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List of works by Richard T Eastman

A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence

scientific article

A class of tricyclic compounds blocking malaria parasite oocyst development and transmission

scientific article

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model

scientific article published on 18 January 2022

A single nucleotide polymorphism in the Plasmodium falciparum atg18 gene associates with artemisinin resistance and confers enhanced parasite survival under nutrient deprivation

article

A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.

scientific article published on 10 October 2013

A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria.

scientific article published on 11 April 2018

Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts ⬇️

scientific article published on 14 October 2015

An OpenData portal to share COVID-19 drug repurposing data in real time

scientific article published on 05 June 2020

Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection

scientific article

Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model

scientific article published on 19 November 2018

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

scientific article published in December 2009

C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins

scientific article published on March 2007

Canvass: A Crowd-Sourced, Natural Product Screening Library for Exploring Biological Space

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

Cloning and analysis of Trypanosoma cruzi lanosterol 14alpha-demethylase

scientific article published on December 2003

Cloning, heterologous expression, and substrate specificities of protein farnesyltransferases from Trypanosoma cruzi and Leishmania major

scientific article

Correction to Remdesivir: A Review of Its Discovery and Development Leading to Human Clinical Trials for Treatment of COVID-19

scientific article published on 16 June 2020

Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.

scientific article

Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro

scientific article published on 30 June 2020

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

scientific article published on 18 August 2020

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

scientific article

Ex vivo susceptibility of Plasmodium falciparum to antimalarial drugs in western, northern, and eastern Cambodia, 2011-2012: association with molecular markers

scientific article published on 12 August 2013

Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear architecture and reconfigurations associated with antigenic variation

scientific article published on 30 September 2013

High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations

scientific article

Leishmania inactivation in human pheresis platelets by a psoralen (amotosalen HCl) and long-wavelength ultraviolet irradiation.

scientific article published in September 2005

Mechanism of splenic cell death and host mortality in a Plasmodium yoelii malaria model

scientific article published on 5 September 2017

Modulation of Triple Artemisinin-Based Combination Therapy Pharmacodynamics by <i>Plasmodium falciparum</i> Genotype

scientific article published on 02 November 2020

Oxidosqualene cyclase inhibitors as antimicrobial agents.

scientific article

PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers

scientific article (publication date: 5 May 2016)

Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites

scientific article

Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross

scientific article published on 20 September 2019

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

scientific article

Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis.

scientific article

Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue

scientific article published on 31 October 2011

Recent highlights in antimalarial drug resistance and chemotherapy research

scientific article published on 18 October 2008

Regulation of Plasmodium yoelii oocyst development by strain- and stage-specific small-subunit rRNA

scientific article published on 10 March 2015

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

scientific article published on 04 May 2020

Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase

scientific article

Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum

scientific article published on 20 January 2005

Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate

scientific article

Synergistic and Antagonistic Drug Combinations against SARS-CoV-2

scientific article published on 14 December 2020

Targeting ACE2-RBD Interaction as a Platform for COVID-19 Therapeutics: Development and Drug-Repurposing Screen of an AlphaLISA Proximity Assay

scientific article published on 17 November 2020

Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation

scientific article

Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors

scientific article published on 23 November 2020

Trypanosoma cruzi inactivation in human platelet concentrates and plasma by a psoralen (amotosalen HCl) and long-wavelength UV.

scientific article

mQC: A Heuristic Quality-Control Metric for High-Throughput Drug Combination Screening.

scientific article

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