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List of works by Kin-Hing Lau

1,25-Dihydroxyvitamin D suppresses M1 macrophages and promotes M2 differentiation at bone injury sites

scientific article published on 06 September 2018

1,25-Dihydroxyvitamin D3 Suppresses TLR8 Expression and TLR8-Mediated Inflammatory Responses in Monocytes In Vitro and Experimental Autoimmune Encephalomyelitis In Vivo ⬇️

scientific article published on March 14, 2013

1,25-Dihydroxyvitamin D3 stimulates both alkaline phosphatase gene transcription and mRNA stability in human bone cells

scientific article published on December 1991

A Mouse Noninvasive Intraarticular Tibial Plateau Compression Loading-Induced Injury Model of Posttraumatic Osteoarthritis

scientific article published on 26 September 2019

A differential scanning calorimetric-thin-layer chromatographic study of 5-halo-2′-deoxynucleosides ⬇️

scientific article published on September 15, 1976

A mouse tumor-derived osteolytic factor stimulates bone resorption by a mechanism involving local prostaglandins production in bone

scientific article published on 01 May 1985

A novel miR17/protein tyrosine phosphatase-oc/EphA4 regulatory axis of osteoclast activity

article

A proposed mechanism of the mitogenic action of fluoride on bone cells: inhibition of the activity of an osteoblastic acid phosphatase

scientific article published on 01 September 1989

A transmembrane osteoclastic protein-tyrosine phosphatase regulates osteoclast activity in part by promoting osteoclast survival through c-Src-dependent activation of NFkappaB and JNK2

scientific article published on 15 March 2007

An Osteoclastic Transmembrane Protein-Tyrosine Phosphatase Enhances Osteoclast Activity in Part by Dephosphorylating EphA4 in Osteoclasts.

scientific article

An improved mouse Sca-1+ cell-based bone marrow transplantation model for use in gene- and cell-based therapeutic studies.

scientific article published on 8 November 2006

An osteoclastic protein-tyrosine phosphatase is a potential positive regulator of the c-Src protein-tyrosine kinase activity: a mediator of osteoclast activity.

scientific article

An osteoclastic protein-tyrosine phosphatase may play a role in differentiation and activity of human monocytic U-937 cell-derived, osteoclast-like cells.

scientific article published in October 2004

An osteoclastic protein-tyrosine phosphatase regulates the β3-integrin, syk, and shp1 signaling through respective src-dependent phosphorylation in osteoclasts ⬇️

scientific article published on March 28, 2012

Antisense oligodeoxynucleotide evidence that a unique osteoclastic protein-tyrosine phosphatase is essential for osteoclastic resorption.

scientific article

Bidirectional ephrin signaling in bone

scientific article published on 07 June 2016

Bone cell mitogenic action of fluoroaluminate and aluminum fluoride but not that of sodium fluoride involves upregulation of the insulin-like growth factor system.

scientific article

Bone loss in patients with untreated chronic obstructive pulmonary disease is mediated by an increase in bone resorption associated with hypercapnia

scientific article published on 01 November 2001

Cellular and molecular mechanisms of accelerated fracture healing by COX2 gene therapy: studies in a mouse model of multiple fractures.

scientific article published on 11 January 2013

Characterization and comparison of the intronic promoter of murine osteoclastic protein-tyrosine phosphatase, PTP-oc, with the human PTP-oc promoter.

scientific article published on 15 May 2007

Chick osteoblasts contain fluoride-sensitive acid phosphatase activity

scientific article published in September 1988

Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation ⬇️

scientific article published on July 1, 2012

Conditional Disruption of miR17~92 in Osteoclasts Led to Activation of Osteoclasts and Loss of Trabecular Bone In Part Through Suppression of the miR17-Mediated Downregulation of Protein-Tyrosine Phosphatase-oc in Mice.

scientific article published in October 2017

Conditional deletion of IGF-I in osteocytes unexpectedly accelerates bony union of the fracture gap in mice.

scientific article published on 9 August 2016

Conditional disruption of IGF-I gene in type 1α collagen-expressing cells shows an essential role of IGF-I in skeletal anabolic response to loading

scientific article published on 30 August 2011

Construction of a BAC contig for a 3 cM biologically significant region of mouse chromosome 1.

