Search filters

List of works by Manuel Carlos López

A 12-mer repetitive antigenic epitope from Trypanosoma cruzi is a potential marker of therapeutic efficacy in chronic Chagas' disease.

scientific article published on 12 April 2016

A DEVH-box RNA Helicase from Leishmania braziliensis is Associated to mRNA Cytoplasmic Granules.

scientific article

A Parasite Biomarker Set for Evaluating Benznidazole Treatment Efficacy in Patients with Chronic Asymptomatic Trypanosoma cruzi Infection

scientific article published on 23 September 2019

A head-to-tail tandem organization of hsp70 genes in Trypanosoma cruzi

scientific article published in February 1988

A potential Z-DNA-forming sequence is located between two transcription units alternatively expressed during development of Drosophila hydei

scientific article

A trial of the synthetic malaria vaccine SPf66 in Tanzania: rationale and design

scientific article

Activity of rhodium(III) complexes against Trypanosoma cruzi

scientific article published in February 1988

Altering the motility of Trypanosoma cruzi with rabbit polyclonal anti-peptide antibodies reduces infection to susceptible mammalian cells.

scientific article published on 26 January 2015

An observational longitudinal study to evaluate tools and strategies available for the diagnosis of Congenital Chagas Disease in a non-endemic country

scientific article published on 05 August 2019

Antiparasitic Treatment Induces an Improved CD8+ T Cell Response in Chronic Chagasic Patients.

scientific article published on 3 March 2017

Antitrypanosomal action of cis-diamminedichloroplatinum (II) analogs

article published in 1987

Benznidazole treatment reduces the induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity in Chagas disease symptomatic patients

scientific article published in May 2013

Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review.

scientific article published on April 2014

Biology of Trypanosoma cruzi Retrotransposons: From an Enzymatic to a Structural Point of View.

scientific article published in February 2018

Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives

scientific article published on 28 April 2015

Breaking the non-responsiveness of C57BL/6 mice to the malarial antigen EB200--the role of carrier and adjuvant molecules

scientific article published in October 2003

Calcium-induced conformational changes in Leishmania infantum kinetoplastid membrane protein-11.

scientific article

Cellular Location of KMP-11 Protein in Trypanosoma rangeli

scientific article published on 01 January 2008

Chagasic patients are able to respond against a viral antigen from influenza virus.

scientific article

Changes in saliva of dogs with canine leishmaniosis: A proteomic approach

scientific article published on 28 June 2019

Characterising the KMP-11 and HSP-70 recombinant antigens' humoral immune response profile in chagasic patients.

scientific article

Characterization of SPf(66)n: a chimeric molecule used as a malaria vaccine.

scientific article

Characterization of a highly repeated interspersed DNA sequence of Trypanosoma cruzi: its potential use in diagnosis and strain classification

scientific article

Characterization of a non-long terminal repeat retrotransposon cDNA (L1Tc) from Trypanosoma cruzi: homology of the first ORF with the ape family of DNA repair enzymes.

scientific article published on March 1995

Characterization of a short interspersed reiterated DNA sequence of Trypanosoma cruzi located at the 3'-end of a poly(A)+ transcript.

scientific article published in September 1994

Characterization of an immunodominant antigenic epitope from Trypanosoma cruzi as a biomarker of chronic Chagas' disease pathology.

scientific article published on 7 December 2011

Characterization of reverse transcriptase activity of the L1Tc retroelement from Trypanosoma cruzi

scientific article published in December 2003

Complete nucleotide sequence of the hsp70 gene of T. cruzi

scientific article published on January 1989

Control mechanisms of the H2A genes expression in Trypanosoma cruzi

scientific article published in May 1998

Cytoplasmic-nuclear translocation of the Hsp70 protein during environmental stress in Trypanosoma cruzi

scientific article published on 01 November 1993

DNA binding properties and antileukemic (L1210) activity of a Pt-pentamidine complex

scientific article published on January 1991

DNA immunization with Trypanosoma cruzi HSP70 fused to the KMP11 protein elicits a cytotoxic and humoral immune response against the antigen and leads to protection.

scientific article

Dataset for distribution of SIDER2 elements in the Leishmania major genome and transcriptome.

scientific article published on 10 January 2017

Diagnosis of infections with Leishmania infantum using PCR-ELISA

scientific article published on 01 June 2001

Differential CD86 and CD40 co-stimulatory molecules and cytokine expression pattern induced by Trypanosoma cruzi in APCs from resistant or susceptible mice

scientific article published on 01 January 2003

Differential phenotypic and functional profiles of TcCA-2 -specific cytotoxic CD8+ T cells in the asymptomatic versus cardiac phase in Chagasic patients.

