List of works - Mamuka Kvaratskhelia

-Methyladenosine-binding proteins suppress HIV-1 infectivity and viral production

scientific article published in Journal of Biological Chemistry

A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain

scientific article

A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase

scientific article

A new structural insight into XPA-DNA interactions

scientific article

Akt activation by human T-cell leukemia virus tax oncoprotein

scientific article published on 28 August 2015

Allosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target Cells

scientific article published on 14 June 2017

Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies

scientific article published on 9 August 2016

Allosteric inhibition of HIV-1 integrase activity

scientific article published on 03 May 2013

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

scientific article

Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction

scientific article

An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule

scientific article

Analysis of Recombinant CD24 Glycans by MALDI-TOF-MS Reveals Prevalence of Sialyl-T Antigen

scientific article

BET proteins promote efficient murine leukemia virus integration at transcription start sites

scientific article published on July 2013

Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes

scientific article published on 11 February 2014

Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A.

scientific article published on 8 July 2009

Comparative host protein interactions with HTLV-1 p30 and HTLV-2 p28: insights into difference in pathobiology of human retroviruses ⬇️

scientific article published on August 9, 2012

Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase

scientific article published on 03 August 2016

Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites

scientific article

Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

scientific article

Development of Potent Antiviral Drugs Inspired by Viral Hexameric DNA-Packaging Motors with Revolving Mechanism

scientific article published on 29 June 2016

Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein

scientific article published on 18 September 2008

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75 ⬇️

scientific article published on July 19, 2011

Features of double-stranded RNA-binding domains of RNA helicase A are necessary for selective recognition and translation of complex mRNAs

scientific article

HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis

scientific article published on August 2016

HIV-1 Integrase-DNA Recognition Mechanisms ⬇️

scientific article published on November 5, 2009

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence

article

HIV-1 integrase multimerization as a therapeutic target

scientific article published on January 2015

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

scientific article

High resolution footprinting of the hepatitis C virus polymerase NS5B in complex with RNA.

scientific article published on 18 April 2007

Human T-lymphotropic Virus Type 1 p30 Interacts with REGγ and Modulates ATM (Ataxia Telangiectasia Mutated) to Promote Cell Survival ⬇️

scientific article published on January 7, 2011

Human T-lymphotropic virus type 1 p30 interacts with REGγ and ATM (Ataxia Telangiectasia Mutated) to promote cell survival

Identification and characterization of HTLV-1 HBZ post-translational modifications

scientific article

Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry

scientific article published on 26 April 2004

Identification of glycosylation sites in the SU component of the Avian Sarcoma/Leukosis virus Envelope Glycoprotein (Subgroup A) by mass spectrometry

scientific article published on August 2004

Identification of host proteins associated with HIV-1 preintegration complexes isolated from infected CD4+ cells

scientific article published on 11 August 2010

Identification of specific HIV-1 reverse transcriptase contacts to the viral RNA:tRNA complex by mass spectrometry and a primary amine selective reagent

scientific article

Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2)

scientific article

Interactions between HIV-1 Gag molecules in solution: an inositol phosphate-mediated switch

scientific article published on 26 October 2006

Interactions of HIV-1 Gag with assembly cofactors

scientific article

Interactions of the Disordered Domain II of Hepatitis C Virus NS5A with Cyclophilin A, NS5B, and Viral RNA Show Extensive Overlap

scientific article published on 27 September 2016

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes

scientific article

Mass spectrometric identification of lysines involved in the interaction of human replication protein a with single-stranded DNA.

scientific article

Mass spectrometry-based footprinting of protein-protein interactions

scientific article

Methods for Identifying and Examining HTLV-1 HBZ Post-translational Modifications

scientific article published on January 2017

Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase

scientific article published on January 2016

Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B.

scientific article published on 9 July 2005

Molecular mechanisms of retroviral integration site selection

scientific article

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors ⬇️

scientific article published on March 21, 2012

N6-methyladenosine Binding Proteins Negatively Regulate HIV-1 Infectivity and Viral Production

article

Nonpolar thymine isosteres in the Ty3 polypurine tract DNA template modulate processing and provide a model for its recognition by Ty3 reverse transcriptase

scientific article published on 30 April 2003

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

article

Pre-existing distortions in nucleic acid structure aid polypurine tract selection by HIV-1 reverse transcriptase

scientific article published in March 2002

Probing conformational changes of human DNA polymerase lambda using mass spectrometry-based protein footprinting

scientific article published on 23 May 2009

Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol proteolytic processing

scientific article published on 28 September 2017

Stability of the HTLV-1 Antisense-Derived Protein, HBZ, Is Regulated by the E3 Ubiquitin-Protein Ligase, UBR5.

