List of works by Wai Keung Leung

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone promoted gastric cancer growth through prostaglandin E receptor (EP2 and EP4) in vivo and in vitro.

scientific article published on 14 March 2011

A middle-aged woman with recurrent haemetemesis

scientific article published on 01 September 2002

ACE (Angiotensin-Converting Enzyme) Inhibitors/Angiotensin Receptor Blockers Are Associated With Lower Colorectal Cancer Risk: A Territory-Wide Study With Propensity Score Analysis

scientific article published on 06 July 2020

Accuracy of capsule colonoscopy in detecting colorectal polyps in a screening population

scientific article

Activation of adenosine A3 receptor inhibits inflammatory cytokine production in colonic mucosa of patients with ulcerative colitis by down-regulating the nuclear factor-kappa B signaling

scientific article published on 17 December 2019

Agranulocytosis in a drug addict with recurrent Staphylococcus aureus septicaemia.

scientific article published on December 1995

Agreements among traditional Chinese medicine practitioners in the diagnosis and treatment of irritable bowel syndrome.

scientific article published in November 2004

Alterations in Gastric Microbiota After H. Pylori Eradication and in Different Histological Stages of Gastric Carcinogenesis

scientific article published on 21 March 2017

Alterations of frizzled (FzE3) and secreted frizzled related protein (hsFRP) expression in gastric cancer.

scientific article published in December 2001

Anti-proliferative and pro-apoptotic effects of herbal medicine on hepatic stellate cell.

scientific article published on August 2005

Anti-sense trefoil factor family-3 (intestinal trefoil factor) inhibits cell growth and induces chemosensitivity to adriamycin in human gastric cancer cells.

scientific article

Asia Pacific Consensus Statements on Crohn's disease. Part 1: Definition, diagnosis, and epidemiology: (Asia Pacific Crohn's Disease Consensus--Part 1).

scientific article published on 25 March 2015

Asia-Pacific consensus statements on Crohn's disease. Part 2: Management.

scientific article published on 25 March 2015

Aspirin and Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study.

scientific article published on 19 January 2018

Association Between Acute Neuropsychiatric Events and Helicobacter pylori Therapy Containing Clarithromycin.

scientific article

Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer.

scientific article published on February 2001

Association between emergency admission for peptic ulcer bleeding and air pollution: a case-crossover analysis in Hong Kong's elderly population

scientific article published on 05 May 2017

Association of intestinal granulomas with smoking, phenotype, and serology in Chinese patients with Crohn's disease

scientific article published on 01 May 2006

Atrophy and intestinal metaplasia one year after cure of H. pylori infection: a prospective, randomized study

scientific article published on 01 July 2000

Best practices on immunomodulators and biologic agents for ulcerative colitis and Crohn's disease in Asia

scientific article published on 31 May 2019

Bleeding-related hospital admissions and 30-day readmissions in patients with non-valvular atrial fibrillation treated with dabigatran versus warfarin.

scientific article published on 17 August 2017

Calcium channel blockers are associated with lower gastric cancer risk: a territory-wide study with propensity score analysis

scientific article published on 05 November 2020

Cancer Risk in 2621 Chinese Patients with Inflammatory Bowel Disease: A Population-based Cohort Study

scientific article published on 6 October 2017

Capsule endoscopy or angiography in patients with acute overt obscure gastrointestinal bleeding: a prospective randomized study with long-term follow-up

scientific article published on 24 July 2012

Celecoxib versus diclofenac plus omeprazole in high-risk arthritis patients: results of a randomized double-blind trial.

scientific article published in October 2004

Changes in Crohn's disease phenotype over time in the Chinese population: validation of the Montreal classification system

scientific article published on 01 April 2008

Chemoprevention of gastric cancer by celecoxib in rats.

scientific article published in February 2004

Colon capsule endoscopy for inflammatory bowel disease

scientific article published on 26 June 2018

Colorectal neoplasia in Asia: a multicenter colonoscopy survey in symptomatic patients.

scientific article published on November 2006

Colorectal neoplasm in asymptomatic Asians: a prospective multinational multicenter colonoscopy survey

scientific article published on 01 June 2007

Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial.

