List of works - Ajith Welihinda

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

scientific article

C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes

scientific article published on 16 June 2011

Conformationally constrained spiro C-arylglucosides as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors

scientific article published on 01 June 2010

Conservation and divergence of the yeast and mammalian unfolded protein response. Activation of specific mammalian endoplasmic reticulum stress element of the grp78/BiP promoter by yeast Hac1.

scientific article published on October 1999

Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes

scientific article published on 12 February 2014

EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats

scientific article published on 05 January 2011

Enhancement of inosine-mediated A2AR signaling through positive allosteric modulation.

scientific article published on 7 November 2017

Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

scientific article

Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcriptional coactivator complex containing Ada5p

scientific article

Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1

scientific article (publication date: 16 August 2002)

O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

scientific article published on 12 August 2009

On the regulation of Na+/H+ and K+/H+ antiport in yeast mitochondria: Evidence for the absence of an Na+-selective Na+/H+ antiporter

article

Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation

scientific article published on 28 November 2014

Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase.

scientific article

The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias.

scientific article published on 19 February 2016

The cellular response to protein misfolding in the endoplasmic reticulum.

scientific article

The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

scientific journal article

ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

scientific article published on 29 April 2010

List of works by Ajith Welihinda

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes

Conformationally constrained spiro C-arylglucosides as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors

Conservation and divergence of the yeast and mammalian unfolded protein response. Activation of specific mammalian endoplasmic reticulum stress element of the grp78/BiP promoter by yeast Hac1.

Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes

EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats

Enhancement of inosine-mediated A2AR signaling through positive allosteric modulation.

Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcriptional coactivator complex containing Ada5p

Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1

O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

On the regulation of Na+/H+ and K+/H+ antiport in yeast mitochondria: Evidence for the absence of an Na+-selective Na+/H+ antiporter

Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation

Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase.

The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias.

The cellular response to protein misfolding in the endoplasmic reticulum.

The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.