scientific article published on 30 January 2018

Structural Studies and Biological Evaluation of T30695 Variants Modified with Single Chiral Glycerol-T Reveal the Importance of LEDGF/p75 for the Aptamer Anti-HIV-Integrase Activities

article

Structural analysis of protein-RNA interactions with mass spectrometry

scientific article published on January 2008

Structural basis for dimerization of LAP2alpha, a component of the nuclear lamina

scientific article

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

scientific article

Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction

scientific article published on 8 February 2016

Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding

scientific article

TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism

scientific article

The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

scientific article

The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency

scientific article published on 24 February 2016

The FACT Complex Promotes Avian Leukosis Virus DNA Integration

scientific article published on 25 January 2017

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase

scientific article

Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins

scientific article

Use of chemical modification and mass spectrometry to identify substrate-contacting sites in proteinaceous RNase P, a tRNA processing enzyme

scientific article

Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity

scientific article

List of works by Mamuka Kvaratskhelia

-Methyladenosine-binding proteins suppress HIV-1 infectivity and viral production

A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain

A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase

A new structural insight into XPA-DNA interactions

Akt activation by human T-cell leukemia virus tax oncoprotein

Allosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target Cells

Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies

Allosteric inhibition of HIV-1 integrase activity

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction

An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule

Analysis of Recombinant CD24 Glycans by MALDI-TOF-MS Reveals Prevalence of Sialyl-T Antigen

BET proteins promote efficient murine leukemia virus integration at transcription start sites

Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes

Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A.

Comparative host protein interactions with HTLV-1 p30 and HTLV-2 p28: insights into difference in pathobiology of human retroviruses ⬇️

Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase

Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites

Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

Development of Potent Antiviral Drugs Inspired by Viral Hexameric DNA-Packaging Motors with Revolving Mechanism

Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75 ⬇️

Features of double-stranded RNA-binding domains of RNA helicase A are necessary for selective recognition and translation of complex mRNAs

HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis

HIV-1 Integrase-DNA Recognition Mechanisms ⬇️

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence

HIV-1 integrase multimerization as a therapeutic target

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

High resolution footprinting of the hepatitis C virus polymerase NS5B in complex with RNA.

Human T-lymphotropic Virus Type 1 p30 Interacts with REGγ and Modulates ATM (Ataxia Telangiectasia Mutated) to Promote Cell Survival ⬇️

Human T-lymphotropic virus type 1 p30 interacts with REGγ and ATM (Ataxia Telangiectasia Mutated) to promote cell survival

Identification and characterization of HTLV-1 HBZ post-translational modifications

Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry

Identification of glycosylation sites in the SU component of the Avian Sarcoma/Leukosis virus Envelope Glycoprotein (Subgroup A) by mass spectrometry

Identification of host proteins associated with HIV-1 preintegration complexes isolated from infected CD4+ cells

Identification of specific HIV-1 reverse transcriptase contacts to the viral RNA:tRNA complex by mass spectrometry and a primary amine selective reagent

Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2)

Interactions between HIV-1 Gag molecules in solution: an inositol phosphate-mediated switch

Interactions of HIV-1 Gag with assembly cofactors

Interactions of the Disordered Domain II of Hepatitis C Virus NS5A with Cyclophilin A, NS5B, and Viral RNA Show Extensive Overlap

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes

Mass spectrometric identification of lysines involved in the interaction of human replication protein a with single-stranded DNA.

Mass spectrometry-based footprinting of protein-protein interactions

Methods for Identifying and Examining HTLV-1 HBZ Post-translational Modifications

Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase

Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B.

Molecular mechanisms of retroviral integration site selection

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors ⬇️

N6-methyladenosine Binding Proteins Negatively Regulate HIV-1 Infectivity and Viral Production

Nonpolar thymine isosteres in the Ty3 polypurine tract DNA template modulate processing and provide a model for its recognition by Ty3 reverse transcriptase

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

Pre-existing distortions in nucleic acid structure aid polypurine tract selection by HIV-1 reverse transcriptase

Probing conformational changes of human DNA polymerase lambda using mass spectrometry-based protein footprinting

Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol proteolytic processing

Stability of the HTLV-1 Antisense-Derived Protein, HBZ, Is Regulated by the E3 Ubiquitin-Protein Ligase, UBR5.

Structural Studies and Biological Evaluation of T30695 Variants Modified with Single Chiral Glycerol-T Reveal the Importance of LEDGF/p75 for the Aptamer Anti-HIV-Integrase Activities

Structural analysis of protein-RNA interactions with mass spectrometry

Structural basis for dimerization of LAP2alpha, a component of the nuclear lamina

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction

Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding

TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism

The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency

The FACT Complex Promotes Avian Leukosis Virus DNA Integration

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase

Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins

Use of chemical modification and mass spectrometry to identify substrate-contacting sites in proteinaceous RNase P, a tRNA processing enzyme

Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity