List of works - Vincent M. Christoffels

52 Genetic Loci Influencing Myocardial Mass

scientific article

A common genetic variant within SCN10A modulates cardiac SCN5A expression

scientific article published on 18 March 2014

A gain-of-function TBX5 mutation is associated with atypical Holt-Oram syndrome and paroxysmal atrial fibrillation

scientific article published on 01 May 2008

A gene of Acinetobacter calcoaceticus BD413 encodes a periplasmic peptidyl-prolyl cis-trans isomerase of the cyclophilin sub-class that is not essential for growth.

scientific article published on November 1994

A large permissive regulatory domain exclusively controls Tbx3 expression in the cardiac conduction system.

scientific article published on 24 June 2014

A mechanistic model for the development and maintenance of portocentral gradients in gene expression in the liver

scientific article published on 01 April 1999

A molecular and genetic outline of cardiac morphogenesis.

scientific article published on February 2013

A mutation in the Kozak sequence ofGATA4hampers translation in a family with atrial septal defects

scientific article published on 05 August 2014

A single regulatory module of the carbamoylphosphate synthetase I gene executes its hepatic program of expression.

scientific article published on December 2000

A transgenic mouse model for the simultaneous monitoring of ANF and BNP gene activity during heart development and disease

scientific article

Absence of an anatomical origin for altered ductus venosus flow velocity waveforms in first-trimester human fetuses with increased nuchal translucency

scientific article published on 6 April 2016

Anatomic substrates for cardiac conduction.

scientific article

Architectural plan for the heart: early patterning and delineation of the chambers and the nodes.

scientific article

Atrial cardiomyocyte-specific expression of Cre recombinase driven by an Nppa gene fragment.

scientific article published on September 2003

Atrial fibrillation: a developmental point of view.

scientific article published on 15 July 2009

Canonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties.

scientific article

Cardiac chamber formation: development, genes, and evolution.

scientific article published on October 2003

Cardiac defects, nuchal edema and abnormal lymphatic development are not associated with morphological changes in the ductus venosus.

scientific article published on 9 July 2016

Cardiac expression of Gal4 causes cardiomyopathy in a dose-dependent manner.

scientific article published in January 2003

Cardiomyocytes derived from embryonic stem cells resemble cardiomyocytes of the embryonic heart tube.

scientific article published in May 2003

Cardiomyocytes purified from differentiated embryonic stem cells exhibit characteristics of early chamber myocardium.

scientific article published on December 2003

Chamber formation and morphogenesis in the developing mammalian heart

scientific journal article

Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries

scientific article published on 10 December 2021

Comparative analysis of the natriuretic peptide precursor gene cluster in vertebrates reveals loss of ANF and retention of CNP-3 in chicken.

scientific article published in July 2005

Comparative cardiovascular physiology: future trends, opportunities and challenges

scientific article published on 23 October 2013

Controversies concerning the anatomical definition of the conduction tissues.

scientific article published in September 2004

Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation

scientific article

Developing insights into cardiac regeneration.

scientific article

Development of the building plan of the heart.

scientific article published on May 2004

Development of the cardiac conduction system: a matter of chamber development.

scientific article

Development of the human aortic arch system captured in an interactive three-dimensional reference model

scientific article published on 23 April 2013

Development of the pacemaker tissues of the heart.

scientific article published on February 2010

Developmental aspects of cardiac arrhythmogenesis ⬇️

scientific article published on May 12, 2011

Developmental origin, growth, and three-dimensional architecture of the atrioventricular conduction axis of the mouse heart.

scientific article published on 29 July 2010

Developmental pattern of ANF gene expression reveals a strict localization of cardiac chamber formation in chicken ⬇️

scientific article published on February 1, 2002

Direct Reprograming to Regenerate Myocardium and Repair Its Pacemaker and Conduction System.

scientific article

Distinct regulation of developmental and heart disease-induced atrial natriuretic factor expression by two separate distal sequences.

scientific article published on 14 February 2008

EMERGE: a flexible modelling framework to predict genomic regulatory elements from genomic signatures.

scientific article published on 3 November 2015

Early repolarization in mice causes overestimation of ventricular activation time by the QRS duration

scientific article published on 20 September 2012

Effect of amiodarone and dronedarone administration in rats on thyroid hormone-dependent gene expression in different cardiac components

scientific article published on 01 June 2007

Electrophysiological patterning of the heart.

scientific article published on 25 February 2012

Electrotransfection with "intracellular" buffer.

scientific article published on January 1995

Embryonic Tbx3+ cardiomyocytes form the mature cardiac conduction system by progressive fate restriction

scientific article published on 03 September 2018

Embryonic development of the right ventricular outflow tract and arrhythmias

scientific article

Evolution and development of the building plan of the vertebrate heart ⬇️

scientific article published on October 11, 2012

Excessive trabeculations in noncompaction do not have the embryonic identity.

