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List of works by John Keaney

17 beta-estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine

scientific article published on 01 May 1994

A pragmatic view of the new cholesterol treatment guidelines.

scientific article published on 27 November 2013

AMP-activated protein kinase: a stress-responsive kinase with implications for cardiovascular disease.

scientific article published on 08 January 2010

AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells.

scientific article published in November 2004

Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy.

scientific article published on 3 August 2017

Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols.

scientific article

Acute hypertriglyceridemia is associated with peripheral vasodilation and increased basal flow in healthy young adults.

scientific article

Adipose Tissue Depots and Their Cross-Sectional Associations With Circulating Biomarkers of Metabolic Regulation

scientific article published on 04 May 2016

Antioxidant Protection of LDL by Physiological Concentrations of 17β-Estradiol

scientific article published on 01 March 1997

Antioxidant protection of LDL by physiologic concentrations of estrogens is specific for 17-beta-estradiol.

scientific article published in June 1998

Antioxidants and Atherosclerotic Heart Disease ⬇️

scientific article published on August 7, 1997

Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor

scientific article published on 01 June 1993

Are ACE inhibitors a "magic bullet" against oxidative stress?

scientific article published on 01 September 2001

Ascorbate Prevents the Interaction of Superoxide and Nitric Oxide Only at Very High Physiological Concentrations

scientific article published on 01 November 1998

Ascorbic Acid and Glutathione Modulate the Biological Activity of S- Nitrosoglutathione

scientific article published on 01 August 2000

Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin.

scientific article

Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease.

scientific article published in March 1996

Association of Multiple Inflammatory Markers with Carotid Intimal Medial Thickness and Stenosis (from the Framingham Heart Study)

article

Association of exhaled carbon monoxide with subclinical cardiovascular disease and their conjoint impact on the incidence of cardiovascular outcomes

scientific article

Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study

scientific article

Balancing the risks and benefits of dual platelet inhibition

scientific article published on 14 March 2015

Beyond LDL oxidation: ROS in vascular signal transduction.

scientific article

Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality

scientific article

Brachial Artery Vasodilator Function and Systemic Inflammation in the Framingham Offspring Study

article

CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study

scientific article

CHIP-ping Away at Atherosclerosis.

scientific article published on 21 June 2017

Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance.

scientific article

Cholesterol reduction in cardiovascular disease. Clinical benefits and possible mechanisms.

scientific article published on February 1995

Chronic activation of AMP-activated protein kinase prevents 20-hydroxyeicosatetraenoic acid-induced endothelial dysfunction.

scientific article

Circulating biomarkers in acute coronary syndromes: something different or more of the same?

scientific article published on 01 August 2005

Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sample

scientific article published on 20 May 2008

Clinical Correlates of Circulating Visfatin Levels in a Community-Based Sample

scientific article published on 29 January 2007

Clinical and genetic factors associated with lipoprotein-associated phospholipase A2 in the Framingham Heart Study

scientific article

Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham Heart Study

scientific article published on February 2004

Clinical correlates of change in inflammatory biomarkers: The Framingham Heart Study

scientific article published on 4 February 2013

Clinical correlates, heritability, and genetic linkage of circulating CD40 ligand in the Framingham Offspring Study

scientific article published on 02 October 2008

Common Statistical Pitfalls in Basic Science Research

scientific article

Contribution of Clinical Correlates and 13 C-Reactive Protein Gene Polymorphisms to Interindividual Variability in Serum C-Reactive Protein Level

article

Coronary artery perforation during excimer laser coronary angioplasty. The percutaneous Excimer Laser Coronary Angioplasty Registry.

scientific article published on April 1993

Coronary endothelial dysfunction is not rapidly reversible with ascorbic acid.

scientific article

Creating and Maintaining a Successful Service Line in an Academic Medical Center at the Dawn of Value-Based Care: Lessons Learned From the Heart and Vascular Service Line at UMass Memorial Health Care.

scientific article published in October 2015

Cross-Sectional Associations of Computed Tomography (CT)-Derived Adipose Tissue Density and Adipokines: The Framingham Heart Study

scientific article published on 29 February 2016

Cross-Sectional Correlates of Serum Heat Shock Protein 70 in the Community

scientific article published on 01 February 2006

Cross-sectional relations of multiple inflammatory biomarkers to peripheral arterial disease: The Framingham Offspring Study

scientific article published on 09 July 2008

Decreased aortic early atherosclerosis in hypercholesterolemic hamsters fed oleic acid-rich TriSun oil compared to linoleic acid-rich sunflower oil

scientific article published on 01 July 2002

Decreased neointimal formation in Nox2-deficient mice reveals a direct role for NADPH oxidase in the response to arterial injury.

scholarly article

Determination of phospholipid oxidation in cultured cells

scientific article published on 01 January 1999

Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits.

scientific article published on December 1993

Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators

scientific article

Effect of acute and chronic tea consumption on platelet aggregation in patients with coronary artery disease.

