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List of works by Marcel van der Heyden

A 2015 focus on preventing drug-induced arrhythmias.

scientific article

A Heart too Drunk to Drive; AV Block following Acute Alcohol Intoxication.

scientific article published on 29 February 2016

A New In Vitro Co-Culture Model Using Magnetic Force-Based Nanotechnology.

scientific article published on 12 February 2016

A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane.

scientific article

A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs.

scientific article

AV-block and conduction slowing prevail over TdP arrhythmias in the methoxamine-sensitized pro-arrhythmic rabbit model.

scientific article published on 19 September 2014

Anesthesia and arrhythmogenesis in the chronic atrioventricular block dog model.

scientific article published in June 2010

Barium toxicity and the role of the potassium inward rectifier current

scientific article

Beat-to-Beat Variability in Preload Unmasks Latent Risk of Torsade de Pointes in Anesthetized Chronic Atrioventricular Block Dogs.

scientific article published on 6 May 2016

Beat-to-beat variability of repolarization as a new biomarker for proarrhythmia in vivo.

scientific article published on 15 May 2012

Beta-, not alpha-adrenergic stimulation enhances conduction velocity in cultures of neonatal cardiomyocytes

scientific article published on 01 June 2007

Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent

scientific article published on 29 June 2016

Cardiac cell-cell junctions in health and disease: Electrical versus mechanical coupling.

scientific article published on April 2009

Cardiac ion channel trafficking defects and drugs.

scientific article published on 02 April 2013

Cardiomyocytes from human and mouse embryonic stem cells.

scientific article published on January 2007

Class III antiarrhythmic drugs amiodarone and dronedarone impair KIR 2.1 backward trafficking

scientific article published on 19 April 2017

Cloning and functional characterization of a novel connexin expressed in somites of Xenopus laevis.

scientific article published in July 2005

Cloning, sequence analysis and phylogeny of connexin43 isolated from American black bear heart

scientific article published on 01 October 2007

Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes

scientific article published on January 2012

Connexin43 expression during Xenopus development.

scientific article published in October 2001

Connexin43 orthologues in vertebrates: phylogeny from fish to man.

scientific article

Connexin43 repression following epithelium-to-mesenchyme transition in embryonal carcinoma cells requires Snail1 transcription factor.

scientific article published on March 2007

Disease Associated Mutations in KIR Proteins Linked to Aberrant Inward Rectifier Channel Trafficking

scientific article published on 25 October 2019

Dominant missense mutations in ABCC9 cause Cantú syndrome.

scientific article

Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity

scientific article published on 27 May 2011

Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon?

scientific article published on 3 December 2007

Efficacy of pentamidine analogue 6 in dogs with chronic atrial fibrillation

scientific article published on 05 August 2018

Epidermal growth factor-induced activation and translocation of c-Src to the cytoskeleton depends on the actin binding domain of the EGF-receptor.

scientific article published on December 1997

Epigenetics: DNA demethylation promotes skeletal myotube maturation.

scientific article

Expression of the electrophysiological system during murine embryonic stem cell cardiac differentiation.

scientific article published in January 2003

Foetal and adult cardiomyocyte progenitor cells have different developmental potential

scientific article

Fraud and misconduct in science: the stem cell seduction: Implications for the peer-review process.

scientific article published on January 2009

Glibenclamide and HMR1098 normalize Cantú syndrome-associated gain-of-function currents

scientific article published on 22 May 2019

Grayanotoxin poisoning: 'mad honey disease' and beyond

scientific article

High-rate pacing reduces variability of repolarization and prevents repolarization-dependent arrhythmias in dogs with chronic AV block

scientific article published on 01 December 2010

Human cardiomyocyte progenitor cell-derived cardiomyocytes display a maturated electrical phenotype.

scientific article

Identification of an intracellular domain of the EGF receptor required for high-affinity binding of EGF.

scientific article published on June 1997

Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine.

scientific article published on 29 November 2012

Inhibition of cardiac inward rectifier currents by cationic amphiphilic drugs.

scientific article published on September 2013

Inhibition of cardiomyocyte automaticity by electrotonic application of inward rectifier current from Kir2.1 expressing cells.

scientific article published on 20 April 2006

Insights in KIR2.1 channel structure and function by an evolutionary approach; cloning and functional characterization of the first reptilian inward rectifier channel KIR2.1, derived from the California kingsnake (Lampropeltis getula californiae).

scientific article

LUF7244 plus dofetilide rescues aberrant Kv11.1 trafficking and produces functional IKv11.1.

scientific article published on 02 April 2020

LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model

scientific article published on 30 August 2019

Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density.

scientific article published on 7 January 2008

Maximal epidermal growth-factor-induced cytosolic phospholipase A2 activation in vivo requires phosphorylation followed by an increased intracellular calcium concentration.

scientific article

Mechanisms for Kir channel inhibition by quinacrine: acute pore block of Kir2.x channels and interference in PIP2 interaction with Kir2.x and Kir6.2 channels

scientific article published on 22 July 2011

Mesenchymal stem cells repair conduction block

scientific article published on 09 June 2006

Molecular aspects of adrenergic modulation of cardiac L-type Ca2+ channels.

scientific article

Molecular aspects of adrenergic modulation of the transient outward current.

scientific article published on 27 April 2006

P19 embryonal carcinoma cells: a suitable model system for cardiac electrophysiological differentiation at the molecular and functional level.

scientific article

Personalized medicine and the role of induced pluripotent stem cells

scientific article published on 20 July 2012

Pharmacological exploration of the resting membrane potential reserve: Impact on atrial fibrillation

scientific article

Reduced plakoglobin immunoreactivity in arrhythmogenic cardiomyopathy: methodological considerations.

scientific article published on 17 May 2013

Regulated expression of the X. tropicalis connexin43 promoter.

scientific article

Regulatory roles of the ubiquitin-proteasome system in cardiomyocyte apoptosis.

scientific article published on February 2010

Review of case reports on hyperkalemia induced by dietary intake: not restricted to chronic kidney disease patients

scientific article published on 27 March 2018

Rewiring the heart: stem cell therapy to restore normal cardiac excitability and conduction.

scientific article published on January 2009

Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.

scientific article

Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.

scientific article

Selectivity in enrichment of cAMP-dependent protein kinase regulatory subunits type I and type II and their interactors using modified cAMP affinity resins.

scientific article published on 31 December 2008

Sex hormones and jumping heart beats

scientific article published on 21 April 2019

Short-term variability of repolarization predicts ventricular tachycardia and sudden cardiac death in patients with structural heart disease: a comparison with QT variability index

scientific article published on 10 May 2011

Spotlight on stem cells--makes old hearts fresh

scientific article published on 01 May 2003

Structure–Affinity Relationships (SARs) and Structure–Kinetics Relationships (SKRs) of Kv11.1 Blockers

scientific article published on 17 July 2015

The actin binding domain of the epidermal growth factor receptor is required for EGF-stimulated tissue invasion.

scientific article published on August 1997

The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.

scientific article

The hidden secrets of the hibernator's heart may protect against arrhythmias

scientific article published on 01 September 2005

The secrets of hibernators' cardiac conduction reserve

scientific article published on 06 September 2008

Toward specific cardiac I(K1) modulators for in vivo application: old drugs point the way.

scientific article published on 02 February 2011

Towards the Development of AgoKirs: New Pharmacological Activators to Study Kir2.x Channel and Target Cardiac Disease

scientific article published on 11 August 2020

Vernakalant is devoid of proarrhythmic effects in the complete AV block dog model

scientific article published on 05 November 2013

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