scientific article published on 9 November 2016

Exploring a neurogenic basis of velopharyngeal dysfunction in Tbx1 mutant mice: no difference in volumes of the nucleus ambiguus.

scientific article published in May 2013

Expression and regulation of the atrial natriuretic factor encoding gene Nppa during development and disease.

scientific article

Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse

scientific journal article

Expression of Irx6 during mouse morphogenesis.

scientific article published in May 2001

Expression pattern and ontogenesis of thyroid hormone receptor isoforms in the mouse heart

scientific article published on 01 May 2006

Formation of the Venous Pole of the Heart From an Nkx2-5-Negative Precursor Population Requires Tbx18

scientific article published in June 2006

Formation of the building plan of the human heart: morphogenesis, growth, and differentiation

scientific article published on 01 March 2011

From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning.

scientific article published on 17 December 2013

GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development.

scientific article published on 28 April 2014

GATA-dependent transcriptional and epigenetic control of cardiac lineage specification and differentiation.

scientific article published on July 2015

Gene and cluster-specific expression of the Iroquois family members during mouse development

scientific article published on 01 September 2001

Gene regulatory elements of the cardiac conduction system ⬇️

scientific article published on August 22, 2013

Genetic determinants of P wave duration and PR segment

scientific article

Genetics of congenital heart disease: the contribution of the noncoding regulatory genome.

scientific article published on 30 July 2015

HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme

scientific article

Homeobox transcription factor Pitx2: The rise of an asymmetry gene in cardiogenesis and arrhythmogenesis.

scientific article published on 15 August 2013

Hypoglycemia-associated hyperammonemia caused by impaired expression of ornithine cycle enzyme genes in C/EBPalpha knockout mice.

scientific article published in October 1998

Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress

scientific article published on 5 April 2016

Identification of the building blocks of ventricular septation in monitor lizards (Varanidae)

scientific article published on 29 July 2019

Identifying the evolutionary building blocks of the cardiac conduction system.

scientific article

Inactivation of the Sema5a gene results in embryonic lethality and defective remodeling of the cranial vascular system

scientific article

Increased nuchal translucency origins from abnormal lymphatic development and is independent of the presence of a cardiac defect

scientific article published on 4 September 2015

Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis ⬇️

scientific article published on June 1, 2013

Integrating multi-scale knowledge on cardiac development into a computational model of ventricular trabeculation.

scientific article published on 6 October 2014

Involvement of a cis-acting element in the suppression of carbamoyl phosphate synthetase I gene expression in the liver of carnitine-deficient mice

scientific article published on 01 November 1999

Involvement of neurons and retinoic acid in lymphatic development: new insights in increased nuchal translucency

scientific article published on 22 August 2014

Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development

scientific article

Left and right ventricular contributions to the formation of the interventricular septum in the mouse heart

scientific article published on 03 May 2006

Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis

scientific article

Letter by Anderson et al Regarding Article, “Abnormal Conduction and Morphology in the Atrioventricular Node of Mice With Atrioventricular Canal–Targeted Deletion of Alk3/Bmpr1a Receptor”

scientific article published on 01 August 2008

Lineage and morphogenetic analysis of the cardiac valves.

scientific article

Lineages of the Cardiac Conduction System

scientific article published on 2 May 2017

Localized and Temporal Gene Regulation in Heart Development

scientific article published on January 1, 2012

Low incidence of atrial septal defects in nonmammalian vertebrates

scientific article published on 09 October 2019

Mkk4 is a negative regulator of the transforming growth factor beta 1 signaling associated with atrial remodeling and arrhythmogenesis with age.

scientific article

Molecular analysis of patterning of conduction tissues in the developing human heart.

scientific article published on 16 May 2011

Morpho-functional characterization of the systemic venous pole of the reptile heart

scientific article published on 27 July 2017

Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial-mesenchymal transition via Bmp2.

scientific article published on October 2011

Nuclear Recruitment Assay as a Tool to Validate Transcription Factor Interactions in Mammalian Cells ⬇️

scientific article published on January 1, 2013

Origin and development of the atrioventricular myocardial lineage: Insight into the development of accessory pathways ⬇️

scientific article published on May 31, 2011

Origins and consequences of congenital heart defects affecting the right ventricle

scientific article published in October 2017

Partial Absence of Pleuropericardial Membranes in Tbx18- and Wt1-Deficient Mice ⬇️

scientific article published on September 11, 2012

Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.

scientific article

Popeye proteins: muscle for the aging sinus node.

scientific article published on 22 February 2012

Presence of functional sarcoplasmic reticulum in the developing heart and its confinement to chamber myocardium.

scientific article published in July 2000

Reduced sodium channel function unmasks residual embryonic slow conduction in the adult right ventricular outflow tract.

scientific article published on 9 May 2013

Regenerative medicine: Muscle for a damaged heart

scientific article published in Nature

Regulation of expression of atrial and brain natriuretic peptide, biomarkers for heart development and disease.

scientific article published on 12 July 2013

Regulatory modules in the developing heart.

scientific article

Second heart field cardiac progenitor cells in the early mouse embryo.

scientific article published on 07 October 2012

Sinus venosus incorporation: contentious issues and operational criteria for developmental and evolutionary studies

scientific article published on 12 March 2019

Specialized impulse conduction pathway in the alligator heart.

scientific article published on 22 March 2018

Structure and function of the Nppa-Nppb cluster locus during heart development and disease

scientific article published on 4 January 2018

Systematic analysis of the development of the ductus venosus in wild type mouse and human embryos.

scientific article

T-box factors determine cardiac design.

scientific article published on March 2007

T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system

scientific article published on 16 July 2020

T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.

scientific article published on 14 March 2012

TBX3 and its splice variant TBX3 + exon 2a are functionally similar.

scientific article published on 26 April 2008

TBX5 overexpression stimulates differentiation of chamber myocardium in P19C16 embryonic carcinoma cells.

scientific article published on January 2003

Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart.

scientific article published on 4 September 2014

Tbx2 Terminates Shh/Fgf Signaling in the Developing Mouse Limb Bud by Direct Repression of Gremlin1 ⬇️

scientific article published on April 25, 2013

Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung.

scientific article published on 06 October 2016

Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b

scientific article

Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal

scientific journal article

Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2

scientific journal article

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

scientific article

The Tbx2+ primary myocardium of the atrioventricular canal forms the atrioventricular node and the base of the left ventricle.

scientific article published on 7 May 2009

The ambiguous role of NKX2-5 mutations in thyroid dysgenesis.

scientific article

The atrioventricular node: origin, development, and genetic program

scientific journal article

The cardiac pacemaker and conduction system develops from embryonic myocardium that retains its primitive phenotype.

scientific article published on July 2010

The far-upstream enhancer of the carbamoyl-phosphate synthetase I gene is responsible for the tissue specificity and hormone inducibility of its expression.

scientific article

The formation and function of the cardiac conduction system

scientific article

The formation of the atrioventricular conduction axis is linked in development to ventricular septation

scientific article published on 12 October 2020

The heart-forming fields: one or multiple?

scientific article published on August 2007

The past, present, and future of pacemaker therapies

scientific article published on 20 February 2015

The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart.

scientific article published on June 2004

Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction

scientific article published on 16 July 2020

Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system

scientific journal article

Transcriptional regulation of the cardiac conduction system

scientific article published on 01 October 2018

Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium

scientific article

Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program

scientific article published on 25 April 2019

Two Distinct Pools of Mesenchyme Contribute to the Development of the Atrial Septum

scientific article published on 18 August 2006

Vasopressin-induced vasoconstriction is dependent on MAPKerk1/2 phosphorylation.

scientific article

Why increased nuchal translucency is associated with congenital heart disease: a systematic review on genetic mechanisms.

scientific article

Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2.

scientific article published on 28 April 2011

Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns.

scientific article

List of works by Vincent M. Christoffels

52 Genetic Loci Influencing Myocardial Mass

A common genetic variant within SCN10A modulates cardiac SCN5A expression

A gain-of-function TBX5 mutation is associated with atypical Holt-Oram syndrome and paroxysmal atrial fibrillation

A gene of Acinetobacter calcoaceticus BD413 encodes a periplasmic peptidyl-prolyl cis-trans isomerase of the cyclophilin sub-class that is not essential for growth.

A large permissive regulatory domain exclusively controls Tbx3 expression in the cardiac conduction system.

A mechanistic model for the development and maintenance of portocentral gradients in gene expression in the liver

A molecular and genetic outline of cardiac morphogenesis.

A mutation in the Kozak sequence ofGATA4hampers translation in a family with atrial septal defects

A single regulatory module of the carbamoylphosphate synthetase I gene executes its hepatic program of expression.

A transgenic mouse model for the simultaneous monitoring of ANF and BNP gene activity during heart development and disease

Absence of an anatomical origin for altered ductus venosus flow velocity waveforms in first-trimester human fetuses with increased nuchal translucency

Anatomic substrates for cardiac conduction.

Architectural plan for the heart: early patterning and delineation of the chambers and the nodes.

Atrial cardiomyocyte-specific expression of Cre recombinase driven by an Nppa gene fragment.

