List of works - Lydie Combaret

4E-BP1 and 4E-BP2 double knockout mice are protected from aging-associated sarcopenia

scientific article published on 29 March 2019

A dietary supplementation with leucine and antioxidants is capable to accelerate muscle mass recovery after immobilization in adult rats

scientific article

A muscle-specific MuRF1-E2 network requires stabilization of MuRF1-E2 complexes by telethonin, a newly identified substrate.

scientific article published on 22 December 2017

A new method of purification of proteasome substrates reveals polyubiquitination of 20 S proteasome subunits.

scientific article published on 21 December 2006

Altered responses in skeletal muscle protein turnover during aging in anabolic and catabolic periods.

scientific article

Apoptosis in capillary endothelial cells in ageing skeletal muscle

scientific article

Chemotherapy inhibits skeletal muscle ubiquitin-proteasome-dependent proteolysis.

scientific article

Contrarily to whey and high protein diets, dietary free leucine supplementation cannot reverse the lack of recovery of muscle mass after prolonged immobilization during ageing.

scientific article published on 20 February 2012

Curcumin treatment prevents increased proteasome and apoptosome activities in rat skeletal muscle during reloading and improves subsequent recovery.

scientific article

Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state.

scientific article

Differential regulation of the lysosomal, Ca2+-dependent and ubiquitin/proteasome-dependent proteolytic pathways in fast-twitch and slow-twitch rat muscle following hyperinsulinaemia ⬇️

scientific article published on December 1, 2001

Divergent N-Terminal Sequences Target an Inducible Testis Deubiquitinating Enzyme to Distinct Subcellular Structures.

scientific article published in February 2001

Docosahexaenoic acid-supplementation prior to fasting prevents muscle atrophy in mice

scientific article published on 15 February 2016

Does long-term intermittent treatment with glutamine improve the well-being of fed and fasted very old rats?

scientific article published in November 2007

Down-regulation of genes in the lysosomal and ubiquitin-proteasome proteolytic pathways in calpain-3-deficient muscle.

scientific article published in May 2003

Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice.

scientific article

Effects of ornithine alpha-ketoglutarate on protein metabolism in Yoshida sarcoma-bearing rats

scientific article published on 25 June 2007

Erratum: Polge, C., et al. UBE2E1 Is Preferentially Expressed in the Cytoplasm of Slow-Twitch Fibers and Protects Skeletal Muscles from Exacerbated Atrophy upon Dexamethasone Treatment. Cells 2018, 7, 214

scientific article published on 04 December 2018

Expression of subunits of the 19S complex and of the PA28 activator in rat skeletal muscle.

scientific article published on March 1997

Flavanone metabolism in healthy and tumor-bearing rats

scientific article published on 28 August 2006

Glucocorticoids regulate mRNA levels for subunits of the 19 S regulatory complex of the 26 S proteasome in fast-twitch skeletal muscles.

scientific article published on February 2004

High intensity interval training promotes total and visceral fat mass loss in obese Zucker rats without modulating gut microbiota

scientific article published on 09 April 2019

Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting

scientific article

Involvement of the calcium-dependent proteolytic system in skeletal muscle aging

scientific article published on 14 September 2007

Lack of muscle recovery after immobilization in old rats does not result from a defect in normalization of the ubiquitin-proteasome and the caspase-dependent apoptotic pathways

scientific article published on 29 November 2010

Lower skeletal muscle capillarization in hypertensive elderly men.

scientific article published on 27 January 2016

Lysosomal and proteasome-dependent proteolysis are differentially regulated by insulin and/or amino acids following feeding in young, mature and old rats.

scientific article published on 11 September 2008

Manipulation of the ubiquitin-proteasome pathway in cachexia: pentoxifylline suppresses the activation of 20S and 26S proteasomes in muscles from tumor-bearing rats

scientific article published on 01 April 1999

Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells.

scientific article

Milk casein-based diet containing TGF-beta controls the inflammatory reaction in the HLA-B27 transgenic rat model

scientific journal article

Mitophagy and Mitochondria Biogenesis Are Differentially Induced in Rat Skeletal Muscles during Immobilization and/or Remobilization ⬇️

scientific article published on 23 May 2020

Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways.

scientific article published on April 1996

Muscle wasting in patients with end-stage renal disease or early-stage lung cancer: common mechanisms at work

scientific article published on 29 January 2019

Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy

scientific article published on 12 October 2006

No alteration in gene expression of components of the ubiquitin-proteasome proteolytic pathway in dystrophin-deficient muscles

scientific article published on 01 September 1996

Oleate-enriched diet improves insulin sensitivity and restores muscle protein synthesis in old rats

scientific article published on 22 June 2011

Presence of low-grade inflammation impaired postprandial stimulation of muscle protein synthesis in old rats.

