on effector cells in cell-mediated cytotoxicity in vitro. Evidence for functional heterogeneity related to the surface phenotype of T cells ⬇️

scientific article published on January 1, 1975

Expression profiling analysis of the CD5+ diffuse large B-cell lymphoma subgroup: development of a CD5 signature

scientific article published on 13 July 2006

First Case of Cytokine Release Syndrome after Nivolumab for Gastric Cancer

scientific article published on 01 January 2019

Gastric mucosa-associated lymphoid tissue lymphoma with a focal high-grade component diagnosed by EUS and endoscopic mucosal resection for histologic evaluation

scientific article published on 01 June 2000

Gene expression profiling of diffuse large B-Cell lymphomas supervised by CD5 expression

scientific article published on 26 May 2015

Gene expression profiling of peripheral T-cell lymphoma including gammadelta T-cell lymphoma.

scientific article

Gene-modified human α/β-T cells expressing a chimeric CD16-CD3ζ receptor as adoptively transferable effector cells for anticancer monoclonal antibody therapy

scientific article published on 3 January 2014

Generation of peptide-specific CD8+ T cells by phytohemagglutinin-stimulated antigen-mRNA-transduced CD4+ T cells.

scientific article published on 19 June 2006

Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen-specific CD8+ T cells with tumor regression.

scientific article

Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types

scientific article

HER2-specific T-cell immune responses in patients vaccinated with truncated HER2 protein complexed with nanogels of cholesteryl pullulan

scientific article published on 01 December 2006

Heterogeneous copy numbers of API2-MALT1 chimeric transcripts in mucosa-associated lymphoid tissue lymphoma ⬇️

scientific article published on 01 December 2003

High expression of MAGE-A4 and MHC class I antigens in tumor cells and induction of MAGE-A4 immune responses are prognostic markers of CHP-MAGE-A4 cancer vaccine.

scientific article published on 13 September 2014

Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis.

scientific article

Human melanoma antigen AH is an autoantigenic ganglioside related to GD2.

scientific article

IFN-gamma controls the generation/activation of CD4+ CD25+ regulatory T cells in antitumor immune response.

scientific article published on October 2005

IL-2-Dependent ATL cell lines with phenotypes differing from the original leukemia cells ⬇️

scientific article published on January 1, 1991

Identification of an immunogenic neo-epitope encoded by mouse sarcoma using CXCR3 ligand mRNAs as sensors

scientific article

Immunohistochemical expression and clinicopathological assessment of the cancer testis antigens NY-ESO-1 and MAGE-A4 in high-grade soft-tissue sarcoma

scientific article published on 14 February 2019

Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells

scientific article published on 16 January 2008

Improved expression and reactivity of transduced tumor-specific TCRs in human lymphocytes by specific silencing of endogenous TCR.

scientific article published on 10 November 2009

In vitro stimulation of CD8 and CD4 T cells by dendritic cells loaded with a complex of cholesterol-bearing hydrophobized pullulan and NY-ESO-1 protein: Identification of a new HLA-DR15-binding CD4 T-cell epitope.

scientific article published on March 2006

In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccines.

scientific article

Increased soluble fibrin in plasma of patients with disseminated intravascular coagulation

scientific article published on 01 July 2003

Increased soluble fibrin monomer and soluble thrombomodulin levels in non-insulin-dependent diabetes mellitus ⬇️

scientific article published on July 1, 1997

Induction of immune response against NY-ESO-1 by CHP-NY-ESO-1 vaccination and immune regulation in a melanoma patient

scientific article published on 01 March 2008

Induction of regulatory T cell-resistant helper CD4+ T cells by bacterial vector.

scientific article published on 6 November 2007

Interleukin-17 induces an atypical M2-like macrophage subpopulation that regulates intestinal inflammation

scientific article

Intracellular tumor-associated antigens represent effective targets for passive immunotherapy.

scientific article published on 8 February 2012

Intratumoral injection of Propionibacterium acnes suppresses malignant melanoma by enhancing Th1 immune responses.

scientific article

Limited expression of cancer-testis antigens in renal cell carcinoma patients

scientific article

Ly phenotype of cytotoxic T cells for syngeneic tumor

scientific article

Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: potential utility for adoptive immunotherapy.

