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List of works by Karel Ulbrich

Acquired and specific immunological mechanisms co-responsible for efficacy of polymer-bound drugs

scientific article published in January 2002

Adenovirus-derived vectors for prostate cancer gene therapy

scientific article published on July 2010

Antiproliferative effect of a lectin- and anti-Thy-1.2 antibody-targeted HPMA copolymer-bound doxorubicin on primary and metastatic human colorectal carcinoma and on human colorectal carcinoma transfected with the mouse Thy-1.2 gene

scientific article published on September 2000

Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin. Immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro

scientific article published on 01 July 1989

Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting

scientific article

Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy

scientific article published on 15 June 2011

Chemical conjugation of cowpea mosaic viruses with reactive HPMA-based polymers

scientific article published on 9 June 2010

Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity

scientific article published on 2 November 2005

Clinical adenoviral gene therapy for prostate cancer

scientific article published on July 2010

Coating of DNA/poly(L-lysine) complexes by covalent attachment of poly[N-(2-hydroxypropyl)methacrylamide].

scientific article published in January 2006

Coating of adeno-associated virus with reactive polymers can ablate virus tropism, enable retargeting and provide resistance to neutralising antisera

scientific article published in April 2008

Coating of vesicles with hydrophilic reactive polymers

scientific article published on 11 June 2008

Coiled coil peptides as universal linkers for the attachment of recombinant proteins to polymer therapeutics.

scientific article

Comparison between linear and star-like HPMA conjugated pirarubicin (THP) in pharmacokinetics and antitumor activity in tumor bearing mice

scientific article

Comparison of the pharmacological and biological properties of HPMA copolymer-pirarubicin conjugates: A single-chain copolymer conjugate and its biodegradable tandem-diblock copolymer conjugate

scientific article published on 17 May 2017

Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting

scientific article

Cytostatic and immunomobilizing activities of polymer-bound drugs: experimental and first clinical data

scientific article published in August 2003

DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers

scientific article published in March 2000

Detection and cellular localisation of the synthetic soluble macromolecular drug carrier pHPMA.

scientific article published on 25 May 2002

Differences in the intracellular fate of free and polymer-bound doxorubicin

scientific article

Doxorubicin attached to HPMA copolymer via amide bond modifies the glycosylation pattern of EL4 cells

scientific article published on 24 February 2010

Doxorubicin bound to a HPMA copolymer carrier through hydrazone bond is effective also in a cancer cell line with a limited content of lysosomes

scientific article

Drug-HPMA-HuIg conjugates effective against human solid cancer.

scientific article

Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release II: impact of release rate on biodistribution

scientific article published on 19 May 2013

Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release: synthesis and characterization of distribution and tumor accumulation in mice by noninvasive multispectral optical imaging

scientific article published on 10 February 2012

Effect of intratumoral injection on the biodistribution and the therapeutic potential of HPMA copolymer-based drug delivery systems

scientific article published on October 2006

Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers

scientific article published on 7 November 2005

Fine tuning of the pH-dependent drug release rate from polyHPMA-ellipticinium conjugates

scientific article published on 27 July 2013

Gamma scintigraphy of a 123I-labelled N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugate containing galactosamine following intravenous administration to nude mice bearing hepatic human colon carcinoma

scientific article published on January 1996

HPMA Copolymer-Conjugated Pirarubicin in Multimodal Treatment of a Patient with Stage IV Prostate Cancer and Extensive Lung and Bone Metastases.

scientific article published in February 2016

HPMA Copolymer-Drug Conjugates with Controlled Tumor-Specific Drug Release

scientific article published on 14 August 2017

HPMA based macromolecular therapeutics: internalization, intracellular pathway and cell death depend on the character of covalent bond between the drug and the peptidic spacer and also on spacer composition

scientific article published on July 2006

HPMA copolymer conjugate with pirarubicin: In vitro and ex vivo stability and drug release study

scientific article

HPMA copolymer conjugates of DOX and mitomycin C for combination therapy: physicochemical characterization, cytotoxic effects, combination index analysis, and anti-tumor efficacy

scientific article published on 12 September 2013

HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release

scientific article

HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity

scientific article

HPMA copolymer-bound doxorubicin induces immunogenic tumor cell death

scientific article published on January 2013

HPMA copolymer-doxorubicin conjugates: The effects of molecular weight and architecture on biodistribution and in vivo activity

scientific article

HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity

scientific article

HPMA-based biodegradable hydrogels containing different forms of doxorubicin. Antitumor effects and biocompatibility.

scientific article published on December 1997

HPMA-based polymer conjugates with drug combination.

