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List of works by David Tosh

A new paradigm in cell therapy for diabetes: turning pancreatic α-cells into β-cells

scientific article published on 27 August 2010

A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3.

scientific article published on 24 May 2011

Alterted GLUT4 subcellular trafficking in primary cultures of rat adipocytes

scientific article published on 01 August 1997

Barrett's metaplasia as a paradigm for understanding the development of cancer ⬇️

scientific article published on September 11, 2012

Barrett's metaplasia: molecular mechanisms and nutritional influences.

scientific article published in April 2010

Beta cells occur naturally in extrahepatic bile ducts of mice.

scientific article

Betacellulin inhibits amylase and glucagon production and promotes beta cell differentiation in mouse embryonic pancreas.

scientific article published on 12 June 2007

Bile ducts as a source of pancreatic beta cells.

scientific article published in September 2004

C/EBPalpha and C/EBPbeta are markers of early liver development

scientific article

Cell penetrating peptides fail to induce an innate immune response in epithelial cells in vitro: Implications for continued therapeutic use ⬇️

scientific article published on September 1, 2013

Characterization of liver function in transdifferentiated hepatocytes.

scientific article published on January 2006

Clofibrate induces carnitine acyltransferases in periportal and perivenous zones of rat liver and does not disturb the acinar zonation of gluconeogenesis.

scientific article published in September 1989

Conversion of columnar to stratified squamous epithelium in the developing mouse oesophagus.

scientific article published on August 2005

Conversion of one cell type into another: implications for understanding organ development, pathogenesis of cancer and generating cells for therapy.

scientific article published on June 2014

Copper deprivation in rats induces islet hyperplasia and hepatic metaplasia in the pancreas

scientific article published on 01 January 2007

Dexamethasone treatment induces the reprogramming of pancreatic acinar cells to hepatocytes and ductal cells.

scientific article

Differentiation of pancreatic acinar cells to hepatocytes requires an intermediate cell type.

scientific article published on 20 February 2010

Epithelial metaplasia and the development of cancer.

scientific article published on 26 May 2007

Expression of liver-enriched nuclear factors and their isoforms in alpha-fetoprotein-producing gastric carcinoma cells.

scientific article published on 14 August 2006

Glucocorticoids suppress β-cell development and induce hepatic metaplasia in embryonic pancreas ⬇️

scientific article published on October 1, 2003

Glycogen degradation by adrenergic agonists and glucagon in periportal and perivenous rat hepatocyte cultures

scientific article published on 01 April 1994

HNF4alpha expression amplifies the glucocorticoid-induced conversion of a human pancreatic cell line to an hepatocyte-like cell

scientific article published on 26 July 2018

Hepatic differentiation of murine embryonic stem cells

scientific article (publication date: 2002)

Hepatic glucokinase activityin animals fed glucose at birth ⬇️

scientific article published on May 1, 1995

Hepatic progenitor cells ⬇️

scientific article published on October 19, 2010

Hepatocyte-ductal transdifferentiation is mediated by reciprocal repression of SOX9 and C/EBPα.

scientific article

Heterogeneous expression of sulphotransferases in periportal and perivenous hepatocytes prepared from male and female rat liver.

scientific article published in February 1996

Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity.

scientific article published on 16 December 2016

Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium.

scientific article published on 19 November 2016

Hollow fibre membrane bioreactors for tissue engineering applications

scientific article

How does inflammation cause Barrett's metaplasia?

scientific article published on 12 October 2009

In vitro culture of embryonic mouse intestinal epithelium: cell differentiation and introduction of reporter genes.

scientific article published on 25 May 2006

In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression.

scientific article published on 16 September 2014

In vitro reprogramming of pancreatic cells to hepatocytes.

scientific article published on January 2010

In vitro transdifferentiation of hepatoma cells into functional pancreatic cells.