scientific article published on May 2007

Comparison of EUS and ERCP in the investigation with suspected biliary obstruction caused by choledocholithiasis: a randomized study

scientific article published on 26 December 2007

Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line

scientific article published on October 2004

Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS).

scientific article

Detection of colorectal adenoma by narrow band imaging (HQ190) vs. high-definition white light colonoscopy: a randomized controlled trial

scientific article published on 22 April 2014

Detection of epigenetic changes in fecal DNA as a molecular screening test for colorectal cancer: a feasibility study

scientific article published on 01 November 2004

Detection of hypermethylated DNA or cyclooxygenase-2 messenger RNA in fecal samples of patients with colorectal cancer or polyps

scientific article published on 22 March 2007

Detection rates of proximal or large serrated polyps in Chinese patients undergoing screening colonoscopy

scientific article published on 01 September 2012

Developing the use of mismatch binding proteins for discovering rare somatic mutations.

scientific article

Diabetes Increases Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study With Propensity Score Analysis

scientific article published on 11 July 2019

Diagnosis of Helicobacter pylori infection after gastric surgery for peptic ulcer: is the rapid urease test useful?

scientific article published on 01 June 1998

Distributions of colorectal cancer in two Chinese cities with contrasting colorectal cancer epidemiology

scientific article published on 11 June 2015

Divergent trends of hospitalizations for upper and lower gastrointestinal bleeding based on population prescriptions of aspirin, proton pump inhibitors and Helicobacter pylori eradication therapy: Trends of upper and lower gastrointestinal bleeding

Does eradication of Helicobacter pylori impair healing of nonsteroidal anti-inflammatory drug associated bleeding peptic ulcers? A prospective randomized study

scientific article published on 01 December 1998

Dosage effects of histamine-2 receptor antagonist on the primary prophylaxis of non-steroidal anti-inflammatory drug (NSAID)-associated peptic ulcers: a retrospective cohort study

scientific article published in September 2014

Dysfunction of oesophageal motility in Helicobacter pylori-infected patients with reflux oesophagitis

scientific article published on 01 December 2001

Effect of Helicobacter pylori eradication on oesophageal acid exposure in patients with reflux oesophagitis.

scientific article published in March 2002

Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells.

scientific article published on March 2004

Effect of suboptimal anticoagulation treatment with antiplatelet therapy and warfarin on clinical outcomes in patients with nonvalvular atrial fibrillation: A population-wide cohort study

scientific article published on 28 March 2016

Effects of Helicobacter PYLORI Treatment on Incidence of Gastric Cancer in Older Individuals.

scientific article

Effects of long-term rofecoxib on gastric intestinal metaplasia: results of a randomized controlled trial

scientific article published on 01 August 2006

Effects of neonatal maternal separation on neurochemical and sensory response to colonic distension in a rat model of irritable bowel syndrome.

scientific article published on 16 November 2006

Effects of nucleoside analogue prescription for hepatitis B on the incidence of liver cancer in Hong Kong: a territory-wide ecological study.

scientific article published on 15 December 2016

Efficacy of cap-assisted colonoscopy in comparison with regular colonoscopy: a randomized controlled trial

scientific article published on 01 January 2009

Empirical treatment based on "typical" reflux symptoms is inappropriate in a population with a high prevalence of Helicobacter pylori infection.

scientific article published on April 2002

Endoscopic prediction of deeply submucosal invasive carcinoma with use of artificial intelligence

scientific article published on 03 April 2019

Epidemiology, characteristics, and survival of post-colonoscopy colorectal cancer in Asia: A population-based study

scientific article published on 15 May 2019

Evaluation of three commercial enzyme-linked immunosorbent assay kits for diagnosis of Helicobacter pylori in Chinese patients

scientific article published on 01 May 1999

Expression and cellular localization of COX-1 and -2 in Helicobacter pylori gastritis

scientific article published on 01 February 2001

Expression of HBx and COX-2 in chronic hepatitis B, cirrhosis and hepatocellular carcinoma: implication of HBx in upregulation of COX-2.

scientific article published on October 2004

Expression of a cyclo-oxygenase-2 transgene in murine liver causes hepatitis.

scientific article

Expression of peroxisome proliferator-activated receptor delta in human gastric cancer and its response to specific COX-2 inhibitor.