Atrial fibrillation: a developmental point of view.

Canonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties.

Cardiac chamber formation: development, genes, and evolution.

Cardiac defects, nuchal edema and abnormal lymphatic development are not associated with morphological changes in the ductus venosus.

Cardiac expression of Gal4 causes cardiomyopathy in a dose-dependent manner.

Cardiomyocytes derived from embryonic stem cells resemble cardiomyocytes of the embryonic heart tube.

Cardiomyocytes purified from differentiated embryonic stem cells exhibit characteristics of early chamber myocardium.

Chamber formation and morphogenesis in the developing mammalian heart

Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries

Comparative analysis of the natriuretic peptide precursor gene cluster in vertebrates reveals loss of ANF and retention of CNP-3 in chicken.

Comparative cardiovascular physiology: future trends, opportunities and challenges

Controversies concerning the anatomical definition of the conduction tissues.

Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation

Developing insights into cardiac regeneration.

Development of the building plan of the heart.

Development of the cardiac conduction system: a matter of chamber development.

Development of the human aortic arch system captured in an interactive three-dimensional reference model

Development of the pacemaker tissues of the heart.

Developmental aspects of cardiac arrhythmogenesis ⬇️

Developmental origin, growth, and three-dimensional architecture of the atrioventricular conduction axis of the mouse heart.

Developmental pattern of ANF gene expression reveals a strict localization of cardiac chamber formation in chicken ⬇️

Direct Reprograming to Regenerate Myocardium and Repair Its Pacemaker and Conduction System.

Distinct regulation of developmental and heart disease-induced atrial natriuretic factor expression by two separate distal sequences.

EMERGE: a flexible modelling framework to predict genomic regulatory elements from genomic signatures.

Early repolarization in mice causes overestimation of ventricular activation time by the QRS duration

Effect of amiodarone and dronedarone administration in rats on thyroid hormone-dependent gene expression in different cardiac components

Electrophysiological patterning of the heart.

Electrotransfection with "intracellular" buffer.

Embryonic Tbx3+ cardiomyocytes form the mature cardiac conduction system by progressive fate restriction

Embryonic development of the right ventricular outflow tract and arrhythmias

Evolution and development of the building plan of the vertebrate heart ⬇️

Excessive trabeculations in noncompaction do not have the embryonic identity.

Exploring a neurogenic basis of velopharyngeal dysfunction in Tbx1 mutant mice: no difference in volumes of the nucleus ambiguus.

Expression and regulation of the atrial natriuretic factor encoding gene Nppa during development and disease.

Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse

Expression of Irx6 during mouse morphogenesis.

Expression pattern and ontogenesis of thyroid hormone receptor isoforms in the mouse heart

Formation of the Venous Pole of the Heart From an Nkx2-5-Negative Precursor Population Requires Tbx18

Formation of the building plan of the human heart: morphogenesis, growth, and differentiation

From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning.

GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development.

GATA-dependent transcriptional and epigenetic control of cardiac lineage specification and differentiation.

Gene and cluster-specific expression of the Iroquois family members during mouse development

Gene regulatory elements of the cardiac conduction system ⬇️

Genetic determinants of P wave duration and PR segment

Genetics of congenital heart disease: the contribution of the noncoding regulatory genome.

HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme

Homeobox transcription factor Pitx2: The rise of an asymmetry gene in cardiogenesis and arrhythmogenesis.

Hypoglycemia-associated hyperammonemia caused by impaired expression of ornithine cycle enzyme genes in C/EBPalpha knockout mice.

Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress

Identification of the building blocks of ventricular septation in monitor lizards (Varanidae)

Identifying the evolutionary building blocks of the cardiac conduction system.

Inactivation of the Sema5a gene results in embryonic lethality and defective remodeling of the cranial vascular system

Increased nuchal translucency origins from abnormal lymphatic development and is independent of the presence of a cardiac defect

Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis ⬇️

Integrating multi-scale knowledge on cardiac development into a computational model of ventricular trabeculation.

Involvement of a cis-acting element in the suppression of carbamoyl phosphate synthetase I gene expression in the liver of carnitine-deficient mice

Involvement of neurons and retinoic acid in lymphatic development: new insights in increased nuchal translucency

Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development

Left and right ventricular contributions to the formation of the interventricular septum in the mouse heart

Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis

Letter by Anderson et al Regarding Article, “Abnormal Conduction and Morphology in the Atrioventricular Node of Mice With Atrioventricular Canal–Targeted Deletion of Alk3/Bmpr1a Receptor”

Lineage and morphogenetic analysis of the cardiac valves.

Lineages of the Cardiac Conduction System

Localized and Temporal Gene Regulation in Heart Development