List of works - Kim L.R. Brouwer

A Challenge for Clinical Pharmacologists: How Can We Measure Scientific Impact of Publications in Drug Development and in Regulatory Decision Making?

scientific article published on 11 November 2018

A modified residual method to estimate the zero-order absorption rate constant in a one-compartment model

scientific article published on 01 March 1997

A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function.

scientific article

A perspective on efflux transport proteins in the liver

scientific article published on 05 September 2012

A semiphysiologically based pharmacokinetic modeling approach to predict the dose-exposure relationship of an antiparasitic prodrug/active metabolite pair.

scientific article published on 27 September 2011

Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

scientific article published on 12 September 2018

Age-dependent intestinal absorption of valproic acid in the rat

scientific article published on 01 February 1995

Age-dependent intestinal hydrolysis of valproate glucuronide in rat

scientific article published on 01 March 1995

Age-related changes in valproic acid binding to rat serum proteins in vitro

scientific article published on 01 April 1996

Airway deposition and clearance and systemic pharmacokinetics of amiloride following aerosolization with an ultrasonic nebulizer to normal airways

scientific article published on 01 November 1997

Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis

scientific article published on 3 July 2015

Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease

scientific article published on 03 June 2019

Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer's Disease

scientific article published on 22 August 2018

Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease

scientific article published on 30 November 2018

Altered hepatobiliary disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice

scientific article published on 24 January 2006

Altered morphine glucuronide and bile acid disposition in patients with nonalcoholic steatohepatitis

scientific article published on 15 March 2015

An experimental approach to evaluate the impact of impaired transport function on hepatobiliary drug disposition using Mrp2-deficient TR- rat sandwich-cultured hepatocytes in combination with Bcrp knockdown.

scientific article published on 30 January 2014

Analysis of human C24 bile acids metabolome in serum and urine based on enzyme digestion of conjugated bile acids and LC-MS determination of unconjugated bile acids

scientific article published on 16 June 2018

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.

scientific article published on 21 September 2016

Assessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes.

scientific article

Bile Acids as Potential Biomarkers to Assess Liver Impairment in Polycystic Kidney Disease

article

Biotransformation and transport of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in bile duct-cannulated wild-type and Mrp2/Abcc2-deficient (TR ) Wistar rats.

scientific article published on 27 August 2007

Characterization of p-hydroxyphenobarbital glucuronide generated from immobilized rat hepatic UDP-glucuronosyltransferase

scientific article published on 01 September 1995

Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis

scientific article published on 8 July 2016

Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats.

scientific article

Comparison of the acute pharmacodynamic responses after single doses of ephedrine or sibutramine in healthy, overweight volunteers.

scientific article published in August 2004

Contribution of morphine-6-glucuronide to antinociception following intravenous administration of morphine to healthy volunteers.

scientific article

Cyclophosphamide and 4‐hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis ⬇️

scientific article published on September 1, 2012

Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats

scientific article

Determination of intracellular unbound concentrations and subcellular localization of drugs in rat sandwich-cultured hepatocytes compared with liver tissue.

scientific article published on 29 August 2013

Determination of the biliary excretion of piperacillin in humans using a novel method.

scientific article published in September 2006

Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes.

scientific article

Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity.

scientific article published on 20 March 2007

Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium

scientific article published on 12 July 2018

Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor alpha-converting enzyme inhibitor, on the disposition of methotrexate: a transport

scientific article published on 01 March 2007

Effect of Liver Disease on Hepatic Transporter Expression and Function

scientific article published on 29 April 2017

Effect of a Common Genetic Variant (p.V444A) in the Bile Salt Export Pump on the Inhibition of Bile Acid Transport by Cholestatic Medications

scientific article published on 25 January 2019

Effect of culture conditions on the expression and function of Bsep, Mrp2, and Mdr1a/b in sandwich-cultured rat hepatocytes

scientific article published on 15 March 2006

Effect of pancreatico-biliary secretions and GI transit time on the absorption and pharmacokinetic profile of ranitidine in humans

scientific article published on August 1, 1998

Evaluation of (99m)technetium-mebrofenin and (99m)technetium-sestamibi as specific probes for hepatic transport protein function in rat and human hepatocytes

scientific article

Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice

scientific article published on 20 September 2006

Evidence for reversible sequestration of morphine in rat liver

scientific article published on 01 August 1996

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury.