scientific article

Construction of a Tc1-like transposon Sleeping Beauty-based gene transfer plasmid vector for generation of stable transgenic mammalian cell clones

scientific article published on 01 November 2002

Cyclooxygenase 2 augments osteoblastic but suppresses chondrocytic differentiation of CD90+ skeletal stem cells in fracture sites

scientific article published on 31 July 2019

Daily Oral Magnesium Supplementation Suppresses Bone Turnover in Young Adult Males1 ⬇️

scientific article published on August 1, 1998

Deficient Arginase II Expression without Alteration in Arginase I Expression Attenuated Experimental Autoimmune Encephalomyelitis in Mice

scientific article published on 25 March 2018

Dendritic cells, engineered to overexpress 25-hydroxyvitamin D 1α-hydroxylase and pulsed with a myelin antigen, provide myelin-specific suppression of ongoing experimental allergic encephalomyelitis

scientific article

Dephosphorylation of glycogen synthase in rat heart extracts by E. coli alkaline phosphatase. Use of an exogenous phosphatase to study substrate-mediated regulation of dephosphorylation.

scientific article published in May 1982

Development of a heterologous radioimmunoassay for canine osteocalcin.

scientific article published in August 1994

Dexamethasone enhances the osteogenic effects of fluoride in human TE85 osteosarcoma cells in vitro

scientific article published on 01 May 1996

Dietary boron supplementation enhanced the action of estrogen, but not that of parathyroid hormone, to improve trabecular bone quality in ovariectomized rats.

scientific article published in January 2001

Dietary boron supplementation enhances the effects of estrogen on bone mineral balance in ovariectomized rats.

scientific article

Differential effects of bacterial toxins on mitogenic actions of sodium fluoride and those of aluminum fluoride in human TE85 osteosarcoma cells.

scientific article published in December 2001

Differential effects of two protein tyrosine kinase inhibitors, tyrphostin and genistein, on human bone cell proliferation as compared with differentiation.

scientific article published on September 1998

Direct effects of ethanol on bone resorption and formation in vitro

scientific article published on 01 April 1985

Direct lentiviral-cyclooxygenase 2 application to the tendon-bone interface promotes osteointegration and enhances return of the pull-out tensile strength of the tendon graft in a rat model of biceps tenodesis.

scientific article

Disruption of the insulin-like growth factor-1 gene in osteocytes impairs developmental bone growth in mice.

scientific article published on 29 September 2012

Effect of aging on stem cells.

scientific article published on 20 February 2017

Effects of Short-Term Calcium Depletion and Repletion on Biochemical Markers of Bone Turnover in Young Adult Women1 ⬇️

scientific article published on June 1, 1998

Effects of calcium depletion and repletion on serum insulin-like growth factor I and binding protein levels in weanling rats ⬇️

scientific article published on March 1, 1998

Efficient generation of integration-free ips cells from human adult peripheral blood using BCL-XL together with Yamanaka factors

scientific article

Efficient reprogramming of human cord blood CD34+ cells into induced pluripotent stem cells with OCT4 and SOX2 alone.

scientific article published on 22 November 2011

Erythroid Promoter Confines FGF2 Expression to the Marrow after Hematopoietic Stem Cell Gene Therapy and Leads to Enhanced Endosteal Bone Formation ⬇️

scientific article published on May 18, 2012

Evaluation of the usefulness of serum phosphatases and osteocalcin as serum markers in a calcium depletion-repletion rat model ⬇️

scientific article published on February 1, 1991

Evidence for a lack of functional receptors for nerve growth factor (NGF) in chick bone cells in vitro

scientific article published on October 7, 1992

Ex vivo gene therapy with stromal cells transduced with a retroviral vector containing the BMP4 gene completely heals critical size calvarial defect in rats.

scientific article

Expression of the fibroblast growth factor receptor genes in fracture repair

scientific article published on 01 October 2002

Extracellular signal-regulated kinase-1 and -2 are both essential for the shear stress-induced human osteoblast proliferation.

scientific article

Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways.

scientific article published in March 2003

Fluid shear stress synergizes with insulin-like growth factor-I (IGF-I) on osteoblast proliferation through integrin-dependent activation of IGF-I mitogenic signaling pathway.

