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List of works by Nicholas P. Restifo

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016

scientific article published oln 16 November 2016

A "big data" view of the tumor "immunome"

scientific article

A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer.

scientific article published on 13 December 2010

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants

scientific article published on 09 August 2019

A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed

scientific article published on 9 February 2018

A human memory T cell subset with stem cell-like properties

scientific article

A nonimmunogenic sarcoma transduced with the cDNA for interferon gamma elicits CD8+ T cells against the wild-type tumor: correlation with antigen presentation capability

scientific article

A novel chimeric antigen receptor against prostate stem cell antigen mediates tumor destruction in a humanized mouse model of pancreatic cancer.

scientific article

A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response

scientific article

ASXL3 Is a Novel Pluripotency Factor in Human Respiratory Epithelial Cells and a Potential Therapeutic Target in Small Cell Lung Cancer

scientific article

Acquired resistance to immunotherapy and future challenges

scientific article published in January 2016

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

scientific article

Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor-associated antigen

scientific article

Adoptive T cell therapy of cancer

scientific article published on 26 March 2009

Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens

scientific article

Adoptive cell transfer as personalized immunotherapy for human cancer

scientific article published in April 2015

Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma

scientific article

Adoptive cell transfer: a clinical path to effective cancer immunotherapy

scientific article

Adoptive immunotherapy combined with intratumoral TLR agonist delivery eradicates established melanoma in mice

scientific article

Adoptive immunotherapy for cancer: building on success

scientific article

Adoptive immunotherapy for cancer: harnessing the T cell response

scientific article

Adoptive immunotherapy of cancer using CD4(+) T cells

scientific article published on 13 March 2009

Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.

scientific article published on 17 September 2008

Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

scientific article

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

scientific article published on 24 September 2009

Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity

scientific article

Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.

scientific article

Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways

scientific article

Altered CD8(+) T-cell responses when immunizing with multiepitope peptide vaccines

scientific article

An effective mouse model for adoptive cancer immunotherapy targeting neoantigens.

scientific article published on 16 May 2019

Anti-tumor activity of cytotoxic T lymphocytes elicited with recombinant and synthetic forms of a model tumor-associated antigen

scientific article published on October 1995

Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer

scientific article

Antiangiogenic gene therapy of cancer utilizing a recombinant adenovirus to elevate systemic endostatin levels in mice.

scientific article

Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens

scientific article published on 29 January 2020

Antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor vaccine

scientific article

Antigen processing in vivo and the elicitation of primary CTL responses

scientific article

Antigen-specific tumor vaccine efficacy in vivo against prostate cancer with low class I MHC requires competent class II MHC.

scientific article

Antisense targeting of CD47 enhances human cytotoxic T-cell activity and increases survival of mice bearing B16 melanoma when combined with anti-CTLA4 and tumor irradiation

scientific article published on 18 October 2019

Apoptosis is essential for the increased efficacy of alphaviral replicase-based DNA vaccines.

scientific article

Apoptotic death of CD8+ T lymphocytes after immunization: induction of a suppressive population of Mac-1+/Gr-1+ cells

scientific article

Arginine Arms T Cells to Thrive and Survive

scientific article published on 01 November 2016

Assumptions of the tumor 'escape' hypothesis

scientific article

Autoimmunity and the immunotherapy of cancer: targeting the "self" to destroy the "other".

scientific article published in January 2000

Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4.

scientific article

B16 as a mouse model for human melanoma

scientific article published on May 2001

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

scientific article published on 22 May 2017

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers

scientific article published on 09 May 2016

BACH2 represses effector programmes to stabilize Treg-mediated immune homeostasis - a new target in tumor immunotherapy?

scientific article published on 7 November 2013

BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.

scientific article published on 02 June 2013

Bcl-2 overexpression enhances tumor-specific T-cell survival

scientific article

Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer

scientific article

Big bang theory of stem-like T cells confirmed.

scientific article

Both CD4 and CD8 T cells mediate equally effective in vivo tumor treatment when engineered with a highly avid TCR targeting tyrosinase.

scientific article published on 28 April 2010

Building better vaccines: how apoptotic cell death can induce inflammation and activate innate and adaptive immunity

scientific article

CD4+CD25+ T regulatory cells, immunotherapy of cancer, and interleukin-2.

