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List of works by Moshe Oren

3'UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells.

scientific article

A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism

article

A novel Chk1/2–Lats2–14-3-3 signaling pathway regulates P-body formation in response to UV damage ⬇️

scientific article published on November 30, 2010

A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

scientific article

ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence.

scientific article published on 09 August 2013

Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy

scientific article

All common p210 and p190 Bcr-abl variants can be targeted by RNA interference

scientific article published on 01 February 2005

Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features

scientific article published on 04 June 2018

BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma.

scientific article published on 25 October 2005

CD74 induces TAp63 expression leading to B-cell survival

scientific article published on 10 September 2007

Cancer cells cue the p53 response of cancer-associated fibroblasts to cisplatin

scientific article published on 07 September 2012

Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides.

scientific article

Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation.

scientific article

Caught in the cross fire: p53 in inflammation.

scientific article

Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy.

scientific article

DePICTing p53 activation: a new nucleolar link to cancer

scientific article published on 01 September 2011

Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients

scientific article published on 19 May 2022

Down-regulation of beta-catenin by activated p53.

scientific article published on October 2001

Early Loss of Histone H2B Monoubiquitylation Alters Chromatin Accessibility and Activates Key Immune Pathways That Facilitate Progression of Ovarian Cancer

scientific article published on 18 December 2018

Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy.

scientific article

Functional characterization of the p53 “mutome”

scientific article published on 25 September 2018

Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease

scientific article published on 7 April 2016

Global and local architecture of the mammalian microRNA-transcription factor regulatory network.

scientific article

Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis ⬇️

scientific article published on January 27, 2012

Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

scientific article (publication date: 24 June 1999)

Involvement of stromal p53 in tumor-stroma interactions.

scientific article

LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state

scientific article published on 30 October 2018

Lats2 is critical for the pluripotency and proper differentiation of stem cells

scientific article published on 10 January 2014

Lats2 phosphorylates p21/CDKN1A after UV irradiation and regulates apoptosis.

scientific article published on 25 July 2013

Life, death, and ubiquitin: taming the mule.

scientific article

Mdm2: p53's lifesaver?

scientific article published in March 2007

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells

scientific article published on 01 March 2007

Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.

scientific article published on 18 January 2018

Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.

scientific article published on May 2013

Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis

scientific article published on April 2011

Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress

scientific article

Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation ⬇️

scientific article published on April 1, 2003

Nucleosome Organization Affects the Sensitivity of Gene Expression to Promoter Mutations ⬇️

scientific article published on March 29, 2012

PAX8 activates a p53-p21-dependent pro-proliferative effect in high grade serous ovarian carcinoma.

scientific article published on 30 January 2018

RNF20 Inhibits TFIIS-Facilitated Transcriptional Elongation to Suppress Pro-oncogenic Gene Expression ⬇️

scientific article published on May 20, 2011

RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer

scientific article published on 3 February 2016

RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation

scientific article

RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer

scientific article

RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response.

scientific article published on 04 August 2011

Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth.

scientific article published on 16 January 2015

Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival

scientific article published on 19 December 2016

Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53

scientific article

Repression of transposable-elements - a microRNA anti-cancer defense mechanism?

scientific article published on 22 April 2010

Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks

scientific article

Simultaneous measurement of genome-wide transcription elongation speeds and rates of RNA polymerase II transition into active elongation with 4sUDRB-seq.

scientific article published on 26 March 2015

Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models

scientific article published on 23 August 2018

Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription.

scientific article published on 8 August 2013

TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria

scientific article

TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma.

scientific article

TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response.

scientific article published on 14 October 2016

TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma

scientific article published on 13 April 2018

The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation

scientific article published on 24 March 2016

The PI3K inhibitor LY294002 prevents p53 induction by DNA damage and attenuates chemotherapy-induced apoptosis.

scientific article published on 3 June 2005

The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.

scientific article

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

scientific article

The first 30 years of p53: growing ever more complex

scientific article

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

scientific article

The liver-specific microRNA-122*, the complementary strand of microRNA-122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitry.

scientific article published on 15 June 2016

The majority of endogenous microRNA targets within Alu elements avoid the microRNA machinery ⬇️

scientific article published on January 29, 2013

The sunny side of p53

scientific article published on 01 March 2007

The translation initiation factor DAP5 promotes IRES-driven translation of p53 mRNA.

scientific article published on 14 January 2013

Tiny actors, great roles: microRNAs in p53's service.

scientific article published on 19 August 2007

Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53-associated features

scientific article published on 02 June 2020

Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals

scientific article

hTERT-immortalized prostate epithelial and stromal-derived cells: an authentic in vitro model for differentiation and carcinogenesis

scientific article

let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery

scientific article published on 12 June 2017

miR-661 downregulates both Mdm2 and Mdm4 to activate p53.

scientific article published on 18 October 2013

microRNAs and Alu elements in the p53-Mdm2-Mdm4 regulatory network.

scientific article

p53 shades of Hippo.

scientific article

p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner.

scientific article

p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.

scientific article

p53-dependent non-coding RNA networks in chronic lymphocytic leukemia.

scientific article published on 14 May 2015

p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation.

scientific article

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