scientific article

Expression of trefoil peptides (TFF1, TFF2, and TFF3) in gastric carcinomas, intestinal metaplasia, and non-neoplastic gastric tissues.

scientific article

Fecal viral load and norovirus-associated gastroenteritis.

scientific article published on August 2006

Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer

scientific article

Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer

scientific article

Gastroesophageal Reflux Disease: Cross-Sectional Study Demonstrating Rising Prevalence in a Chinese Population.

scientific article published on 6 March 2015

Gastrointestinal bleeding in patients on novel oral anticoagulants: Risk, prevention and management.

scientific article

Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control.

scientific article published on 11 August 2015

H. pylori genotypes and cytokine gene polymorphisms influence the development of gastric intestinal metaplasia in a Chinese population

scientific article published on 01 April 2006

Helicobacter pylori associated gastric intestinal metaplasia: Treatment and surveillance

scientific article

Helicobacter pylori impairs DNA mismatch repair in gastric epithelial cells.

scientific article

Helicobacter pylori infection in 1st degree relatives of Chinese gastric cancer patients

scientific article published on 01 March 2006

Histo-blood group antigens and susceptibility to infection with norovirus genogroup II genotype 4

scientific article published on 01 September 2008

Identification of a second MutL DNA mismatch repair complex (hPMS1 and hMLH1) in human epithelial cells

scientific article published on 01 May 2000

Identification of retinoic acid-regulated nuclear matrix-associated protein as a novel regulator of gastric cancer.

scientific article published on August 2009

Identification of serum miR-139-3p as a non-invasive biomarker for colorectal cancer.

scientific article

Immunoglobulin G4-related disease in Hong Kong: clinical features, treatment practices, and its association with multisystem disease

scientific article published on September 2017

Impacts of COVID-19 Pandemic on Gastrointestinal Endoscopy Volume and Diagnosis of Gastric and Colorectal Cancers: A Population-based Study

scientific article published on 17 May 2020

Inactivation of helicase-like transcription factor by promoter hypermethylation in human gastric cancer.

scientific article

Incidences, temporal trends and risks of hospitalisation for gastrointestinal bleeding in new or chronic low-dose aspirin users after treatment for Helicobacter pylori: a territory-wide cohort study

scientific article published on 17 May 2019

Increased risk of advanced neoplasms among asymptomatic siblings of patients with colorectal cancer.

scientific article published on 13 November 2012

Indoleamine 2,3-dioxygenase 1, Increased in Human Gastric Pre-Neoplasia, Promotes Inflammation and Metaplasia in Mice and is Associated with Type II Hypersensitivity/Autoimmunity

scientific article published on 11 September 2017

Infection-related hospitalizations in the first year after inflammatory bowel disease diagnosis.

scientific article

Initial experience of real-time capsule endoscopy in monitoring progress of the videocapsule through the upper GI tract

scientific article published on 22 October 2007

Initial treatment with lansoprazole in young dyspeptic patients with negative urea breath test result: a randomized controlled trial with 12-month follow-up.

scientific article published in July 2007

Inter-observer variations on interpretation of capsule endoscopies.

scientific article

Interaction of Helicobacter pylori eradication and non-steroidal anti-inflammatory drugs on gastric epithelial apoptosis and proliferation: implications on ulcerogenesis

scientific article published on 01 July 2000

Intrahepatic hepatitis B virus replication and liver histology in subjects with occult hepatitis B infection.

scientific article

Inverse association between cyclooxygenase-2 overexpression and microsatellite instability in gastric cancer

scientific article published on 01 July 2001

Is non-Helicobacter pylori, non-NSAID peptic ulcer a common cause of upper GI bleeding? A prospective study of 977 patients

scientific article (publication date: April 2001)

