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List of works by Carolyn Williamson

A multigene HIV type 1 subtype C modified vaccinia Ankara (MVA) vaccine efficiently boosts immune responses to a DNA vaccine in mice

scientific article published in February 2008

A multivalent clade C HIV-1 Env trimer cocktail elicits a higher magnitude of neutralizing antibodies than any individual component

scientific article

A novel candidate HIV vaccine vector based on the replication deficient Capripoxvirus, Lumpy skin disease virus (LSDV) ⬇️

scientific article published on May 30, 2011

A prime-boost immunisation regimen using recombinant BCG and Pr55(gag) virus-like particle vaccines based on HIV type 1 subtype C successfully elicits Gag-specific responses in baboons

scientific article published on 9 June 2009

A rev1-vpu polymorphism unique to HIV-1 subtype A and C strains impairs envelope glycoprotein expression from rev-vpu-env cassettes and reduces virion infectivity in pseudotyping assays

scientific article published on 8 December 2009

African AIDS vaccine programme for a coordinated and collaborative vaccine development effort on the continent

scientific article published in December 2008

Alphavirus replicon particles as candidate HIV vaccines

scientific article

Anaemia in acute HIV-1 subtype C infection

scientific article

Approaches to the induction of HIV broadly neutralizing antibodies

scientific article

Association of HIV-specific and total CD8+ T memory phenotypes in subtype C HIV-1 infection with viral set point

scientific article published on April 2009

Brief Report: Selection of HIV-1 Variants With Higher Transmission Potential by 1% Tenofovir Gel Microbicide

scientific article

Broad, high-magnitude and multifunctional CD4+ and CD8+ T-cell responses elicited by a DNA and modified vaccinia Ankara vaccine containing human immunodeficiency virus type 1 subtype C genes in baboons

scientific article published in February 2009

CAPRISA 004 tenofovir microbicide trial: no impact of tenofovir gel on the HIV transmission bottleneck

scientific article

CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients

scientific article published on 20 December 2006

CTL response to HIV type 1 subtype C is poorly predicted by known epitope motifs

scientific article published in August 2007

Case report: mechanisms of HIV elite control in two African women

scientific article published on 25 January 2018

Cervicovaginal Inflammation Facilitates Acquisition of Less Infectious HIV Variants

scientific article published on 29 September 2016

Challenges of diagnosing acute HIV-1 subtype C infection in African women: performance of a clinical algorithm and the need for point-of-care nucleic-acid based testing ⬇️

scientific article

Characterization and selection of HIV-1 subtype C isolates for use in vaccine development

scientific article published on February 2003

Characterization of HIV-1 gag and nef in Cameroon: further evidence of extreme diversity at the origin of the HIV-1 group M epidemic

scientific article published on 22 January 2013

Combined single-clade candidate HIV-1 vaccines induce T cell responses limited by multiple forms of in vivo immune interference

scientific article published in February 2007

Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design

scientific article published on 24 April 2013

Conserved positive selection signals in gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infection

scientific article

Construction and characterisation of a candidate HIV-1 subtype C DNA vaccine for South Africa ⬇️

scientific article published on October 1, 2003

Construction, characterization, and immunogenicity of a multigene modified vaccinia Ankara (MVA) vaccine based on HIV type 1 subtype C.

scientific article published in February 2008

Cooperation between Strain-Specific and Broadly Neutralizing Responses Limited Viral Escape and Prolonged the Exposure of the Broadly Neutralizing Epitope

scientific article published on 5 July 2017

Correction for Anthony et al., "Cooperation between Strain-Specific and Broadly Neutralizing Responses Limited Viral Escape and Prolonged the Exposure of the Broadly Neutralizing Epitope".

scientific article published on 13 April 2018

Correction for Hraber et al., "Panels of HIV-1 Subtype C Env Reference Strains for Standardized Neutralization Assessments".