scientific article

CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge

scientific article

CD8+ Enriched “Young” Tumor Infiltrating Lymphocytes Can Mediate Regression of Metastatic Melanoma ⬇️

scientific article published on July 28, 2010

CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.

scientific article

CD8+ T-cell memory in tumor immunology and immunotherapy

scientific article

CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent.

scientific article

Can Antitumor Immunity Help to Explain “Oncogene Addiction”? ⬇️

scientific article published on November 16, 2010

Cancer immunotherapy

scientific article published on 01 September 2008

Cancer immunotherapy: moving beyond current vaccines

scientific article

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

scientific article

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

scientific article

Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy

scientific article published on February 2013

Cancer regression in patients after transfer of genetically engineered lymphocytes

scientific article

Cancer therapy using a self-replicating RNA vaccine

scientific article

Cancer vaccines '98: a reductionistic approach. Bethesda, MD, USA, 27-28 April 1998

scientific article published on 01 August 1998

Cancer vaccines: progress reveals new complexities

scientific article

Cell transfer therapy for cancer: lessons from sequential treatments of a patient with metastatic melanoma

scientific article published on September 2003

Cellular constituents of immune escape within the tumor microenvironment

scientific article published on 21 June 2012

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

scientific article

Chemokine receptor targeting efficiently directs antigens to MHC class I pathways and elicits antigen-specific CD8+ T-cell responses

scientific article published on 2 March 2006

Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance

scientific article

Cish actively silences tcr signaling in CD8+ T cells to maintain tumor tolerance.

scientific article published on 4 November 2015

Cish attenuates proximal TCR-signaling and CD8+ T cell immunity

Classification of current anticancer immunotherapies

scientific article

Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.

scientific article published on 5 May 2015

Clinical scale zinc finger nuclease (ZFN)-driven gene-editing of PD-1 in tumor infiltrating lymphocytes (TIL) for the potential treatment of metastatic melanoma.

scientific article published on 6 November 2014

Cloning and characterization of the genes encoding the murine homologues of the human melanoma antigens MART1 and gp100

scientific article published on January 1997

Collapse of the tumor stroma is triggered by IL-12 induction of Fas.

scientific article published on 09 April 2013

Complete regression of metastatic cervical cancer after treatment with human papillomavirus-targeted tumor-infiltrating T cells.

scientific article published on 30 March 2015

Consensus nomenclature for CD8(+) T cell phenotypes in cancer

scientific article published on 25 February 2015

Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets.

scientific article published on 06 June 2016

Construction and characterization of a triple-recombinant vaccinia virus encoding B7-1, interleukin 12, and a model tumor antigen

scientific article published in December 1998

Correction to: Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation

scientific article published on 17 December 2020

Costimulation enhances the active immunotherapy effect of recombinant anticancer vaccines.

scientific article

Countering the 'counterattack' hypothesis.

scientific article published on March 2001

Cross-priming utilizes antigen not available to the direct presentation pathway.

scientific article published on 8 June 2006

Customizing Functionality and Payload Delivery for Receptor-Engineered T Cells

scientific article published in October 2016

Cutting edge: CD4+ T cell control of CD8+ T cell reactivity to a model tumor antigen

scientific article

Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases.

scientific article

Cytokine secretion by genetically modified nonimmunogenic murine fibrosarcoma. Tumor inhibition by IL-2 but not tumor necrosis factor

scientific article

DNA and RNA-based vaccines: principles, progress and prospects

scientific article

DNA vaccines and apoptosis: to kill or not to kill?

scientific article

De novo induction of a cancer/testis antigen by 5-aza-2'-deoxycytidine augments adoptive immunotherapy in a murine tumor model.

scientific article published in January 2006

Defective presentation of endogenous antigens by a murine sarcoma. Implications for the failure of an anti-tumor immune response

scientific article

Defining 'T cell exhaustion'

scientific article published on 30 September 2019

Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation

scientific article published on 24 November 2020

Dendritic Cells Infected with PoxvIn Vitro iruses Encoding MART-1/ Melan A Sensitize T Lymphocytes In Vitro ⬇️

scientific article published on July 1, 1997

Dendritic cells strongly boost the antitumor activity of adoptively transferred T cells in vivo.

scientific article

Detection of shared MHC-restricted human melanoma antigens after vaccinia virus-mediated transduction of genes coding for HLA

scientific article

Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice

scientific article

Developing neoantigen-targeted T cell-based treatments for solid tumors

scientific article published on 07 October 2019

Developing recombinant and synthetic vaccines for the treatment of melanoma.

scientific article

Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition

scientific article published on 22 May 2008

Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity.

scientific article published on 7 February 2010

Different adjuvanticity of incomplete freund's adjuvant derived from beef or vegetable components in melanoma patients immunized with a peptide vaccine.

scientific article published on July 2010

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

scientific article published on 01 November 2018

Do CD4+ CD25+ immunoregulatory T cells hinder tumor immunotherapy?

scientific article

Does IL-17 promote tumor growth?

scientific article published on 01 July 2009

Dose-dependent and schedule-dependent effects of interleukin-12 on antigen-specific CD8 responses

scientific article published in June 2000

Double or nothing on cancer immunotherapy

scientific article published in January 2013

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting.

scientific article published on 13 December 2016

Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy

scientific article

Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity

scholarly article

Elevated potassium levels suppress T cell activation within tumors.

scientific article published on 4 November 2015

Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy

scientific article

Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model.

scientific article published on 19 April 2018

Engineering the immune response to "self" for effective cancer immunotherapy

scientific article published on 6 November 2014

Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.

scientific article

Enhanced efficacy and limited systemic cytokine exposure with membrane-anchored interleukin-12 T-cell therapy in murine tumor models

scientific article published on 01 January 2020

Enhancement of cellular immunity in melanoma patients immunized with a peptide from MART-1/Melan A

scientific article published on January 1997

Enhancement of tumor-specific immune response with plasmid DNA replicon vectors.

scientific article

Enhancing the recognition of tumour associated antigens.

scientific article published on January 1994

Epigenetic control of CD8+ T cell differentiation.

scientific article

Essentials of Th17 cell commitment and plasticity

scientific article published on 16 January 2013

Evaluation of prime/boost regimens using recombinant poxvirus/tyrosinase vaccines for the treatment of patients with metastatic melanoma

scientific article

Expression of a "self-"antigen by human tumor cells enhances tumor antigen-specific CD4(+) T-cell function.

scientific article

Extrathymic generation of tumor-specific T cells from genetically engineered human hematopoietic stem cells via Notch signaling

scientific article

Fas-mediated suicide of tumor-reactive T cells following activation by specific tumor: selective rescue by caspase inhibition

scientific article

Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction

scientific article published on 23 December 2016

GILT accelerates autoimmunity to the melanoma antigen tyrosinase-related protein 1.

scientific article

Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice ⬇️

scientific article published on October 11, 2010

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

scientific article

Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System.

scientific article published in March 2018

Generation of polyclonal rabbit antisera to mouse melanoma associated antigens using gene gun immunization.

scientific article

Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies.

scientific article

Genetic vaccination with "self" tyrosinase-related protein 2 causes melanoma eradication but not vitiligo

scientific article

Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas

scientific article published on 02 December 2020

Glucocorticoids do not inhibit antitumor activity of activated CD8+ T cells

scientific article

HLA associations in the antitumor response against malignant melanoma.

scientific article published on November 1995

Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells

scientific article published on February 2007

Hierarchy, Tolerance, and Dominance in the Antitumor T-Cell Response

scientific article published on 01 May 2001

Hierarchy, tolerance, and dominance in the antitumor T-cell response.

scientific article published in May 2001

High efficiency TCR gene transfer into primary human lymphocytes affords avid recognition of melanoma tumor antigen glycoprotein 100 and does not alter the recognition of autologous melanoma antigens

scientific article

High-avidity autoreactive CD4+ T cells induce host CTL, overcome T(regs) and mediate tumor destruction

scientific article published on September 2009

High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation

scientific article

Highlights of the society for immunotherapy of cancer (SITC) 27th annual meeting

scientific article published on 29 May 2013

Highly attenuated modified vaccinia virus Ankara (MVA) as an effective recombinant vector: a murine tumor model

scientific article

Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells

scientific article published on 12 August 2019

Host range restricted, non-replicating vaccinia virus vectors as vaccine candidates

scientific article published on January 1996

Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.

scientific article

Human melanoma cells do not express Fas (Apo-1/CD95) ligand

scientific article

Human memory T cells: generation, compartmentalization and homeostasis

scientific article

IFN-gamma-receptor signaling ameliorates transplant vasculopathy through attenuation of CD8+ T-cell-mediated injury of vascular endothelial cells

scientific article published on March 2010

IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines: enhancement by simultaneous B7-1 expression.

scientific article

IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors.

scientific article published on 7 November 2011

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

scientific article

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

scientific article published on 14 February 2008

IL-2 enhances the function of recombinant poxvirus-based vaccines in the treatment of established pulmonary metastases

scientific article

Identification of CD4+ T cell epitopes from NY-ESO-1 presented by HLA-DR molecules

scientific article published in July 2000

Identification of Novel Targets for Lung Cancer Therapy Using an Induced Pluripotent Stem Cell Model

scientific article published in April 2018

Identification of Small Molecule Enhancers of Immunotherapy for Melanoma

scientific article published on 30 March 2020

Identification of T-cell Receptors Targeting KRAS-Mutated Human Tumors

scientific article published on 23 December 2015

Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells.

scientific article published on December 2000

Identification of a Kb-restricted CTL epitope of beta-galactosidase: potential use in development of immunization protocols for "self" antigens

scientific article published on June 1997

Identification of a MHC class II-restricted human gp100 epitope using DR4-IE transgenic mice

scientific article

Identification of essential genes for cancer immunotherapy.

scientific article published on 7 August 2017

Identification of human cancers deficient in antigen processing

scientific article

Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing

scientific article

Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells.

scientific article published on 6 December 2012

Identifying the source of tumour-infiltrating T cells

scientific article published on 01 December 2019

Immune Evasion by Murine Melanoma Mediated through CC Chemokine Receptor-10 ⬇️

scientific article published on October 27, 2003

Immune selection of hot-spot beta 2-microglobulin gene mutations, HLA-A2 allospecificity loss, and antigen-processing machinery component down-regulation in melanoma cells derived from recurrent metastases following immunotherapy

scientific article

Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia

scientific article published on 27 May 2013

Immunization against endogenous retroviral tumor-associated antigens.

scientific article

Immunization of patients with metastatic melanoma using both class I- and class II-restricted peptides from melanoma-associated antigens

scientific article

Immunizing patients with metastatic melanoma using recombinant adenoviruses encoding MART-1 or gp100 melanoma antigens

scientific article

Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

scientific article

Immunologic ignorance of vascular endothelial cells expressing minor histocompatibility antigen

scientific article

Immunological and antitumor effects of IL-23 as a cancer vaccine adjuvant

scientific article

Immunotherapy Bridge 2016 and Melanoma Bridge 2016: meeting abstracts.

scientific article

Immunotherapy Bridge 2017 and Melanoma Bridge 2017: meeting abstracts

scientific article published on 15 January 2018

Immunotherapy generates selective pressure for acquisition of immunogenic neoantigens in escape tumors.

scientific article published on 4 November 2015

Immunotherapy: Treatment of aggressive lymphomas with anti-CD19 CAR T cells.

scientific article published on 11 November 2014

Impact of cytokine administration on the generation of antitumor reactivity in patients with metastatic melanoma receiving a peptide vaccine

scientific article

Improving Adoptive Immunotherapy Using Less-Differentiated T Cells ⬇️

scholarly article

Improving Adoptive T Cell Therapy by Targeting and Controlling IL-12 Expression to the Tumor Environment ⬇️

scientific article published on February 1, 2011

Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen.

scientific article

Increased frequency of suppressive regulatory T cells and T cell-mediated antigen loss results in murine melanoma recurrence

scientific article published on 20 June 2012

Increased immunogenicity of an anchor-modified tumor-associated antigen is due to the enhanced stability of the peptide/MHC complex: implications for vaccine design

scientific article

Increased intensity lymphodepletion and adoptive immunotherapy--how far can we go?

scientific article published on December 2006

Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells

scientific article published on January 2010

Induction of CD4(+) T cell-dependent antitumor immunity by TAT-mediated tumor antigen delivery into dendritic cells

scientific article

Induction of an acute vitamin A-deficient state following total body irradiation impairs anti-tumor immunity by altering the homeostasis of pre-cDC derived dendritic cells.

scientific article

Induction of tumor antigen-specific immunity in vivo by a novel vaccinia vector encoding safety-modified simian virus 40 T antigen

scientific article

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.

scientific article published on 16 September 2013

Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy

scientific article published on 7 December 2017

Inhibition of TGF-β signaling in genetically engineered tumor antigen-reactive T cells significantly enhances tumor treatment efficacy.