Isolation of Helicobacter pylori from vomitus in children and its implication in gastro-oral transmission

scientific article published on 01 October 1999

Joint recommendations on management of anaemia in patients with gastrointestinal bleeding in Hong Kong

scientific article published on 01 August 2018

Letter: non-steroidal anti-inflammatory drugs reduce the risk of post-colonoscopy colorectal cancer-authors' reply

scientific article published on 01 January 2021

Linked color imaging versus narrow-band imaging for colorectal polyp detection: a prospective randomized tandem colonoscopy study

scientific article published on 02 July 2019

Lipoprotein lipase activator ameliorates the severity of dietary steatohepatitis

scientific article published on 05 March 2007

Long-term follow-up of patients with obscure gastrointestinal bleeding after negative capsule endoscopy

scientific article published on 01 June 2006

Long-term follow-up of ulcerative colitis in the Chinese population

scientific article published on 03 February 2009

Long-term outcome of Helicobacter pylori-negative idiopathic bleeding ulcers: a prospective cohort study

scientific article published on 01 June 2005

Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study.

scientific article published on 31 October 2017

Low-dose azathioprine is effective in maintaining remission in steroid-dependent ulcerative colitis: results from a territory-wide Chinese population-based IBD registry

scientific article published on 19 April 2016

Machine learning models in the prediction of 1-year mortality in patients with advanced hepatocellular cancer on immunotherapy: a proof-of-concept study

scientific article published in 2022

Magnetic resonance cholangiogram patterns and clinical profiles of ketamine-related cholangiopathy in drug users

scientific article published on 16 March 2018

Magnetic resonance colonography in the detection of colonic neoplasm in high-risk and average-risk individuals

scientific article published on 01 January 2004

Methylated Septin 9 and Carcinoembryonic Antigen for Serological Diagnosis and Monitoring of Patients with Colorectal Cancer After Surgery

scientific article published on 17 July 2019

NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors.

scientific article published on 15 November 2010

Narrow-Band Imaging for Detection of Neoplasia at Colonoscopy: A Meta-analysis of Data From Individual Patients in Randomized Controlled Trials

scientific article published on 15 April 2019

Natural History of Elderly-onset Ulcerative Colitis: Results from a Territory-wide Inflammatory Bowel Disease Registry.

scientific article published on 28 October 2015

Nonsteroidal anti-inflammatory drugs but not aspirin are associated with a lower risk of post-colonoscopy colorectal cancer

scientific article published on 22 March 2020

Obscure gastrointestinal bleeding: where do we go from here?

scientific article published on 21 March 2010

One-week ranitidine bismuth citrate in combinations with metronidazole, amoxycillin and clarithromycin in the treatment of Helicobacter pylori infection: the RBC-MACH study.

scientific article published in August 1999

One-week use of ranitidine bismuth citrate, amoxycillin and clarithromycin for the treatment of Helicobacter pylori-related duodenal ulcer

scientific article published on 01 August 1998

Pathogenesis of pre-neoplastic lesions of the stomach: targets for prevention.

scientific article

Peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism, Helicobacter pylori infection and non-cardia gastric carcinoma in Chinese.

scientific article

Potential Strategies in the Prevention of Nonsteroidal Anti-inflammatory Drugs-Associated Adverse Effects in the Lower Gastrointestinal Tract

scientific article published on 01 March 2020

Potential diagnostic and prognostic values of detecting promoter hypermethylation in the serum of patients with gastric cancer.

scientific article published on June 2005

Predicting mortality in patients with bleeding peptic ulcers after therapeutic endoscopy.

scientific article

Prevalence and distribution of Helicobacter pylori in gastroesophageal reflux disease: a study from the East

scientific article published on 01 July 1999

Prevention of Dabigatran-Related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study.

scientific article published on 7 May 2015

Prevention of post-sphincterotomy bleeding by proton pump inhibitor: A randomized controlled trial

scientific article published on 24 May 2018

Prior gastroscopy and mortality in patients with gastric cancer: a matched retrospective cohort study.

scientific article

Prolonged esophageal transit during wireless capsule endoscopy: a series of five cases and analysis of risk factors.

scientific article published in February 2006

Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer.

scientific article

Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer.

scientific article published in October 2005

Randomised clinical trial: rifaximin versus placebo for the treatment of functional dyspepsia.

scientific article published on 23 January 2017

Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer

scientific article published on 10 October 2018

Relationship between Helicobacter pylori babA2 status with gastric epithelial cell turnover and premalignant gastric lesions.

