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List of works by Jean Francois Arnal

17 beta-estradiol prevents fatty streak formation in apolipoprotein E-deficient mice.

scientific article published in November 1997

17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo.

scientific article published on 16 June 2010

Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing

scientific article

Alteration in endothelial estrogen receptor expression: a potential key of vasculoprotection by estrogens?

scientific article published in November 2002

Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress

scientific article

Association of estrogens and selective estrogens receptors modulators: towards a renewal of the hormonal treatment?

scientific article published on 13 August 2015

Association of neutrophil count with microembolization in patients with symptomatic carotid artery stenosis.

scientific article

Associations between hepatic miRNA expression, liver triacylglycerols and gut microbiota during metabolic adaptation to high-fat diet in mice

scientific article

Atorvastatin-induced increase in progenitor cell levels is rather caused by enhanced receptor activator of NF-kappaB ligand (RANKL) cell proliferation than by bone marrow mobilization

scientific article published on January 4, 2013

Atrial natriuretic factor influences in vivo plasma, lung and aortic wall cGMP concentrations differently

scientific article published on 01 June 1993

Cardiac angiotensin converting enzyme overproduction indicates interstitial activation in renovascular hypertension

scientific article published on 01 August 1995

Changes in Gene Expression and Estrogen Receptor Cistrome in Mouse Liver Upon Acute E2 Treatment

scientific article

Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the phosphatidylinositol 3-kinase pathway.

scientific article published in June 2008

Chronic estradiol treatment reduces platelet responses and protects mice from thromboembolism through the hematopoietic estrogen receptor α.

scientific article published on 9 July 2012

Combined estrogenic and anti-estrogenic properties of estetrol on breast cancer may provide a safe therapeutic window for the treatment of menopausal symptoms.

scientific article

Correction of RT-qPCR data for genomic DNA-derived signals with ValidPrime.

scientific article

Correction: High-Fat Diet Induces Periodontitis in Mice through Lipopolysaccharides (LPS) Receptor Signaling: Protective Action of Estrogens.

scientific article

Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice

scientific article

Detection of superoxide anion released extracellularly by endothelial cells using cytochrome c reduction, ESR, fluorescence and lucigenin-enhanced chemiluminescence techniques

scientific article published on 01 September 2000

Determinants of flow-mediated outward remodeling in female rodents: respective roles of age, estrogens, and timing

scientific article

Differential effects of interleukin-1 receptor antagonist and tumor necrosis factor binding protein on fatty-streak formation in apolipoprotein E-deficient mice

scientific article published on 01 January 1998

Discrepancy between plasma and aortic wall cyclic guanosine monophosphate in an experimental model of congestive heart failure

scientific article published on 01 June 1993

Discrepancy between plasma and lung angiotensin-converting enzyme activity in experimental congestive heart failure. A novel aspect of endothelium dysfunction

scientific article published on 01 September 1994

Effect of chronic estradiol plus progesterone treatment on experimental arterial and venous thrombosis in mouse.

scientific article

Effect of estetrol, a selective nuclear estrogen receptor modulator, in mouse models of arterial and venous thrombosis

scientific article published on 19 June 2018

Effect of perindopril in rat cardiac volume overload

scientific article published on 01 September 1993

Effect of treatment on maxillary sinus and nasal nitric oxide concentrations in patients with nosocomial maxillary sinusitis.

scientific article published in September 2005

Electron spin resonance detection of extracellular superoxide anion released by cultured endothelial cells

scientific article published on 01 November 1998

Endothelial estrogen receptor-alpha plays a crucial role in the atheroprotective action of 17beta-estradiol in low-density lipoprotein receptor-deficient mice.

scientific article published on 7 December 2009

Essential role of bone marrow fibroblast growth factor-2 in the effect of estradiol on reendothelialization and endothelial progenitor cell mobilization.

scientific article published on November 2006

Essential thrombocythemia and pregnancy.

scientific article

Estetrol, a Fetal Selective Estrogen Receptor Modulator, Acts on the Vagina of Mice through Nuclear Estrogen Receptor α Activation.

scientific article published on 18 August 2017

Estradiol accelerates endothelial healing through the retrograde commitment of uninjured endothelium.

scientific article published on 25 April 2008

Estradiol administration controls eosinophilia through estrogen receptor-alpha activation during acute peritoneal inflammation.

scientific article

Estradiol increases rat aorta endothelium-derived relaxing factor (EDRF) activity without changes in endothelial NO synthase gene expression: possible role of decreased endothelium-derived superoxide anion production

scientific article published on 01 March 1999

Estradiol increases urethral tone through the local inhibition of neuronal nitric oxide synthase expression

scientific article

Estradiol promotes functional responses in inflammatory and steady-state dendritic cells through differential requirement for activation function-1 of estrogen receptor α.

scientific article published on 26 April 2013

Estrogen Therapy Delays Autoimmune Diabetes and Promotes the Protective Efficiency of Natural Killer T-Cell Activation in Female Nonobese Diabetic Mice.

scientific article published on 20 October 2015

Estrogen receptor alpha expression in both endothelium and hematopoietic cells is required for the accelerative effect of estradiol on reendothelialization.

scientific article published on 16 July 2009

Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production

scientific article published in March 2008

Estrogen receptor subcellular localization and cardiometabolism

scientific article published on 16 May 2018

Estrogen receptors and endothelium.

scientific article published on August 2010

Estrogen-related receptor-γ: conductor of muscle angiogenesis through conversion of fast- to slow-twitch fibers?

scientific article published on 01 April 2012

Estrogens and atherosclerosis.

scientific article published on February 2004

Estrogens are needed for the improvement in endothelium-mediated dilation induced by a chronic increase in blood flow in rat mesenteric arteries.

scientific article published on 12 October 2015

Estrogens in vascular biology and disease: where do we stand today?

scientific article published on October 2007

Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice.

scientific article published on 22 January 2009

Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production.

scientific article published on April 1996

Expression of nitric oxide synthases in primary ciliary dyskinesia

scientific article published on 12 June 2011

FGF2 translationally induced by hypoxia is involved in negative and positive feedback loops with HIF-1alpha.

scientific article

Failure of L-nitroarginine to inhibit the activity of aortic inducible nitric oxide synthase.

scientific article published in May 2001

From in vivo gene targeting of oestrogen receptors to optimization of their modulation in menopause.

scientific article published on January 2012

From the Women's Health Initiative to the combination of estrogen and selective estrogen receptor modulators to avoid progestin addition

scientific article published on 26 July 2015

Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes

scientific article published on 11 February 2008

High-fat diet induces periodontitis in mice through lipopolysaccharides (LPS) receptor signaling: protective action of estrogens

scientific article

Hyperglycemia upregulates translation of the fibroblast growth factor 2 mRNA in mouse aorta via internal ribosome entry site.

scientific article

Hyperproliferation of aortic smooth muscle cells and fibroblasts from young SHR rats is not shared by endothelial cells

scientific article published on 01 December 1994

Impact of chronic obstructive pulmonary disease severity on symptoms and prognosis in patients with systolic heart failure

scientific article published on 09 April 2012

In vivo dissection of the estrogen receptor alpha: uncoupling of its physiological effects and medical perspectives

scientific article published on 06 April 2013

Influence of sildenafil on micturition and urethral tone in ovariectomized and non-ovariectomized mice.

scientific article published on 6 December 2011

Insulin secretion in rats with chronic nitric oxide synthase blockade.

scientific article published in September 1994

Interactions between L-arginine and L-glutamine change endothelial NO production. An effect independent of NO synthase substrate availability.

scientific article

Involvement of interleukin-6 in atherosclerosis but not in the prevention of fatty streak formation by 17beta-estradiol in apolipoprotein E-deficient mice.

scientific article published in June 2001

Key role of estrogens and endothelial estrogen receptor α in blood flow-mediated remodeling of resistance arteries.

scientific article published on 3 January 2013

Lessons from the dissection of the activation functions (AF-1 and AF-2) of the estrogen receptor alpha in vivo

scientific article

Long term expression of bicistronic vector driven by the FGF-1 IRES in mouse muscle

scientific article

Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications.

scientific article

Microparticles from apoptotic vascular smooth muscle cells induce endothelial dysfunction, a phenomenon prevented by beta3-integrin antagonists.

scientific article published in October 2005

Molecular plasticity of vascular wall during N(G)-nitro-L-arginine methyl ester-induced hypertension: modulation of proinflammatory signals.

scientific article published in July 2000

Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions.

scientific article

Nasal nitric oxide concentration in paranasal sinus inflammatory diseases.

scientific article

Nasal nitric oxide concentration is decreased in heart failure patients receiving nitrates.

scientific article published in January 1998

Nasal nitric oxide is increased in allergic rhinitis

scientific article published on 01 April 1997

Nasal polyp-derived superoxide anion: dose-dependent inhibition by nitric oxide and pathophysiological implications.

scientific article

Nitric oxide in the pathogenesis of hypertension

scientific article published on March 1, 1995

Nitric oxide pathway and female lower urinary tract. Physiological and pathophysiological role

scientific article

Nuclear and Membrane Actions of Estrogen Receptor Alpha: Contribution to the Regulation of Energy and Glucose Homeostasis.

scientific article published in January 2017

Omapatrilat, a dual angiotensin-converting enzyme and neutral endopeptidase inhibitor, prevents fatty streak deposit in apolipoprotein E-deficient mice.

scientific article published in April 2001

Oral enoximone as a substitute for intravenous catecholamine support in end-stage congestive heart failure

scientific article published on 01 February 1994

Oxidized LDLs Induce Massive Apoptosis of Cultured Human Endothelial Cells Through a Calcium-Dependent Pathway

article

Physiologic and pathologic changes of platelets in pregnancy.

scientific article

Platelet Adhesion and Thrombus Formation in Whole Blood at Arterial Shear Rate at the End of Pregnancy

scientific article published on 04 October 2015

Predominant Role of Nuclear Versus Membrane Estrogen Receptor α in Arterial Protection: Implications for Estrogen Receptor α Modulation in Cardiovascular Prevention/Safety

scientific article published on 29 June 2018

Prevention of fatty streak formation of 17beta-estradiol is not mediated by the production of nitric oxide in apolipoprotein E-deficient mice

scientific article published on 01 November 1997

Prevention of obesity and insulin resistance by estrogens requires ERα activation function-2 (ERαAF-2), whereas ERαAF-1 is dispensable

scientific article published on 31 July 2013

Prevention of skin flap necrosis by estradiol involves reperfusion of a protected vascular network.

scientific article

Protective Hematopoietic Effect of Estrogens in a Mouse Model of Thrombosis: Respective Roles of Nuclear Versus Membrane Estrogen Receptor α

scientific article

Relevance of sexual dimorphism to regulatory T cells: estradiol promotes IFN-gamma production by invariant natural killer T cells.

scientific article published on 21 September 2004

Renal hypertensive angiopathy. Comparison between chronic NO suppression and DOCA-salt intoxication

scientific article published on 01 February 1995

Respective role of membrane and nuclear estrogen receptor (ER) α in the mandible of growing mice: implications for ERα modulation

scientific article published on 6 April 2018

Resveratrol Improved Flow-Mediated Outward Arterial Remodeling in Ovariectomized Rats with Hypertrophic Effect at High Dose.

scientific article published on 6 January 2016

Role for the membrane estrogen receptor alpha in the sexual differentiation of the brain

scientific article published on 13 December 2019

Role of ERαMISS in the Effect of Estradiol on Cancellous and Cortical Femoral Bone in Growing Female Mice

scientific article published on 22 April 2016

Role of estrogens and age in flow-mediated outward remodeling of rat mesenteric resistance arteries

scientific article published in August 2014

Role of fibroblast growth factor-2 isoforms in the effect of estradiol on endothelial cell migration and proliferation.

scientific article published on 8 April 2004

Role of human smooth muscle cell progenitors in atherosclerotic plaque development and composition

article

Role of inflammatory cytokines in the effect of estradiol on atheroma.

scientific article

Selective Activation of Estrogen Receptor α Activation Function-1 Is Sufficient to Prevent Obesity, Steatosis, and Insulin Resistance in Mouse

scientific article

Selective Liver Estrogen Receptor α Modulation Prevents Steatosis, Diabetes, and Obesity Through the Anorectic Growth Differentiation Factor 15 Hepatokine in Mice

scientific article published on 29 April 2019

Selective isolation of rat aortic wall layers and their cell types in culture--application to converting enzyme activity measurement

scientific article published on 01 December 1994

Sex differences in metabolic regulation and diabetes susceptibility

scientific article published on 21 November 2019

Stromal estrogen receptor-α promotes tumor growth by normalizing an increased angiogenesis.

scientific article

Structure-function relationship of estrogen receptors in cardiovascular pathophysiological models

scientific article published on October 2012

Sustained Increase in Aortic Endothelial Nitric Oxide Synthase Expression In Vivo in a Model of Chronic High Blood Flow

scientific article published in October 1996

Tamoxifen elicits atheroprotection through estrogen receptor α AF-1 but does not accelerate reendothelialization

scientific article published on 10 May 2013

Testosterone Prevents Cutaneous Ischemia and Necrosis in Males Through Complementary Estrogenic and Androgenic Actions.

scientific article published on 30 March 2017

The AF-1 activation function of estrogen receptor α is necessary and sufficient for uterine epithelial cell proliferation in vivo

scientific article published on 11 April 2013

The AF-1-deficient estrogen receptor ERα46 isoform is frequently expressed in human breast tumors

scientific article published on 07 December 2016

The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells.

scientific article

The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor α signaling.

scientific article published on 16 November 2011

The antagonist properties of Bazedoxifene after acute treatment are shifted to stimulatory action after chronic exposure in the liver but not in the uterus

scientific article published on 25 November 2017

The atheroprotective effect of 17 beta-estradiol is not altered in P-selectin- or ICAM-1-deficient hypercholesterolemic mice.

scientific article published in January 2003

The atheroprotective effect of 17beta-estradiol depends on complex interactions in adaptive immunity

scientific article published on July 2005

The estrogen effects on endothelial repair and mitogen-activated protein kinase activation are abolished in endothelial nitric-oxide (NO) synthase knockout mice, but not by NO synthase inhibition by N-nitro-L-arginine methyl ester

scientific article

The mitogenic effect of 17beta-estradiol on in vitro endothelial cell proliferation and on in vivo reendothelialization are both dependent on vascular endothelial growth factor.

scientific article published in May 2000

The tissue-specific effects of different 17β-estradiol doses reveal the key sensitizing role of AF1 domain in ERα activity

scientific article published on 28 January 2020

The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol

scientific article

The transcriptional activities and cellular localization of the human estrogen receptor alpha are affected by the synonymous Ala87 mutation.

scientific article

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

scientific article

Timing of the vascular actions of estrogens in experimental and human studies: why protective early, and not when delayed?

scientific article published on 16 December 2010

Toll-like receptors 2-deficient mice are protected against postischemic coronary endothelial dysfunction

scientific article published on 01 March 2007

Towards optimization of estrogen receptor modulation in medicine

scientific article published on 03 May 2018

Transforming growth factor activity is a key determinant for the effect of estradiol on fatty streak deposit in hypercholesterolemic mice

scientific article published on 09 August 2007

Understanding the oestrogen action in experimental and clinical atherosclerosis.

scientific article published on December 2006

Use of local estrogenotherapy in urology and pelviperineology: A systematic review

scientific article published on 11 February 2015

Usefulness of experimental models to understand the vascular effects of estrogens

scientific article published in December 2003

Vaginal lubrication after cervicovaginal stimulation is facilitated by phosphodiesterase type 5 inhibition in ovariectomized mice.

scientific article

Vasculoprotective effects of oestrogens.

scientific article

[Tissue-specific membrane effects of estrogen receptor alpha]

scientific article published on 16 December 2015

[Towards an optimization of the modulation of the estrogen receptor during menopausal hormonal therapy]

scientific article published on 01 December 2018