scientific article published on 13 September 2012

Inhibition of the T cell oxygen sensing machinery promotes anti-tumor efficacy.

scientific article

Insertion signal sequence fused to minimal peptides elicits specific CD8+ T-cell responses and prolongs survival of thymoma-bearing mice.

scientific article

Intensity of the vaccine-elicited immune response determines tumor clearance

scientific article

Interleukin-10 enhances the therapeutic effectiveness of a recombinant poxvirus-based vaccine in an experimental murine tumor model

scientific article published on November 1999

Interleukin-2-dependent mechanisms of tolerance and immunity in vivo

scientific article

Interleukin-7-dependent expansion and persistence of melanoma-specific T cells in lymphodepleted mice lead to tumor regression and editing.

scientific article

In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen-experienced cells.

scientific article

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

scientific article published on 14 September 2016

Less is more: lymphodepletion followed by hematopoietic stem cell transplant augments adoptive T-cell-based anti-tumor immunotherapy.

scientific article

Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape

scientific article

Lineage relationship of effector and memory T cells

scientific article

Local delivery of interleukin-12 using T cells targeting VEGF receptor-2 eradicates multiple vascularized tumors in mice.

scientific article published on 30 January 2012

Locus-specific analysis of human leukocyte antigen class I expression in melanoma cell lines

scientific article published on July 1994

Loss of functional beta 2-microglobulin in metastatic melanomas from five patients receiving immunotherapy

scientific article

MHC class I and class II presentation of tumor antigen in retrovirally and adenovirally transduced dendritic cells

scientific article published on November 2002

MHC class II presentation of gp100 epitopes in melanoma cells requires the function of conventional endosomes and is influenced by melanosomes.

scientific article

Memoirs of a reincarnated T cell.

scientific article

Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy

scientific article published on 14 December 2015

Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy

scientific article

Metabolic reprograming of anti-tumor immunity

scientific article published on 13 April 2017

Methods for selecting therapy for a cancer patient

US patent 11312998

Mg2+ regulation of kinase signaling and immune function

scientific article published on 13 June 2019

MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer

scientific article published on April 2013

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8 T cells via TLR4 signaling

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling.

scientific article published in August 2007

Microbiota modulation of myeloid cells in cancer therapy

scientific article

Minimal determinant expressed by a recombinant vaccinia virus elicits therapeutic antitumor cytolytic T lymphocyte responses

scientific article

Mining the melanosome for tumor vaccine targets: P.polypeptide is a novel tumor-associated antigen

scientific article

Mining the mutanome: developing highly personalized Immunotherapies based on mutational analysis of tumors

scientific article

Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.

scientific article published on 7 December 2015

Mitochondrial activity regulates T cell memory, self renewal and anti tumor function in CD8+ T cells

scientific article published on 7 November 2013

Modulating immunometabolism of tumor specific CD8 T cells to enhance T cell based therapy for cancer

scientific article published on 6 November 2014

Modulating immunometabolism of tumor specific mouse and human lymphocytes to enhance T cell based therapy for cancer.

scientific article published on 4 November 2015

Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails.

scientific article published on 4 December 2012

Molecular characterization of defective antigen processing in human prostate cancer.

scientific article

Molecular mechanisms used by tumors to escape immune recognition: immunogenetherapy and the cell biology of major histocompatibility complex class I.

scientific article published on October 1993

Mouse model for pre-clinical study of human cancer immunotherapy.

scientific article

Moving T memory stem cells to the clinic.

scientific article published in January 2013

Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies

scientific article published on 01 June 2020

Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy

scientific article published on 13 April 2020

Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors

scientific article

Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.

scientific article

Natural killer cell lines kill autologous β2-microglobulin-deficient melanoma cells: Implications for cancer immunotherapy ⬇️

scientific article published on November 25, 1997

Natural selection of tumor variants in the generation of "tumor escape" phenotypes

scientific article

Natural variation of the expression of HLA and endogenous antigen modulates CTL recognition in an in vitro melanoma model

scientific article

Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers

scientific article published on 04 February 2019

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer

scientific article

Nine lives for TH9s?