scientific article

Fluconazole population pharmacokinetics and dosing for prevention and treatment of invasive Candidiasis in children supported with extracorporeal membrane oxygenation.

scientific article published on 20 April 2015

Fractures of the medial column of the distal humerus in adults

scientific article published on March 2009

Gastrointestinal transit and distribution of ranitidine in the rat

scientific article published on 01 September 1995

Heat treatment of human serum to inactivate HIV does not alter protein binding of selected drugs.

scientific article published in August 1997

Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk

scientific article published on 03 March 2020

Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes

scientific article published on 10 September 2013

Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver.

scientific article published on 30 September 2013

Hepatic disposition of acetaminophen and metabolites. Pharmacokinetic modeling, protein binding and subcellular distribution

scientific article published on 01 August 1993

Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2).

scientific article published on 07 August 2008

Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes

scientific article published on 11 May 2006

Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation.

scientific article

Hepatobiliary disposition of valproic acid and valproate glucuronide: use of a pharmacokinetic model to examine the rate-limiting steps and potential sites of drug interactions

scientific article published on 01 April 1996

Hepatocellular exposure of troglitazone metabolites in rat sandwich-cultured hepatocytes lacking Bcrp and Mrp2: interplay between formation and excretion.

scientific article

High-performance liquid chromatographic evaluation of the effect of heat treatment on trimethoprim and sulfamethoxazole stability in serum

scientific article published on 01 August 1995

Identification of Key Amino Acids that Impact Organic Solute Transporter <i>α</i>/<i>β</i> (OSTα/β)

scientific article published on 01 October 2021

Identification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substrates

scientific article

Identification of novel MRP3 inhibitors based on computational models and validation using an in vitro membrane vesicle assay

scientific article

Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers.

scientific article published on 14 February 2008

Impact of reduced P-glycoprotein function on digoxin concentrations in patients with dementia

scientific article published on 19 August 2019

In vitro and in vivo determination of piperacillin metabolism in humans.

scientific article published on 28 December 2006

In vitro biliary clearance of angiotensin II receptor blockers and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in sandwich-cultured rat hepatocytes: comparison with in vivo biliary clearance.

scientific article published on 23 June 2008

In vitro to in vivo extrapolation for high throughput prioritization and decision making.

scientific article published in December 2017

In vitro-in vivo correlation of hepatobiliary drug clearance in humans.

scientific article published on 18 January 2007

In vivo alterations in drug metabolism and transport pathways in patients with chronic kidney diseases.

scientific article published on 06 September 2013

Influence of drug transport proteins on the pharmacokinetics and drug interactions of HIV protease inhibitors.

scientific article published on 22 June 2011

Influence of seeding density and extracellular matrix on bile Acid transport and mrp4 expression in sandwich-cultured mouse hepatocytes.

scientific article published on April 2010

Intestinal Permeability and Oral Absorption of Selected Drugs Are Reduced in a Mouse Model of Familial Alzheimer's Disease

scientific article published on 08 April 2020

Intravenous epoprostenol sodium does not increase hepatic microsomal enzyme activity in rats

scientific article published on 01 November 1995

Key Role for the 12-Hydroxy Group in the Negative Ion Fragmentation of Unconjugated C24 Bile Acids.

scientific article

Lack of effect of ondansetron on the pharmacokinetics and analgesic effects of morphine and metabolites after single-dose morphine administration in healthy volunteers

scientific article

Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes

scientific article published on 22 October 2007

Magnetic resonance imaging signal abnormalities in enthesopathy of the extensor carpi radialis longus origin

scientific article published on 05 June 2009

Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models.

scientific article

Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid-Mediated DILI

scientific article

Mechanistic Modeling of the Hepatic Disposition of Estradiol-17β-Glucuronide in Sandwich-Cultured Human Hepatocytes

scientific article published on 19 November 2019

Medication use and medical comorbidity in patients with chronic hepatitis C from a US commercial claims database: high utilization of drugs with interaction potential.

scientific article

Membrane transporters in drug development

scientific article (publication date: March 2010)

Modelling the cardiovascular effects of ephedrine

scientific article published in May 2004

Modulation of hepatic canalicular or basolateral transport proteins alters hepatobiliary disposition of a model organic anion in the isolated perfused rat liver.

scientific article published on 20 May 2005

Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1.

scientific article published on 28 April 2005

Nonunion of Operatively Treated Capitellum and Trochlear Fractures ⬇️

scientific article published on March 23, 2011

Novel in Vitro Method Reveals Drugs That Inhibit Organic Solute Transporter Alpha/Beta (OSTα/β)

scientific article published on 14 December 2018

Novel mechanism of impaired function of organic anion-transporting polypeptide 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation.

scientific article

Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions

scientific article published on 01 August 2019

Organic Solute Transporter OSTα/ß is Over-Expressed in Nonalcoholic Steatohepatitis and Modulated by Drugs Associated with Liver Injury.

scientific article

Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes.

scientific article published on 16 May 2013

P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide.

scientific article published in July 2004

Perspectives on a pharmacokinetics legend: C versus T (contributions over time).

scientific article

Pharmacogenetics: is the right drug for the right patient sufficient?

scientific article published on 01 November 2002

Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers.

scientific article published in March 2018

Pharmacokinetics and Safety of Micafungin in Infants Supported With Extracorporeal Membrane Oxygenation

scientific article published on 16 June 2016

Pharmacokinetics and bioavailability of zidovudine and its glucuronidated metabolite in patients with human immunodeficiency virus infection and hepatic disease (AIDS Clinical Trials Group protocol 062).

scientific article

Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation.

scientific article

Phase I trial of a 96 h paclitaxel infusion with filgrastim support in refractory solid tumor patients

scientific article published on 01 August 1998

Phenobarbital alters hepatic Mrp2 function by direct and indirect interactions.

scientific article published in July 2003

Physiologic pharmacokinetic modeling of gastrointestinal blood flow as a rate-limiting step in the oral absorption of digoxin: implications for patients with congestive heart failure receiving epoprostenol.

scientific article published in May 1996

Physiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO

scientific article published on 13 August 2018

Population Pharmacokinetics of Morphine in Patients With Nonalcoholic Steatohepatitis (NASH) and Healthy Adults.

scientific article

Population pharmacokinetics of azithromycin in whole blood, peripheral blood mononuclear cells, and polymorphonuclear cells in healthy adults.

scientific article

Precision Dosing: Public Health Need, Proposed Framework, and Anticipated Impact.

scientific article published on 10 August 2017

Radiolabeling of methylphosphonate and phosphorothioate oligonucleotides and evaluation of their transport in everted rat jejunum sacs

scientific article published on June 1, 1995

Regional gastrointestinal absorption of ranitidine in the rat

scientific article published on 01 September 1995

Relationship between drug/metabolite exposure and impairment of excretory transport function.

scientific article published on 20 November 2008

Relative bioavailability of tolvaptan administered via nasogastric tube and tolvaptan tablets swallowed intact

scientific article published on 01 July 2013

Resection of heterotopic ossification of the elbow: a comparison of ankylosis and partial restriction

scientific article published on 11 June 2010

Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4.

scientific article published on 23 October 2013

Ritonavir, saquinavir, and efavirenz, but not nevirapine, inhibit bile acid transport in human and rat hepatocytes

scientific article published on 23 May 2006

Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital.

scientific article

Role of glycosylation in trafficking of Mrp2 in sandwich-cultured rat hepatocytes.

scientific article published on 20 January 2005

Role of hepatic efflux transporters in regulating systemic and hepatocyte exposure to xenobiotics.

scientific article published on 23 October 2013

Role of multidrug resistance-associated protein 4 in the basolateral efflux of hepatically derived enalaprilat.