scientific article published on 17 February 2005

In vitro treatment of carcinoma cell lines with pancreatic (pro)enzymes suppresses the EMT programme and promotes cell differentiation

scientific article published on 16 May 2013

Induction and regulation of acute phase proteins in transdifferentiated hepatocytes.

scientific article published on January 2004

Inhibition of Hes1 activity in gall bladder epithelial cells promotes insulin expression and glucose responsiveness.

scientific article published in December 2009

Islet-like cell clusters occur naturally in human gall bladder and are retained in diabetic conditions.

scientific article

Isolation and culture of embryonic pancreas and liver.

scientific article published in January 2010

Isolation, culture, and characterisation of mouse embryonic oesophagus and intestine.

scientific article

Keratinocyte serum-free medium maintains long-term liver gene expression and function in cultured rat hepatocytes by preventing the loss of liver-enriched transcription factors.

scientific article published on 28 October 2006

Lactate and pyruvate stimulate the conversion of glucose to glycogen in hepatocytes by a mechanism that does not involve gluconeogenic flux

scientific article published on 01 August 1995

Liver specification: a new role for Wnts in liver development.

scientific article published in September 2006

Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism.

scientific article published on 5 March 2009

Maternal vitamin A deficiency during pregnancy affects vascularized islet development.

scientific article published on 4 August 2016

MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity.

scientific article

Molecular aspects of esophageal development.

scientific article published in September 2011

New sources of beta-cells for treating diabetes.

scientific article published on 06 May 2009

Next generation liver model design: Combining a permeable polystyrene membrane with a transdifferentiated cell line

scientific article published on 01 November 2018

Ontogenesis of Hepatic and Pancreatic Stem Cells ⬇️

scientific article published on June 1, 2012

Origin of beta-cells in regenerating pancreas

scientific article published on 01 July 2008

Origin of pancreatic endocrine cells from biliary duct epithelium.

scientific article published in November 2008

Phosphoinositide 3-kinase alpha-dependent regulation of branching morphogenesis in murine embryonic lung: evidence for a role in determining morphogenic properties of FGF7

scientific article

Regulation of glucose-6-phosphatase by the extracellular matrix

scientific article published on 01 August 1997

Reprogramming of liver to pancreas.

scientific article

Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway.

scientific article published on 9 February 2018

Streptozotocin-induced diabetes modulates action potentials and ion channel currents from the rat atrioventricular node

scientific article published on 27 November 2009

The Wnt/beta-catenin pathway: master regulator of liver zonation?

scientific article published on 01 November 2006

The contribution of pyruvate cycling to loss of [6-3H]glucose during conversion of glucose to glycogen in hepatocytes: effects of insulin, glucose and acinar origin of hepatocytes

scientific article

The enone motif of (+)-grandifloracin is not essential for 'anti-austerity' antiproliferative activity.

scientific article published on 5 May 2014

The molecular basis of transdifferentiation.

scientific article

The role of Cdx2 in Barrett's metaplasia.

scientific article published on April 2010

Therapeutic potential of transdifferentiated cells.

scientific article

Transdifferentiation in developmental biology, disease, and in therapy.

scientific article published on December 2007

Transdifferentiation of pancreas to liver

scientific article

Transdifferentiation of pancreatic cells to hepatocytes.

scientific article published on January 2010

Transdifferentiation of pancreatic progenitor cells to hepatocyte-like cells is not serum-dependent when facilitated by extracellular matrix proteins.

scientific article

Transdifferentiation, metaplasia and tissue regeneration.

scientific article published on October 2004

Ultrastructural and molecular analyzes of insulin-producing cells induced from human hepatoma cells

scientific article published on 22 July 2010

Xanthine oxidoreductase is asymmetrically localised on the outer surface of human endothelial and epithelial cells in culture.

scientific article published on April 1998

Xanthine oxidoreductase is present in bile ducts of normal and cirrhotic liver.

scientific article published in October 2004

Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells

scientific article

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