List of works - Sandrine Humbert

A pathogenic proteolysis-resistant huntingtin isoform induced by an antisense oligonucleotide maintains huntingtin function

scientific article published in 2022

A phase II, open-label evaluation of cysteamine tolerability in patients with Huntington's disease.

scientific article

Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's Disease human lymphoblasts.

scientific article published on 20 May 2014

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.

scientific article published on 12 August 2010

Beyond the brain: huntingtin in breast cancers

scientific article published on 12 September 2016

Cancer: From Wild-Type to Mutant Huntingtin.

scientific article published in January 2018

Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease

scientific article

Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin

scientific article published on 01 July 2020

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

scientific article

Cysteamine restores intracellular dynamics and BDNF secretion in Huntington's disease

scientific article

Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

scientific article

Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells

scientific article

Elongator – an emerging role in neurological disorders

scientific article published on 23 December 2009

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

scientific article published on March 2007

Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC

scientific article

Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouse

scientific article

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

scientific journal article

Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis

scientific article

Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.

scientific article published in May 2013

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

scientific article

Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.

scientific article

Huntingtin regulates mammary stem cell division and differentiation.

scientific article published on 03 April 2014

Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology.

scientific article published on 20 December 2016

Huntingtin: here, there, everywhere!

scientific article

Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.

scientific article published on November 2006

Huntington's disease: how does huntingtin, an anti-apoptotic protein, become toxic?

scientific article

IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice.

scientific article published on 18 December 2013

In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: implication of a calpain-mediated cleavage of active caspase-3.

scientific article published on 12 August 2003

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

scientific article published in February 2006

Is Huntington disease a developmental disorder? ⬇️

scientific article published on December 1, 2010

Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death.

scientific article

Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms

scientific article published on 23 April 2014

Mutant huntingtin affects cortical progenitor cell division and development of the mouse neocortex

scientific article published in July 2014

Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease

scientific article

Partial characterization of the DNA repair protein complex, containing the ERCC1, ERCC4, ERCC11 and XPF correcting activities ⬇️

scientific article published on July 1, 1995

Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment

scientific article (publication date: 10 June 2005)

Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.

scientific article

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.

scientific article published on 4 September 2008

Recreating mouse cortico-hippocampal neuronal circuit in microfluidic devices to study BDNF axonal transport upon glucocorticoid treatment

scientific article published on 08 March 2021

Serine 421 regulates mutant huntingtin toxicity and clearance in mice.

scientific article

Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors.

scientific article

Synaptic localization of p39, a neuronal activator of cdk5

scientific article (publication date: 14 July 2000)

The Biology of Huntingtin.

scientific article published on March 2016

The DNA-dependent ATPase activity associated with the class II basic transcription factor BTF2/TFIIH.

scientific article published on April 1994

The biology of Huntington's disease.

scientific article published in January 2008

The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.

scientific article

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

scientific article published on 9 March 2018

Toward cell specificity in SCA1

scientific article (publication date: 30 May 2002)

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation.

scientific article

[Huntingtin, mitosis and cell fate].

scientific article published in February 2011

p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment

scientific journal article

p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair

scientific article

List of works by Sandrine Humbert

A pathogenic proteolysis-resistant huntingtin isoform induced by an antisense oligonucleotide maintains huntingtin function

A phase II, open-label evaluation of cysteamine tolerability in patients with Huntington's disease.

Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's Disease human lymphoblasts.

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.

Beyond the brain: huntingtin in breast cancers

Cancer: From Wild-Type to Mutant Huntingtin.

Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease

Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

Cysteamine restores intracellular dynamics and BDNF secretion in Huntington's disease

Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells

Elongator – an emerging role in neurological disorders

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC

Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouse

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis

Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.

Huntingtin regulates mammary stem cell division and differentiation.

Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology.

Huntingtin: here, there, everywhere!

Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.

Huntington's disease: how does huntingtin, an anti-apoptotic protein, become toxic?

IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice.

In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: implication of a calpain-mediated cleavage of active caspase-3.

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

Is Huntington disease a developmental disorder? ⬇️

Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death.

Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms

Mutant huntingtin affects cortical progenitor cell division and development of the mouse neocortex

Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease

Partial characterization of the DNA repair protein complex, containing the ERCC1, ERCC4, ERCC11 and XPF correcting activities ⬇️

Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment

Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.

Recreating mouse cortico-hippocampal neuronal circuit in microfluidic devices to study BDNF axonal transport upon glucocorticoid treatment

Serine 421 regulates mutant huntingtin toxicity and clearance in mice.

Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors.

Synaptic localization of p39, a neuronal activator of cdk5

The Biology of Huntingtin.

The DNA-dependent ATPase activity associated with the class II basic transcription factor BTF2/TFIIH.

The biology of Huntington's disease.

The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

Toward cell specificity in SCA1

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation.

[Huntingtin, mitosis and cell fate].

p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment

p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair