List of works - Shailja Singh

A C2 domain containing plasma membrane protein of Plasmodium falciparum merozoites mediates calcium-dependent binding and invasion to host erythrocytes

scientific article published in 2022

A De novo Peptide from a High Throughput Peptide Library Blocks Myosin A -MTIP Complex Formation in Plasmodium falciparum

scientific article published on 26 August 2020

A natural product based DOS library of hybrid systems

scientific article published on 14 March 2015

A novel spiroindoline targets cell cycle and migration via modulation of microtubule cytoskeleton

scientific article

A small bioactive glycoside inhibits epsilon toxin and prevents cell death ⬇️

scientific article published on 10 October 2019

A thrombospondin structural repeat containing rhoptry protein from Plasmodium falciparum mediates erythrocyte invasion

scientific article (publication date: August 2013)

Ca2+-mediated exocytosis of subtilisin-like protease 1: a key step in egress ofPlasmodium falciparummerozoites ⬇️

scientific article published on December 28, 2012

Calcium-dependent permeabilization of erythrocytes by a perforin-like protein during egress of malaria parasites

scientific article (publication date: 2013)

Calcium-dependent phosphorylation of Plasmodium falciparum serine repeat antigen-5 triggers merozoite egress

scientific article

Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion

scientific article published in July 2013

Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion. ⬇️

scientific article published on 30 November 2012

Chorismate synthase mediates cerebral malaria pathogenesis by eliciting salicylic acid dependent autophagy response in parasite

scientific article published on 02 December 2020

Correction to: Enhanced uptake, high selective and microtubule disrupting activity of carbohydrate fused pyrano-pyranones derived from natural coumarins attributes to its anti-malarial potential

scientific article published on 24 March 2020

Cytotoxic effect of carotenoid phytonutrient lycopene on P. falciparum infected erythrocytes

scientific article published on 27 September 2014

Decoding Crucial LncRNAs Implicated in Neurogenesis and Neurological Disorders

scientific article published on 17 January 2017

Deconvolution of Human Brain Cell Type Transcriptomes Unraveled Microglia-Specific Potential Biomarkers.

scientific article

Design and synthesis of imidazolidinone derivatives as potent anti-leishmanial agents by bioisosterism

scientific article published on 25 February 2019

Design, synthesis and biological evaluation of small molecules as potent glucosidase inhibitors

scientific article published on 30 April 2015

Designing synthetic drugs against Plasmodium falciparum: a computational study of histone-lysine N-methyltransferase (PfHKMT)

scientific article

Development of novel anti-malarial from structurally diverse library of molecules, targeting plant-like CDPK1, a multistage growth regulator of P. falciparum

scientific article published on 13 May 2020

Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites

scientific article (publication date: February 2010)

Diversity oriented synthesis for novel anti-malarials.

scientific article

Dynamic Palmitoylation of Red Cell Membrane Proteins Governs Susceptibility to Invasion by the Malaria Parasite, Plasmodium falciparum

scientific article published in 2022

Enhanced uptake, high selective and microtubule disrupting activity of carbohydrate fused pyrano-pyranones derived from natural coumarins attributes to its anti-malarial potential

scientific article published on 11 October 2019

Erratum to: Diversity oriented synthesis for novel anti-malarials

scientific article published on 18 July 2015

Flow cytometry-based methods for measurement of cytosolic calcium and surface protein expression in Plasmodium falciparum merozoites.

scientific article published in January 2013

Highly potent anti-malarial activity of benzopyrano(4,3-b)benzopyran derivatives and in silico interaction analysis with putative target Plasmodium falciparum lactate dehydrogenase

scientific article published on 08 January 2021

Identification and Characterization of a Novel Palmitoyl Acyltransferase as a Druggable Rheostat of Dynamic Palmitoylome in L. donovani.

scientific article published on 20 June 2018

Identification and functional characterization of a bacterial homologue of Zeta toxin in Leishmania donovani

scientific article published on 24 May 2019

Immunogenicity of a recombinant malaria vaccine based on receptor binding domain of Plasmodium falciparum EBA-175.