scientific article published on 01 August 2012

Normal tissue depresses while tumor tissue enhances human T cell responses in vivo to a novel self/tumor melanoma antigen, OA1

scientific article

Novel "Elements" of Immune Suppression within the Tumor Microenvironment

scientific article published on June 2017

Nutrient Competition: A New Axis of Tumor Immunosuppression

scientific article published on 01 September 2015

Ocular and systemic autoimmunity after successful tumor-infiltrating lymphocyte immunotherapy for recurrent, metastatic melanoma

scientific article published on May 2009

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

scientific article

Partly MHC Matched Allogeneic Tumor Specific T Cells Mediate Tumor Regression without Inducing GVHD in Immunosuppressed Host. ⬇️

scholarly article

Paths to stemness: building the ultimate antitumour T cell.

scientific article

Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68

scientific article

Pharmacologic induction of CD8+ T cell memory: better living through chemistry

scientific article published on December 2009

Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma

scientific article

Pilot Trial of Adoptive Transfer of Chimeric Antigen Receptor-transduced T Cells Targeting EGFRvIII in Patients With Glioblastoma

scientific article published on 01 May 2019

Polymeric structure and host Toll-like receptor 4 dictate immunogenicity of NY-ESO-1 antigen in vivo

scientific article

Poor immunogenicity of a self/tumor antigen derives from peptide-MHC-I instability and is independent of tolerance

scientific article published on August 2004

Preclinical Evaluation of Chimeric Antigen Receptors Targeting CD70-Expressing Cancers

scientific article published in November 2016

Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization.

scientific article

Primary pulmonary cytotoxic T lymphocytes induced by immunization with a vaccinia virus recombinant expressing influenza A virus nucleoprotein peptide do not protect mice against challenge

scientific article published on June 1994

Programming CD8+ T cells for effective immunotherapy.

scientific article

Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination.

scientific article published on 26 June 2009

Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness.

scientific article

Prospects for gene-engineered T cell immunotherapy for solid cancers. ⬇️

scientific article

Quantitative correlation between HLA class I allele expression and recognition of melanoma cells by antigen-specific cytotoxic T lymphocytes

scientific article

Randomized selection design trial evaluating CD8+-enriched versus unselected tumor-infiltrating lymphocytes for adoptive cell therapy for patients with melanoma.

scientific article published on 06 May 2013

Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma

scientific article

Reassessing target antigens for adoptive T-cell therapy

scientific article

Recognition of neuroectodermal tumors by melanoma-specific cytotoxic T lymphocytes: evidence for antigen sharing by tumors derived from the neural crest

scientific article

Recombinant fowlpox viruses encoding the anchor-modified gp100 melanoma antigen can generate antitumor immune responses in patients with metastatic melanoma

scientific article

Recombinant virus vaccination against "self" antigens using anchor-fixed immunogens

scientific article

Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1

scientific article

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

scientific article

Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells

scientific article published on 6 November 2011

Reprogramming antitumor immunity

scientific article

Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells

scientific article published on 02 September 2013

Retroviral transduction of interferon-gamma cDNA into a nonimmunogenic murine fibrosarcoma: generation of T cells in draining lymph nodes capable of treating established parental metastatic tumor

scientific article

Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance

scientific article published on 31 January 2019

Route of immunization and the therapeutic impact of recombinant anticancer vaccines

scientific article published on March 1997

STING agonist promotes CAR T cell trafficking and persistence in breast cancer

scientific article published on 01 February 2021

Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy

scientific article

Sensitization of B16 tumor cells with a CXCR4 antagonist increases the efficacy of immunotherapy for established lung metastases.

scientific article

Silencing stemness in T cell differentiation.

scientific article

Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice.

scientific article published on 30 April 2013

Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy.

scientific article

Sorting through subsets: which T-cell populations mediate highly effective adoptive immunotherapy?

scientific article

Stem cells and cancer immunotherapy: Arrowhead’s 2nd annual cancer immunotherapy conference.

scientific article

Strength in Numbers: Identifying Neoantigen Targets for Cancer Immunotherapy

scientific article published on 01 October 2020

Structures of MART-126/27–35 Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition

scientific article

Super-enhancers delineate disease-associated regulatory nodes in T cells

scientific article

Superior T memory stem cell persistence supports long-lived T cell memory

scientific article published on 2 January 2013

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

scientific article published on 30 October 2009

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.

scientific article

Synthetic oligonucleotide expressed by a recombinant vaccinia virus elicits therapeutic CTL

scientific article

T cell receptor affinity and avidity defines antitumor response and autoimmunity in T cell immunotherapy

scientific article published on 7 November 2013

T cell stemness and dysfunction in tumors are triggered by a common mechanism

scientific article

T cell-tumor cell: a fatal interaction?

