List of works by Tim Hewitson

A novel fluorescent probe-based flow cytometric assay for mineral-containing nanoparticles in serum.

scientific article

AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis

scientific article published on 11 September 2019

Aberrant protein expression in plasma and kidney tissue during experimental obstructive nephropathy.

scientific article published on 4 August 2009

Acute renal failure in IgA nephropathy

scientific article published on 01 December 1994

Aldosterone in clinical nephrology--old hormone, new questions.

scientific article published on 3 June 2009

Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension.

scientific article published on 13 December 2016

Animal Models to Study Links between Cardiovascular Disease and Renal Failure and Their Relevance to Human Pathology

scientific article

Anti-fibrotic actions of relaxin.

scientific article published on June 2016

Antifibrotic Actions of Serelaxin - New Roles for an Old Player.

scientific article published on 17 March 2016

Antifibrotic properties of relaxin: in vivo mechanism of action in experimental renal tubulointerstitial fibrosis

scientific article published on 08 September 2010

Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice

scientific article published on 01 January 1997

Biochemical transformation of calciprotein particles in uraemia

scientific article published on 27 February 2018

Caffeine potentiation of mefenamic acid-induced lesions in the rat renal medulla ⬇️

scientific article published on December 1, 1991

Calciprotein Particle Formation in Peritoneal Dialysis Effluent Is Dependent on Dialysate Calcium Concentration

scientific article published on 23 May 2018

Changes in Markers of Mineral Metabolism After Living Kidney Donation.

scientific article published on 28 March 2017

Clinical and histological correlations of decline in renal function in diabetic patients with proteinuria

scientific article published on 01 August 1994

Collecting duct epithelium and injury: not all cells are created equal

scientific article published on 01 October 2007

Corticotropin effects on blood pressure and fluid and electrolyte homeostasis in five strains of rats

scientific article (publication date: May 1992)

Current and potential therapeutic strategies for the management of vascular calcification in patients with chronic kidney disease including those on dialysis

scientific article published on 07 May 2018

Development of second generation peptides modulating cellular adiponectin receptor responses.

scientific article

Dipyridamole inhibits in vitro renal fibroblast proliferation and collagen synthesis.

scientific article

Diurnal variation and short-term pre-analytical stability of serum soluble α-klotho in healthy volunteers: a pilot study

scientific article published on 21 November 2014

Editorial: Novel Therapeutic Targets and Emerging Treatments for Fibrosis

scientific article published on 14 November 2017

Effect of dietary calcium on the development of hypertension and hypertensive vascular lesions in DOCA-salt and two-kidney, one clip hypertensive rats

scientific article published on 01 February 1994

Effect of inhibition of farnesylation and geranylgeranylation on renal fibrogenesis in vitro

scientific article published on 20 September 2005

Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis

scientific article published on 09 November 2006

Endothelin and endothelin A/B receptors are increased after ischaemic acute renal failure

scientific article published on 01 January 2001

Epigenetic Modifications to H3K9 in Renal Tubulointerstitial Cells after Unilateral Ureteric Obstruction and TGF-β1 Stimulation

scientific article

Estrogens do not protect, but androgens exacerbate, collagen accumulation in the female mouse kidney after ureteric obstruction

scientific article published on 29 June 2016

Evolution of tubulointerstitial fibrosis in experimental renal infection and scarring

scientific article published on 01 April 1998

Explanting is an ex vivo model of renal epithelial-mesenchymal transition.

scientific article

FGF23 activates injury-primed renal fibroblasts via FGFR4-dependent signalling and enhancement of TGF-β autoinduction

scientific article

FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts

scientific article

Fetuin-A in the peritoneal effluent of patients with encapsulating peritoneal sclerosis-more than a protein?

scientific article

Fibrosis in the kidney: is a problem shared a problem halved?

scientific article

Glomerular density and progression

scientific article published on 01 May 2012

Glomerulosclerosis and hyalinosis in rabbits

scientific article published on 01 July 1992

High-intensity physical exercise increases serum -klotho levels in healthy volunteers

scientific article published on 01 January 2018

Histochemical localization of apoptosis with in situ labeling of fragmented DNA.

scientific article published on January 2006

Histochemical localization of cell proliferation using in situ hybridization for histone mRNA.

scientific article published on January 2006

Human renal fibroblast contraction of collagen I lattices is an integrin-mediated process

scientific article published on 01 November 2000

Hyaluronan and rat renal fibroblasts: in vitro studies

scientific article published on 01 August 2001

Hypoxia and hypoxia signaling in tissue repair and fibrosis.

scientific article published on January 2012

Hypoxia in tissue repair and fibrosis

scientific article

Immuno and lectin histochemistry for renal light microscopy

scientific article published on 01 January 2009

Impact of statin treatment on 1-year functional and histologic renal allograft outcome.

scientific article published in August 2005

In situ end-labeling of fragmented DNA and the localization of apoptosis

scientific article published on 01 January 2000

In situ hybridization using cRNA probes: isotopic and nonisotopic detection methods.

scientific article published on January 2006

In situ localization of apoptosis using TUNEL

scientific article published on 01 January 2010

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice.

scientific article published on 23 June 2015

Interstitial myofibroblasts in IgA glomerulonephritis.

scientific article published on January 1995

Intracellular cyclic nucleotide analogues inhibit in vitro mitogenesis and activation of fibroblasts derived from obstructed rat kidneys

scientific article published on 01 January 2004

Ischemic acute renal failure: Long-term histology of cell and matrix changes in the rat

scientific article published on 01 June 2000

Laser Capture Microdissection of Archival Kidney Tissue for qRT-PCR.

scientific article published in January 2016

Long-term mineralocorticoid receptor blockade ameliorates progression of experimental diabetic renal disease.