scientific article published in April 2009

HPMA-based polymer therapeutics improve the efficacy of surgery, of radiotherapy and of chemotherapy combinations

scientific article published on December 2010

HPMA-hydrogels containing cytostatic drugs. Kinetics of the drug release and in vivo efficacy

scientific article published in May 2002

Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1.

scientific article published on 08 January 2009

Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study

scientific article published on 25 October 2013

Image-guided and passively tumour-targeted polymeric nanomedicines for radiochemotherapy

scientific article published on September 2008

Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation

scientific article

In vitro and in vivo effect of HPMA copolymer-bound doxorubicin targeted to transferrin receptor of B-cell lymphoma 38C13.

scientific article

Incorporation of a laminin-derived peptide (SIKVAV) on polymer-modified adenovirus permits tumor-specific targeting via alpha6-integrins

scientific article published on 19 January 2007

Induction of systemic antitumour resistance with targeted polymers

scientific article

Influence of hydrophilicity of cationic polymers on the biophysical properties of polyelectrolyte complexes formed by self-assembly with DNA.

scientific article published in July 2000

Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier ⬇️

scientific article published on January 1, 1995

Intracerebral implantation of hydrogel-coupled adhesion peptides: tissue reaction

scientific article published in January 1995

Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy

scientific article published on 2 November 2012

Macromolecular HPMA-based nanoparticles with cholesterol for solid-tumor targeting: detailed study of the inner structure of a highly efficient drug delivery system

scientific article published in August 2012

Micelles of zinc protoporphyrin conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer for imaging and light-induced antitumor effects in vivo

scientific article published on 3 December 2012

Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate-mediated targeting in vitro and prolonged plasma circulation in vivo

scientific article published in September 2002

Molecular weight and polydispersity of calf-thymus DNA: static light-scattering and size-exclusion chromatography with dual detection

scientific article published in November 2009

Multi-component polymeric system for tumour cell-specific gene delivery using a universal bungarotoxin linker

scientific article published on 19 March 2010

Multi-responsive polymer micelles as ellipticine delivery carriers for cancer therapy.

scientific article

Multifunctional cytotoxic stealth nanoparticles. A model approach with potential for cancer therapy

scientific article

N-(2-Hydroxypropyl)methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specific or passive tumour targeting. Synthesis by RAFT polymerisation and physicochemical characterisation

scientific article published on 7 August 2010

Nanomedicines for inflammatory arthritis: head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes

scientific article published on 27 December 2013

New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting

scientific article

New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties

scientific article

New bioerodable thermoresponsive polymers for possible radiotherapeutic applications

scientific article published on 22 February 2007

Noninvasive optical imaging of nanomedicine biodistribution

scientific article published on 24 October 2012

Novel IL-2-Poly(HPMA)Nanoconjugate Based Immunotherapy

scientific article published in September 2015

Oligopeptides as targeting structures in cancer theraPY.

scientific article published in January 2005

Overcoming cellular multidrug resistance using classical nanomedicine formulations

scientific article published on September 2011

Overcoming multidrug resistance in Dox-resistant neuroblastoma cell lines via treatment with HPMA copolymer conjugates containing anthracyclines and P-gp inhibitors.

scientific article

Passive tumour targeting of polymer-coated adenovirus for cancer gene therapy

scientific article published in August 2007

Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin

scientific article

Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations.

scientific article

Poly(Hpma)-coated liposomes demonstrate prolonged circulation in mice

scientific article published in January 2001

Poly[N-(2-hydroxypropyl)methacrylamide] polymers diffuse in brain extracellular space with same tortuosity as small molecules

scientific article

Poly[N-(2-hydroxypropyl)methacrylamide]-based tissue-embedding medium compatible with MALDI mass spectrometry imaging experiments

scientific article

Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA.

scientific article published in November 1999

Polymer carriers for anticancer drugs targeted to EGF receptor

scientific article

Polymer coatings for delivery of nucleic acid therapeutics

scientific article published on 18 February 2012

Polymer conjugates of doxorubicin bound through an amide and hydrazone bond: Impact of the carrier structure onto synergistic action in the treatment of solid tumours

scientific article published on 13 March 2014

Polymer inhibitors of ABC transporter overcoming multidrug resistance: Synthesis, characterization and in vitro evaluation.

scientific article published on 19 August 2015

Polymer therapeutics with a coiled coil motif targeted against murine bcl1 leukemia

scientific article published on 14 February 2013

Polymer-coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction

scientific article published on March 2004

Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice

scientific article published in February 2004

Polymeric anticancer drugs with pH-controlled activation

scientific article published on April 2004

Polymeric drug-carriers containing doxorubicin and melanocyte-stimulating hormone: in vitro and in vivo evaluation against murine melanoma

scientific article published on January 1993

Polymeric micellar pH-sensitive drug delivery system for doxorubicin

scientific article published on 15 December 2004

Preclinical evaluation of linear HPMA-doxorubicin conjugates with pH-sensitive drug release: efficacy, safety, and immunomodulating activity in murine model

scientific article

Preparation of DNA complexes with diblock copolymers of poly[N(2-hydroxypropyl)methacrylamide] and polycations