scientific article published on 27 March 2015

Do non-long terminal repeat retrotransposons have nuclease activity?

scientific article published in August 1996

Dynamics of T cells repertoire during Trypanosoma cruzi infection and its post-treatment modulation

article

Effect of secondary anchor amino acid substitutions on the immunogenic properties of an HLA-A*0201-restricted T cell epitope derived from the Trypanosoma cruzi KMP-11 protein

scientific article published on 5 February 2016

Effect of storage on acetylcholinesterase activity

scientific article published on 01 February 1986

Evaluating Chagas disease progression and cure through blood-derived biomarkers: a systematic review

scientific article

Evaluation of IFN-gamma production by CD8+ T lymphocytes in response to the K1 peptide from KMP-11 protein in patients infected with Trypanosoma cruzi

article

Expression of inhibitory receptors and polyfunctional responses of T cells are linked to the risk of congenital transmission of T. cruzi

scientific article

Frequency of specific CD8+ T cells for a promiscuous epitope derived from Trypanosoma cruzi KMP-11 protein in chagasic patients

scientific article published in July 2010

Genomic cartography and proposal of nomenclature for the repeated, interspersed elements of the Leishmania major SIDER2 family and identification of SIDER2-containing transcripts.

scientific article published on 26 December 2016

Genomic clustering of the Trypanosoma cruzi nonlong terminal L1Tc retrotransposon with defined interspersed repeated DNA elements

scientific article published on 01 August 2000

Genomic repetitive DNA elements of Trypanosoma cruzi

scientific article published on 01 July 1996

HSP70 from Trypanosoma cruzi is endowed with specific cell proliferation potential leading to apoptosis

scientific article published on 01 December 2000

Identification of HLA-A∗02:01-restricted CTL epitopes in Trypanosoma cruzi heat shock protein-70 recognized by Chagas disease patients.

scientific article published on 12 June 2011

Identification of a Trypanosoma cruzi antigenic epitope implicated in the infectivity of fibroblast LLC-MK2 cells.

scientific article published on January 1997

Identification of a type I nitroreductase gene in non-virulent Trypanosoma rangeli.

scientific article published on July 2017

Identification of an hepatitis delta virus-like ribozyme at the mRNA 5'-end of the L1Tc retrotransposon from Trypanosoma cruzi

scientific article

Identification of non-autonomous non-LTR retrotransposons in the genome of Trypanosoma cruzi

scientific article published on 01 September 2002

Immune responses to Plasmodium falciparum antigens during a malaria vaccine trial in Tanzanian children

scientific article

Immunogenicity of HSP-70, KMP-11 and PFR-2 leishmanial antigens in the experimental model of canine visceral leishmaniasis

article

Immunological and structural characterization of an epitope from the Trypanosoma cruzi KMP-11 protein

article

Impact of benznidazole treatment on the functional response of Trypanosoma cruzi antigen-specific CD4+CD8+ T cells in chronic Chagas disease patients.

scientific article published on 11 May 2018

Inhibitory Receptor Expression on CD8+ T Cells Is Linked to Functional Responses against Trypanosoma cruzi Antigens in Chronic Chagasic Patients.

scientific article published on 18 September 2015

Isolation and characterization of the gene encoding histone H2A from Trypanosoma cruzi

scientific article published in March 1994

L1Tc non-LTR retrotransposons from Trypanosoma cruzi contain a functional viral-like self-cleaving 2A sequence in frame with the active proteins they encode

scientific article published on 01 June 2006

Label-free quantitative proteomic analysis reveals potential biomarkers for early healing in cutaneous leishmaniasis

scientific article published on 11 January 2019

Locations of Z-DNA in polytene chromosomes.

scientific article

Longitudinal monitoring of anti-saliva antibodies as markers of repellent efficacy against Phlebotomus perniciosus and Phlebotomus papatasi in dogs

scientific article published on 18 November 2018

Mapping of the antigenic determinants of the T. cruzi kinetoplastid membrane protein-11. Identification of a linear epitope specifically recognized by human Chagasic sera

scientific article

Microbial heat shock protein 70 stimulatory properties have different TLR requirements

scientific article published on 05 October 2006

Mode of action of intercalating drug, cis-Pt(II)(DDH)Cl2, cis-Pt(II)(DDH) (metafluorobenzoic)2, and cis-Pt(II)(DDH)(mucubromic)2, on Trypanosoma cruzi

scientific article published on 01 March 1987

Molecular and immunological characterization of L14 ribosomal protein from Leishmania braziliensis.

