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List of works by Nancy Rothwell

100 NF-κB Activation by Mal/Tirap is Regulated by Caspase-1

scholarly article by Sinead M. Miggin et al published July 2007 in Cytokine

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke

scientific article published on 30 September 2015

A dual role for interleukin-1 in LTP in mouse hippocampal slices

scientific article published in November 2003

A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke

scientific article published on 5 August 2009

A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat

scientific article published on 10 August 2007

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.

scientific article

Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection.

scientific article published on 7 July 2013

An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis

scientific article published in June 2003

An immortalised astrocyte cell line maintains the in vivo phenotype of a primary porcine in vitro blood–brain barrier model ⬇️

scientific article published on August 24, 2012

Animal experiments and the development of surgical therapies

scientific article published on 01 January 2005

Animal experiments and the doctor

scientific article published on 01 October 2002

Boron-Based Inhibitors of the NLRP3 Inflammasome

scientific article published in September 2017

Brain inflammation is induced by co-morbidities and risk factors for stroke

scientific article

CNS injury: the role of the cytokine IL-1.

scientific article published in November 2004

Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages

scientific article published in March 2003

Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death

scientific article published on 6 February 2007

Caspases Mediate 6-Hydroxydopamine-Induced Apoptosis but Not Necrosis in PC12 Cells

Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice

scientific article

Cerebrospinal fluid and plasma cytokines after subarachnoid haemorrhage: CSF interleukin-6 may be an early marker of infection.

scientific article

Characterization of a conditional interleukin-1 receptor 1 mouse mutant using the Cre/LoxP system

scientific article published on 22 December 2015

Choices in neuroscience careers

scientific article published in May 2008

Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice

scientific article published on July 2010

Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity

scientific article

Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production

scientific article

Correlation of systemic inflammatory response with infarct volume in acute ischemic stroke patients

scientific article published on 29 December 2004

Cytokines in the Nervous System

Dear diary..

scientific article published in Nature

Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat.

scientific article published on 26 August 2003

Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats

scientific article

Differential actions of IL-1 alpha and IL-1 beta in glial cells share common IL-1 signalling pathways

scientific journal article

Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones

scientific article

Does inflammation predispose to recurrent vascular events after recent transient ischaemic attack and minor stroke? The North West of England transient ischaemic attack and minor stroke (NORTHSTAR) study

scientific article (publication date: June 2011)

Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis

scientific article published on 31 March 2016

Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

scientific article

Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia.

scientific article published in July 2003

Experimental stroke-induced changes in the bone marrow reveal complex regulation of leukocyte responses

scientific article published on 3 November 2010

Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells

scientific article published in November 2002

Extracellular ATP and P2X7 receptors in neurodegeneration

scientific article

Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain

scientific article published in April 2006

IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice

scientific article

IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells

scientific article published in June 2003

Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain

scientific journal article

Improving outcome after stroke: overcoming the translational roadblock

scientific article published on 22 February 2008

Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke

scientific article published on 14 October 2009

Inflammation as a predictor for delayed cerebral ischemia after aneurysmal subarachnoid haemorrhage

scientific article published on 05 September 2012

Inflammation in central nervous system injury

scientific article

Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra

scientific article published in October 2007

Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons

scientific journal article

Interleukin-1 and neuronal injury

scientific article

Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential ⬇️

scientific article published on June 1, 2003

Interleukin-1 and stroke: biomarker, harbinger of damage, and therapeutic target

scientific article

Interleukin-1 as a pharmacological target in acute brain injury

scientific article published on 12 June 2015

Interleukin-1 drives cerebrovascular inflammation via MAP kinase-independent pathways

scientific article published on November 2010

Interleukin-1 exacerbates focal cerebral ischemia and reduces ischemic brain temperature in the rat.

scientific article

Interleukin-1 in Stroke: From Bench to Bedside

scientific article

Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor.

scientific article

Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons

Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis

scientific article

Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro

scientific article

Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology

scientific article published on 31 May 2012

Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations

scientific article

Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression

scientific article published on 22 March 2012

Interleukin-1-induced neurotoxicity is mediated by glia and requires caspase activation and free radical release

scientific article published in July 2006

Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1 beta

scientific article

Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study

scientific article

Involvement of caspases and calpains in cerebrocortical neuronal cell death is stimulus-dependent

scientific article published in February 2002

Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanism

scientific article published on 10 April 2007

Long-term functional recovery and compensation after cerebral ischemia in rats

scientific article published on 10 May 2014

Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity

scientific journal article

Mechanisms of interleukin-6 synthesis and release induced by interleukin-1 and cell depolarisation in neurones

scientific article

Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices.