scientific article

Roles of P-glycoprotein, Bcrp, and Mrp2 in biliary excretion of spiramycin in mice.

scientific article

Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.

scientific article published on February 2016

Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.

scientific article

Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver.

scientific article published on June 2009

Short-term regulation of multidrug resistance-associated protein 3 in rat and human hepatocytes

scientific article published on 13 January 2005

Solid-phase extraction and determination of ranitidine in human plasma by a high-performance liquid chromatographic method utilizing midbore chromatography.

scientific article published in January 1997

Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury

scientific article published on 23 February 2015

Sulindac and its metabolites inhibit multiple transport proteins in rat and human hepatocytes.

scientific article

Sumatriptan absorption from different regions of the human gastrointestinal tract

scientific article published on 01 January 1995

Systems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicity

scientific article published on 28 July 2014

The complexities of hepatic drug transport: current knowledge and emerging concepts.

scientific article published on May 2004

The important role of Bcrp (Abcg2) in the biliary excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in mice

scientific article published on 07 September 2006

Toward predicting drug-induced liver injury: parallel computational approaches to identify multidrug resistance protein 4 and bile salt export pump inhibitors

scientific article published on 3 March 2015

Toxicokinetics of intravenous methanol in the female rat

scientific article published on 01 July 1993

Transporter-mediated Alterations in Patients with NASH Increase Systemic and Hepatic Exposure to an OATP and MRP2 Substrate.

scientific article published on 22 December 2017

Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport.

scientific article

Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity.

scientific article published on 27 October 2007

Use of sandwich-cultured human hepatocytes to predict biliary clearance of angiotensin II receptor blockers and HMG-CoA reductase inhibitors.

scientific article published on 15 December 2008

Use of the InteliSite capsule to study ranitidine absorption from various sites within the human intestinal tract.

scientific article published on December 1998

Vancomycin serum concentrations in patients with renal dysfunction: a comparison of fluorescence polarization immunoassay and the enzyme-multiplied immunoassay technique

scientific article published on 01 December 1996

Viability assessment in sandwich-cultured rat hepatocytes after xenobiotic exposure.

scientific article published in December 2004

List of works by Kim L.R. Brouwer

A Challenge for Clinical Pharmacologists: How Can We Measure Scientific Impact of Publications in Drug Development and in Regulatory Decision Making?

A modified residual method to estimate the zero-order absorption rate constant in a one-compartment model

A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function.

A perspective on efflux transport proteins in the liver

A semiphysiologically based pharmacokinetic modeling approach to predict the dose-exposure relationship of an antiparasitic prodrug/active metabolite pair.

Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

Age-dependent intestinal absorption of valproic acid in the rat

Age-dependent intestinal hydrolysis of valproate glucuronide in rat

Age-related changes in valproic acid binding to rat serum proteins in vitro

Airway deposition and clearance and systemic pharmacokinetics of amiloride following aerosolization with an ultrasonic nebulizer to normal airways

Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis

Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease

Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer's Disease

Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease

Altered hepatobiliary disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice

Altered morphine glucuronide and bile acid disposition in patients with nonalcoholic steatohepatitis

An experimental approach to evaluate the impact of impaired transport function on hepatobiliary drug disposition using Mrp2-deficient TR- rat sandwich-cultured hepatocytes in combination with Bcrp knockdown.

Analysis of human C24 bile acids metabolome in serum and urine based on enzyme digestion of conjugated bile acids and LC-MS determination of unconjugated bile acids

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.

Assessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes.

Bile Acids as Potential Biomarkers to Assess Liver Impairment in Polycystic Kidney Disease

Biotransformation and transport of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in bile duct-cannulated wild-type and Mrp2/Abcc2-deficient (TR ) Wistar rats.

Characterization of p-hydroxyphenobarbital glucuronide generated from immobilized rat hepatic UDP-glucuronosyltransferase

Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis

Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats.

Comparison of the acute pharmacodynamic responses after single doses of ephedrine or sibutramine in healthy, overweight volunteers.

Contribution of morphine-6-glucuronide to antinociception following intravenous administration of morphine to healthy volunteers.