scientific article published in February 2004

Molecular characterization of KMP11 from Trypanosoma cruzi: a cytoskeleton-associated protein regulated at the translational level

scientific article published on 01 January 2000

Molecular characterization of calcineurin B from the non-virulent Trypanosoma rangeli kinetoplastid indicates high gene conservation

scientific article published on 16 May 2013

Molecular characterization of the histone H2A gene from the parasite Trypanosoma rangeli.

scientific article published in November 2000

Molecular characterization of the kinetoplastid membrane protein-11 genes from the parasite Trypanosoma rangeli

scientific article published on 01 June 2005

Molecular characterization of the short interspersed repetitive element SIRE in the six discrete typing units (DTUs) of Trypanosoma cruzi.

scientific article published on 28 June 2012

Molecular cloning of a Drosophila potential Z-DNA forming sequence hybridizing in situ to a developmentally regulated subdivision of the polytene chromosomes

scientific article

Monocyte-derived dendritic cells from chagasic patients vs healthy donors secrete differential levels of IL-10 and IL-12 when stimulated with a protein fragment of Trypanosoma cruzi heat-shock protein-70

scientific article published on 8 January 2008

Multiprimer PCR system for differential identification of mycobacteria in clinical samples.

scientific article published on February 1996

Natural CD4+ T-cell responses against Trypanosoma cruzi KMP-11 protein in chronic chagasic patients

scientific article published on 28 October 2008

Nucleic-acid-binding properties of the C2-L1Tc nucleic acid chaperone encoded by L1Tc retrotransposon

scientific article published on 10 December 2009

One-year follow-up of anti-Leishmania antibody concentrations in serum and saliva from experimentally infected dogs

scientific article published on 13 September 2019

Oral transmission of Chagas disease: typing of Trypanosoma cruzi from five outbreaks occurred in Venezuela shows multiclonal and common infections in patients, vectors and reservoirs

scientific article published on 6 April 2013

Performance of Leishmania PFR1 recombinant antigen in serological diagnosis of asymptomatic canine leishmaniosis by ELISA

scientific article published on 23 October 2017

Phage recovery by electroporation of naked DNA into host cells avoids the use of packaging extracts.

scientific article

Phenotypic and Functional Profiles of Antigen-Specific CD4 and CD8 T Cells Associated With Infection Control in Patients With Cutaneous Leishmaniasis

scientific article published on 19 November 2018

Plasticity of the histone H2A genes in a Brazilian and six Colombian strains of Trypanosoma cruzi.

scientific article

Pr77 and L1TcRz

scientific article

Promiscuous Recognition of a Trypanosoma cruzi CD8+ T Cell Epitope among HLA-A2, HLA-A24 and HLA-A1 Supertypes in Chagasic Patients.

scientific article

Rabbit serum against K1 peptide, an immunogenic epitope of the Trypanosoma cruzi KMP-11, decreases parasite invasion to cells

scientific article published on 08 June 2012

Randomised trial of efficacy of SPf66 vaccine against Plasmodium falciparum malaria in children in southern Tanzania.

scientific article published on October 1994

Regulation of hsp70 expression in Trypanosoma cruzi by temperature and growth phase

scientific article published on 01 July 1992

Reverse transcriptase-like activity in Trypanosoma cruzi

scientific article published on 01 February 1997

Risk factors and primary prevention of congenital Chagas disease in a nonendemic country.

scientific article published on 24 October 2012

SPf66, a chemically synthesized subunit malaria vaccine, is safe and immunogenic in Tanzanians exposed to intense malaria transmission

scientific article published in March 1994

Sensitive detection of cereal fractions that are toxic to celiac disease patients by using monoclonal antibodies to a main immunogenic wheat peptide

scientific article published on 01 February 2008

Sequence and expression of the Drosophila phenylalanine hydroxylase mRNA.

scientific article published in September 1990

Sequence polymorphism in the Trypanosoma rangeli HSP70 coding genes allows typing of the parasite KP1(+) and KP1(−) groups

scientific article published on 16 January 2013

Serum proteome of dogs at subclinical and clinical onset of canine leishmaniosis

scientific article published on 26 September 2019

Short-term follow-up of chagasic patients after benzonidazole treatment using multiple serological markers.

scientific article

Studies on the interaction between antitrypanosome cis-DDP analogs with dna

scientific article published on 01 July 1986

The L1Tc C-terminal domain from Trypanosoma cruzi non-long terminal repeat retrotransposon codes for a protein that bears two C2H2 zinc finger motifs and is endowed with nucleic acid chaperone activity.