scientific article published on 8 September 2011

Longitudinal changes in bone and mineral metabolism after cessation of cinacalcet in dialysis patients with secondary hyperparathyroidism.

scientific article

Lovastatin downregulates renal myofibroblast function in vitro

scientific article published on 01 August 2002

Macrophage and myofibroblast involvement in ischemic acute renal failure is attenuated by endothelin receptor antagonists

scientific article published on 01 January 1999

Mineral adaptations following kidney transplantation

scientific article published on 25 January 2017

Myofibroblast involvement in chronic transplant rejection

scientific article published on 01 October 1997

Myofibroblasts and arteriolar sclerosis in human diabetic nephropathy

scientific article published on 01 June 1997

Parenteral iron polymaltose changes i:c-terminal FGF23 ratios in iron deficiency, but not in dialysis patients.

scientific article published on 16 November 2016

Pharmacological intervention in renal fibrosis and vascular sclerosis.

scientific article

Phosphate levels--time for a rethink?

scientific article published on 14 May 2009

Pirfenidone reduces in vitro rat renal fibroblast activation and mitogenesis.

scientific article

Platelet-derived growth factor mesangial deposits in mesangial IgA glomerulonephritis

scientific article published on 01 January 1991

Profiling histone modifications in the normal mouse kidney and after unilateral ureteric obstruction

scientific article published on 03 July 2019

Progression of Tubulointerstitial Fibrosis and the Chronic Kidney Disease Phenotype - Role of Risk Factors and Epigenetics

scientific article

Propagation and Culture of Human Renal Fibroblasts

scientific article published on 01 January 2016

Qualitative and Quantitative Analysis of Histone Deacetylases in Kidney Tissue Sections

scientific article published in January 2016

Qualitative and quantitative analysis of fibrosis in the kidney

scientific article published on 01 November 2014

Quantitation of in situ hybridization using image analysis of radioactively labeled RNA probes

scientific article published on 01 January 2002

Relationship between timed and spot urine collections for measuring phosphate excretion.

scientific article published on 14 November 2015

Relative abundance of fetuin- A in peritoneal dialysis effluent and its association with in situ formation of calciprotein particles: an observational pilot study

scientific article published on 01 January 2015

Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy

scientific article published on 03 April 2008

Relaxin and the progression of kidney disease.

scientific article published on January 2009

Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro

scientific article published on 01 March 2004

Relaxin in cardiovascular and renal disease.

scientific article

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

scientific journal article

Relaxin regulates collagen overproduction associated with experimental progressive renal fibrosis

scientific article published on 01 May 2005

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

scientific article published on 15 January 2014

Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS.

scientific article

Renal myofibroblasts contract collagen I matrix lattices in vitro

scientific article published on 01 January 1999

Renal tubulointerstitial fibrosis: common but never simple.

scientific article published on 14 January 2009

Role of the phosphatidylinositol 3-kinase and mTOR pathways in the regulation of renal fibroblast function and differentiation

scientific article published on 18 August 2006

SELDI-TOF mass spectrometry-based protein profiling of kidney tissue.

scientific article

Serelaxin is a more efficacious antifibrotic than enalapril in an experimental model of heart disease.

scientific article published in August 2014

Small animal models of kidney disease: a review.

scientific article published on January 2009

Soluble klotho may be a marker of phosphate reabsorption.

scientific article

TGF-β1 modifies histone acetylation and acetyl-coenzyme A metabolism in renal myofibroblasts

scientific article published on 09 January 2019

Targeted urine microscopy in Anderson-Fabry disease: a cheap, sensitive and specific diagnostic technique.

scientific article published on 7 March 2011

The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate.

scientific article published on 31 March 2016

The Fibrosis Across Organs Symposium: A Roadmap for Future Research Priorities

scientific article published on 01 May 2019

The Role of Secondary Calciprotein Particles in the Mineralisation Paradox of Chronic Kidney Disease.

scientific article

The anti-fibrotic hormone relaxin is not reno-protective, despite being active, in an experimental model of type 1 diabetes

scientific article published on 01 September 2013

The effects of relaxin and estrogen deficiency on collagen deposition and hypertrophy of nonreproductive organs.

scientific article published on 24 August 2006

The importance of klotho in phosphate metabolism and kidney disease

scientific article published on August 2014

The interstitium in renal disease

scientific article published on 01 August 1997

The phenotype and fate of the antibody-forming cells of the splenic foci

scientific article published on 01 February 1996

The role of tubulointerstitial injury in chronic renal failure.

scientific article

The significance of focal and segmental hyalinosis and sclerosis (FSHS) and nephrotic range proteinuria in IgA nephropathy.

scientific article published in October 1996

Therapeutic effects of serelaxin in acute heart failure.

scientific article published on 23 January 2014

Thrombin is a pro-fibrotic factor for rat renal fibroblasts in vitro.

scientific article published on 7 June 2005

Tissue factor pathway inhibitor expression in human crescentic glomerulonephritis.

scientific article

Tissue preparation for histochemistry: fixation, embedding, and antigen retrieval for light microscopy

scientific article published on 01 January 2010

Urinary platelet factor four (Pf4) levels in mesangial IgA glomerulonephritis and thin basement membrane disease

scientific article published on January 1, 1992

Using in situ hybridisation to localize renal gene expression in tissue sections

scientific article published on 01 January 2009

Vascular expression of clusterin in experimental cyclosporine nephrotoxicity

scientific article published on 01 July 1995

cRNA probes: comparison of isotopic and nonisotopic detection methods

scientific article published on 01 January 2000

αKlotho-FGF23 interactions and their role in kidney disease: a molecular insight

scientific article published on 26 July 2019

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