scientific article published on October 2002

Response to Khosrow-Khavar, Kurteva, and Douros

scientific article published on 01 October 2019

Response to letter to the editor by Moayyedi et al

scientific article published on 18 August 2018

Right-Sided Location Not Associated With Missed Colorectal Adenomas in an Individual-Level Reanalysis of Tandem Colonoscopy Studies

scientific article published on 16 May 2019

Risk factors associated with the development of intestinal metaplasia in first-degree relatives of gastric cancer patients.

scientific article published in December 2005

Risk of gastric cancer development after eradication of Helicobacter pylori.

scientific article

Risks of hospitalization for upper gastrointestinal bleeding in users of selective serotonin reuptake inhibitors after Helicobacter pylori eradication therapy: a propensity score matching analysis

scientific article published on 03 October 2019

Roles of Methylated DNA Biomarkers in Patients with Colorectal Cancer

scientific article published on 03 March 2019

STROBE-Long-Term Exposure to Ambient Fine Particulate Air Pollution and Hospitalization Due to Peptic Ulcers

scientific article

Sapovirus detection by quantitative real-time RT-PCR in clinical stool specimens.

scientific article

Screening for colorectal cancer in Chinese: comparison of fecal occult blood test, flexible sigmoidoscopy, and colonoscopy

scientific article published on 01 March 2003

Screening for gastric cancer in Asia: current evidence and practice.

scientific article published on March 2008

Significant Medical and Surgical Morbidity in Perianal Crohn's Disease: Results from a Territory-Wide Study

scientific article published on 01 November 2018

Small bowel enteropathy associated with chronic low-dose aspirin therapy

scientific article (publication date: 17 February 2007)

Somatic β-catenin mutation in gastric carcinoma – an infrequent event that is not specific for microsatellite instability

scientific article published on 01 February 2001

Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients

scientific article published on 26 February 2019

Stopping anti-tumour necrosis factor therapy in patients with perianal Crohn's disease

scientific article published on 22 October 2019

Systematic review with meta-analysis: the association between the use of calcium channel blockers and gastrointestinal bleeding

scientific article

Systematic review with meta-analysis: the risk of gastrointestinal bleeding in patients taking third-generation P2Y12 inhibitors compared with clopidogrel.

scientific article published on 2 December 2018

Ten day sequential versus 10 day modified bismuth quadruple therapy as empirical firstline and secondline treatment for Helicobacter pylori in Chinese patients: an open label, randomised, crossover trial.

scientific article published on 2 December 2013

The Asia-Pacific consensus on ulcerative colitis.

scientific article published on March 2010

The Impacts of Computer-Aided Detection of Colorectal Polyps on Subsequent Colonoscopy Surveillance Intervals: Simulation Study

The Impacts of Computer-Aided Detection of Colorectal Polyps on Subsequent Colonoscopy Surveillance Intervals: Simulation Study (Preprint)

The antimicrobial susceptibility of Helicobacter pylori in Hong Kong (1997-2001).

scientific article published in October 2002

The association between non-vitamin K antagonist oral anticoagulants and gastrointestinal bleeding: a meta-analysis of observational studies

scientific article published on 17 February 2016

Thromboembolic, bleeding, and mortality risks among patients with nonvalvular atrial fibrillation treated with dual antiplatelet therapy versus oral anticoagulants: A population-based study

scientific article published on 01 August 2019

Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice.

scientific article published on 7 July 2008

Transmission of hepatitis B by human bite--confirmation by detection of virus in saliva and full genome sequencing.

scientific article

Treatment of diarrhea-predominant irritable bowel syndrome with traditional Chinese herbal medicine: a randomized placebo-controlled trial.

scientific article published in July 2006

Ulcer and gastritis

scientific article published on 01 January 2001

Ulcer recurrence after gastric surgery: is Helicobacter pylori the culprit?

scientific article published on 01 June 1998

Ulcers and gastritis

scientific article published on 04 December 2007

Ulcers and gastritis

scientific article published on 01 January 2006

Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells.

scientific article published on January 2004

Use of chopsticks for eating and Helicobacter pylori infection

scientific article published on 01 June 1999

Warfarin interactions with Chinese traditional medicines: danshen and methyl salicylate medicated oil

scientific article published on 01 June 1995

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