scientific article published on November 2005

The L1Tc non-LTR retrotransposon of Trypanosoma cruzi contains an internal RNA-pol II-dependent promoter that strongly activates gene transcription and generates unspliced transcripts.

scientific article published on 16 March 2007

The L1Tc, long interspersed nucleotide element from Trypanosoma cruzi, encodes a protein with 3'-phosphatase and 3'-phosphodiesterase enzymatic activities

scientific article published on August 1999

The SIDER2 elements, interspersed repeated sequences that populate the Leishmania genomes, constitute subfamilies showing chromosomal proximity relationship

scientific article

The Trypanosoma rangeli histone H2A gene sequence serves as a differential marker for KP1 strains

scientific article

The Trypanosomatid Pr77-hallmark contains a downstream core promoter element essential for transcription activity of the Trypanosoma cruzi L1Tc retrotransposon.

scientific article published on 9 February 2016

The anti Z-DNA reactivity of Z-DNA forming sequences is affected by platinum antitumor drugs.

scientific article

The biology and evolution of transposable elements in parasites

scientific article published on 03 May 2010

The effect of temperature on the stability of the synthetic SPf(66)n malaria vaccine.

scientific article published in September 1995

The endonuclease NL1Tc encoded by the LINE L1Tc from Trypanosoma cruzi protects parasites from daunorubicin DNA damage.

scientific article published in April 2003

The genetic immunization with paraflagellar rod protein-2 fused to the HSP70 confers protection against late Trypanosoma cruzi infection

scientific article published on 21 July 2006

The heat shock protein hsp70 binds in vivo to subregions 2-48BC and 3-58D of the polytene chromosomes of Drosophila hydei

scientific article published in September 1990

The immunization of A2/K(b) transgenic mice with the KMP11-HSP70 fusion protein induces CTL response against human cells expressing the T. cruzi KMP11 antigen: identification of A2-restricted epitopes

scientific article published on 01 August 2001

The innate immune response status correlates with a divergent clinical course in congenital Chagas disease of twins born in a non-endemic country.

scientific article published on 19 August 2014

The non-LTR (long terminal repeat) retrotransposon L1Tc from Trypanosoma cruzi codes for a protein with RNase H activity.

scientific article published on 30 May 2002

The open reading frame 1 of the L1Tc retrotransposon of Trypanosoma cruzi codes for a protein with apurinic-apyrimidinic nuclease activity

scientific article

The stability and maturation of the H2A histone mRNAs from Trypanosoma cruzi are implicated in their post-transcriptional regulation

scientific article published on 01 January 2000

The wide expansion of hepatitis delta virus-like ribozymes throughout trypanosomatid genomes is linked to the spreading of L1Tc/ingi clade mobile elements.

scientific article

Toward the assessment of food toxicity for celiac patients: characterization of monoclonal antibodies to a main immunogenic gluten peptide.

scientific article

Towards a paradigm shift in the treatment of chronic Chagas disease.

scientific article

Towards the physical map of the Trypanosoma cruzi nuclear genome: construction of YAC and BAC libraries of the reference clone T. cruzi CL-Brener

scientific article

Transcriptional Profiling of Immune-Related Genes in Leishmania infantum-Infected Mice: Identification of Potential Biomarkers of Infection and Progression of Disease.

scientific article published on 26 June 2018

Trypanosoma cruzi genotyping supports a common source of infection in a school-related oral outbreak of acute Chagas disease in Venezuela.

scientific article

Trypanosoma cruzi heat-shock protein-70 kDa,alone or fused to the parasite KMP11 antigen, induces functional maturation of murine dendritic cells

scientific article published on 01 June 2002

Trypanosoma cruzi paraflagellar rod proteins 2 and 3 contain immunodominant CD8(+) T-cell epitopes that are recognized by cytotoxic T cells from Chagas disease patients.

scientific article

Z-DNA in transcriptionally active chromosomes

scientific article

[Chromosomal localization of the KMP-11 genes in the KP1(+) and KP1(-) strains of Trypanosoma rangeli]

scientific article published on 01 June 2004

[Expression of markers on dendritic cells from chronic chagasic patients stimulated with the KMP-11 protein and the K1 peptide from Trypanosoma cruzi]

scientific article published on 01 January 2007

cis-Dichloro(alpha,omega-diamino carboxylate ethyl ester)palladium(II) as Palladium(II) versus Platinum(II) Model Anticancer Drugs: Synthesis, Solution Equilibria of Their Aqua, Hydroxo, and/or Chloro Species, and in Vitro/in Vivo DNA-Binding Proper

scientific article published on 01 April 1997

Paulina is supported by:

About Paulina

Help