scientific article published on 27 September 2006

In silico analysis of calcium binding pocket of perforin like protein 1: insights into the regulation of pore formation

scientific article published on 8 April 2015

In silico characterization of Plasmodium falciparum purinergic receptor: a novel chemotherapeutic target

scientific article

Interaction of Plasmodium falciparum apicortin with α- and β-tubulin is critical for parasite growth and survival.

scientific article published on 25 February 2021

Localization of apical sushi protein in Plasmodium falciparum merozoites

scientific article (publication date: November 2010)

Metalloprotease Gp63-Targeting Novel Glycoside Exhibits Potential Antileishmanial Activity

scientific article published on 04 May 2022

Molecular Signaling Involved in Entry and Exit of Malaria Parasites from Host Erythrocytes.

scientific article

Molecular dynamics simulations and biochemical characterization of Pf14-3-3 and PfCDPK1 interaction towards its role in growth of human malaria parasite

scientific article published on 02 June 2020

Natural Product Inspired Novel Indole based Chiral Scaffold Kills Human Malaria Parasites via Ionic Imbalance Mediated Cell Death

scientific article published on 28 November 2019

Novel β-carboline-quinazolinone hybrids disrupt Leishmania donovani redox homeostasis and show promising antileishmanial activity

scientific article

Pathogen induced subversion of NAD+ metabolism mediating host cell death: a target for development of chemotherapeutics

scientific article published on 13 January 2021

Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytes

scientific article (publication date: May 2014)

Phosphatidic acid homeostasis regulated by a type-2 phosphatidic acid phosphatase represents a novel druggable target in malaria intervention.

scientific article published in January 2019

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

scientific article

Phosphorylation-Dependent Assembly of a 14-3-3 Mediated Signaling Complex during Red Blood Cell Invasion by Plasmodium falciparum Merozoites

scientific article published on 18 August 2020

Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes

scientific article (publication date: 9 November 2016)

Plasmodium Perforin-Like Protein Pores on the Host Cell Membrane Contribute in Its Multistage Growth and Erythrocyte Senescence

scientific article published on 24 March 2020

Plasmodium falciparum PhIL1-associated complex plays an essential role in merozoite reorientation and invasion of host erythrocytes

scientific article published on 29 July 2021

Plasmodium falciparum reticulocyte binding-like homologue protein 2 (PfRH2) is a key adhesive molecule involved in erythrocyte invasion ⬇️

scientific article

Plasmodium palmitoylation machinery engineered in for high-throughput screening of palmitoyl acyl-transferase inhibitors

Pleiotropic roles of cold shock proteins with special emphasis on unexplored cold shock protein member of Plasmodium falciparum

scientific article published on 27 October 2020

Prefoldin subunit 6 of Plasmodium falciparum binds merozoite surface protein-1 (MSP-1)

scientific article published on 03 November 2020

Protein S-Palmitoylation Is Responsive to External Signals and Plays a Regulatory Role in Microneme Secretion in Plasmodium falciparum Merozoites

scientific article published on 14 February 2020

Receptor-binding residues lie in central regions of Duffy-binding-like domains involved in red cell invasion and cytoadherence by malaria parasites.

scientific article published on 2 September 2004

Reduction of Sphingosine Kinase 1 Phosphorylation and Activity in Plasmodium-Infected Erythrocytes ⬇️

scientific article published on 03 March 2020

Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of 'Papain Superfamily' Cysteine Proteases

scientific article published on 23 December 2020

Role of a patatin-like phospholipase in Plasmodium falciparum gametogenesis and malaria transmission

scientific article published on 14 August 2019

Role of calcineurin and actin dynamics in regulated secretion of microneme proteins inPlasmodium falciparummerozoites during erythrocyte invasion ⬇️

scientific article published on August 21, 2013

Role of exchange protein directly activated by cAMP (EPAC1) in breast cancer cell migration and apoptosis

scientific article

Screening of chemical library against whole cell kinome activity via non-radioactive, high throughput kinase assay

Signalling mechanisms involved in apical organelle discharge during host cell invasion by apicomplexan parasites.

scientific article published on 23 May 2012

Spiro[pyrrolidine-3, 3´-oxindole] as potent anti-breast cancer compounds: Their design, synthesis, biological evaluation and cellular target identification

scientific article

Structural analogs of sialic acid interfere with the binding of erythrocyte binding antigen-175 to glycophorin A, an interaction crucial for erythrocyte invasion by Plasmodium falciparum.

scientific article published in November 2004

Structural insights into a key carotenogenesis related enzyme phytoene synthase of P. falciparum: a novel drug target for malaria

scientific article

Synthesis of novel 5-arylidenethiazolidinones with apoptotic properties via a three component reaction using piperidine as a bifunctional reagent.

scientific article

Targeted repression of Plasmodium apicortin by host microRNA impairs malaria parasite growth and invasion

scientific article published on 03 June 2020

Targeting a Reticulocyte Binding Protein and Duffy Binding Protein to Inhibit Reticulocyte Invasion by Plasmodium vivax. ⬇️

scientific article published on 12 July 2018

The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytes ⬇️

scientific article (publication date: December 2014)

Visualization and quantification of Plasmodium falciparum intraerythrocytic merozoites

scientific article published on 5 April 2015

List of works by Shailja Singh

A C2 domain containing plasma membrane protein of Plasmodium falciparum merozoites mediates calcium-dependent binding and invasion to host erythrocytes

A De novo Peptide from a High Throughput Peptide Library Blocks Myosin A -MTIP Complex Formation in Plasmodium falciparum

A natural product based DOS library of hybrid systems

A novel spiroindoline targets cell cycle and migration via modulation of microtubule cytoskeleton

A small bioactive glycoside inhibits epsilon toxin and prevents cell death ⬇️

A thrombospondin structural repeat containing rhoptry protein from Plasmodium falciparum mediates erythrocyte invasion

Ca2+-mediated exocytosis of subtilisin-like protease 1: a key step in egress ofPlasmodium falciparummerozoites ⬇️

Calcium-dependent permeabilization of erythrocytes by a perforin-like protein during egress of malaria parasites

Calcium-dependent phosphorylation of Plasmodium falciparum serine repeat antigen-5 triggers merozoite egress

Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion

Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion. ⬇️

Chorismate synthase mediates cerebral malaria pathogenesis by eliciting salicylic acid dependent autophagy response in parasite

Correction to: Enhanced uptake, high selective and microtubule disrupting activity of carbohydrate fused pyrano-pyranones derived from natural coumarins attributes to its anti-malarial potential

Cytotoxic effect of carotenoid phytonutrient lycopene on P. falciparum infected erythrocytes

Decoding Crucial LncRNAs Implicated in Neurogenesis and Neurological Disorders

Deconvolution of Human Brain Cell Type Transcriptomes Unraveled Microglia-Specific Potential Biomarkers.

Design and synthesis of imidazolidinone derivatives as potent anti-leishmanial agents by bioisosterism

Design, synthesis and biological evaluation of small molecules as potent glucosidase inhibitors

Designing synthetic drugs against Plasmodium falciparum: a computational study of histone-lysine N-methyltransferase (PfHKMT)

Development of novel anti-malarial from structurally diverse library of molecules, targeting plant-like CDPK1, a multistage growth regulator of P. falciparum

Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites

Diversity oriented synthesis for novel anti-malarials.

Dynamic Palmitoylation of Red Cell Membrane Proteins Governs Susceptibility to Invasion by the Malaria Parasite, <i>Plasmodium falciparum</i>

Enhanced uptake, high selective and microtubule disrupting activity of carbohydrate fused pyrano-pyranones derived from natural coumarins attributes to its anti-malarial potential

Erratum to: Diversity oriented synthesis for novel anti-malarials

Flow cytometry-based methods for measurement of cytosolic calcium and surface protein expression in Plasmodium falciparum merozoites.

Highly potent anti-malarial activity of benzopyrano(4,3-b)benzopyran derivatives and <i>in silico</i> interaction analysis with putative target <i>Plasmodium falciparum</i> lactate dehydrogenase

Identification and Characterization of a Novel Palmitoyl Acyltransferase as a Druggable Rheostat of Dynamic Palmitoylome in L. donovani.

Identification and functional characterization of a bacterial homologue of Zeta toxin in Leishmania donovani

Immunogenicity of a recombinant malaria vaccine based on receptor binding domain of Plasmodium falciparum EBA-175.