Pronounced Cellular Uptake of Pirarubicin versus That of Other Anthracyclines: Comparison of HPMA Copolymer Conjugates of Pirarubicin and Doxorubicin.

scientific article published on 21 November 2016

Properties of HPMA copolymer-doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification

scientific article published on 30 June 2006

Reduced cardiotoxicity of doxorubicin given in the form of N-(2-hydroxypropyl)methacrylamide conjugates: and experimental study in the rat

scientific article

Retargeting polymer-coated adenovirus to the FGF receptor allows productive infection and mediates efficacy in a peritoneal model of human ovarian cancer

scientific article published in March 2008

SYNTHETIC POLYMER MATRICES FOR NEURAL CELL TRANSPLANTATION.

scientific article published in May 1993

Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers

scientific article published on 21 March 2009

Spectral analysis of doxorubicin accumulation and the indirect quantification of its DNA intercalation

scientific article

Star structure of antibody-targeted HPMA copolymer-bound doxorubicin: a novel type of polymeric conjugate for targeted drug delivery with potent antitumor effect

scientific article published in March 2002

Star-shaped immunoglobulin-containing HPMA-based conjugates with doxorubicin for cancer therapy

scientific article

Starlike vs. classic macromolecular prodrugs: two different antibody-targeted HPMA copolymers of doxorubicin studied in vitro and in vivo as potential anticancer drugs

scientific article published on October 1, 2003

Structural and chemical aspects of HPMA copolymers as drug carriers

scientific article

Synergistic action of doxorubicin bound to the polymeric carrier based on N-(2-hydroxypropyl)methacrylamide copolymers through an amide or hydrazone bond

scientific article

Synthesis and Properties of Star HPMA Copolymer Nanocarriers Synthesised by RAFT Polymerisation Designed for Selective Anticancer Drug Delivery and Imaging

scientific article

Synthesis of poly[N-(2-hydroxypropyl)methacrylamide] conjugates of inhibitors of the ABC transporter that overcome multidrug resistance in doxorubicin-resistant P388 cells in vitro

scientific article

Synthetic Polymers Conjugated to Monoclonal Antibodies: Vehicles for Tumour-Targeted Drug Delivery ⬇️

scientific article published on January 1, 1991

Synthetic macromolecular drug carriers: biodistribution of poly[(N-2-hydroxypropyl)methacrylamide] copolymers and their accumulation in solid rat tumors

scientific article published in May 2001

Synthetic polymer derivatives as substrata for neuronal adhesion and growth

scientific article published in January 1993

Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies

scientific article published on 25 April 2016

Targeting adenovirus gene delivery to activated tumour-associated vasculature via endothelial selectins ⬇️

scientific article published on October 18, 2010

The comparison of in vivo properties of water-soluble HPMA-based polymer conjugates with doxorubicin prepared by controlled RAFT or free radical polymerization.

scientific article published in January 2015

The same drug but a different mechanism of action: comparison of free doxorubicin with two different N-(2-hydroxypropyl)methacrylamide copolymer-bound doxorubicin conjugates in EL-4 cancer cell line

scientific article published on 3 April 2007

Thermally Controlled Association in Aqueous Solutions of Diblock Copolymers of Poly[N-(2-hydroxypropyl)methacrylamide] and Poly(N-isopropylacrylamide)

Thermally Controlled Association in Aqueous Solutions of Poly(l-lysine) Grafted with Poly(N-isopropylacrylamide)

Thermoresponsive Polymer Micelles as Potential Nanosized Cancerostatics

scientific article published on 16 July 2015

Traceless bioresponsive shielding of adenovirus hexon with HPMA copolymers maintains transduction capacity in vitro and in vivo

scientific article (publication date: 2014)

Treatment with HPMA copolymer-based doxorubicin conjugate containing human immunoglobulin induces long-lasting systemic anti-tumour immunity in mice.

scientific article published on 25 April 2006

Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer

scientific article published on 18 June 2012

Tumour tropism and anti-cancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16F10 melanoma

scientific article published on October 1994

Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage

scientific article published on 21 November 2013

Use of synthetic vectors for neutralising antibody resistant delivery of replicating adenovirus DNA.

scientific article published on 29 June 2006

[Missile-Type Tumor-Targeting Polymer Drug, P-THP, Seeks Tumors via Three Different Steps Based on the EPR Effect].

scientific article

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