scientific article

Fluoride and bovine bone extract influence cell proliferation and phosphatase activities in human bone cell cultures

scientific article published on August 1, 1988

Fluoride at mitogenic doses induces a sustained activation of p44mapk, but not p42mapk, in human TE85 osteosarcoma cells

scientific article published on 01 April 1997

Fracture healing in mice deficient in plasminogen activator inhibitor-1.

scientific article published on 27 September 2008

Generation of Mesenchymal Stem Cells by Blood Cell Reprogramming

scientific article published on 31 May 2015

High osteoblastic activity in C3H/HeJ mice compared to C57BL/6J mice is associated with low apoptosis in C3H/HeJ osteoblasts

article published in 2006

In Vivo Generation of Gut-Homing Regulatory T Cells for the Suppression of Colitis

scientific article published on 03 May 2019

In vivo and in vitro evidence that the high osteoblastic activity in C3H/HeJ mice compared to C57BL/6J mice is intrinsic to bone cells

scientific article published on 01 September 2004

In vivo bone formation in fracture repair induced by direct retroviral-based gene therapy with bone morphogenetic protein-4.

scientific article published in June 2003

Interactions of growth factors present in bone matrix with bone cells: effects on DNA synthesis and alkaline phosphatase.

scientific article

LMP-1 retroviral gene therapy influences osteoblast differentiation and fracture repair: a preliminary study.

scientific article

Lentiviral-based BMP4 in vivo gene transfer strategy increases pull-out tensile strength without an improvement in the osteointegration of the tendon graft in a rat model of biceps tenodesis

scientific article published on 01 October 2011

Leptin receptor (Lepr) is a negative modulator of bone mechanosensitivity and genetic variations in Lepr may contribute to the differential osteogenic response to mechanical stimulation in the C57BL/6J and C3H/HeJ pair of mouse strains.

scientific article

Local administration of AAV-DJ pseudoserotype expressing COX2 provided early onset of transgene expression and promoted bone fracture healing in mice.

scientific article published on 12 May 2015

Local ex vivo gene therapy with bone marrow stromal cells expressing human BMP4 promotes endosteal bone formation in mice.

scientific article published in January 2004

Loss of sex-specific difference in femoral bone parameters in male leptin knockout mice.

scientific article published on 23 May 2007

Measurements of circulating ionized magnesium level: fresh whole blood samples versus serum samples

scientific article published on 01 June 2000

Mechanism of Mitogenic Action of Aluminum Ion on Human Bone Cells: Potential Involvement of the Insulin-like Growth Factor Regulatory System ⬇️

scientific article published on June 1, 1993

Mechanistic study of the cause of decreased blood 1,25-Dihydroxyvitamin D in sepsis

scientific article published on 02 December 2019

Melatonin at pharmacologic doses increases bone mass by suppressing resorption through down-regulation of the RANKL-mediated osteoclast formation and activation.

scientific article published on July 2002

MicroRNA223 promotes pathogenic T-cell development and autoimmune inflammation in central nervous system in mice.

scientific article

Microarray Analysis of Gene Expression Reveals that Cyclo-oxygenase-2 Gene Therapy Up-regulates Hematopoiesis and Down-regulates Inflammation During Endochondral Bone Fracture Healing

scientific article

Microarray analysis of gene expression during the inflammation and endochondral bone formation stages of rat femur fracture repair

scientific article published on 01 April 2006

Modifications of the fibroblast growth factor-2 gene led to a marked enhancement in secretion and stability of the recombinant fibroblast growth factor-2 protein.

scientific article published on April 2007

Molecular Mechanism of Action of Fluoride on Bone Cells ⬇️

scientific article published on November 1, 1998

Molecular cloning and expression of a unique rabbit osteoclastic phosphotyrosyl phosphatase.

scientific article published on June 1996

Monofluorophosphate is hydrolyzed by alkaline phosphatase and mimics the actions of NaF on skeletal tissues, in vitro

scientific article published on 01 January 1987

Opposing effects of Sca-1(+) cell-based systemic FGF2 gene transfer strategy on lumbar versus caudal vertebrae in the mouse.

scientific article published on 02 March 2016

Osteoblastic tartrate-resistant acid phosphatase: its potential role in the molecular mechanism of osteogenic action of fluoride.

scientific article published on October 2003

Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity.