In silico analysis of calcium binding pocket of perforin like protein 1: insights into the regulation of pore formation

In silico characterization of Plasmodium falciparum purinergic receptor: a novel chemotherapeutic target

Interaction of Plasmodium falciparum apicortin with α- and β-tubulin is critical for parasite growth and survival.

Localization of apical sushi protein in Plasmodium falciparum merozoites

Metalloprotease Gp63-Targeting Novel Glycoside Exhibits Potential Antileishmanial Activity

Molecular Signaling Involved in Entry and Exit of Malaria Parasites from Host Erythrocytes.

Molecular dynamics simulations and biochemical characterization of Pf14-3-3 and PfCDPK1 interaction towards its role in growth of human malaria parasite

Natural Product Inspired Novel Indole based Chiral Scaffold Kills Human Malaria Parasites via Ionic Imbalance Mediated Cell Death

Novel β-carboline-quinazolinone hybrids disrupt Leishmania donovani redox homeostasis and show promising antileishmanial activity

Pathogen induced subversion of NAD<sup>+</sup> metabolism mediating host cell death: a target for development of chemotherapeutics

Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytes

Phosphatidic acid homeostasis regulated by a type-2 phosphatidic acid phosphatase represents a novel druggable target in malaria intervention.

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

Phosphorylation-Dependent Assembly of a 14-3-3 Mediated Signaling Complex during Red Blood Cell Invasion by Plasmodium falciparum Merozoites

Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes

Plasmodium Perforin-Like Protein Pores on the Host Cell Membrane Contribute in Its Multistage Growth and Erythrocyte Senescence

Plasmodium falciparum PhIL1-associated complex plays an essential role in merozoite reorientation and invasion of host erythrocytes

Plasmodium falciparum reticulocyte binding-like homologue protein 2 (PfRH2) is a key adhesive molecule involved in erythrocyte invasion ⬇️

Plasmodium palmitoylation machinery engineered in for high-throughput screening of palmitoyl acyl-transferase inhibitors

Pleiotropic roles of cold shock proteins with special emphasis on unexplored cold shock protein member of Plasmodium falciparum

Prefoldin subunit 6 of Plasmodium falciparum binds merozoite surface protein-1 (MSP-1)

Protein S-Palmitoylation Is Responsive to External Signals and Plays a Regulatory Role in Microneme Secretion in Plasmodium falciparum Merozoites

Receptor-binding residues lie in central regions of Duffy-binding-like domains involved in red cell invasion and cytoadherence by malaria parasites.

Reduction of Sphingosine Kinase 1 Phosphorylation and Activity in Plasmodium-Infected Erythrocytes ⬇️

Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of 'Papain Superfamily' Cysteine Proteases

Role of a patatin-like phospholipase in Plasmodium falciparum gametogenesis and malaria transmission

Role of calcineurin and actin dynamics in regulated secretion of microneme proteins inPlasmodium falciparummerozoites during erythrocyte invasion ⬇️

Role of exchange protein directly activated by cAMP (EPAC1) in breast cancer cell migration and apoptosis

Screening of chemical library against whole cell kinome activity via non-radioactive, high throughput kinase assay

Signalling mechanisms involved in apical organelle discharge during host cell invasion by apicomplexan parasites.

Spiro[pyrrolidine-3, 3´-oxindole] as potent anti-breast cancer compounds: Their design, synthesis, biological evaluation and cellular target identification

Structural analogs of sialic acid interfere with the binding of erythrocyte binding antigen-175 to glycophorin A, an interaction crucial for erythrocyte invasion by Plasmodium falciparum.

Structural insights into a key carotenogenesis related enzyme phytoene synthase of P. falciparum: a novel drug target for malaria

Synthesis of novel 5-arylidenethiazolidinones with apoptotic properties via a three component reaction using piperidine as a bifunctional reagent.

Targeted repression of Plasmodium apicortin by host microRNA impairs malaria parasite growth and invasion

Targeting a Reticulocyte Binding Protein and Duffy Binding Protein to Inhibit Reticulocyte Invasion by Plasmodium vivax. ⬇️

The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytes ⬇️

Visualization and quantification of Plasmodium falciparum intraerythrocytic merozoites