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List of works by Mark John Ingraham Paine

1H, 15N and 13C NMR resonance assignment, secondary structure and global fold of the FMN-binding domain of human cytochrome P450 reductase

scientific article published on 01 July 1997

A cis-regulatory sequence driving metabolic insecticide resistance in mosquitoes: functional characterisation and signatures of selection.

scientific article published on 23 June 2012

A dehydrochlorinase-based pH change assay for determination of DDT in sprayed surfaces

scientific article

A simple colorimetric assay for specific detection of glutathione-S transferase activity associated with DDT resistance in mosquitoes.

scientific article

A simple glutathione transferase-based colorimetric endpoint assay for insecticide detection

scholarly article by Andrew J. Dowd et al published August 2009 in Enzyme and Microbial Technology

Abamectin is metabolized by CYP392A16, a cytochrome P450 associated with high levels of acaricide resistance in Tetranychus urticae.

scientific article

Anopheles gambiae P450 reductase is highly expressed in oenocytes and in vivo knockdown increases permethrin susceptibility.

scientific article published in June 2006

Antimalarial activity of primaquine operates via a two-step biochemical relay

scientific article published on 19 July 2019

Axonal loss and myelin in early ON loss in postacute optic neuritis.

scientific article published in September 2008

Biochemical comparison of Anopheles gambiae and human NADPH P450 reductases reveals different 2'-5'-ADP and FMN binding traits

scientific article

Bioreductive activation of mitoxantrone by NADPH cytochrome P450 reductase. Implications for increasing its ability to inhibit the growth of sensitive and multidrug resistant leukaemia HL60 cells.

scientific article published on 29 March 2006

CYP6 P450 enzymes and ACE-1 duplication produce extreme and multiple insecticide resistance in the malaria mosquito Anopheles gambiae

scientific article (publication date: March 2014)

Characterisation of Anopheles gambiae heme oxygenase and metalloporphyrin feeding suggests a potential role in reproduction.

scientific article

Characterization of inhibitors and substrates of Anopheles gambiae CYP6Z2.

scientific article published in April 2008

Comparative effectiveness of glatiramer acetate and interferon beta formulations in relapsing-remitting multiple sclerosis

scientific article published on 5 December 2014

Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution

scientific article

Crystallization and preliminary X-ray diffraction studies of human cytochrome P450 reductase

scientific article published on 01 March 1996

Development of a colourimetric pH assay for the quantification of pyrethroids based on glutathione-S-transferase

article

Differential Ability of Cytostatics From Anthraquinone Group to Generate Free Radicals in Three Enzymatic Systems: NADH Dehydrogenase, NADPH Cytochrome P450 Reductase, and Xanthine Oxidase ⬇️

scientific article published on January 1, 2003

Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus.

scientific article published on 17 December 2012

Engineering of a functional human NADH-dependent cytochrome P450 system

scientific article

Engineering sensitive glutathione transferase for the detection of xenobiotics.

scientific article published on 4 July 2008

Evaluating the feasibility of using insecticide quantification kits (IQK) for estimating cyanopyrethroid levels for indoor residual spraying in Vanuatu

scientific article

Expression, Purification, and Biochemical Characterization of A Human Cytochrome P450 CYP2D6-NADPH Cytochrome P450 Reductase Fusion Protein ⬇️

scientific article published on December 1, 2001

Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids

scientific article published in November 2008

Functional characterisation of cytochrome P450s involved in insecticide resistance in major malaria vector Anopheles funestus across Africa

scientific article

Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems.

scientific article published on April 1996

Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase.

scientific article published in February 2006

Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana

scientific article published on 28 March 2012

In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.

scientific article published on 13 January 2006

Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.

scientific article

Interrelationship of optical coherence tomography and multifocal visual-evoked potentials after optic neuritis.

scientific article published on 30 December 2009

Metabolic and target-site mechanisms combine to confer strong DDT resistance in Anopheles gambiae

scientific article published in 2014

Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.

scientific article published in January 1997

Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules.

scientific article published on 21 July 2008

Persistence on therapy and propensity matched outcome comparison of two subcutaneous interferon beta 1a dosages for multiple sclerosis

scientific article

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

scientific article published on June 2004

Pinpointing P450s Associated with Pyrethroid Metabolism in the Dengue Vector, Aedes aegypti: Developing New Tools to Combat Insecticide Resistance ⬇️

scientific article published on March 27, 2012

Pyriproxyfen is metabolized by P450s associated with pyrethroid resistance in An. gambiae.

scientific article published on 6 September 2016

Rainbow tags: a visual tag system for recombinant protein expression and purification.

scientific article published in March 2005

Relaxation kinetics of cytochrome P450 reductase: internal electron transfer is limited by conformational change and regulated by coenzyme binding.

scientific article

Remyelination of optic nerve lesions: spatial and temporal factors

scientific article published on 07 June 2010

Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

scientific article published in 2021

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

scientific article

Risk of relapse phenotype recurrence in multiple sclerosis.

scientific article

Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.

scientific article published in March 2003

Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth

scientific article

Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase: implications for increasing the activity against sensitive and multidrug-resistant

scientific article

Seasonal variation of relapse rate in multiple sclerosis is latitude dependent.

scientific article published on 20 October 2014

Sequence characterization of cytochrome P450 CYP6P9 in pyrethroid resistant and susceptible Anopheles funestus (Diptera: Culicidae).

scientific article published on 30 March 2010

Stage specific differences in steady state levels of mRNA encoding the major surface glycoprotein of Brugia pahangi.

scientific article published on December 1994

Structural studies on FMN domain of cytochrome P450 reductase

scientific article published on 01 August 1995

The molecular cloning of a phospholipase A2 from Bothrops jararacussu snake venom: Evolution of venom group II phospholipase A2's may imply gene duplications ⬇️

scientific article published on August 1, 1995

The role of bioreductive activation of antitumour anthracycline drugs in cytotoxic activity against sensitive and multidrug resistant leukaemia HL60 cells ⬇️

scientific article published on November 15, 2011

The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines.

scientific article published on July 2005

Trp-676 Facilitates Nicotinamide Coenzyme Exchange in the Reductive Half-Reaction of Human Cytochrome P450 Reductase: Properties of the Soluble W676H and W676A Mutant Reductases†

article

Validation of Model of Cytochrome P450 2D6: An in Silico Tool for Predicting Metabolism and Inhibition

article

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

scientific article

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