scientific article published in June 2001

Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease

scientific article published on 01 July 2002

Effect of iron overload and iron deficiency on atherosclerosis in the hypercholesterolemic rabbit

scientific article published on 01 November 1997

Effect of short-term antibiotic treatment on Chlamydia pneumoniae and peripheral endothelial function.

scientific article published on March 2003

Effect of sulfasalazine on inflammation and endothelial function in patients with established coronary artery disease.

scientific article published on April 2012

Effect of vitamin E on aortic lipid oxidation and intimal proliferation after arterial injury in cholesterol-fed rabbits ⬇️

scientific article published on November 15, 2001

Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension.

scientific article

Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies

scientific article published on 14 October 2011

Endoscopic versus conventional radial artery harvest for coronary artery bypass grafting: functional and histologic assessment of the conduit.

scientific article published on 4 January 2006

Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling.

scientific article

Endothelial Function

article

Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions

scientific article published on 10 July 2015

Endothelial α1AMPK modulates angiotensin II-mediated vascular inflammation and dysfunction

scientific article published on 14 January 2019

Epigenetic control of angiogenesis via DNA methylation

scientific article published on 13 June 2011

Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase.

scientific article published on 20 June 2005

Evolving concepts of oxidative stress and reactive oxygen species in cardiovascular disease.

scientific article published on October 2012

Exercise Rescues Gene Pathways Involved in Vascular Expansion and Promotes Functional Angiogenesis in Subcutaneous White Adipose Tissue

article

Expression of 5-lipoxygenase in pulmonary artery endothelial cells

scientific article

Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study: Evidence for susceptibility loci on 1q

article

Genome-wide association with select biomarker traits in the Framingham Heart Study

scientific article

Glucose enhancement of LDL oxidation is strictly metal ion dependent

scientific article published on 01 November 2000

Hdac3 regulates lymphovenous and lymphatic valve formation.

scientific article published on 16 October 2017

Heart rate, mortality, and the relation with clinical and subclinical cardiovascular diseases: results from the Gutenberg Health Study

scientific article published on 05 April 2019

Heritability and correlates of intercellular adhesion molecule-1 in the Framingham Offspring Study

scientific article

High-dose heparin decreases nitric oxide production by cultured bovine endothelial cells

scientific article published on 01 April 1997

Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase

scientific article published on 01 July 1997

Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway.

scientific article published on 13 December 2001

Hydrogen peroxide restrains endothelium-derived nitric oxide bioactivity -- role for iron-dependent oxidative stress

scientific article published on 19 May 2006

Hypochlorous acid impairs endothelium-derived nitric oxide bioactivity through a superoxide-dependent mechanism.

scientific article

Immune Modulation of Atherosclerosis ⬇️

scientific article published on November 29, 2011

Impaired Platelet Production of Nitric Oxide Predicts Presence of Acute Coronary Syndromes

scientific article published on 01 October 1998

In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols.

scientific article

Inflammation, kidney function and albuminuria in the Framingham Offspring cohort

scientific article

Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study

scientific article published on 01 August 2006

Iron chelation improves endothelial function in patients with coronary artery disease.

scientific article published in June 2001

JNK and cardiometabolic dysfunction

scientific article published on 18 July 2019

Kynurenine is an endothelium-derived relaxing factor produced during inflammation

scientific article

L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease.

scientific article published on March 1998

Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels

scientific article published on 18 February 2010

Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status.

scientific article published in January 2002

Local shear stress and brachial artery flow-mediated dilation: the Framingham Heart Study

scientific article published on 12 July 2004

Long-Term Ascorbic Acid Administration Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

scientific article published on 01 June 1999

Low plasma ascorbic acid independently predicts the presence of an unstable coronary syndrome.

scientific article published in April 1998

Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits.

scientific article

Measurements of redox control of nitric oxide bioavailability.

scientific article

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels

scientific article

Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Framingham Heart Study

scientific article published on 20 June 2012

Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling.

scientific article published on 4 June 2004

Mitochondrial retrograde signaling connects respiratory capacity to thermogenic gene expression

scientific article published on 17 May 2017

Mitral Valve Repair Versus Replacement in Elderly With Degenerative Disease: Analysis of the STS Adult Cardiac Surgery Database

scientific article published on 26 October 2018

Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community

scientific article published on 02 May 2013

NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation ⬇️

scientific article published on July 25, 2011

NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.

scientific article

New insights on oxidative stress in the artery wall.

scientific article

Nicotine: linking smoking to abdominal aneurysms.

scientific article

Nitric oxide and superoxide detection in human platelets

scientific article published on 01 January 1999

Nitric oxide released from activated platelets inhibits platelet recruitment ⬇️

scientific article published on July 15, 1997

Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm.

scientific article

Nitroglycerin is superior to diltiazem as a coronary bypass conduit vasodilator

scientific article published on 01 May 1999

Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation

scientific article

Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study

scientific article

Oxidative stress and endothelial nitric oxide bioactivity.

scientific article

Oxidative stress, antioxidants, and endothelial function.

scientific article published on May 2004

P2Y12 inhibition in patients with NSTEMI--can later be better?

scientific article published on September 2013

PGC-1α dictates endothelial function through regulation of eNOS expression

scientific article published on 02 December 2016

Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications

scientific article

Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study

scientific article

Pharmacological Concentrations of Ascorbic Acid Are Required for the Beneficial Effect on Endothelial Vasomotor Function in Hypertension

scientific article published on 01 April 2000

Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study).

scientific article

Polyploidy and dysregulated ROS signaling: the school of hard Nox?

scientific article published on 15 March 2009

Postmenopausal Hormone Therapy and Atherosclerosis--Time Is of the Essence

scientific article published on 01 March 2016

Predicting ischemic heart disease in women: the value of endothelial function.

scientific article published in April 2010

Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease.

scientific article published on May 2003

Predictive value of reactive hyperemia for cardiovascular events in patients with peripheral arterial disease undergoing vascular surgery

scientific article published on 23 August 2007

Preparation of lipid hydroperoxide-free low-density lipoproteins

scientific article published on 01 January 1999

Proof That Lower Is Better--LDL Cholesterol and IMPROVE-IT

scientific article published on 03 June 2015

Reactive oxygen species in cardiovascular disease.

scientific article

Regulation of angiogenesis by glycogen synthase kinase-3beta.

scientific article published on 7 August 2002

Relation of multiple inflammatory biomarkers to incident atrial fibrillation

scientific article

Relation of smoking status to a panel of inflammatory markers: the framingham offspring.

scientific article published on 04 March 2008

Relations of Inflammation and Novel Risk Factors to Valvular Calcification

article

Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection

scientific article

Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk

scientific article

Renin-angiotensin system inhibition for aortic stenosis "A II, Bruté?"

scientific article published on 01 August 2011

Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs

scientific article

Serum myeloperoxidase levels independently predict endothelial dysfunction in humans.

scientific article published on 23 August 2004

Short- and Long-Term Black Tea Consumption Reverses Endothelial Dysfunction in Patients With Coronary Artery Disease

scientific article published on 01 July 2001

Short-Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The Framingham Heart Study

scientific article

Short-Term Exposure to Ambient Air Pollution and Biomarkers of Systemic Inflammation: The Framingham Heart Study

scientific article

Short-term exposure to ambient air pollution and circulating biomarkers of endothelial cell activation: The Framingham Heart Study

scientific article published on 28 October 2018

Stimulation of endothelial nitric oxide production by homocyst(e)ine

scientific article published on 01 July 1997

Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development

scientific article published on 09 August 2016

Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction.

scientific article published on September 2008

Systemic Inflammation and COPD

article

The Value of Inflammation for Predicting Unstable Angina

scientific article published on 01 July 2002

The clinical implications of endothelial dysfunction ⬇️

scientific article published on October 1, 2003

The lack of effect of β-carotene on restenosis in cholesterol-fed rabbits

scientific article published on 01 June 1996

The molecular basis of the genesis of basal tone in internal anal sphincter

scientific article published on 22 April 2016

The new cholesterol treatment guidelines

scientific article published on 01 May 2014

The relation of genetic and environmental factors to systemic inflammatory biomarker concentrations

scientific article

The relationship between aldosterone, oxidative stress, and inflammation in chronic, stable human heart failure.

scientific article published in March 2006

Treatment of hypertension with ascorbic acid

scientific article published in The Lancet

Uncoupling Protein 2 Impacts Endothelial Phenotype via p53-Mediated Control of Mitochondrial Dynamics ⬇️

scientific article published on July 2, 2013

VITAL Signs for Dietary Supplementation to Prevent Cancer and Heart Disease

scientific article published on 10 November 2018

Vascular Superoxide Dismutase Deficiency Impairs Endothelial Vasodilator Function Through Direct Inactivation of Nitric Oxide and Increased Lipid Peroxidation

scientific article published on 01 November 1997

Vascular inflammation and sleep disordered breathing in a community-based cohort

scientific article published on May 2013

Vascular oxidative stress and antioxidant protection in atherosclerosis: what do the clinical trials say?

scientific article

Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study

scientific article (publication date: 11 September 2007)

Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study

scientific article

YFP photoconversion revisited: confirmation of the CFP-like species.

scientific article published in October 2007

alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism

scientific article published on 01 November 1996

p38 mitogen-activated protein kinase activates eNOS in endothelial cells by an estrogen receptor alpha-dependent pathway in response to black tea polyphenols.

scientific article

α1AMP-activated protein kinase mediates vascular protective effects of exercise.

scientific article published on 26 April 2012

α1AMPK deletion in myelomonocytic cells induces a pro-inflammatory phenotype and enhances angiotensin II-induced vascular dysfunction

scientific article published on 01 December 2018

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