scientific article published on 17 December 2012

Molecular and phenotypic analysis of Philadelphia chromosome-positive bilineage leukemia: possibility of a lineage switch from T-lymphoid leukemic progenitor to myeloid cells.

scientific article

Myelodysplastic syndrome of del 20q with plasma cell dysplasia.

scientific article published in January 2011

Nanogel-based immunologically stealth vaccine targets macrophages in the medulla of lymph node and induces potent antitumor immunity

scientific article published on 2 September 2014

Notch ligand Delta-1 differentially modulates the effects of gp130 activation on interleukin-6 receptor alpha-positive and -negative human hematopoietic progenitors

scientific article published on 23 July 2007

Overcoming regulatory T-cell suppression by a lyophilized preparation of Streptococcus pyogenes

scientific article published on 26 February 2013

Peptide Vaccine Induces Enhanced Tumor Growth Associated with Apoptosis Induction in CD8+ T Cells ⬇️

scientific article published on August 23, 2010

Peptide-pulsed dendritic cell vaccination targeting interleukin-13 receptor α2 chain in recurrent malignant glioma patients with HLA-A*24/A*02 allele.

scientific article

Post-immune UV irradiation induces Tr1-like regulatory T cells that suppress humoral immune responses

scientific article published on 15 November 2007

Prognostic value of MAGEA4 in primary lung cancer depends on subcellular localization and p53 status

scientific article published on 31 May 2018

RHAMM-R3 peptide vaccination in patients with acute myeloid leukemia, myelodysplastic syndrome, and multiple myeloma elicits immunologic and clinical responses

scientific article published on 31 October 2007

Rapid alphabeta TCR-mediated responses in gammadelta T cells transduced with cancer-specific TCR genes.

scientific article

Reduced Cd4+Cd25+ T cells in patients with idiopathic thrombocytopenic purpura.

scientific article

Regulatory T cell-resistant CD8+ T cells induced by glucocorticoid-induced tumor necrosis factor receptor signaling.

scientific article published in July 2008

Safety and persistence of WT1-specific T-cell receptor gene-transduced lymphocytes in patients with AML and MDS.

scientific article

Serological analysis of cell surface antigens of malignant human brain tumors ⬇️

scientific article published on October 1, 1978

Serological response of melanoma patients receiving melanoma cell vaccines. I. Autologous cultured melanoma cells

scientific article published on 01 October 1982

Serum immunoglobulin E response as a marker for unfavorable prognosis following cholesteryl pullulan-MAGE A4 vaccination.

scientific article published on 10 January 2018

Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation.

scientific article

Stimulation through very late antigen-4 and -5 improves the multifunctionality and memory formation of CD8⁺ T cells.

scientific article published on 11 May 2014

Surface phenotype of nonadherent peritoneal cells effecting cell-mediated cytotoxicity in vitro for allogeneic and syngeneic murine sarcoma cells

scientific article published on 01 April 1976

Systemic CD8+ T cell-mediated tumoricidal effects by intratumoral treatment of oncolytic herpes simplex virus with the agonistic monoclonal antibody for murine glucocorticoid-induced tumor necrosis factor receptor

scientific article

T cell immunomonitoring and tumor responses in patients immunized with a complex of cholesterol-bearing hydrophobized pullulan (CHP) and NY-ESO-1 protein.

scientific article

T-cell receptor gene therapy targeting melanoma-associated antigen-A4 inhibits human tumor growth in non-obese diabetic/SCID/γcnull mice.

scientific article published on 8 November 2011

The membrane proteinase 3 expression on neutrophils was downregulated after treatment with infliximab in patients with rheumatoid arthritis.

scientific article

Time-dependent transition of the immunoglobulin G subclass and immunoglobulin E response in cancer patients vaccinated with cholesteryl pullulan-melanoma antigen gene-A4 nanogel.

scientific article published on 13 October 2016

Tumor progression inhibits the induction of multifunctionality in adoptively transferred tumor-specific CD8+ T cells.

scientific article

Tumor-Specific Antigens ⬇️

scientific article published on January 1, 1980

Tumor-specific crosslinking of GITR as costimulation for immunotherapy

scientific article published on November 2010

Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals.

scientific article

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