scientific article

Correction: Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization

scientific article published on 25 September 2017

DNA-MVA-protein vaccination of rhesus macaques induces HIV-specific immunity in mucosal-associated lymph nodes and functional antibodies

scientific article published on 06 January 2017

Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: a cross-sectional study

scientific article published on 08 August 2014

Defining the human immunodeficiency virus type 1 transmission genetic bottleneck in a region with multiple circulating subtypes and recombinant forms

scientific article

Degenerate Primer IDs and the birthday problem

scientific article published on 19 April 2012

Design and preclinical evaluation of a multigene human immunodeficiency virus type 1 subtype C DNA vaccine for clinical trial

scientific article

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

scientific article

Differences in HIV type 1 neutralization breadth in 2 geographically distinct cohorts in Africa

scientific article published on 14 November 2014

Differential impact of magnitude, polyfunctional capacity, and specificity of HIV-specific CD8+ T cell responses on HIV set point

scientific article

Dual HIV-1 infection associated with rapid disease progression

scientific article (publication date: 21 February 2004)

Early evolution of human leucocyte antigen-associated escape mutations in variable Gag proteins predicts CD4+ decline in HIV-1 subtype C-infected women

scientific article

Enrolling adolescents in research on HIV and other sensitive issues: lessons from South Africa

scientific article published on 18 April 2006

Epidemiology of HIV-1 subtypes among men who have sex with men in Cape Town, South Africa

scientific article published on April 2014

Establishing a cohort at high risk of HIV infection in South Africa: challenges and experiences of the CAPRISA 002 acute infection study

scientific article

Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape

scientific article

Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization

scientific article

Fluidity of HIV-1-specific T-cell responses during acute and early subtype C HIV-1 infection and associations with early disease progression

scientific article

Generation and evaluation of clade C simian-human immunodeficiency virus challenge stocks

scientific article

Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern Africa

scientific article

Genetic characteristics of HIV-1 subtype C envelopes inducing cross-neutralizing antibodies

scientific article published on 16 July 2007

Genetic characterization of HIV before widespread testing of HIV vaccine candidates at a clinical trial site in Pretoria, South Africa

scientific article published on 6 March 2012

Genital inflammation and the risk of HIV acquisition in women

scientific article

Genital tract inflammation during early HIV-1 infection predicts higher plasma viral load set point in women

scientific article published on January 2012

HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth

article

HIV disease progression in seroconvertors from the CAPRISA 004 tenofovir gel pre-exposure prophylaxis trial

scientific article

HIV infection in high school students in rural South Africa: role of transmissions among students

scientific article

HIV molecular epidemiology: transmission and adaptation to human populations

scientific article

HIV type 1 subtype C gag and nef diversity in Southern Africa

scientific article published in March 2007

HIV-1 Superinfection Resembles Primary Infection

scientific article

HIV-1 replication capacity: Setting the pace of disease

scientific article

HIV-1 subtype C Pr55gag virus-like particle vaccine efficiently boosts baboons primed with a matched DNA vaccine

scientific article published in September 2008

Heterosexual transmission of multiple highly conserved viral variants in HIV-1 subtype C-infected seronegative women

scientific article published in October 2004

Human immunodeficiency virus type 1 subtype C Gag virus-like particle boost substantially improves the immune response to a subtype C gag DNA vaccine in mice

scientific article

Human immunodeficiency virus-specific gamma interferon enzyme-linked immunospot assay responses targeting specific regions of the proteome during primary subtype C infection are poor predictors of the course of viremia and set point

scientific article published on 22 October 2008

Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models

scientific article

Impact of clade, geography, and age of the epidemic on HIV-1 neutralization by antibodies

scientific article

Incidence of HIV‐1 Dual Infection and Its Association with Increased Viral Load Set Point in a Cohort of HIV‐1 Subtype C–Infected Female Sex Workers

article

Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for cytomegalovirus-specific CD8+ T cells

scientific article

Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness

scientific article

Intra- and inter-clade cross-reactivity by HIV-1 Gag specific T-cells reveals exclusive and commonly targeted regions: implications for current vaccine trials

scientific article

Investigation of HIV in amniotic fluid from HIV-infected pregnant women at full term

scientific article published on 29 June 2005

Limited HIV-1 superinfection in seroconverters from the CAPRISA 004 Microbicide Trial

scientific article published on 26 December 2013

Limited neutralizing antibody specificities drive neutralization escape in early HIV-1 subtype C infection

scientific article

Longitudinal analysis of HIV type 1 subtype C envelope sequences from South Africa

scientific article published in February 2007

Metabolic Syndrome After HIV Acquisition in South African Women.