scientific article published on 14 April 2009

Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm.

scientific article published on 11 September 2008

Preventive Effect of Spontaneous Physical Activity on the Gut-Adipose Tissue in a Mouse Model That Mimics Crohn's Disease Susceptibility

scientific article published on 09 January 2019

Proteomics of muscle chronological ageing in post-menopausal women

scientific article published on 23 December 2014

Recent progress in elucidating signalling proteolytic pathways in muscle wasting: potential clinical implications.

scientific article

Regulation of ATP-ubiquitin-dependent proteolysis in muscle wasting.

scientific article published on January 1994

Regulation of proteolysis during reloading of the unweighted soleus muscle

scientific article published on 01 May 2003

Regulation of skeletal muscle proteolysis by amino acids.

scientific article

Regulation of ubiquitin-proteasome dependent muscular proteolysis by hormones and nutrients

scientific article published in January 2002

Repeated cures with paracetamol worsen sarcopenia in old rats with suboptimal food intake

scientific article published in October 2016

Skeletal muscle lipid content and oxidative activity in relation to muscle fiber type in aging and metabolic syndrome.

scientific article

Skeletal muscle proteolysis in aging.

scientific article published on January 2009

Soluble Milk Proteins Improve Muscle Mass Recovery after Immobilization-Induced Muscle Atrophy in Old Rats but Do not Improve Muscle Functional Property Restoration.

scientific article published in January 2017

The delayed recovery of the remobilized rat tibialis anterior muscle reflects a defect in proliferative and terminal differentiation that impairs early regenerative processes

scientific article published on 31 March 2015

The role of ubiquitin-proteasome-dependent proteolysis in the remodelling of skeletal muscle.

scientific article published in May 2004

The ubiquitin-proteasome pathway: limitations and opportunities

scientific article published on 01 May 2005

The worsening of tibialis anterior muscle atrophy during recovery post-immobilization correlates with enhanced connective tissue area, proteolysis, and apoptosis.

scientific article

Tissue-Specific Oxidative Stress Modulation by Exercise: A Comparison between MICT and HIIT in an Obese Rat Model

scientific article published on 14 July 2019

UBE2B is implicated in myofibrillar protein loss in catabolic C2C12 myotubes

scientific article published on 19 November 2015

UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension

scientific article

Ubiquitin-proteasome-dependent muscle proteolysis responds slowly to insulin release and refeeding in starved rats.

scientific article

Ubiquitin-proteasome-dependent proteolysis in skeletal muscle.

scientific article published in March 1998

Ubiquitin-proteasome-dependent proteolytic activity remains elevated after zymosan-induced sepsis in rats while muscle mass recovers

scientific article published on 01 October 2005

Unilateral hindlimb casting induced a delayed generalized muscle atrophy during rehabilitation that is prevented by a whey or a high protein diet but not a free leucine-enriched diet

scientific article

Upregulation of MuRF1 and MAFbx participates to muscle wasting upon gentamicin-induced acute kidney injury.

scientific article

Whey proteins are more efficient than casein in the recovery of muscle functional properties following a casting induced muscle atrophy

scientific article

List of works by Lydie Combaret

4E-BP1 and 4E-BP2 double knockout mice are protected from aging-associated sarcopenia

A dietary supplementation with leucine and antioxidants is capable to accelerate muscle mass recovery after immobilization in adult rats

A muscle-specific MuRF1-E2 network requires stabilization of MuRF1-E2 complexes by telethonin, a newly identified substrate.

A new method of purification of proteasome substrates reveals polyubiquitination of 20 S proteasome subunits.

Altered responses in skeletal muscle protein turnover during aging in anabolic and catabolic periods.

Apoptosis in capillary endothelial cells in ageing skeletal muscle

Chemotherapy inhibits skeletal muscle ubiquitin-proteasome-dependent proteolysis.

Contrarily to whey and high protein diets, dietary free leucine supplementation cannot reverse the lack of recovery of muscle mass after prolonged immobilization during ageing.

Curcumin treatment prevents increased proteasome and apoptosome activities in rat skeletal muscle during reloading and improves subsequent recovery.

Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state.

Differential regulation of the lysosomal, Ca2+-dependent and ubiquitin/proteasome-dependent proteolytic pathways in fast-twitch and slow-twitch rat muscle following hyperinsulinaemia ⬇️

Divergent N-Terminal Sequences Target an Inducible Testis Deubiquitinating Enzyme to Distinct Subcellular Structures.

Docosahexaenoic acid-supplementation prior to fasting prevents muscle atrophy in mice

Does long-term intermittent treatment with glutamine improve the well-being of fed and fasted very old rats?