Cyclophosphamide and 4‐hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis ⬇️

Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats

Determination of intracellular unbound concentrations and subcellular localization of drugs in rat sandwich-cultured hepatocytes compared with liver tissue.

Determination of the biliary excretion of piperacillin in humans using a novel method.

Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes.

Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity.

Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium

Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor alpha-converting enzyme inhibitor, on the disposition of methotrexate: a transport

Effect of Liver Disease on Hepatic Transporter Expression and Function

Effect of a Common Genetic Variant (p.V444A) in the Bile Salt Export Pump on the Inhibition of Bile Acid Transport by Cholestatic Medications

Effect of culture conditions on the expression and function of Bsep, Mrp2, and Mdr1a/b in sandwich-cultured rat hepatocytes

Effect of pancreatico-biliary secretions and GI transit time on the absorption and pharmacokinetic profile of ranitidine in humans

Evaluation of (99m)technetium-mebrofenin and (99m)technetium-sestamibi as specific probes for hepatic transport protein function in rat and human hepatocytes

Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice

Evidence for reversible sequestration of morphine in rat liver

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury.

Fluconazole population pharmacokinetics and dosing for prevention and treatment of invasive Candidiasis in children supported with extracorporeal membrane oxygenation.

Fractures of the medial column of the distal humerus in adults

Gastrointestinal transit and distribution of ranitidine in the rat

Heat treatment of human serum to inactivate HIV does not alter protein binding of selected drugs.

Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk

Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes

Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver.

Hepatic disposition of acetaminophen and metabolites. Pharmacokinetic modeling, protein binding and subcellular distribution

Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2).

Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes

Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation.

Hepatobiliary disposition of valproic acid and valproate glucuronide: use of a pharmacokinetic model to examine the rate-limiting steps and potential sites of drug interactions

Hepatocellular exposure of troglitazone metabolites in rat sandwich-cultured hepatocytes lacking Bcrp and Mrp2: interplay between formation and excretion.

High-performance liquid chromatographic evaluation of the effect of heat treatment on trimethoprim and sulfamethoxazole stability in serum

Identification of Key Amino Acids that Impact Organic Solute Transporter <i>α</i>/<i>β</i> (OSTα/β)

Identification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substrates

Identification of novel MRP3 inhibitors based on computational models and validation using an in vitro membrane vesicle assay

Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers.

Impact of reduced P-glycoprotein function on digoxin concentrations in patients with dementia

In vitro and in vivo determination of piperacillin metabolism in humans.

In vitro biliary clearance of angiotensin II receptor blockers and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in sandwich-cultured rat hepatocytes: comparison with in vivo biliary clearance.

In vitro to in vivo extrapolation for high throughput prioritization and decision making.

In vitro-in vivo correlation of hepatobiliary drug clearance in humans.

In vivo alterations in drug metabolism and transport pathways in patients with chronic kidney diseases.

Influence of drug transport proteins on the pharmacokinetics and drug interactions of HIV protease inhibitors.

Influence of seeding density and extracellular matrix on bile Acid transport and mrp4 expression in sandwich-cultured mouse hepatocytes.

Intestinal Permeability and Oral Absorption of Selected Drugs Are Reduced in a Mouse Model of Familial Alzheimer's Disease

Intravenous epoprostenol sodium does not increase hepatic microsomal enzyme activity in rats

Key Role for the 12-Hydroxy Group in the Negative Ion Fragmentation of Unconjugated C24 Bile Acids.

Lack of effect of ondansetron on the pharmacokinetics and analgesic effects of morphine and metabolites after single-dose morphine administration in healthy volunteers

Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes

Magnetic resonance imaging signal abnormalities in enthesopathy of the extensor carpi radialis longus origin

Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models.

Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid-Mediated DILI

Mechanistic Modeling of the Hepatic Disposition of Estradiol-17β-Glucuronide in Sandwich-Cultured Human Hepatocytes

Medication use and medical comorbidity in patients with chronic hepatitis C from a US commercial claims database: high utilization of drugs with interaction potential.