scientific article published on 28 May 2013

Osteocyte-derived insulin-like growth factor I is not essential for the bone repletion response in mice

scientific article

PDGFB-based stem cell gene therapy increases bone strength in the mouse

scientific article published on 6 July 2015

Phenytoin and fluoride act in concert to stimulate bone formation and to increase bone volume in adult male rats.

scientific article published in May 1995

Phenytoin at micromolar concentrations is an osteogenic agent for human-mandible-derived bone cells in vitro.

scientific article

Phenytoin increases markers of osteogenesis for the human species in vitro and in vivo ⬇️

scientific article published on August 1, 1995

Picomolar norethindrone in vitro stimulates the cell proliferation and activity of a human osteosarcoma cell line and increases bone collagen synthesis without an effect on bone resorption.

scientific article published on May 1994

Protein tyrosine kinase inhibitors block the stimulatory actions of phosphotyrosine phosphatase inhibitors to increase cell proliferation, alkaline phosphatase activity, and collagen synthesis in normal human bone cells.

scientific article published on March 2000

Rapid and efficient reprogramming of human fetal and adult blood CD34+ cells into mesenchymal stem cells with a single factor.

scientific article published on 12 March 2013

Rationale for active vitamin D analog therapy in senile osteoporosis.

scientific article published in January 1997

Regulation of bone volume is different in the metaphyses of the femur and vertebra of C3H/HeJ and C57BL/6J mice

scientific article published on 01 March 2002

Retroviral-based gene therapy with cyclooxygenase-2 promotes the union of bony callus tissues and accelerates fracture healing in the rat.

scientific article published in March 2008

Role of Osteocyte-derived Insulin-Like Growth Factor I in Developmental Growth, Modeling, Remodeling, and Regeneration of the Bone.

scientific article published on 28 February 2014

Role of protein-tyrosine phosphatases in regulation of osteoclastic activity.

scientific article published on June 2009

Serum 1,25-dihydroxyvitamin D: an outcome prognosticator in human sepsis

scientific article

Sodium fluoride does not increase human bone cell proliferation or protein synthesis in vitro ⬇️

scientific article published on January 1, 1992

Stem cell antigen-1 positive cell-based systemic human growth hormone gene transfer strategy increases endosteal bone resorption and bone loss in mice

scientific article published on 01 February 2011

Stem cell antigen-1+ cell-based bone morphogenetic protein-4 gene transfer strategy in mice failed to promote endosteal bone formation.

scientific article published in October 2009

Stimulation of cellular alkaline phosphatase activity and its messenger RNA level in a human osteosarcoma cell line by 1,25-dihydroxyvitamin D3.

scientific article published on December 1989

Targeted 25-hydroxyvitamin D3 1α-hydroxylase adoptive gene therapy ameliorates dss-induced colitis without causing hypercalcemia in mice

scientific article published on 20 October 2014

Targeted Overexpression of Osteoactivin in Cells of Osteoclastic Lineage Promotes Osteoclastic Resorption and Bone Loss in Mice ⬇️

scientific article published on April 20, 2012

Targeted deletion of the osteoclast protein-tyrosine phosphatase (PTP-oc) promoter prevents RANKL-mediated osteoclastic differentiation of RAW264.7 cells.

scientific article published on 4 May 2007

The EphA4 Signaling is Anti-catabolic in Synoviocytes but Pro-anabolic in Articular Chondrocytes

scientific article published on 20 August 2020

The role of IGF system in the rise and fall in bone density with age

scientific article published on 01 October 2007

Unique Regenerative Mechanism to Replace Bone Lost During Dietary Bone Depletion in Weanling Mice.

scientific article published on 26 January 2017

Unique anabolic action of stem cell gene therapy overexpressing PDGFB-DSS6 fusion protein in OVX osteoporosis mouse model

scientific article published on 11 December 2019

Urokinase plasminogen activator gene deficiency inhibits fracture cartilage remodeling ⬇️

scientific article published on May 23, 2013

Vitamin D deficiency causes a selective reduction in deposition of transforming growth factor beta in rat bone: possible mechanism for impaired osteoinduction

scientific article published on May 1991

Vitamin D therapy of osteoporosis: plain vitamin D therapy versus active vitamin D analog (D-hormone) therapy.

scientific article

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