Down-regulation of genes in the lysosomal and ubiquitin-proteasome proteolytic pathways in calpain-3-deficient muscle.

Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice.

Effects of ornithine alpha-ketoglutarate on protein metabolism in Yoshida sarcoma-bearing rats

Erratum: Polge, C., et al. UBE2E1 Is Preferentially Expressed in the Cytoplasm of Slow-Twitch Fibers and Protects Skeletal Muscles from Exacerbated Atrophy upon Dexamethasone Treatment. Cells 2018, 7, 214

Expression of subunits of the 19S complex and of the PA28 activator in rat skeletal muscle.

Flavanone metabolism in healthy and tumor-bearing rats

Glucocorticoids regulate mRNA levels for subunits of the 19 S regulatory complex of the 26 S proteasome in fast-twitch skeletal muscles.

High intensity interval training promotes total and visceral fat mass loss in obese Zucker rats without modulating gut microbiota

Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting

Involvement of the calcium-dependent proteolytic system in skeletal muscle aging

Lack of muscle recovery after immobilization in old rats does not result from a defect in normalization of the ubiquitin-proteasome and the caspase-dependent apoptotic pathways

Lower skeletal muscle capillarization in hypertensive elderly men.

Lysosomal and proteasome-dependent proteolysis are differentially regulated by insulin and/or amino acids following feeding in young, mature and old rats.

Manipulation of the ubiquitin-proteasome pathway in cachexia: pentoxifylline suppresses the activation of 20S and 26S proteasomes in muscles from tumor-bearing rats

Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells.

Milk casein-based diet containing TGF-beta controls the inflammatory reaction in the HLA-B27 transgenic rat model

Mitophagy and Mitochondria Biogenesis Are Differentially Induced in Rat Skeletal Muscles during Immobilization and/or Remobilization ⬇️

Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways.

Muscle wasting in patients with end-stage renal disease or early-stage lung cancer: common mechanisms at work

Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy

No alteration in gene expression of components of the ubiquitin-proteasome proteolytic pathway in dystrophin-deficient muscles

Oleate-enriched diet improves insulin sensitivity and restores muscle protein synthesis in old rats

Presence of low-grade inflammation impaired postprandial stimulation of muscle protein synthesis in old rats.

Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm.

Preventive Effect of Spontaneous Physical Activity on the Gut-Adipose Tissue in a Mouse Model That Mimics Crohn's Disease Susceptibility

Proteomics of muscle chronological ageing in post-menopausal women

Recent progress in elucidating signalling proteolytic pathways in muscle wasting: potential clinical implications.

Regulation of ATP-ubiquitin-dependent proteolysis in muscle wasting.

Regulation of proteolysis during reloading of the unweighted soleus muscle

Regulation of skeletal muscle proteolysis by amino acids.

Regulation of ubiquitin-proteasome dependent muscular proteolysis by hormones and nutrients

Repeated cures with paracetamol worsen sarcopenia in old rats with suboptimal food intake

Skeletal muscle lipid content and oxidative activity in relation to muscle fiber type in aging and metabolic syndrome.

Skeletal muscle proteolysis in aging.

Soluble Milk Proteins Improve Muscle Mass Recovery after Immobilization-Induced Muscle Atrophy in Old Rats but Do not Improve Muscle Functional Property Restoration.

The delayed recovery of the remobilized rat tibialis anterior muscle reflects a defect in proliferative and terminal differentiation that impairs early regenerative processes

The role of ubiquitin-proteasome-dependent proteolysis in the remodelling of skeletal muscle.

The ubiquitin-proteasome pathway: limitations and opportunities

The worsening of tibialis anterior muscle atrophy during recovery post-immobilization correlates with enhanced connective tissue area, proteolysis, and apoptosis.

Tissue-Specific Oxidative Stress Modulation by Exercise: A Comparison between MICT and HIIT in an Obese Rat Model

UBE2B is implicated in myofibrillar protein loss in catabolic C2C12 myotubes

UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension

Ubiquitin-proteasome-dependent muscle proteolysis responds slowly to insulin release and refeeding in starved rats.

Ubiquitin-proteasome-dependent proteolysis in skeletal muscle.

Ubiquitin-proteasome-dependent proteolytic activity remains elevated after zymosan-induced sepsis in rats while muscle mass recovers

Unilateral hindlimb casting induced a delayed generalized muscle atrophy during rehabilitation that is prevented by a whey or a high protein diet but not a free leucine-enriched diet

Upregulation of MuRF1 and MAFbx participates to muscle wasting upon gentamicin-induced acute kidney injury.

Whey proteins are more efficient than casein in the recovery of muscle functional properties following a casting induced muscle atrophy