scientific article

T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy

scientific article published on 25 February 2019

T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis.

scientific article

T helper 17 cells promote cytotoxic T cell activation in tumor immunity

scientific article

T(H)17 cells in tumour immunity and immunotherapy.

scientific article published on April 2010

T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

scientific article published on April 2013

T-cell receptor gene therapy of established tumors in a murine melanoma model

scientific article

T-cell recognition of human melanoma antigens

scientific article published on August 1993

TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation

scientific journal article

Targeting Akt in cell transfer immunotherapy for cancer

scientific article published on 29 December 2015

Th17 cells are long lived and retain a stem cell-like molecular signature

scientific article

Th17-Derived Memory Cells Are Long-Lived and Retain a Stem-Like Molecular Signature ⬇️

scholarly article

The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction

scientific article published on 01 August 2019

The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8+ T cells.

scientific article published on 28 March 2018

The effects of euglycemic hyperinsulinemia and amino acid infusion on regional and whole body glucose disposal in man

scientific article published on 01 January 1991

The in vivo expansion rate of properly stimulated transferred CD8+ T cells exceeds that of an aggressively growing mouse tumor.

scientific article

The interplay of effector and regulatory T cells in cancer.

scientific article

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

scientific article published on 22 May 2015

The new vaccines: building viruses that elicit antitumor immunity.

scientific article

The next wave of recombinant and synthetic anticancer vaccines

scientific article

The promise of nucleic acid vaccines

scientific article

The stoichiometric production of IL-2 and IFN-γ mRNA defines memory T cells that can self-renew after adoptive transfer in humans.

scientific article published in August 2012

The transcription factor BACH2 promotes tumor immunosuppression.

scientific article published on 5 January 2016

The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity

scientific article published on 18 February 2019

Therapeutic antitumor response after immunization with a recombinant adenovirus encoding a model tumor-associated antigen

scientific article

Therapeutic cancer vaccines: are we there yet? ⬇️

scientific article published on January 1, 2011

Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning

scientific article published on 16 February 2016

Toll-like receptors in tumor immunotherapy

scientific article

Transcriptional profiles reveal a stepwise developmental program of memory CD8(+) T cell differentiation.

scientific article published on November 2014

Transfectant influenza A viruses are effective recombinant immunogens in the treatment of experimental cancer

scientific article published on September 1998

Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity ⬇️

scientific article published on November 15, 2010

Treatment of Established B16 Murine Melanoma Tumors with Tyrp-1 Specific CD4+ Lymphocytes. ⬇️

scholarly article

Treatment of established lung metastases with tumor-infiltrating lymphocytes derived from a poorly immunogenic tumor engineered to secrete human TNF-alpha

scientific article

Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines

scientific article published on September 2008

Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanoma

scientific article published in November 2005

Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

scientific article

Tumor-infiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy of metastatic melanoma

scientific article published on 18 February 2015

Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

scientific article

Tumor-specific CD4+ T cells maintain effector and memory tumor-specific CD8+ T cells

scientific article

Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts

scientific article

Tumor-specific Th17-polarized cells eradicate large established melanoma

scientific article

Type 17 CD8+ T cells display enhanced antitumor immunity.

scientific article published on 26 May 2009

Type I Interferons are essential for the efficacy of replicase-based DNA vaccines.

scientific article

Type I cytokines synergize with oncogene inhibition to induce tumor growth arrest

scientific article

Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy

scientific article published on January 2014

Unopposed production of granulocyte-macrophage colony-stimulating factor by tumors inhibits CD8+ T cell responses by dysregulating antigen-presenting cell maturation.

scientific article

Use of standard criteria for assessment of cancer vaccines.

scientific article

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells

scientific article published on 24 October 2019

Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes.

scientific article

Vaccine-stimulated, adoptively transferred CD8+ T cells traffic indiscriminately and ubiquitously while mediating specific tumor destruction.

scientific article

Viral sequestration of antigen subverts cross presentation to CD8(+) T cells

scientific article

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

scientific article

Wnt/β-Catenin Signaling in T-Cell Immunity and Cancer Immunotherapy ⬇️

scientific article published on August 5, 2010

gp100/pmel 17 is a murine tumor rejection antigen: induction of "self"-reactive, tumoricidal T cells using high-affinity, altered peptide ligand

scientific article

miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines.

scientific article

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