scientific article

Multiple HIV-1 infections with evidence of recombination in heterosexual partnerships in a low risk Rural Clinical Cohort in Uganda

scientific article

Multiple pathways of escape from HIV broadly cross-neutralizing V2-dependent antibodies

scientific article published on 13 February 2013

Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure

scientific article published on 3 September 2014

No evidence for selection of HIV-1 with enhanced gag-protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial

scientific article

Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection

scientific article

Panels of HIV-1 Subtype C Env Reference Strains for Standardized Neutralization Assessments

scientific article

Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression

scientific article

Positive Selection at Key Residues in the HIV Envelope Distinguishes Broad and Strain-Specific Plasma Neutralizing Antibodies

article

Potent and broad neutralization of HIV-1 subtype C by plasma antibodies targeting a quaternary epitope including residues in the V2 loop

scientific article

Preparing developing countries for efficacy trials

scientific article published on July 2006

Rapid disease progression in HIV-1 subtype C-infected South African women

scientific article

Rapid, complex adaptation of transmitted HIV-1 full-length genomes in subtype C-infected individuals with differing disease progression

scientific article published on February 2013

Regional clustering of shared neutralization determinants on primary isolates of clade C human immunodeficiency virus type 1 from South Africa

scientific article

Relationship between Levels of Inflammatory Cytokines in the Genital Tract and CD4+Cell Counts in Women with Acute HIV‐1 Infection

article

Replication Capacity of Viruses from Acute Infection Drives HIV-1 Disease Progression

scientific article published on February 2017

Response to 'single genome amplification and sequencing methods require appropriate thresholds for viral transmission and evolution studies'.

scientific article published on January 2014

Sequential Immunization with gp140 Boosts Immune Responses Primed by Modified Vaccinia Ankara or DNA in HIV-Uninfected South African Participants

scientific article

Short Communication: A Recombinant Variant with Increased Envelope Entry Efficiency Emerged During Early Infection of an HIV-1 Subtype C Dual Infected Rapid Progressor

scientific article published on 23 April 2015

Short communication decreased incidence of dual infections in South african subtype C-infected women compared to a cohort ten years earlier

scientific article published on 9 February 2011

South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication

scientific article published on 24 June 2015

South African HIV-1 vaccine candidates - the journey from the bench to clinical trials

scientific article published on 02 March 2012

Striking lack of T cell immunodominance in both a multiclade and monoclade HIV-1 epidemic: implications for vaccine development

scientific article published on 2 March 2014

Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site

scientific article published on 31 August 2016

Subtype C gp140 Vaccine Boosts Immune Responses Primed by the South African AIDS Vaccine Initiative DNA-C2 and MVA-C HIV Vaccines after More than a 2-Year Gap

scientific article published on 20 April 2016

Symptomatic vaginal discharge is a poor predictor of sexually transmitted infections and genital tract inflammation in high-risk women in South Africa

scientific article

The HIV-1 Epidemic: Low- to Middle-Income Countries ⬇️

scientific article published on March 1, 2012

The PTAP sequence duplication in HIV-1 subtype C Gag p6 in drug-naive subjects of India and South Africa

scientific article

The Replication-Competent HIV-1 Latent Reservoir is Primarily Established Near the Time of Therapy Initiation: Supplemental Material for Abrahams et al

article

The c3-v4 region is a major target of autologous neutralizing antibodies in human immunodeficiency virus type 1 subtype C infection

scientific article

The challenges of HIV vaccine development and testing

scientific article

The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection

scientific article

Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage

scientific article

Utilizing nucleic acid amplification to identify acute HIV infection

scientific article published in March 2007

Vertical HIV transmission in South Africa: translating research into policy and practice

scientific article published on March 2002

Vertical T cell immunodominance and epitope entropy determine HIV-1 escape

scientific article

Viral and host factors associated with the HIV-1 viral load setpoint in adults from Mbeya Region, Tanzania

scientific article

Viral dynamics and CD4+ T cell counts in subtype C human immunodeficiency virus type 1-infected individuals from southern Africa

scientific article published in April 2005

Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes

scientific article

Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies

scientific article

Virological features associated with the development of broadly neutralizing antibodies to HIV-1

scientific article

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