scientific article published on 13 February 2013

Modeling Risk Factors and Confounding Effects in Stroke

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.

scholarly article

Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

scientific article published on 3 October 2012

Neuronal injury induces the release of pro-interleukin-1beta from activated microglia in vitro

scientific journal article

Neuroprotective actions of endogenous interleukin-1 receptor antagonist (IL-1ra) are mediated by glia.

scientific article published on April 2006

Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by phosphatidylinositol 3-kinase/AKT signaling

scientific article published in January 2005

Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA.

scientific article

No paradox in the control of energy intake (reply)

journal article; published in Nature, 1978-09

No role for interleukin-18 in acute murine stroke-induced brain injury

scientific article

One more thing...

scientific article published in February 2004

PRL-releasing peptide interacts with leptin to reduce food intake and body weight

scientific article published in February 2002

Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc

scientific article published on February 2009

Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome

scientific article

Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage

scientific article published on 13 September 2007

Platelet interleukin-1alpha drives cerebrovascular inflammation

scientific article published on 3 March 2010

Potential surrogate markers of cerebral microvascular angiopathy in asymptomatic subjects at risk of stroke

scientific article

Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production

scientific article published on 12 November 2001

Psychoneuroimmunology of stroke

scientific article published on May 2009

Psychoneuroimmunology of stroke

scientific article published in August 2006

Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism

scientific article published in February 2002

Rapid brain penetration of interleukin-1 receptor antagonist in rat cerebral ischaemia: pharmacokinetics, distribution, protection

scientific article published on May 2010

Reduction of inflammation after administration of interleukin-1 receptor antagonist following aneurysmal subarachnoid hemorrhage: results of the Subcutaneous Interleukin-1Ra in SAH (SCIL-SAH) study.

scientific article

Regulation of expression of the novel IL-1 receptor family members in the mouse brain

scientific article published on 08 August 2005

Release of interleukin-1α or interleukin-1β depends on mechanism of cell death

scientific article published on 30 April 2014

Reparative effects of interleukin-1 receptor antagonist in young and aged/co-morbid rodents after cerebral ischemia

scientific article published on 14 November 2016

Requirement for interleukin-1 to drive brain inflammation reveals tissue-specific mechanisms of innate immunity.

scientific article published on 24 November 2014

Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures

scientific article published in March 2002

Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo

scientific article published in March 2003

SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke): A Randomized Controlled Phase 2 Trial

scientific article published on 22 March 2018

Site-specific actions of interleukin-1 on excitotoxic cell death in the rat striatum

scientific article published in February 2002

Small, Thin Graphene Oxide Is Anti-inflammatory Activating Nuclear Factor Erythroid 2-Related Factor 2 via Metabolic Reprogramming

scientific article published on 20 November 2018

Streptococcus pneumoniaeworsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα

scientific article published on 14 April 2014

Study design and population pharmacokinetic analysis of a phase II dose-ranging study of interleukin-1 receptor antagonist

scientific article

Surgical manipulation compromises leukocyte mobilization responses and inflammation after experimental cerebral ischemia in mice

scientific article published on January 2013

Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice.

scientific article published on September 2008

Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1- and neutrophil-dependent mechanisms

scientific article

The acute-phase protein PTX3 is an essential mediator of glial scar formation and resolution of brain edema after ischemic injury

scientific article published on 18 December 2013

The dynamics and mechanisms of interleukin-1alpha and beta nuclear import

scientific article published on 7 October 2008

The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial.

scientific article published on 03 January 2014

The expanding interleukin-1 family and its receptors: do alternative IL-1 receptor/signaling pathways exist in the brain?

scientific article

The influence of litter size on brain damage caused by hypoxic-ischemic injury in the neonatal rat.

scientific article published in November 2002

The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce IL-1beta signalling responses

scientific article

The role of inflammation in CNS injury and disease

scientific article

Translational pharmacokinetics: challenges of an emerging approach to drug development in stroke.

scientific article

Up-regulation of IL-18BP, but not IL-18 mRNA in rat liver by LPS

scientific journal article

Variability of the systemic acute phase response after ischemic stroke

scientific article published on 7 November 2006

[18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats

scientific article

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